AOR Ortho Sleep 443mg - GABA Theanine 5-HTP Melatonin Herbal Formula | 60-120 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1-2 capsules before bedtime |
| Licensed Natural Health Product | NPN 80028811 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- SEVEN REAL ACTIVES IN ONE FORMULA: AOR Ortho Sleep combines GABA, L-theanine, 5-HTP, melatonin, valerian root, passionflower and lemon balm (Cyracos) - 443 mg of medicinal ingredients per capsule.
- HELPS INCREASE TOTAL SLEEP TIME: Licensed under Health Canada NPN 80028811 to help increase total sleep time in people suffering from sleep restriction or an altered sleep schedule, such as shift-work or jet lag.
- HELPS REDUCE TIME TO FALL ASLEEP: Also authorized to help reduce the time it takes to fall asleep in people with delayed sleep phase disorder.
- MELATONIN FOR THE SLEEP-WAKE CYCLE: 1.5 mg of melatonin per capsule helps signal nighttime to the body's internal clock, alongside 3 mg at the maximum 2-capsule dose.
- GABA, L-THEANINE AND 5-HTP FOR CALM: The amino acids GABA, L-theanine and 5-HTP (from griffonia seed) are included alongside the herbal actives to support a relaxed transition into sleep.
- TRADITIONAL HERBAL SLEEP SUPPORT: Valerian root, passionflower and lemon balm (Cyracos-brand extract) are traditionally used in Herbal Medicine as sleep aids and calming agents.
- FLEXIBLE 1-2 CAPSULE DOSING: Take 1 to 2 capsules before bedtime, with or without food, to fit your own routine.
- VEGAN, NON-GMO, GLUTEN-FREE: Made in Canada by Advanced Orthomolecular Research (AOR) in a GMP-compliant facility, licensed under Health Canada NPN 80028811.
Product Description
Seven Real Actives for a Complete Sleep Formula
AOR Ortho Sleep 443 mg combines GABA, L-theanine, 5-HTP, melatonin, valerian root, passionflower and lemon balm (Cyracos) in one capsule - made in Canada under Health Canada NPN 80028811. Licensed Natural Health Product NPN 80028811.
Why AOR Ortho Sleep
A multi-nutrient sleep formula - not just melatonin alone.
7 Actives in One Capsule
GABA, L-theanine, 5-HTP, melatonin, valerian root, passionflower and lemon balm work together across sleep onset, duration and relaxation, instead of relying on a single ingredient.
Flexible 1-2 Capsule Dosing
Take 1 to 2 vegan-friendly capsules before bedtime, with or without food, or as directed by a qualified health care practitioner.
Advanced Ingredients, Superior Results
A closer look at what each of the 7 actives contributes to a night's rest.
GABA (Gamma-Aminobutyric Acid)
The brain's primary inhibitory neurotransmitter, included at a dose studied for supporting relaxation and calm brain-wave activity.
50 mg per capsuleL-Theanine
An amino acid from tea leaves studied for promoting calm, relaxation-linked brain activity without next-day drowsiness.
100 mg per capsuleL-5-Hydroxytryptophan (5-HTP)
A direct precursor the body converts into serotonin, supporting the same serotonin pathway involved in sleep regulation.
50 mg per capsule, from griffonia seedMelatonin
The hormone that signals nighttime to the body's internal clock, helping regulate the sleep-wake cycle.
1.5 mg per capsule
Valerian Root Extract
A traditional herbal sleep aid used in Herbal Medicine to help promote sleep and ease nervous tension.
75 mg per capsule (Valeriana officinalis, 3-6:1)Passionflower Extract
A flowering herb traditionally used to help ease anxiety and support relaxation before sleep.
16 mg per capsule (Passiflora incarnata, 3.5-7:1)Lemon Balm Extract (Cyracos)
A standardized lemon balm extract studied for supporting relaxation, mood and sleep quality.
150 mg per capsule (Melissa officinalis, 5-8:1)AOR Ortho Sleep: Supplement Facts
Each capsule contains:
- GABA (gamma-aminobutyric acid)50 mg
- L-Theanine100 mg
- L-5-Hydroxytryptophan (from griffonia seed)50 mg
- Melatonin1.5 mg
- Valerian root extract (Valeriana officinalis, 3-6:1)75 mg
- Passionflower extract (Passiflora incarnata, 3.5-7:1)16 mg
- Lemon balm extract (Melissa officinalis, 5-8:1)150 mg
Non-Medicinal Ingredients: Maltodextrin (corn), gum arabic, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose, sodium copper chlorophyllin.
Recommended Use or Purpose: Traditionally used in Herbal Medicine as a sleep aid. Helps increase the total sleep time in people suffering from sleep restriction or altered sleep schedule, e.g. shift-work and jet lag. Helps to reduce the time it takes to fall asleep in people with delayed sleep phase disorder.
Recommended Dose (Adults 18 years and older): Take 1 to 2 capsules before bedtime, with or without food, or as directed by a qualified health care practitioner. Do not blend, mix or crush capsules; swallow capsules whole. Do not exceed the recommended dose unless directed by a health care practitioner. Consult a health care practitioner for use beyond 3 weeks.
Cautions and Warnings: This product contains corn allergens. Do not use if you are pregnant, nursing or trying to conceive, or if you have scleroderma. Do not drive or use machinery for 5 hours after taking this product. Avoid alcohol or other products that may cause drowsiness while using this product. Consult a health care practitioner before use if you have asthma, cardiovascular disease, immune system disease, a hormonal disorder, diabetes or hypoglycemia, liver or chronic kidney disease, cerebral palsy, a seizure disorder, migraine, depression and/or hypertension, or if you are taking sedative, hypnotic or psychotropic medications, blood pressure medication, an anticoagulant, an anticonvulsant, immunosuppressive medications or steroids. Consult a health care practitioner before use if you are taking carbidopa or any drug or health product with serotonergic activity, including L-tryptophan, S-adenosylmethionine (SAMe), St. John's Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, or anti-nausea or anti-migraine medication. Consult a health care practitioner if sleeplessness persists continuously for more than 3 weeks (chronic insomnia), or if symptoms persist or worsen. Stop use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain, or if you experience skin changes. Known adverse reactions: some people may experience drowsiness; mild gastrointestinal symptoms (e.g. nausea, vomiting or cramping) and hypersensitivity/allergic reactions have also been reported.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. Manufactured by Advanced Orthomolecular Research (AOR), Calgary, Alberta. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- GABA (acide gamma-aminobutyrique)50 mg
- L-Théanine100 mg
- L-5-Hydroxytryptophane (de graines de griffonia)50 mg
- Mélatonine1.5 mg
- Extrait de racine de valériane (Valeriana officinalis, 3-6:1)75 mg
- Extrait de passiflore (Passiflora incarnata, 3,5-7:1)16 mg
- Extrait de mélisse (Melissa officinalis, 5-8:1)150 mg
Ingrédients non médicinaux : Maltodextrine (maïs), gomme arabique, dioxyde de silicium, stéarylfumarate de sodium. Capsule : hypromellose, chlorophylline cuprique sodique.
Usage ou fins recommandés : Utilisé traditionnellement en phytothérapie comme aide-sommeil. Aide à augmenter la durée totale de sommeil chez les personnes souffrant de restriction de sommeil ou d'un horaire de sommeil modifié, par exemple le travail par quarts et le décalage horaire. Aide à réduire le temps nécessaire pour s'endormir chez les personnes ayant un syndrome de phase de sommeil retardée.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 à 2 capsules avant le coucher, avec ou sans nourriture, ou selon les recommandations d'un praticien de soins de santé qualifié. Ne pas écraser, mélanger ou broyer les capsules; avaler les capsules entières. Ne pas dépasser la dose recommandée sauf sur indication d'un praticien de soins de santé. Consulter un praticien de soins de santé pour un usage de plus de 3 semaines.
Mises en garde et précautions : Ce produit contient des allergènes de maïs. Ne pas utiliser si vous êtes enceinte, si vous allaitez ou prévoyez le devenir, ou si vous avez la sclérodermie. Ne pas conduire ou utiliser de la machinerie pendant les 5 heures suivant la prise de ce produit. Évitez de consommer de l'alcool ou tout autre produit pouvant causer de la somnolence lorsque vous utilisez ce produit. Consultez un praticien de soins de santé avant l'utilisation si vous souffrez d'asthme, d'une maladie cardiovasculaire, d'une maladie du système immunitaire, d'un trouble hormonal, de diabète ou d'hypoglycémie, d'une maladie du foie ou d'une maladie rénale chronique, de paralysie cérébrale, d'un trouble convulsif, de migraine, de dépression et/ou d'hypertension, ou si vous prenez des médicaments sédatifs, hypnotiques ou psychotropes, des médicaments pour la tension artérielle, un anticoagulant, un anticonvulsivant, des médicaments immunosuppresseurs ou des stéroïdes. Consultez un praticien de soins de santé avant l'utilisation si vous prenez du carbidopa ou tout autre produit de santé à activité sérotoninergique, y compris le L-tryptophane, la S-adénosylméthionine (SAMe), le millepertuis, des antidépresseurs, des analgésiques, des médicaments contre la toux ou le rhume contenant du dextrométhorphane, ou des médicaments contre les nausées ou la migraine. Consultez un praticien de soins de santé si l'insomnie persiste continuellement pendant plus de 3 semaines (insomnie chronique), ou si les symptômes persistent ou s'aggravent. Cessez l'utilisation et consultez un praticien de soins de santé si vous présentez des signes de faiblesse, des ulcères buccaux, ou des douleurs abdominales accompagnées de douleurs musculaires sévères, ou si vous présentez des changements cutanés. Réactions indésirables connues : certaines personnes peuvent ressentir de la somnolence; des symptômes gastro-intestinaux légers (par ex. nausées, vomissements ou crampes) et de l'hypersensibilité/des réactions allergiques ont aussi été signalés.
NPN 80028811
Support a complete night's rest with 7 real sleep-support actives
Get AOR Ortho Sleep on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy People Choose AOR Ortho Sleep
A multi-ingredient formula built around real, studied sleep-support actives.
Complete Sleep Formula
Combines melatonin, amino acids (GABA, L-theanine, 5-HTP) and herbal extracts (valerian, passionflower, lemon balm) in one capsule.
Real, Licensed Claims
Health Canada NPN 80028811 authorizes real claims: helps increase total sleep time and helps reduce the time it takes to fall asleep.
Flexible Dosing
1 to 2 capsules before bedtime lets you find the amount that works for your own routine.
Trusted Canadian Manufacturing
Made in Canada by Advanced Orthomolecular Research (AOR), a science-based supplement brand since 1991.
Inside every capsule
443 mg of medicinal ingredients per capsule - GABA, L-theanine, 5-HTP, melatonin, valerian root, passionflower and lemon balm (Cyracos), in one complete sleep formula.
How to Use
Take before bedtime
Adults 18 years and older: take 1 to 2 capsules before bedtime, with or without food, or as directed by a qualified health care practitioner.
Swallow whole
Do not blend, mix or crush the capsules - swallow them whole.
Keep to short-term use
Consult a health care practitioner for use beyond 3 weeks, or if sleeplessness persists or symptoms worsen.
What the Research Says About Ortho Sleep's 7 Ingredients
Peer-reviewed studies on GABA, L-theanine, 5-HTP, melatonin, valerian root, passionflower and lemon balm - shared for education, not as claims about this finished product. AOR Ortho Sleep's own claims are the statements authorized under its Natural Health Product licence, NPN 80028811.
Alpha brain waves rose within an hour
In a human study, orally administered GABA significantly increased alpha-wave and decreased beta-wave brain activity within about 60 minutes, alongside higher salivary IgA during a stressful task - a pattern consistent with relaxation and reduced anxiety.
Human studyA 28-day trial saw calmer brain-wave patterns
Daily consumption of GABA-fortified oolong tea for 28 days was associated with increases in relaxation-linked alpha brain waves and improved quality-of-life scores in adult participants.
Human studyPaired with L-theanine, sleep latency dropped
A GABA and L-theanine mixture decreased the time it took to fall asleep and increased non-REM sleep duration compared with either ingredient alone in an animal model.
Animal studyA systematic review of 13 human trials
Across 13 trials in 550 people, supplementing with 200-450 mg per day of L-theanine was associated with benefits for sleep latency, maintenance, efficiency and perceived sleep satisfaction.
Systematic review200 mg before bed, without sedation
A review of L-theanine's mechanism and clinical evidence concluded that around 200 mg taken before bed can support sleep quality through anxiolysis rather than sedation, without inducing next-day drowsiness.
ReviewBlunting caffeine's effect on sleep
In a crossover trial in healthy young women, L-theanine suppressed the caffeine-induced increase in wake-after-sleep-onset time, helping preserve sleep quality when caffeine was also consumed that day.
Human RCTThe chronobiotic basis for jet lag and shift-work claims
A pharmacology review explains how exogenous melatonin's chronobiotic activity - shifting the body's internal clock depending on timing - is the pharmacological basis for its use in jet lag, shift-work misalignment and delayed sleep phase syndrome.
ReviewA 28-day trial confirmed better sleep efficiency
In a randomized, double-blind, placebo-controlled trial, adults with poor sleep quality taking a 2 mg sustained-release melatonin capsule nightly for 28 days showed significantly improved polysomnography-confirmed sleep efficiency, shorter sleep-onset latency and less wake-after-sleep-onset versus placebo.
Human RCTShift-work is a recognized driver of circadian disruption
A systematic review of healthcare workers found night-shift work was consistently linked to greater circadian misalignment and suppressed melatonin secretion, and noted melatonin supplementation among the strategies studied to help mitigate that disruption.
Systematic reviewA meta-analysis pooling 60 studies
A systematic review and meta-analysis pooling 60 studies found valerian root improved subjective sleep quality and reduced anxiety, with no severe adverse events reported across the studies analyzed.
Systematic reviewBetter sleep quality after a real-world surgical stay
In a triple-blind randomized trial, patients given 530 mg of valerian root extract nightly for 30 nights after cardiac bypass surgery showed significantly better sleep quality, latency, duration and efficiency than those given placebo.
Human RCTModest but real, and well tolerated
An evidence review of valerian for anxiety and sleep disorders concluded the data for insomnia, while limited by study quality, suggest some benefit for mild to moderate insomnia, and that valerian itself is well tolerated with infrequent, benign side effects.
Evidence reviewA review of 9 clinical trials on anxiety
A systematic review of 9 clinical trials found Passiflora incarnata preparations reduced anxiety levels in most studies, with no adverse effects on memory or psychometric performance observed.
Systematic reviewSleep-inducing effects tied to GABA receptors and melatonin
In a rodent study, Passiflora incarnata leaf-and-fruit extract increased sleep time and altered GABA receptor mRNA expression, and was also associated with higher blood melatonin levels after dosing.
Animal studyThe species behind the calming reputation
A comparative pharmacology study of five Passiflora species used Passiflora incarnata - the species in this formula - as the anxiolytic benchmark against which the other species' calming effects were measured.
Animal studyA double-blind trial cut insomnia severity scores
In a double-blind, placebo-controlled crossover trial, a standardized lemon balm (Melissa officinalis) extract significantly reduced Insomnia Severity Index scores and increased slow-wave sleep compared with placebo.
Human RCTA dose-dependent benefit over 3 weeks
Adults with poor sleep quality or emotional distress taking a lemon balm phospholipid complex for 3 weeks saw significant improvements in Pittsburgh Sleep Quality Index scores, with the larger, 400 mg/day dose producing greater and earlier benefit than the lower dose.
Human studyA calming reputation with a mechanistic explanation
A review of lemon balm's clinical evidence describes how it modulates GABAergic, cholinergic and serotonergic signalling pathways, consistent with its traditional use as an anxiolytic and sleep-quality-enhancing herb.
ReviewA shared family of calming nutrients and herbs
A review of dietary supplements for relaxation and anxiolytic action grouped GABA, L-theanine, tryptophan/5-HTP, valerian, passionflower and lemon balm together as a class of ingredients reported to promote relaxation, largely through GABA-receptor-related pathways.
ReviewTwo herbs, two receptor pathways, one hypnotic effect
A mixture of lemon balm (Melissa officinalis) and St. John's Wort extract reduced sleep-onset latency and prolonged sleep in mice by acting through both adenosine and melatonin receptor signalling at once.
Animal studyCombinations outperformed single herbs in a 23-plant review
An updated review of 23 medicinal plants for insomnia and anxiety concluded that combining valerian with hops and passionflower produced better clinical results than any of the reviewed herbs used alone.
ReviewWhy sleep-support products caution against alcohol
A controlled human trial combining a sleep-support medication with alcohol found additive sedation and psychomotor impairment (body sway, alertness, reaction measures) versus either alone - the same general pharmacological principle behind label cautions against combining any sleep-support product with alcohol.
Human RCTEven a low dose of alcohol affects GABA signalling
A controlled human study found that low doses of alcohol - easily reached during social drinking - measurably altered cortical plasticity, an effect the researchers linked to alcohol's action on GABA-A receptor-mediated inhibition, the same inhibitory system several sleep-support ingredients act on.
Human studyWhy the serotonergic drug-interaction caution exists
A case report described a patient who developed serotonin syndrome, with complications requiring emergency surgery, after combining an SSRI antidepressant with dietary supplements - a documented example of why labels caution against combining serotonergic ingredients with antidepressants and related medications.
Case reportFrequently Asked Questions
What is AOR Ortho Sleep and how is it different from a single-ingredient sleep aid?
AOR Ortho Sleep 443 mg combines seven real actives - GABA, L-theanine, 5-HTP, melatonin, valerian root, passionflower and lemon balm (Cyracos) - in one capsule, under Health Canada NPN 80028811, rather than relying on just one ingredient.
How is Ortho Sleep different from AOR's standalone 5-HTP or GABA products?
AOR also makes single-ingredient 5-HTP (NPN 80010414) and GABA (NPN 80038082) products at their own doses and licensed uses. Ortho Sleep is a separate, seven-ingredient formula licensed under its own NPN, 80028811, that includes 5-HTP and GABA as two of seven actives alongside melatonin, valerian, passionflower and lemon balm - each ingredient's dose and use in this formula is set by Ortho Sleep's own licence, not by the standalone products.
How do I take it?
Adults 18 years and older: take 1 to 2 capsules before bedtime, with or without food, or as directed by a qualified health care practitioner. Swallow capsules whole - do not blend, mix or crush them.
What does the Health Canada licence authorize this product to do?
NPN 80028811 authorizes AOR Ortho Sleep, traditionally used in Herbal Medicine as a sleep aid, to help increase total sleep time in people with sleep restriction or an altered sleep schedule (e.g. shift-work or jet lag), and to help reduce the time it takes to fall asleep in people with delayed sleep phase disorder.
Who should not use it?
Do not use if you are pregnant, nursing or trying to conceive, or if you have scleroderma. Do not drive or use machinery for 5 hours after taking this product, and avoid alcohol or other products that may cause drowsiness while using it.
Can I take it with my antidepressant or other medication?
Consult a health care practitioner before use if you are taking carbidopa or any drug or health product with serotonergic activity - including L-tryptophan, SAMe, St. John's Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, or anti-nausea/anti-migraine medication - or sedative, hypnotic, psychotropic, blood pressure, anticoagulant, anticonvulsant or immunosuppressive medications, or steroids.
What's the difference between the 60- and 120-capsule sizes?
Both contain the exact same 443 mg, seven-ingredient formula under the same NPN licence - the 60-capsule bottle is a 60-day supply and the 120-capsule bottle is a 120-day supply, at 1 to 2 capsules per night.
Is it vegan and allergen-friendly?
Yes - vegan, non-GMO and gluten-free. It does contain corn (from maltodextrin), so it is not corn-free.
Support a complete night's rest with 7 real sleep-support actives
Get AOR Ortho Sleep on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80028811. Traditionally used in Herbal Medicine as a sleep aid; helps increase total sleep time in people with sleep restriction or an altered sleep schedule, and helps reduce the time it takes to fall asleep in people with delayed sleep phase disorder. The research summaries below concern the individual ingredients GABA, L-theanine, 5-HTP, melatonin, valerian root, passionflower and lemon balm and are educational - they are not claims about this finished product. Read and follow the label. Do not use if pregnant, nursing or trying to conceive, or if you have scleroderma. Do not drive or use machinery for 5 hours after taking this product, and avoid alcohol or other products that may cause drowsiness. Consult a health care practitioner before use if taking carbidopa or any drug with serotonergic activity, or any of the other medications listed on the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: This product contains corn allergens. Do not use if you are pregnant, nursing or trying to conceive, or if you have scleroderma. Do not drive or use machinery for 5 hours after taking this product. Avoid alcohol or other products that may cause drowsiness while using this product. Consult a health care practitioner before use if you have asthma, cardiovascular disease, immune system disease, a hormonal disorder, diabetes or hypoglycemia, liver or chronic kidney disease, cerebral palsy, a seizure disorder, migraine, depression and/or hypertension, or if you are taking sedative, hypnotic or psychotropic medications, blood pressure medication, an anticoagulant, an anticonvulsant, immunosuppressive medications or steroids. Consult a health care practitioner before use if you are taking carbidopa or any drug or health product with serotonergic activity, including L-tryptophan, S-adenosylmethionine (SAMe), St. John's Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, or anti-nausea or anti-migraine medication. Consult a health care practitioner if sleeplessness persists continuously for more than 3 weeks (chronic insomnia), or if symptoms persist or worsen. Stop use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain, or if you experience skin changes. Known adverse reactions: some people may experience drowsiness; mild gastrointestinal symptoms (e.g. nausea, vomiting or cramping) and hypersensitivity/allergic reactions have also been reported.
Indications
Recommended Use or Purpose: Traditionally used in Herbal Medicine as a sleep aid. Helps increase the total sleep time in people suffering from sleep restriction or altered sleep schedule, e.g. shift-work and jet lag. Helps to reduce the time it takes to fall asleep in people with delayed sleep phase disorder.
Ingredients
Medicinal Ingredients (per 1 capsule): GABA (gamma-aminobutyric acid) 50 mg, L-Theanine 100 mg, L-5-Hydroxytryptophan (griffonia seed) 50 mg, Melatonin 1.5 mg, Valeriana officinalis L. (valerian root extract 3-6:1, DHE 0.225-0.45 g; 0.8% valerenic acid) 75 mg, Passiflora incarnate L. (passionflower extract 3.5-7:1, aerial parts, DHE 0.056-0.112 g) 16 mg, Melissa officinalis L. (lemon balm extract 5-8:1, aerial parts, DHE 0.75-1.2 g) 150 mg. Cyracos is a registered trademark of Naturex, Inc. Recommended dose provides 1-2 capsules. Non-medicinal Ingredients: Maltodextrin (corn), gum arabic, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose, sodium copper chlorophyllin. Contains corn. Vegan, Non-GMO and Gluten-Free. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 to 2 capsules before bedtime, with or without food, or as directed by a qualified health care practitioner. Do not blend, mix or crush capsules; swallow capsules whole. Do not exceed the recommended dose unless directed by a health care practitioner. Consult a health care practitioner for use beyond 3 weeks.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. Manufactured by Advanced Orthomolecular Research (AOR), Calgary, Alberta. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.