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Health Canada NPN 80025762 42 Active Ingredients - Vitamins, Minerals & Antioxidants Vegetarian · Non-GMO · Gluten-Free Made in Canada - GMP facility
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AOR Ortho Core - 42-Ingredient Multi-Vitamin/Mineral Complex | 180 Caps

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$59.75 CAD
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BrandAOR
Serving1 to 6 capsules daily with meals - 180 capsules per bottle
Licensed Natural Health ProductNPN 80025762
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • A COMPREHENSIVE 42-INGREDIENT FORMULA: Vitamins A, B-complex, C, D3, E and K2, 13 essential minerals, and a phytonutrient/antioxidant blend - one formula covering a broad spectrum of nutrients rather than a single ingredient.
  • ACTIVE, BIOAVAILABLE NUTRIENT FORMS: Methylcobalamin B12, pyridoxal-5'-phosphate B6, calcium L-5-MTHF folate, menatetrenone K2, and mixed tocopherols/tocotrienols vitamin E - forms chosen for absorption and utilization.
  • PHYTONUTRIENT & ANTIOXIDANT BLEND: Coenzyme Q10, (R)-alpha-lipoic acid, trans-resveratrol, grape seed extract (85% oligomeric proanthocyanidins), green tea extract and N-acetylcysteine (NAC) alongside the core vitamins and minerals.
  • FLEXIBLE 1 TO 6 CAPSULE DAILY DOSING: Take 1 to 6 capsules daily with meals, or as directed by a qualified health care practitioner - 180 capsules per bottle, up to a 6-month supply.
  • SUPPORTS BONES, IMMUNE FUNCTION & ANTIOXIDANT PROTECTION: Helps in the development and maintenance of bones and teeth, helps to maintain immune function, and is a source of antioxidants for the maintenance of good health - the authorized claims on this product's own Natural Health Product licence.
  • VEGETARIAN, NON-GMO & GLUTEN-FREE FORMULA: A vegetarian hypromellose capsule with no gluten-containing ingredients, for those avoiding animal-derived capsules or wheat, barley or rye in their supplements.
  • A FOUNDATIONAL DAILY FORMULA: Designed as a broad daily foundation rather than a replacement for AOR's targeted single-ingredient supplements - each ingredient here is included at a supportive cofactor level within a comprehensive formula, its own independently licensed formula and dose.
  • TRUSTED CANADIAN QUALITY: Manufactured in a GMP-compliant Canadian facility by Advanced Orthomolecular Research (AOR), a licensed Natural Health Product, NPN 80025762.

Product description

Ortho Core - A Comprehensive 42-Ingredient Multi-Vitamin, Mineral & Antioxidant Formula

AOR Ortho Core

A closer look at AOR Ortho Core - a comprehensive, balanced multi-vitamin and mineral supplement with 42 active ingredients spanning vitamins A, B-complex, C, D3, E and K2, 13 essential minerals, and a phytonutrient/antioxidant blend (CoQ10, (R)-alpha-lipoic acid, trans-resveratrol, grape seed extract, green tea extract and NAC). Take 1 to 6 capsules daily with meals. Licensed Natural Health Product, NPN 80025762. Licensed Natural Health Product NPN 80025762.

Un regard plus approfondi sur AOR Ortho Core - un supplément de vitamines et de minéraux complet et équilibré avec 42 ingrédients actifs couvrant les vitamines A, complexe B, C, D3, E et K2, 13 minéraux essentiels, et un mélange de phytonutriments et d'antioxydants (CoQ10, acide (R)-alpha-lipoïque, trans-resvératrol, extrait de pépins de raisin, extrait de thé vert et NAC). Prendre 1 à 6 capsules par jour avec les repas. Produit de santé naturel homologué, NPN 80025762.

Ortho Core lifestyle
AOR Ortho Core
42 Active Ingredients · Vitamins, Minerals & Antioxidants

Why One Comprehensive Formula

A broad spectrum of vitamins, minerals and antioxidants in flexible 1 to 6 capsule daily dosing - not a narrow, single-nutrient formula.

Backed by science

Each vitamin, mineral and phytonutrient in Ortho Core has its own studied role - from B-vitamins in energy metabolism to CoQ10, alpha-lipoic acid and green tea extract as antioxidants. Research on each is summarized below.

The AOR difference

42 active ingredients in bioavailable forms (methylcobalamin B12, P-5-P B6, L-5-MTHF folate, menatetrenone K2, mixed tocopherols/tocotrienols) plus a phytonutrient/antioxidant blend - vegetarian, non-GMO, gluten-free, and made in Canada.

Vitamin, Mineral & Antioxidant Synergy

42 active ingredients grouped by role - a comprehensive daily foundation, not a single-note formula.

Complete Fat-Soluble Vitamin Support

Vitamin A (retinol palmitate) with natural source mixed carotenoids, vitamin D3 (vegan cholecalciferol), a full mixed tocopherol/tocotrienol vitamin E complex, and vitamin K2 (menatetrenone) - helping in the development and maintenance of bones.

Full B-Complex for Energy Metabolism

Benfotiamine (B1), riboflavin (B2), niacin from inositol hexanicotinate (B3), pantothenate (B5), P-5-P (B6), methylcobalamin (B12), calcium L-5-MTHF (folate), biotin, choline and inositol - active forms supporting energy metabolism.

Vitamin C & Bioflavonoid Antioxidants

Vitamin C (from magnesium ascorbate), mixed citrus bioflavonoids and quercetin (from Dimorphandra mollis) - a source of antioxidants for the maintenance of good health.

13 Essential Minerals

Boron, calcium, chromium, copper, iodine, magnesium, potassium, manganese, molybdenum, selenium, silicon, vanadium and zinc - supporting bone health, glucose metabolism, thyroid function and immune function.

Phytonutrient & Antioxidant Blend

Coenzyme Q10, (R)-alpha-lipoic acid, trans-resveratrol, grape seed extract (85% oligomeric proanthocyanidins), green tea extract and N-acetylcysteine (NAC) round out the formula's antioxidant support.

AOR Ortho Core: Supplement Facts

AOR™Ortho Core
English

Medicinal Ingredients (per 6 capsules; Serving Size: 6 Capsules)

  • Vitamin A (Retinol Palmitate) 220 mcg Vitamin A Complex with natural source mixed carotenoids (below)110 mcg RAE / 200 mcg
  • Beta-Carotene (natural source mixed carotenoids)1.8 mg
  • Cryptoxanthin250 mcg
  • Lutein6.8 mg
  • Astaxanthin2 mg
  • Lycopene5 mg
  • Vitamin B1 (Thiamin, as Benfotiamine)9 mg
  • Vitamin B2 (Riboflavin)2.5 mg
  • Vitamin B3 (Niacin, from inositol hexanicotinate) provides 126 mg inositol hexanicotinate115 mg
  • Vitamin B5 (as d-Calcium Pantothenate)100 mg
  • Vitamin B6 (as Pyridoxal-5'-Phosphate)100 mg
  • Vitamin B12 (as Methylcobalamin)647 mcg
  • Folic Acid (as calcium L-5-MTHF)800 mcg
  • Biotin300 mcg
  • Choline (from choline bitartrate)100 mg
  • Inositol100 mg
  • Vitamin C (from magnesium ascorbate)120 mg
  • Mixed Citrus Bioflavonoids25 mg
  • Quercetin (from Dimorphandra mollis)65 mg
  • Vitamin D3 (as Cholecalciferol, vegan)25 mcg / 1000 IU
  • Mixed Tocopherols (Vitamin E) Alpha-Tocopherol 13.8 mg, Gamma-Tocopherol 58.2 mg, Delta-Tocopherol 27.6 mg99.6 mg
  • Mixed Tocotrienols Alpha-Tocotrienol 3 mg, Gamma-Tocotrienol 5.5 mg, Delta-Tocotrienol 1.5 mg10 mg
  • Vitamin K2 (as Menatetrenone)120 mcg
  • Boron (from boron citrate)700 mcg
  • Calcium (from calcium carbonate, citrate malate)300 mg
  • Chromium (from chromium picolinate)100 mcg
  • Copper (from copper citrate)1.5 mg
  • Iodine (from potassium iodide)150 mcg
  • Magnesium (from magnesium aspartate, oxide, and ascorbate)210 mg
  • Potassium (from potassium chloride and iodide)50 mg
  • Manganese (from manganese bisglycinate)2.3 mg
  • Molybdenum (from sodium molybdate)45 mcg
  • Selenium (as selenomethionine)55 mcg
  • Silicon (from sodium metasilicate)25 mg
  • Vanadium (from vanadium citrate)18 mcg
  • Zinc (from zinc citrate)11 mg
  • trans-Resveratrol1.8 mg
  • Grape Seed Extract Vitis vinifera seed; >=85% oligomeric proanthocyanidins100 mg
  • (R)-Alpha-Lipoic Acid150 mg
  • Coenzyme Q10 (as ubiquinone)30 mg
  • Green Tea Extract Camellia sinensis leaf; 15:1 extract, DHE 2099.7 mg; 45% EGCG, 1% caffeine140 mg
  • N-Acetylcysteine (NAC)200 mg

Non-Medicinal Ingredients: Broccoli extract (7.1 mg), chlorophyllin copper complex, tocopherols (soy), olive oil, starch (pea, rice, soy, corn, modified food, tapioca), cellulose gum, acacia gum, sodium alginate, sucrose, silicon dioxide, dicalcium and tricalcium phosphate, dextrin (corn and tapioca), maltodextrin (corn), hydroxypropyl cellulose, microcrystalline cellulose, glycine, aspartic acid, citric acid, lecithin (sunflower), DL-alpha tocopherol. Capsule: hypromellose.

Recommended Use or Purpose: Ortho Core is a comprehensive, balanced multi-vitamin and mineral supplement. It contains a broad spectrum of vitamins, minerals, antioxidants and other factors, including phytonutrients, for the maintenance of good health and to help the body metabolize nutrients. Helps in the development and maintenance of bones and teeth. Helps to maintain immune function. Source of antioxidants for the maintenance of good health. Licensed Natural Health Product, NPN 80025762.

Recommended Dose (Adults 18 years and over): Take 1 to 6 capsules daily with meals, or as directed by a qualified health care practitioner. Take a few hours before or after taking other medications or natural health products. Do not crush, blend, or mix the capsules; swallow the capsule whole. Do not exceed the daily dose unless instructed by a healthcare practitioner.

Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant, breastfeeding, taking blood thinners, blood pressure medication, antibiotics, or nitroglycerin, or if you have diabetes, cystinuria, a liver disorder, or an iron deficiency. Consult a health care practitioner for use beyond 12 weeks. Known Adverse Reactions: Stop use of vitamin B6-containing products and consult a health care practitioner if you develop symptoms of sensory nerve problems, such as numbness, tingling, or pain in the extremities. Stop use and consult a health care practitioner if you experience sweating, paleness, chills, headache, dizziness, or confusion, as these may be symptoms of serious low blood sugar. Stop use and consult a health care practitioner if you experience any new symptoms including yellowing of the eyes or skin, dark urine, nausea, vomiting, or stomach pain. Allergens: This product contains corn and soy derived ingredients. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.

Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.

Français

Ingrédients médicinaux (par 6 capsules; Format de portion : 6 capsules)

  • Vitamine A (Palmitate de rétinol) 220 mcg de complexe de vitamine A avec caroténoïdes mixtes de source naturelle (ci-dessous)110 mcg RAE / 200 mcg
  • Bêta-carotène (caroténoïdes mixtes de source naturelle)1.8 mg
  • Cryptoxanthine250 mcg
  • Lutéine6.8 mg
  • Astaxanthine2 mg
  • Lycopène5 mg
  • Vitamine B1 (Thiamine, sous forme de benfotiamine)9 mg
  • Vitamine B2 (Riboflavine)2.5 mg
  • Vitamine B3 (Niacine, d'hexanicotinate d'inositol) fournit 126 mg d'hexanicotinate d'inositol115 mg
  • Vitamine B5 (D-pantothénate de calcium)100 mg
  • Vitamine B6 (Pyridoxal-5'-phosphate)100 mg
  • Vitamine B12 (Méthylcobalamine)647 mcg
  • Acide folique (calcium L-5-MTHF)800 mcg
  • Biotine300 mcg
  • Choline (à partir de bitartrate de choline)100 mg
  • Inositol100 mg
  • Vitamine C (l'ascorbate de magnésium)120 mg
  • Bioflavonoïdes mixtes d'agrumes25 mg
  • Quercétine (Dimorphandra mollis)65 mg
  • Vitamine D3 (Cholécalciférol, végétalien)25 mcg / 1000 IU
  • Tocophérols mixtes (Vitamine E) Alpha-tocophérol 13,8 mg, Gamma-tocophérol 58,2 mg, Delta-tocophérol 27,6 mg99.6 mg
  • Tocotriénols mixtes Alpha-tocotriénol 3 mg, Gamma-tocotriénol 5,5 mg, Delta-tocotriénol 1,5 mg10 mg
  • Vitamine K2 (Ménatétrénone)120 mcg
  • Bore (à partir de citrate de bore)700 mcg
  • Calcium (à partir de carbonate de calcium, citrate-malate)300 mg
  • Chrome (à partir de picolinate de chrome)100 mcg
  • Cuivre (à partir de citrate de cuivre)1.5 mg
  • Iode (à partir d'iodure de potassium)150 mcg
  • Magnésium (à partir d'aspartate, d'oxyde et d'ascorbate de magnésium)210 mg
  • Potassium (à partir de chlorure et d'iodure de potassium)50 mg
  • Manganèse (à partir de bisglycinate de manganèse)2.3 mg
  • Molybdène (à partir de molybdate de sodium)45 mcg
  • Sélénium (Sélénométhionine)55 mcg
  • Silicium (à partir de métasilicate de sodium)25 mg
  • Vanadium (à partir de citrate de vanadium)18 mcg
  • Zinc (à partir de citrate de zinc)11 mg
  • trans-Resvératrol1.8 mg
  • Extrait de pépins de raisin graine de Vitis vinifera; >=85% proanthocyanidines oligomériques100 mg
  • Acide (R)-alpha-lipoïque150 mg
  • Coenzyme Q10 (sous forme d'ubiquinone)30 mg
  • Extrait de thé vert feuille de Camellia sinensis; extrait 15:1, DHE 2099,7 mg; 45% EGCG, 1% caféine140 mg
  • N-acétylcystéine (NAC)200 mg

Ingrédients non médicinaux : Extrait de brocoli (7,1 mg), complexe cuivre-chlorophylline, tocophérols (soya), huile d'olive, amidon (pois, riz, soya, maïs, aliment modifié, tapioca), gomme de cellulose, gomme d'acacia, alginate de sodium, sucrose, dioxyde de silicium, phosphate dicalcique et tricalcique, dextrine (maïs et tapioca), maltodextrine (maïs), hydroxypropylcellulose, cellulose microcristalline, glycine, acide aspartique, acide citrique, lécithine (tournesol), DL-alpha tocophérol. Capsule : hypromellose.

Usage ou fins recommandés : Ortho Core est un supplément de vitamines et de minéraux complet et équilibré. Il contient un large éventail de vitamines, de minéraux, d'antioxydants et d'autres facteurs, y compris des phytonutriments, pour le maintien d'une bonne santé et pour aider l'organisme à métaboliser les nutriments. Aide au développement et au maintien des os et des dents. Aide à maintenir les fonctions immunitaires. Source d'antioxydants pour le maintien d'une bonne santé. Produit de santé naturel homologué, NPN 80025762.

Dose recommandée (Adultes de 18 ans et plus) : Prendre 1 à 6 capsules par jour avec les repas, ou selon les indications d'un professionnel de la santé qualifié. Prendre à quelques heures d'intervalle des autres médicaments ou produits de santé naturels. Ne pas écraser, broyer ni mélanger les capsules; avaler la capsule entière. Ne pas dépasser la dose quotidienne, sauf indication contraire d'un professionnel de la santé.

Mises en garde et précautions : Consultez un professionnel de la santé avant l'utilisation si vous êtes enceinte, si vous allaitez, si vous prenez des anticoagulants, des médicaments pour la tension artérielle, des antibiotiques ou de la nitroglycérine, ou si vous êtes diabétique, si vous souffrez de cystinurie, d'un trouble hépatique ou d'une carence en fer. Consultez un professionnel de la santé pour un usage dépassant 12 semaines. Réactions indésirables connues : Cessez d'utiliser les produits contenant de la vitamine B6 et consultez un professionnel de la santé si vous développez des symptômes de troubles nerveux sensoriels, tels qu'un engourdissement, des picotements ou une douleur aux extrémités. Cessez l'utilisation et consultez un professionnel de la santé si vous ressentez de la transpiration, une pâleur, des frissons, des maux de tête, des étourdissements ou de la confusion, car ces symptômes peuvent indiquer une hypoglycémie grave. Cessez l'utilisation et consultez un professionnel de la santé si vous présentez de nouveaux symptômes, notamment un jaunissement des yeux ou de la peau, des urines foncées, des nausées, des vomissements ou des douleurs à l'estomac. Allergènes : Ce produit contient des ingrédients dérivés du maïs et du soya. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec.

NPN 80025762

42 active ingredients · vitamins, minerals & antioxidantsVegetarian · Non-GMO · Gluten-Free180 capsules · up to a 6-month supplyMade in Canada

One comprehensive formula for daily vitamin, mineral and antioxidant support

Get AOR Ortho Core on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Why AOR Ortho Core

One comprehensive formula covering vitamins, minerals and antioxidants - flexible daily dosing for men and women.

42 Active Ingredients

Vitamins A, B-complex, C, D3, E and K2, 13 minerals, and a phytonutrient/antioxidant blend in one formula.

Bioavailable Forms

Methylcobalamin B12, P-5-P B6, L-5-MTHF folate, menatetrenone K2 and mixed tocopherols/tocotrienols - not the cheapest synthetic forms.

Flexible 1-6 Capsule Dosing

Take 1 to 6 capsules daily with meals, or as directed by a qualified health care practitioner - 180 capsules, up to a 6-month supply.

Premium Canadian Brand

AOR - Advanced Orthomolecular Research, since 1991. Vegetarian, non-GMO, gluten-free. NPN 80025762.

How to use

Take 1 to 6 capsules with meals

Adults (18 years and over) take 1 to 6 capsules daily, with meals, or as directed by a qualified health care practitioner. Supplement Facts are declared per 6 capsules (Serving Size: 6 Capsules); start low and adjust within this range.

Swallow the capsule whole

Do not crush, blend or mix the capsules - swallow the capsule whole.

Space apart from medications

Take a few hours before or after taking other medications or natural health products.

Stay consistent

One 180-capsule bottle lasts up to 6 months at 1 capsule daily, or 30 days at the full 6-capsule serving. Do not exceed the daily dose unless instructed by a healthcare practitioner.

What the research says about Ortho Core's vitamins, minerals and antioxidants

Peer-reviewed studies and reviews on the vitamins, minerals and phytonutrients in this formula - shared for education, not as claims about this finished product. Ortho Core's claims are the statements authorized under its Natural Health Product licence, NPN 80025762.

Fat-Soluble Vitamins: Bone & Immune Support

Meta-analysis: vitamin K2 and bone health

A meta-analysis of 16 randomized controlled trials (6,425 participants) found vitamin K2 supplementation improved lumbar spine bone mineral density and reduced fracture incidence in postmenopausal women.

Meta-analysis
Ma et al., Frontiers in Public Health (2022)
Fat-Soluble Vitamins: Bone & Immune Support

Calcium and vitamin D reduce fracture risk

A National Osteoporosis Foundation meta-analysis of 8 randomized controlled trials (30,970 participants) found combined calcium and vitamin D supplementation reduced total fracture risk by 15% and hip fracture risk by 30%.

Meta-analysis
Weaver et al., Osteoporosis International (2015)
Fat-Soluble Vitamins: Bone & Immune Support

Vitamin D and respiratory infection risk

A meta-analysis of individual participant data from 25 randomized controlled trials found vitamin D supplementation reduced the risk of acute respiratory tract infection overall, with the greatest benefit in those who were vitamin D deficient, and no excess of serious adverse events.

Meta-analysis
Martineau et al., BMJ (2017)
B-Vitamin Complex & Energy Metabolism

How B-vitamins support energy metabolism and reduce fatigue

A narrative review of thiamin, riboflavin, niacin, pantothenic acid, B6 and B12 (alongside vitamin C, iron, magnesium and zinc) describes their mechanistic roles in energy metabolism, and evaluates evidence for reducing fatigue and supporting cognitive performance.

Review
Tardy et al., Nutrients (2020)
B-Vitamin Complex & Energy Metabolism

Benfotiamine's absorption advantage over standard thiamine

A crossover pharmacokinetic study in healthy volunteers found benfotiamine's oral bioavailability of thiamine was approximately 11 times higher than thiamine hydrochloride.

Human RCT (crossover PK)
Xie et al., Journal of Clinical Pharmacology (2014)
B-Vitamin Complex & Energy Metabolism

Why 5-MTHF folate may have advantages over folic acid

A review of calcium L-5-methyltetrahydrofolate (5-MTHF) versus folic acid found 5-MTHF is absorbed independently of the enzyme needed to convert folic acid, avoids masking a vitamin B12 deficiency, and bypasses common MTHFR-gene-variant conversion issues.

Review
Scaglione & Panzavolta, Xenobiotica (2014)
Vitamin C, Bioflavonoids & Antioxidants

Cochrane review: vitamin C and the common cold

A Cochrane meta-analysis found regular vitamin C supplementation did not reduce cold incidence in the general population, but consistently reduced cold duration (8% in adults, 14% in children) and cut incidence by 48% in people under heavy short-term physical stress such as marathon runners and soldiers.

Meta-analysis (Cochrane)
Hemilä & Chalker, Cochrane Database of Systematic Reviews (2013)
Vitamin C, Bioflavonoids & Antioxidants

Vitamin C's role in immune cell function

A review describes how vitamin C supports both innate and adaptive immune cell function, with deficiency shown to impair immunity and increase susceptibility to infection.

Review
Carr & Maggini, Nutrients (2017)
Vitamin C, Bioflavonoids & Antioxidants

Quercetin as a dietary antioxidant

A review describes quercetin as a potent dietary flavonoid antioxidant with anti-inflammatory properties, protective associations in several age-related conditions, and the ability to cross the blood-brain barrier.

Review
Deepika & Maurya, Molecules (2022)
Trace Minerals: Chromium, Selenium & Zinc

Chromium and insulin sensitivity

A review of controlled clinical trials found chromium supplementation, including as chromium picolinate, improved insulin binding and sensitivity and glucose-insulin regulation in a dose-dependent manner.

Review
Anderson, Journal of the American College of Nutrition (1997)
Trace Minerals: Chromium, Selenium & Zinc

Selenium's antioxidant and thyroid roles - more is not always better

A review of selenium describes its selenoproteins' antioxidant, anti-inflammatory and thyroid-hormone-regulating roles, noting the relationship with health outcomes is U-shaped - supplementation helps primarily when baseline status is low.

Review
Rayman, The Lancet (2012)
Trace Minerals: Chromium, Selenium & Zinc

Systematic review: zinc and common cold duration

A systematic review of randomized controlled trials found zinc supplementation reduced the duration of the common cold by approximately 2.25 days in otherwise healthy adults.

Systematic review
Wang, Win & Pang, American Journal of Tropical Medicine and Hygiene (2020)
Phytonutrient & Antioxidant Blend: CoQ10, Alpha-Lipoic Acid & Grape Seed

Meta-analysis: CoQ10 and fatigue

A systematic review and meta-analysis of 13 randomized controlled trials (1,126 participants) found coenzyme Q10 supplementation significantly reduced fatigue scores compared with placebo, with a favorable safety profile.

Meta-analysis
Tsai et al., Frontiers in Pharmacology (2022)
Phytonutrient & Antioxidant Blend: CoQ10, Alpha-Lipoic Acid & Grape Seed

Alpha-lipoic acid and metabolic/antioxidant markers

A narrative review of alpha-lipoic acid trials found improved glucose metabolism markers, reduced oxidative stress, and improved endothelial function across the studies examined.

Review
Jeffrey, Isaac Samraj & Sundara Raj, Journal of Dietary Supplements (2021)
Phytonutrient & Antioxidant Blend: CoQ10, Alpha-Lipoic Acid & Grape Seed

Meta-analysis: grape seed extract and blood pressure

A meta-analysis of 16 randomized controlled trials (810 participants) found grape seed extract supplementation significantly reduced systolic blood pressure by 6.1 mmHg and diastolic blood pressure by 2.8 mmHg on average.

Meta-analysis
Zhang et al., Medicine - Baltimore (2016)
Safety & Tolerability of Comprehensive Multivitamin Formulas

Systematic review: multivitamin-mineral safety across 15 trials

A systematic review of 15 randomized controlled trials of multivitamin-mineral supplements (at least 9 vitamins plus 3 minerals, doses up to 100% of the reference intake) in pregnant women, healthy adults and the elderly found only minor, nonspecific gastrointestinal adverse effects with no significant difference from placebo, and no increase in mortality with long-term (over 10 years) use.

Systematic review
Biesalski & Tinz, Nutrition (2016)
Safety & Tolerability of Comprehensive Multivitamin Formulas

An antioxidant-enriched multivitamin was well-tolerated over 16 weeks

A multicenter, double-blind randomized controlled trial found an antioxidant-enriched multivitamin was safe and well-tolerated over 16 weeks, with an adverse-event profile similar to a standard control multivitamin.

Human RCT
Sagel et al., American Journal of Respiratory and Critical Care Medicine (2018)
Safety & Tolerability of Comprehensive Multivitamin Formulas

A comprehensive multivitamin-mineral regimen was well-tolerated over 6 months

A randomized controlled trial found an investigational multivitamin-mineral regimen was well-tolerated over 6 months, with higher taste satisfaction and adherence compared with a standard regimen.

Human RCT
Perin et al., Obesity Surgery (2018)
Comparative Multivitamin Research: Cognition & Long-Term Outcomes

COSMOS-Web: daily multivitamin improved episodic memory

A randomized controlled trial of 3,562 older adults (COSMOS-Web) found a daily multivitamin-mineral supplement significantly improved episodic memory recall versus placebo at one year and across three years, an effect equivalent to about 3.1 years of age-related memory change.

Human RCT
Yeung et al., American Journal of Clinical Nutrition (2023)
Comparative Multivitamin Research: Cognition & Long-Term Outcomes

An honest null result: multivitamin use and all-cause mortality

A large prospective cohort study of 390,124 generally healthy adults followed for up to 27 years found multivitamin use was not associated with lower all-cause mortality.

Prospective cohort study
Loftfield et al., JAMA Network Open (2024)
Comparative Multivitamin Research: Cognition & Long-Term Outcomes

Meta-analysis: common multivitamin and mineral supplements and cardiovascular outcomes

A JACC Focus Seminar meta-analysis and systematic review found no significant effect of common multivitamins, vitamin D, or calcium on cardiovascular outcomes or all-cause mortality, while folic acid and B-vitamin supplementation showed a stroke-prevention benefit in the studies reviewed.

Meta-analysis
Jenkins et al., Journal of the American College of Cardiology (2021)
Foundational Micronutrient-Synergy Biochemistry

Triage theory: why modest micronutrient shortfalls matter

A review proposes that modest deficiency in a needed vitamin or mineral triggers a biological rationing mechanism favoring short-term survival proteins over long-term 'longevity' proteins, a mechanism argued to contribute to aging-related disease risk over time.

Review
Ames, Proceedings of the National Academy of Sciences (2018)
Foundational Micronutrient-Synergy Biochemistry

Applying triage theory to vitamin K

A review applies triage theory specifically to vitamin K, describing how under limited status the body prioritizes coagulation proteins over bone (osteocalcin) and vascular (matrix Gla protein) proteins that also depend on vitamin K.

Review
McCann & Ames, American Journal of Clinical Nutrition (2009)
Foundational Micronutrient-Synergy Biochemistry

How micronutrients interact with each other during absorption

A review of micronutrient interactions describes how vitamin C promotes iron absorption while iron, zinc and copper can compete with each other - part of the rationale for formulating balanced, multi-nutrient combinations rather than single high-dose ingredients.

Review
Sandström, British Journal of Nutrition (2001)

Frequently asked questions

What is AOR Ortho Core?

A comprehensive, balanced multi-vitamin and mineral supplement with 42 active ingredients - vitamins A, B-complex, C, D3, E and K2, 13 essential minerals, and a phytonutrient/antioxidant blend (CoQ10, (R)-alpha-lipoic acid, trans-resveratrol, grape seed extract, green tea extract and NAC). It is a licensed Natural Health Product, NPN 80025762.

How do I take it?

Adults (18 years and over) take 1 to 6 capsules daily, with meals, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules - swallow the capsule whole. Take a few hours before or after other medications or natural health products.

What exactly is in each serving?

Per 6 capsules (Serving Size: 6 Capsules): a full spectrum of vitamins A, B1, B2, B3, B5, B6, B12, folic acid, biotin, C, D3, E and K2; the minerals boron, calcium, chromium, copper, iodine, magnesium, potassium, manganese, molybdenum, selenium, silicon, vanadium and zinc; and the phytonutrients trans-resveratrol, grape seed extract, (R)-alpha-lipoic acid, coenzyme Q10, green tea extract and N-acetylcysteine, alongside choline, inositol, mixed citrus bioflavonoids and quercetin. See the full facts panel below for exact amounts.

How long does one bottle last?

One bottle of 180 capsules lasts up to 6 months at the minimum dose of 1 capsule daily, or as few as 30 days at the full 6-capsule daily serving - dose flexibly within the 1 to 6 capsule range.

Is it vegetarian? Does it contain common allergens?

Yes - Ortho Core uses a vegetarian hypromellose capsule and vegan vitamin D3. It contains corn and soy derived non-medicinal ingredients; consult a health care practitioner if you have a related allergy.

Who should not use it?

Consult a health care practitioner before use if you are pregnant or breastfeeding, taking blood thinners, blood pressure medication, antibiotics, or nitroglycerin, or if you have diabetes, cystinuria, a liver disorder, or an iron deficiency. Stop use and consult a health care practitioner if you develop signs of sensory nerve problems (numbness, tingling, or pain in the extremities), symptoms of low blood sugar (sweating, paleness, chills, headache, dizziness or confusion), or new symptoms of liver trouble (yellowing of the eyes or skin, dark urine, nausea, vomiting, or stomach pain).

Does this overlap with AOR's other single-ingredient supplements?

Ortho Core includes several ingredients also sold by AOR as standalone products (for example CoQ10, green tea extract, (R)-alpha-lipoic acid, chromium picolinate, trans-resveratrol, and B-vitamins), but at comprehensive-formula cofactor doses suited to a daily foundation, not the higher, targeted doses of those single-ingredient products. Ortho Core is its own separately licensed formula (NPN 80025762); if you already take one of AOR's targeted single-ingredient products at a therapeutic dose, discuss combining it with a comprehensive multi-vitamin like Ortho Core with a health care practitioner to avoid unintentionally exceeding your intended total intake of that ingredient.

Where do I buy it?

Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.

42 active ingredients · vitamins, minerals & antioxidantsVegetarian · Non-GMO · Gluten-Free180 capsules · up to a 6-month supplyMade in Canada

One comprehensive formula for daily vitamin, mineral and antioxidant support

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Natural Health Product NPN 80025762. Ortho Core is a comprehensive, balanced multi-vitamin and mineral supplement containing a broad spectrum of vitamins, minerals, antioxidants and other factors, including phytonutrients, at 1 to 6 capsules daily. The research summaries below concern these ingredients generally and are educational - they are not claims about this finished product. Read and follow the label. Consult a health care practitioner before use if you are pregnant, breastfeeding, taking blood thinners, blood pressure medication, antibiotics, or nitroglycerin, or if you have diabetes, cystinuria, a liver disorder, or an iron deficiency. Results may vary.

Important information

Safety Information

Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant, breastfeeding, taking blood thinners, blood pressure medication, antibiotics, or nitroglycerin, or if you have diabetes, cystinuria, a liver disorder, or an iron deficiency. Consult a health care practitioner for use beyond 12 weeks. Known Adverse Reactions: Stop use of vitamin B6-containing products and consult a health care practitioner if you develop symptoms of sensory nerve problems, such as numbness, tingling, or pain in the extremities. Stop use and consult a health care practitioner if you experience sweating, paleness, chills, headache, dizziness, or confusion, as these may be symptoms of serious low blood sugar. Stop use and consult a health care practitioner if you experience any new symptoms including yellowing of the eyes or skin, dark urine, nausea, vomiting, or stomach pain. Allergens: This product contains corn and soy derived ingredients. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.

Indications

Recommended Use or Purpose: Ortho Core is a comprehensive, balanced multi-vitamin and mineral supplement. It contains a broad spectrum of vitamins, minerals, antioxidants and other factors, including phytonutrients, for the maintenance of good health and to help the body metabolize nutrients. Helps in the development and maintenance of bones and teeth. Helps to maintain immune function. Source of antioxidants for the maintenance of good health. Licensed Natural Health Product, NPN 80025762.

Ingredients

Medicinal Ingredients (per 6 capsules; Serving Size: 6 Capsules): Vitamin A (Retinol Palmitate) 110 mcg RAE / 200 mcg [220 mcg Vitamin A Complex with natural source mixed carotenoids (below)], Beta-Carotene (natural source mixed carotenoids) 1.8 mg, Cryptoxanthin 250 mcg, Lutein 6.8 mg, Astaxanthin 2 mg, Lycopene 5 mg, Vitamin B1 (Thiamin, as Benfotiamine) 9 mg, Vitamin B2 (Riboflavin) 2.5 mg, Vitamin B3 (Niacin, from inositol hexanicotinate) 115 mg [provides 126 mg inositol hexanicotinate], Vitamin B5 (as d-Calcium Pantothenate) 100 mg, Vitamin B6 (as Pyridoxal-5'-Phosphate) 100 mg, Vitamin B12 (as Methylcobalamin) 647 mcg, Folic Acid (as calcium L-5-MTHF) 800 mcg, Biotin 300 mcg, Choline (from choline bitartrate) 100 mg, Inositol 100 mg, Vitamin C (from magnesium ascorbate) 120 mg, Mixed Citrus Bioflavonoids 25 mg, Quercetin (from Dimorphandra mollis) 65 mg, Vitamin D3 (as Cholecalciferol, vegan) 25 mcg / 1000 IU, Mixed Tocopherols (Vitamin E) 99.6 mg [Alpha-Tocopherol 13.8 mg, Gamma-Tocopherol 58.2 mg, Delta-Tocopherol 27.6 mg], Mixed Tocotrienols 10 mg [Alpha-Tocotrienol 3 mg, Gamma-Tocotrienol 5.5 mg, Delta-Tocotrienol 1.5 mg], Vitamin K2 (as Menatetrenone) 120 mcg, Boron (from boron citrate) 700 mcg, Calcium (from calcium carbonate, citrate malate) 300 mg, Chromium (from chromium picolinate) 100 mcg, Copper (from copper citrate) 1.5 mg, Iodine (from potassium iodide) 150 mcg, Magnesium (from magnesium aspartate, oxide, and ascorbate) 210 mg, Potassium (from potassium chloride and iodide) 50 mg, Manganese (from manganese bisglycinate) 2.3 mg, Molybdenum (from sodium molybdate) 45 mcg, Selenium (as selenomethionine) 55 mcg, Silicon (from sodium metasilicate) 25 mg, Vanadium (from vanadium citrate) 18 mcg, Zinc (from zinc citrate) 11 mg, trans-Resveratrol 1.8 mg, Grape Seed Extract 100 mg [Vitis vinifera seed; >=85% oligomeric proanthocyanidins], (R)-Alpha-Lipoic Acid 150 mg, Coenzyme Q10 (as ubiquinone) 30 mg, Green Tea Extract 140 mg [Camellia sinensis leaf; 15:1 extract, DHE 2099.7 mg; 45% EGCG, 1% caffeine], N-Acetylcysteine (NAC) 200 mg. Non-medicinal Ingredients: Broccoli extract (7.1 mg), chlorophyllin copper complex, tocopherols (soy), olive oil, starch (pea, rice, soy, corn, modified food, tapioca), cellulose gum, acacia gum, sodium alginate, sucrose, silicon dioxide, dicalcium and tricalcium phosphate, dextrin (corn and tapioca), maltodextrin (corn), hydroxypropyl cellulose, microcrystalline cellulose, glycine, aspartic acid, citric acid, lecithin (sunflower), DL-alpha tocopherol. Capsule: hypromellose. NMIs are subject to change - always read and follow the label.

Directions

Recommended Dose (Adults 18 years and over): Take 1 to 6 capsules daily with meals, or as directed by a qualified health care practitioner. Take a few hours before or after taking other medications or natural health products. Do not crush, blend, or mix the capsules; swallow the capsule whole. Do not exceed the daily dose unless instructed by a healthcare practitioner.

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