AOR High Dose R-Lipoic Acid 300mg - Antioxidant & Glucose Support | 60 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 capsule daily (60 per bottle) |
| Licensed Natural Health Product | NPN 80134105 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- The bioactive R-form, not generic alpha-lipoic acid AOR High Dose R-Lipoic Acid provides R(alpha) lipoic acid, sourced from sodium R-(+)-lipoate - the naturally-occurring isomer the body itself produces and uses, rather than a 50/50 R/S racemic blend.
- 300 mg per delayed-release capsule Each capsule provides 300 mg of R-alpha-lipoic acid in a delayed-release format designed to protect this inherently unstable compound and support its absorption.
- Helps promote healthy glucose metabolism Licensed by Health Canada (NPN 80134105) to help promote healthy glucose metabolism.
- A universal, recycling antioxidant R-lipoic acid is a natural cofactor central to mitochondrial energy metabolism and is studied for its role in helping regenerate other antioxidants, including vitamin C, vitamin E and glutathione.
- Simple, once-daily dose Take 1 capsule daily without food - one 60-capsule bottle provides up to a 2-month supply.
- Vegan, Non-GMO, Gluten-free The capsule shell is hypromellose (vegan), with non-GMO sourcing and no gluten-containing ingredients. Contains no wheat, corn, nuts, soy, dairy, egg, fish or shellfish.
- Advanced Orthomolecular Research Made by AOR, a Canadian supplement manufacturer formulating science-based natural health products since 1991.
- Made in Canada Manufactured in Canada to GMP-compliant quality standards.
Product description
AOR High Dose R-Lipoic Acid - The Bioactive R-Form Antioxidant
300 mg of R(alpha) lipoic acid per delayed-release capsule - the naturally-occurring, biologically active form of alpha-lipoic acid (sourced from sodium R-(+)-lipoate), not a generic racemic R/S blend. Licensed by Health Canada to help promote healthy glucose metabolism. Licensed Natural Health Product NPN 80134105.
300 mg d'acide R(alpha)-lipoïque par capsule à libération retardée - la forme naturelle et biologiquement active de l'acide alpha-lipoïque (provenant du R-(+)-lipoate de sodium), et non un mélange racémique R/S générique. Homologué par Santé Canada pour aider à promouvoir un métabolisme sain du glucose.
Why the R-Form Matters
The naturally-occurring isomer your body actually produces and uses - not a 50/50 racemic blend.
Bioactive R-form, not racemic ALA
Most alpha-lipoic acid supplements are a synthetic 50/50 blend of the R- and S-isomers. AOR's High Dose R-Lipoic Acid isolates the R(+)-form specifically, sourced from sodium R-(+)-lipoate, the form the body itself produces and metabolizes.
Delayed-release for stability
Free R-lipoic acid is chemically unstable; AOR delivers it in a delayed-release capsule designed to protect the compound and support its absorption at 300 mg per capsule.
A Universal Antioxidant, Multiple Roles
Research on R-lipoic acid and alpha-lipoic acid spans its role as a mitochondrial cofactor, a regenerator of other antioxidants, and support for healthy glucose metabolism.
Antioxidant Protection
Helps protect cells from oxidative damage caused by free radicals.
Healthy Glucose Metabolism
Licensed by Health Canada to help promote healthy glucose metabolism.
Mitochondrial Energy Support
R-lipoic acid is a natural cofactor in the mitochondrial enzyme complexes that convert nutrients into cellular energy.
Regenerates Other Antioxidants
Studied for its role in helping regenerate vitamin C, vitamin E and glutathione within the body's antioxidant network.
The Bioactive R-Form
Provides the R-isomer your body naturally produces and uses, rather than a racemic R/S blend.
High-Dose, Once Daily
300 mg per delayed-release capsule, taken once daily without food.
AOR High Dose R-Lipoic Acid: Supplement Facts
Medicinal Ingredient (per capsule)
- R(alpha) Lipoic Acid sourced from sodium R-(+)-lipoate300 mg
Non-Medicinal Ingredients: Sodium stearyl fumarate, microcrystalline cellulose. Capsule: hypromellose.
Recommended Use or Purpose: Source of an antioxidant that helps protect cells against free radicals. Helps to promote healthy glucose metabolism.
Recommended Dose (Adults 18 years and older): Take 1 capsule daily without food, or as directed by a qualified health care practitioner. Swallow capsule whole. Do not exceed the daily dose unless instructed by a healthcare practitioner.
Cautions and Warnings: Ask a health care practitioner before use if you are pregnant or breastfeeding. Ask a health care practitioner before use if you have diabetes. Stop use and ask a health care practitioner if you experience sweating, paleness, chills, headache, dizziness and/or confusion, as these may be symptoms of serious low blood sugar.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Ingrédient médicinal (par capsule)
- Acide R(alpha)-lipoïque provenant du R-(+)-lipoate de sodium300 mg
Ingrédients non médicinaux : Fumarate de stéaryle de sodium, cellulose microcristalline. Capsule : hypromellose.
Usage ou fins recommandés : Fournit un antioxydant qui aide à protéger les cellules contre les radicaux libres. Aide à promouvoir un métabolisme sain du glucose.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule par jour, sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Avaler la capsule entière. Ne pas dépasser la dose quotidienne, sauf sur les conseils d'un professionnel de la santé.
Mises en garde et précautions : Si vous êtes enceinte ou si vous allaitez, consulter un praticien de santé avant d'en faire l'usage. Si vous avez le diabète, consulter un praticien de santé avant d'en faire l'usage. Pour les produits fournissant 21 milligrammes ou plus d'acide R-alpha-lipoïque par jour : si vous développez des symptômes tels que de la transpiration, de la pâleur, des frissons, des maux de tête, des étourdissements et/ou de la confusion, cesser l'utilisation et consulter un praticien de santé (car ces symptômes peuvent être causés par un faible taux de sucre dans le sang).
NPN 80134105
Get a high-dose, bioactive R-form antioxidant for glucose metabolism support
Get AOR High Dose R-Lipoic Acid on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR High Dose R-Lipoic Acid
The bioactive R-form, at a meaningful dose, in a delayed-release capsule built for stability.
R-Form, Not Racemic
Sourced from sodium R-(+)-lipoate - the naturally-occurring isomer, not a 50/50 R/S synthetic blend.
300 mg High Dose
A meaningful 300 mg per capsule - at Health Canada's permitted daily maximum for R-alpha-lipoic acid.
Delayed-Release Stability
A delayed-release capsule designed to protect this inherently unstable compound and support absorption.
Clean, Vegan Formula
Vegan, non-GMO and gluten-free, made in Canada in a GMP-compliant facility.
How to use
Take 1 capsule daily
Adults 18 years and older: take 1 capsule daily without food, or as directed by a qualified health care practitioner.
Swallow whole
Swallow the delayed-release capsule whole. Do not exceed the daily dose unless instructed by a healthcare practitioner.
Watch for low blood sugar symptoms
Stop use and consult a health care practitioner if you experience sweating, paleness, chills, headache, dizziness and/or confusion.
What the research says about R-lipoic acid
Educational summaries of published research on R-lipoic acid and alpha-lipoic acid generally; not product-specific claims. AOR High Dose R-Lipoic Acid's claim is the licensed use under NPN 80134105.
A foundational review of lipoic acid as a biological antioxidant
This foundational review describes how lipoic acid and its reduced form, dihydrolipoate, react directly with reactive oxygen species and interact with vitamin C and glutathione, which in turn can help recycle vitamin E.
Foundational ReviewMapping lipoic acid's antioxidant and anti-inflammatory pathways
This review describes lipoic acid's capacity to scavenge free radicals directly and to recycle intracellular glutathione, alongside its broader anti-inflammatory and mitochondrial-support properties.
ReviewHow lipoic acid's antioxidant action may support glucose uptake
This review outlines lipoic acid's antioxidant properties alongside its ability to increase glucose uptake through recruitment of the GLUT-4 glucose transporter, a mechanism shared with insulin-stimulated glucose uptake.
ReviewOral alpha-lipoic acid improved insulin sensitivity in a placebo-controlled pilot trial
In this placebo-controlled pilot trial, 74 patients with type 2 diabetes received 4 weeks of oral alpha-lipoic acid (600-1800 mg/day) or placebo; insulin-stimulated glucose disposal improved significantly more with active treatment.
Human RCTLipoic acid lowered lactate and pyruvate and improved glucose effectiveness
In lean and obese patients with type 2 diabetes, 4 weeks of oral lipoic acid (600 mg twice daily) reduced elevated serum lactate and pyruvate levels after glucose loading and improved glucose effectiveness.
Human Clinical StudyA controlled-release formulation aimed at steadier glycemic support
This study found a controlled-release oral lipoic acid formulation sustained plasma concentrations longer than a quick-release formulation, was well tolerated, and reduced plasma fructosamine over 12 weeks in patients with type 2 diabetes already on standard antidiabetic medications.
Human RCTThe SYDNEY 2 trial: oral alpha-lipoic acid eased neuropathic symptoms
In this multicenter, randomized, double-blind, placebo-controlled trial, 181 diabetic patients with polyneuropathy took oral alpha-lipoic acid (600-1800 mg once daily) for 5 weeks; all active-treatment doses significantly reduced neuropathic symptom scores versus placebo, with 600 mg once daily offering the best risk-to-benefit ratio.
Human RCTALADIN II: a two-year trial on nerve conduction in diabetic polyneuropathy
This two-year, multicenter, randomized, double-blind, placebo-controlled trial (ALADIN II) found oral thioctic acid (alpha-lipoic acid) associated with improvements in several electrophysiological measures of peripheral nerve conduction versus placebo.
Human RCTA critical review of seven controlled trials in diabetic polyneuropathy
This critical review summarizes seven randomized controlled trials of thioctic acid (ALADIN I-III, DEKAN, ORPIL, SYDNEY, NATHAN II) in diabetic polyneuropathy, concluding that short-term intravenous treatment reduces neuropathic symptoms and longer oral treatment tends to reduce neuropathic deficits, with a favorable safety profile across studies.
Critical ReviewOnly the natural R-enantiomer is active at physiological concentrations
Chemoproteomic profiling identified histone deacetylases as molecular targets of reduced lipoic acid, and found that only the naturally-occurring (R)-enantiomer inhibits these targets at physiologically relevant concentrations - the (S)-form does not.
Mechanism StudyWhy the R-form is harder to deliver orally - and how formulators address it
This medicinal chemistry study notes that dietary (R)-alpha-lipoic acid has poor oral bioavailability due to low gastric stability, and describes prodrug approaches designed to protect the R-form until it reaches the bloodstream.
Pharmaceutical Chemistry StudyA stabilized sodium R-lipoate form studied for neuroprotective effects
This study used Sodium R-Lipoate (NaRLA) - described as a modified form of lipoic acid with improved stability and efficacy - alongside another compound in a rodent model, reporting reduced neuroinflammation and improved motor outcomes.
Preclinical StudyA rare hypoglycemia-related syndrome reported with alpha-lipoic acid
This case report describes a patient with type 2 diabetes who developed recurrent insulin autoimmune syndrome (a rare cause of low blood sugar) after taking alpha-lipoic acid, underscoring why product labels warn to stop use and seek care if symptoms of low blood sugar occur.
Case ReportInsulin autoimmune syndrome cases in Caucasian patients taking lipoic acid
This case series reports six Caucasian patients who developed insulin autoimmune syndrome (Hirata disease) after taking lipoic acid (600 mg/day), with hypoglycemic symptoms resolving after discontinuation - part of the evidence behind the mandatory low-blood-sugar warning on higher-dose lipoic acid products.
Case SeriesAlpha-lipoic acid was safe and well tolerated in a head-and-neck cancer RCT
In this randomized controlled trial, 70 head-and-neck cancer patients received oral alpha-lipoic acid (600 mg twice daily) or placebo during radiotherapy; ALA use was reported as safe and tolerable while reducing the severity of radiation-induced oral mucositis.
Human RCTComparing lipoic acid and vitamin E head-to-head on oxidative stress markers
In healthy adults, 2 months of oral lipoic acid (600 mg/day) reduced markers of oxidative stress (urinary F2-isoprostanes, LDL oxidizability) similarly to alpha-tocopherol supplementation, though combining both did not add further benefit beyond either alone.
Human RCTAn antioxidant blend including lipoic acid improved vascular function in COPD
In a randomized, double-blind, placebo-controlled crossover trial, an oral antioxidant cocktail (vitamin C, vitamin E and alpha-lipoic acid) improved blood-vessel flow-mediated dilation in patients with chronic obstructive pulmonary disease, a population with lower baseline antioxidant levels.
Human RCTAn honest null result: an antioxidant combination did not slow cognitive decline
In a 2-year randomized, placebo-controlled trial in adults with Down syndrome and dementia, a combination of vitamin E, vitamin C and alpha-lipoic acid was safe and well tolerated but did not improve or stabilize cognitive function versus placebo - a reminder that antioxidant research findings vary by condition and population.
Human RCT(R)-lipoic acid's structural role as a central metabolic cofactor
X-ray crystallography research describes (R)-lipoic acid as an essential cofactor in central carbon metabolism, where it catalyzes the generation of acetyl-CoA and succinyl-CoA, linking glycolysis to the tricarboxylic acid (Krebs) cycle.
Structural Biology StudyWhy the lipoic acid cofactor matters to human mitochondrial enzymes
This study of human dihydrolipoamide dehydrogenase - part of the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase enzyme complexes - shows how the lipoic acid cofactor these complexes depend on can be damaged under oxidative stress, affecting cellular respiration.
Mechanism StudyMapping how cells build lipoic acid from scratch
This study describes lipoic acid's natural biosynthesis pathway, built onto the E2 subunit of the pyruvate dehydrogenase enzyme complex - foundational biochemistry underlying lipoic acid's role as a cofactor in every cell that uses it.
Biochemistry StudyLipoic acid plus CoQ10 activated a master regulator of energy metabolism
In cultured skeletal muscle cells, a combination of alpha-lipoic acid and coenzyme Q10 increased nuclear levels of PGC-1alpha - a master switch of mitochondrial energy metabolism and biogenesis - alongside a four-fold increase in cellular glutathione.
Cell StudyRestoring mitochondrial function and ATP production under cellular stress
In vascular cells under calcifying stress, alpha-lipoic acid reversed reductions in mitochondrial membrane potential and ATP production, restored mitochondrial structural integrity, and reduced markers of mitochondria-driven cell death.
Cell & Animal StudyA broader look at lipoic acid's role in mitochondrial and neurological health
This review surveys clinical and mechanistic research on alpha-lipoic acid's modulation of oxidative stress, mitochondrial dysfunction and neuro-inflammation across psychiatric and neurological conditions.
ReviewFrequently asked questions
What is AOR High Dose R-Lipoic Acid used for?
It is a Health Canada licensed natural health product (NPN 80134105) that provides R(alpha) lipoic acid to help promote healthy glucose metabolism and to help protect cells against free-radical damage.
What's the difference between R-lipoic acid and regular alpha-lipoic acid?
Most alpha-lipoic acid supplements contain a 50/50 synthetic blend of the R- and S-isomers. This product isolates the R(+)-form specifically (sourced from sodium R-(+)-lipoate) - the form your body naturally produces and uses.
How much R-lipoic acid does each capsule provide?
300 mg of R(alpha) lipoic acid per delayed-release capsule - the only medicinal ingredient in the formula.
How do I take it?
Take 1 capsule daily without food, or as directed by a qualified health care practitioner. Swallow the capsule whole; do not exceed the daily dose.
Why is it a delayed-release capsule?
R-lipoic acid is chemically unstable in its free form. AOR uses a delayed-release capsule to help protect the compound and support its absorption.
Who should not take this product?
Ask a health care practitioner before use if you are pregnant or breastfeeding, or if you have diabetes. Stop use and consult a health care practitioner if you experience sweating, paleness, chills, headache, dizziness and/or confusion, as these may be symptoms of serious low blood sugar.
Is it vegan?
Yes. The capsule shell is hypromellose (vegan), and the formula is non-GMO and gluten-free, with no wheat, corn, nuts, soy, dairy, egg, fish or shellfish.
How long does one bottle last?
Each bottle contains 60 delayed-release capsules - up to a 2-month supply at the recommended dose of 1 capsule daily.
Get a high-dose, bioactive R-form antioxidant for glucose metabolism support
Get AOR High Dose R-Lipoic Acid on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80134105. High Dose R-Lipoic Acid provides R(alpha) lipoic acid (sourced from sodium R-(+)-lipoate) 300 mg per delayed-release capsule to help promote healthy glucose metabolism and provide antioxidant support. The research summaries below concern R-lipoic acid and alpha-lipoic acid generally and are educational - they are not claims about this finished product. Read and follow the label. Ask a health care practitioner before use if you are pregnant or breastfeeding, or if you have diabetes. Stop use and ask a health care practitioner if you experience sweating, paleness, chills, headache, dizziness and/or confusion, as these may be symptoms of serious low blood sugar. Results may vary.
Important information
Safety Information
Cautions and Warnings: Ask a health care practitioner before use if you are pregnant or breastfeeding. Ask a health care practitioner before use if you have diabetes. Stop use and ask a health care practitioner if you experience sweating, paleness, chills, headache, dizziness and/or confusion, as these may be symptoms of serious low blood sugar.
Indications
Recommended Use or Purpose: Source of an antioxidant that helps protect cells against free radicals. Helps to promote healthy glucose metabolism.
Ingredients
Medicinal Ingredient (per capsule): R(alpha) lipoic acid (sourced from sodium R-(+)-lipoate) 300 mg. Non-medicinal Ingredients: Sodium stearyl fumarate, microcrystalline cellulose. Capsule: hypromellose. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule daily without food, or as directed by a qualified health care practitioner. Swallow capsule whole. Do not exceed the daily dose unless instructed by a healthcare practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.