AOR P.E.A.K Activate 400mg - Micronized PEA for Chronic Pain | 90-180 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 vegan capsule |
| Licensed Natural Health Product | NPN 80090272 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- TRANSPARENT, SINGLE-INGREDIENT DOSING: Every capsule delivers a precise 400 mg of palmitoylethanolamide (PEA) - no proprietary blends or fillers, so you always know exactly what you're taking.
- GENUINE ITALIAN-SOURCED, MICRONIZED PEA: AOR uses micronized PEA from a genuine Italian source - reducing particle size is a recognized approach for improving PEA's naturally limited oral absorption.
- STUDIED FOR CHRONIC PAIN RELIEF: The authorized use of this product: studies show PEA may be used as an anti-inflammatory to help relieve chronic pain.
- SUPPORTS JOINT COMFORT & MOBILITY: PEA has been studied for its role in supporting joint comfort and mobility, particularly where the body's own PEA signaling may be reduced.
- VEGAN-FRIENDLY FORMULA: Capsules use a vegan hypromellose shell, so they fit plant-based routines without compromising the formula.
- NON-GMO & GLUTEN-FREE: Formulated without genetically modified ingredients and free from gluten, for a clean-label supplement you can verify on the package.
- PRECISE, FLEXIBLE DOSING SCHEDULE: Take 1 capsule three times daily with or without food - an even, predictable dosing rhythm across the day.
Product Description
P.E.A.K Activate - Palmitoylethanolamide (PEA) 400 mg
A single-ingredient, 400 mg dose of palmitoylethanolamide (PEA) in a vegan capsule - the body's own fatty-acid signaling molecule, studied as an anti-inflammatory to help relieve chronic pain. Genuine Italian-sourced, micronized PEA, with no unnecessary fillers. Licensed Natural Health Product NPN 80090272.
Une dose à ingrédient unique de 400 mg de palmitoyléthanolamide (P.E.A) dans une capsule végane - la propre molécule de signalisation lipidique du corps, étudiée comme anti-inflammatoire pour aider à soulager la douleur chronique. P.E.A micronisé, de source italienne authentique. Produit de santé naturel homologué. NPN 80090272.
400 mg Micronized PEA, Genuine Italian Source
Single-ingredient, vegan, non-GMO, gluten-free - built for precise, transparent dosing
Exact, Transparent Dosing
Each capsule delivers a precise 400 mg of palmitoylethanolamide - no proprietary blends, so you always know exactly what you're taking.
Micronized for Absorption
AOR uses genuine Italian-sourced, micronized PEA - particle-size reduction is a recognized approach to improving PEA's naturally low oral bioavailability.
Why People Take PEA
Research on palmitoylethanolamide spans joint comfort, nerve-related discomfort, exercise recovery and the body's broader anti-inflammatory response.
Joint Comfort & Mobility
Studied for supporting comfort and mobility in aging or stressed joints, where natural PEA signaling can run low.
Chronic & Nerve-Related Discomfort
The authorized use for this product: studies show PEA may be used as an anti-inflammatory to help relieve chronic pain.
Active Lifestyle & Recovery
Explored by athletes and active adults as a non-NSAID option to support recovery from training stress.
The Body's Own Lipid Signal
PEA is produced naturally in the body on demand at sites of stress, acting through the same lipid-signaling pathways researchers continue to study.
AOR P.E.A.K Activate: Supplement Facts
Each capsule contains:
- Palmitoylethanolamide (P.E.A)* *Micronized; genuine Italian source400 mg
Non-Medicinal Ingredients: Microcrystalline cellulose. Capsule: Hypromellose.
Recommended Use or Purpose: Studies show that palmitoylethanolamide (PEA) may be used as an anti-inflammatory to help relieve chronic pain.
Recommended Dose (Adults 19 years and older): Take 1 capsule three times daily with or without food, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules; swallow whole. Do not exceed the daily dose unless directed by a health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 40 days, or if symptoms persist or worsen.
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms persist or worsen, or for use beyond 40 days. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place, away from children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.
Chaque capsule contient :
- Palmitoyléthanolamide (P.E.A)* *Micronisé; source italienne authentique400 mg
Ingrédients non médicinaux : Cellulose microcristalline. Capsule : Hypromellose.
Usage ou fins recommandés : Des études démontrent que le palmitoyléthanolamide (P.E.A) peut être utilisé comme anti-inflammatoire pour aider à soulager la douleur chronique.
Dose recommandée (adultes de 19 ans et plus) : Prendre 1 capsule trois fois par jour avec ou sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas écraser, mélanger ou briser les capsules; avaler les capsules entières. Ne pas dépasser la dose quotidienne sauf indication contraire d'un professionnel de la santé. Durée d'utilisation recommandée : Consulter un professionnel de la santé si l'utilisation se prolonge au-delà de 40 jours ou si les symptômes persistent ou s'aggravent.
Mises en garde : Consulter un professionnel de la santé avant utilisation si vous êtes enceinte ou si vous allaitez. Consulter un professionnel de la santé si les symptômes persistent ou s'aggravent, ou si l'utilisation se prolonge au-delà de 40 jours. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec, hors de la portée des enfants.
NPN 80090272
Support your body's response to chronic pain, the transparent way
Get AOR P.E.A.K Activate on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR P.E.A.K Activate
A precise, single-ingredient PEA capsule from a trusted Canadian formulator.
Single-ingredient purity
Just 400 mg of palmitoylethanolamide per capsule - no proprietary blends to guess at.
Genuine Italian-sourced PEA
Made with micronized PEA from a genuine Italian source, an approach linked to improved absorption.
Backed by a real Health Canada claim
Studies show PEA may be used as an anti-inflammatory to help relieve chronic pain - the authorized use under NPN 80090272.
Premium Canadian brand
AOR - Advanced Orthomolecular Research, Calgary AB, since 1991.
How to use it
1 capsule, 3 times daily
Adults (19 years and older) take 1 capsule three times daily with or without food, or as directed by a qualified health care practitioner.
Swallow whole
Do not crush, blend or mix the capsules - swallow them whole, and do not exceed the daily dose unless directed by a practitioner.
Guided use beyond 40 days
Consult a health care practitioner for use beyond 40 days, or if symptoms persist or worsen.
What the research says about palmitoylethanolamide (PEA)
Educational summaries of published research on PEA; not product-specific claims. AOR P.E.A.K Activate's authorized claim is the statement licensed under NPN 80090272: studies show PEA may be used as an anti-inflammatory to help relieve chronic pain.
PEA levels drop in osteoarthritic joints
In osteoarthritis, mast cells drive joint inflammation and cartilage breakdown; a review notes the body's own natural PEA signaling is measurably reduced in these joints, a key reason researchers study restoring it.
ReviewPEA reduced short-term joint pain in a treatment comparison
A network meta-analysis of 23 randomized trials for painful jaw-joint (TMJ) osteoarthritis found palmitoylethanolamide produced statistically significant short-term pain reductions.
Systematic reviewA candidate for easing joint-related inflammation
Reviewed for its neuroprotective, anti-neuroinflammatory and analgesic actions, ultramicronized PEA is highlighted as a targeted strategy for the low-grade inflammation behind degenerative joint conditions like osteoarthritis.
ReviewPain scores dropped within days in a sciatica pilot trial
In a pilot trial of adults with chronic sciatica-related low back pain, a PEA-containing supplement reduced average pain scores from 5.1 to 1.7 (on a 0-10 scale) over four weeks, with neuropathic pain descriptors improving too.
Pilot clinical trialA reanalysis found a striking number-needed-to-treat
Reanalyzing a controlled trial of micronized PEA (600 mg/day) for low back pain with sciatica, researchers calculated a number-needed-to-treat of just 1.7 for pain relief versus placebo, with the benefit strongest in patients with more neuropathic features.
Post-hoc analysisEased diabetic nerve pain alongside better sleep and mood
In a placebo-controlled trial, adults with diabetes-related peripheral neuropathic pain who took PEA for 8 weeks saw significant reductions in pain, improved sleep quality, better mood scores, and lower inflammatory markers (IL-6, CRP).
Human RCTLower lactate and muscle-damage markers after exercise
In a placebo-controlled trial, healthy men who took PEA before a muscle-damaging leg-press session showed lower blood lactate and myoglobin (a muscle-damage marker) during recovery than the placebo group.
Human RCTNot every recovery study shows a benefit
A double-blind crossover trial found PEA supplementation (350 mg) did not significantly improve muscle soreness, strength or jump performance after a single bout of muscle-damaging eccentric exercise - a reminder that results vary by protocol and dose.
Human RCTTesting whether PEA supports training without blunting gains
Unlike NSAIDs, which can inhibit signaling pathways involved in muscle adaptation, PEA works through different mechanisms; researchers designed an 11-week resistance-training trial to see whether it can support recovery and sleep without interfering with strength and hypertrophy gains.
Trial protocolIdentifying the receptor behind PEA's effects
This landmark paper identified PPAR-alpha, a receptor that regulates inflammatory gene activity, as the molecular target through which PEA exerts its anti-inflammatory action - solving a long-standing puzzle about how PEA works.
MechanismA lipid messenger with more than one target
PEA's anti-inflammatory and analgesic effects are attributed mainly to activation of the PPAR-alpha receptor, with additional pathways (TRPV1, GPR55) also contributing - helping explain its wide-ranging effects in the body.
ReviewA dual anti-inflammatory and nerve-protective pathway
PEA activates PPAR-alpha to dial down NF-kB, a master switch for inflammatory cytokines, while also calming overactive mast cells and glial cells - a mechanism reviewed as supporting both pain relief and neuroprotection.
ReviewA well-tolerated nutrient with a broad safety record
A narrative review describes PEA as showing high tolerability and safety in both animal and human studies, across a wide range of anti-inflammatory, antimicrobial and pain-related applications.
ReviewWell tolerated even at a higher daily dose
In an 8-week randomized trial using 600 mg of PEA twice daily (1200 mg total), safety assessments showed no significant difference in side effects compared with placebo.
Human RCTDecades of preclinical and clinical safety data
A pharmacology review covering ultramicronized PEA across numerous preclinical and clinical studies concludes it is well tolerated, and notes it may help limit certain opioid side effects, including the development of tolerance, when used as an add-on.
ReviewOutperformed an NSAID in a head-to-head trial
In a randomized trial for jaw-joint (TMJ) osteoarthritis pain, PEA produced a significantly greater pain reduction and improvement in mouth opening than ibuprofen over two weeks.
Comparative RCTMapping how PEA compares with standard pain care
This review protocol set out to systematically catalogue clinical studies comparing PEA, alone or alongside standard treatment, against usual pain-management guidelines across a range of chronic pain conditions.
Review protocolThe body's own PEA signal differs in chronic pain
A case-control study found significantly higher circulating PEA (and the related lipid OEA) in women with chronic widespread pain compared to healthy controls, consistent with PEA's proposed role in the body's natural anti-inflammatory response.
Case-control studySix decades of PEA research, from discovery to mechanism
This history traces PEA from its 1950s discovery as an anti-inflammatory compound, through recognition of its analgesic properties in the 1970s, to its emergence as a nutraceutical once its PPAR-alpha mechanism was identified.
Historical reviewThe 'parent' of a family of protective lipid compounds
PEA is described as the founding member of the ALIAmide family - lipid compounds the body produces on demand at the site of stress or injury to help control immune and inflammatory responses and support a return to balance.
ReviewA field built on foundational lipid-signaling research
This collection surveys decades of research into PEA and related ALIAmides, chronicling how foundational biochemistry work shaped today's understanding of the body's natural lipid-signaling response to injury and inflammation.
Review collectionFormulation changes how much PEA the body absorbs
A phospholipid-based PEA formulation increased solubility roughly eight-fold and produced higher blood concentrations than plain PEA, translating into significant pain and quality-of-life improvements in a placebo-controlled trial for chronic neuropathic low back pain.
Human RCTA tapered daily dose for chronic pain
A clinical trial of a 600 mg PEA supplement using a tapering regimen (a higher dose for two weeks, then a lower daily maintenance dose) reported significant reductions in pain intensity and meaningful quality-of-life gains over eight weeks.
Clinical trialDose-response data on PEA's pain-relieving potency
In dose-response testing in a neuropathic pain model, PEA was approximately five to eight times more potent than tramadol at reducing pain hypersensitivity, and low doses of each enhanced the other's effect when combined.
Preclinical studyFrequently asked questions
How do I take AOR P.E.A.K Activate?
Adults (19 years and older) take 1 capsule three times daily with or without food, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules; swallow them whole.
What's actually in the capsule?
Just one medicinal ingredient: 400 mg of micronized palmitoylethanolamide (P.E.A) from a genuine Italian source, in a vegan hypromellose capsule with microcrystalline cellulose as the only non-medicinal ingredient.
How is this different from AOR P.E.A.K Pain Relief?
P.E.A.K Activate is a single-ingredient, 400 mg PEA formula under its own NPN. AOR's P.E.A.K Pain Relief is a different, separately licensed product that combines PEA with four additional ingredients (Univestin, Boswellia, quercetin and magnesium glycinate) under its own separate NPN and its own dose. Choose Activate for straightforward, single-ingredient PEA dosing - the two products are not interchangeable, and each follows its own label.
What's the difference between the 90-capsule and 180-capsule bottles?
Both are the identical 400 mg PEA formula under NPN 80090272 - the 90-capsule bottle is a 30-day supply, and the 180-capsule bottle is a 60-day supply, at the same 1-capsule-three-times-daily dose.
Is it vegan and allergen-friendly?
Yes - the capsules are vegan, non-GMO and gluten-free.
How long can I take it?
Consult a health care practitioner for use beyond 40 days, or if symptoms persist or worsen.
Who should not take this?
Consult a health care practitioner before use if you are pregnant or breastfeeding, and do not use if the safety seal is broken.
Why micronized PEA?
Reducing PEA's particle size (micronization) is a recognized way to increase its surface area and improve its naturally low oral absorption; AOR sources genuine Italian micronized PEA for this formula.
Support your body's response to chronic pain, the transparent way
Get AOR P.E.A.K Activate on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80090272. Studies show that palmitoylethanolamide (PEA) may be used as an anti-inflammatory to help relieve chronic pain. The research summaries below concern palmitoylethanolamide generally and are educational - they are not claims about this finished product beyond its authorized use. Read and follow the label. Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if symptoms persist or worsen, or for use beyond 40 days. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms persist or worsen, or for use beyond 40 days. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place, away from children.
Indications
Recommended Use or Purpose: Studies show that palmitoylethanolamide (PEA) may be used as an anti-inflammatory to help relieve chronic pain.
Ingredients
Medicinal Ingredient (per capsule): Palmitoylethanolamide (P.E.A)* 400 mg. *Micronized; genuine Italian source. Non-medicinal ingredients: Microcrystalline cellulose. Capsule: Hypromellose.
Directions
Recommended Dose (Adults 19 years and older): Take 1 capsule three times daily with or without food, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules; swallow whole. Do not exceed the daily dose unless directed by a health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 40 days, or if symptoms persist or worsen.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.