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Health Canada NPN 80116764 10 Billion Active Cells · L. acidophilus La-14 + L. rhamnosus HN001 Plus 200mg Cranberry · Gluten-Free · Dairy-Free · Soy-Free Not for Immune-Compromised Conditions - Read Before Use
Women's Everyday Probiotic 10B + CranberryWomen's Everyday Probiotic 10B + Cranberry - benefits and key ingredients Women's Everyday Probiotic 10B + Cranberry - lifestyleWomen's Everyday Probiotic 10B + Cranberry - ingredientsWomen's Everyday Probiotic 10B + Cranberry - supplement facts panel

Orange Naturals Women's Everyday Probiotic 10 Billion CFU + Cranberry | 30 Capsules

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BrandOrange
Serving1 capsule per day
Licensed Natural Health ProductNPN 80116764
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • 10 BILLION ACTIVE CELLS, 2 TARGETED STRAINS: Each vegetable capsule delivers Lactobacillus acidophilus La-14 (8 billion CFU) and Lacticaseibacillus rhamnosus HN001 (2 billion CFU) for a total of 10 billion active cells - take 1 capsule per day.
  • PLUS 200MG CRANBERRY EXTRACT: Each capsule also delivers a 50:1 cranberry (Vaccinium macrocarpon) fruit extract, equivalent to 10,000mg of dry fruit - cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs).
  • HELPS SUPPORT VAGINAL HEALTH: Source of probiotics. Helps support vaginal health. Helps restore and maintain healthy vaginal flora.
  • REAL CAUTION - READ BEFORE USE: Do not use if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). Ask a healthcare practitioner prior to use if you are taking blood thinners or have a history of kidney stones.
  • MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals and licensed under NPN 80116764. Gluten-free, dairy-free, soy-free, GMO-free, wheat-free and yeast-free, with no artificial flavours, colours or preservatives. Use for at least 4 weeks to see beneficial effects.

Customer Reviews

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Product Description

Women's Everyday Probiotic - 10 Billion Active Cells, 2 Targeted Strains + Cranberry

Orange Naturals Women's Everyday Probiotic 10B + Cranberry

Orange Naturals Women's Everyday Probiotic delivers Lactobacillus acidophilus La-14 (8 billion CFU) and Lacticaseibacillus rhamnosus HN001 (2 billion CFU) - 10 billion active cells in total - plus a 200mg (50:1) cranberry extract in every vegetable capsule. This formula is a source of probiotics that helps support vaginal health and helps restore and maintain healthy vaginal flora, while cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs). Take 1 capsule per day; use for at least 4 weeks to see beneficial effects. This product also carries a real caution around immune-compromised conditions, blood thinners and kidney stones, see below. Licensed Natural Health Product NPN 80116764.

Women's Everyday Probiotic d'Orange Naturals renferme Lactobacillus acidophilus La-14 (8 milliards d'UFC) et Lacticaseibacillus rhamnosus HN001 (2 milliards d'UFC) - 10 milliards de cellules actives au total - ainsi qu'un extrait de canneberge 50:1 de 200 mg dans chaque capsule végétale. Cette formule est une source de probiotiques qui aide à soutenir la santé vaginale et aide à rétablir et à maintenir une flore vaginale saine, tandis que la canneberge est utilisée en phytothérapie pour aider à prévenir les infections des voies urinaires. Prendre 1 capsule par jour; utiliser pendant au moins 4 semaines pour constater des effets bénéfiques. Ce produit comporte aussi une mise en garde réelle concernant les conditions d'immunodéficience, les anticoagulants et les calculs rénaux, voir ci-dessous. NPN 80116764.

Women's Everyday Probiotic 10B + Cranberry lifestyle
Orange Naturals Women's Everyday Probiotic 10B + Cranberry
10 Billion CFU · 2 Targeted Strains + 200mg Cranberry

2 Targeted Strains + Cranberry for Vaginal Health

Lactobacillus acidophilus La-14 + Lacticaseibacillus rhamnosus HN001 (10 billion active cells) plus 200mg cranberry extract - 1 vegetable capsule daily, formulated in Canada

10 Billion Active Cells, 2 Targeted Strains

Each vegetable capsule delivers Lactobacillus acidophilus La-14 (8 billion CFU) and Lacticaseibacillus rhamnosus HN001 (2 billion CFU) - take 1 capsule per day, at least 2-3 hours before or after antibiotics.

Plus 200mg Cranberry Extract for Urinary Health

A 50:1 cranberry (Vaccinium macrocarpon) fruit extract, equivalent to 10,000mg of dry fruit - cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs).

Advanced Ingredients, Superior Results

This formula's two targeted strains - Lactobacillus acidophilus La-14 and Lacticaseibacillus rhamnosus HN001 - and its added cranberry extract have each been studied, individually or in related published research, for their role in vaginal and urogenital health, and probiotic use in immune-compromised individuals carries a real, well-documented safety caution. Here is what the wider research explores.

Lactobacillus acidophilus La-14

The highest-dosed strain in this formula, a commercial Lactobacillus acidophilus strain studied - individually and combined with this formula's other strain - for vaginal and urogenital health.

8 billion CFU per capsule

Lacticaseibacillus rhamnosus HN001

A well-studied Lacticaseibacillus (Lactobacillus) rhamnosus strain researched for maternal and vaginal microbiota support.

2 billion CFU per capsule

Cranberry (Vaccinium macrocarpon) Extract 50:1

A concentrated cranberry fruit extract; cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs).

200mg per capsule (equivalent to 10,000mg dry fruit)

Orange Naturals Women's Everyday Probiotic 10B + Cranberry: Supplement Facts

Orange™Women's Everyday Probiotic 10B + Cranberry
English

Each vegetable capsule contains:

  • Lactobacillus acidophilus La-148 billion CFU
  • Lacticaseibacillus rhamnosus HN0012 billion CFU
  • Cranberry (Vaccinium macrocarpon fruit) extract 50:1 equivalent to 10,000mg dry fruit200mg

Non-Medicinal Ingredients: Non-medicinal ingredients: Acacia (Fibregum), ascorbic acid, dipotassium phosphate, hypromellose, magnesium stearate, monopotassium phosphate, sodium chloride, sugars (sucrose), trehalose.

Recommended Use or Purpose: Source of probiotics. Helps support vaginal health. Helps restore and maintain healthy vaginal flora. Cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs).

Recommended Dose (Women 19 years of age and older): Take 1 capsule per day. Take at least 2-3 hours before or after antibiotics. Use for at least 4 weeks to see beneficial effects.

Cautions and Warnings: Do not use this product if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). Ask a healthcare practitioner prior to use if you have a fever, you have vomiting, you have bloody diarrhea, you have severe abdominal pain, you are taking blood thinners, or you have a history of kidney stones. Stop use and consult a healthcare practitioner if symptoms persist or worsen, or if symptoms of digestive upset (e.g. diarrhea) occur, worsen and/or persist beyond 3 days. Do not use if the safety seal is broken. Keep out of reach of children.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

Français

Chaque capsule végétale contient :

  • Lactobacillus acidophilus La-148 billion CFU
  • Lacticaseibacillus rhamnosus HN0012 billion CFU
  • Canneberge (fruit de Vaccinium macrocarpon), extrait 50:1 équivalent à 10 000mg de fruit sec200mg

Ingrédients non médicinaux : Ingrédients non médicinaux : Acacia (Fibregum), acide ascorbique, phosphate dipotassique, hypromellose, stéarate de magnésium, phosphate monopotassique, chlorure de sodium, sucres (sucrose), tréhalose.

Usage ou fins recommandés : Source de probiotiques. Aide à soutenir la santé vaginale. Aide à rétablir et à maintenir une flore vaginale saine. La canneberge est utilisée en phytothérapie pour aider à prévenir les infections des voies urinaires.

Posologie recommandée (femmes de 19 ans et plus) : Prendre 1 capsule par jour. Prendre au moins 2 à 3 heures avant ou après la prise d'antibiotiques. Utiliser pendant au moins 4 semaines pour constater des effets bénéfiques.

Mises en garde : Ne pas utiliser ce produit si vous souffrez d'un déficit immunitaire (par ex., sida, lymphome, patients subissant un traitement prolongé aux corticostéroïdes). Consulter un praticien de soins de santé avant d'en faire l'usage si vous souffrez de fièvre, de vomissements, de diarrhée sanglante, de graves douleurs abdominales, si vous prenez des anticoagulants, ou si vous avez des antécédents de calculs rénaux. Cesser l'utilisation et consulter un praticien de soins de santé si les symptômes persistent ou s'aggravent, ou si des symptômes de troubles digestifs (par ex. diarrhée) se manifestent, s'aggravent et/ou persistent au-delà de 3 jours. Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.

NPN 80116764

10 Billion Active Cells · 2 Targeted Lactobacillus Strains30 Vegetable Capsules · 30-Day Supply · Plus 200mg CranberryGluten-Free · Dairy-Free · Soy-Free · GMO-FreeNot for Immune-Compromised Conditions - Read Before Use

Help support vaginal health and healthy vaginal flora with Women's Everyday Probiotic

Get Orange Naturals Women's Everyday Probiotic on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Why Orange Naturals Women's Everyday Probiotic

10 billion active cells across 2 targeted Lactobacillus strains, plus 200mg cranberry extract, per capsule - formulated in Canada, with a real caution you should read before use.

10 Billion Active Cells, 2 Targeted Strains

Each vegetable capsule delivers Lactobacillus acidophilus La-14 and Lacticaseibacillus rhamnosus HN001, totaling 10 billion active cells.

Helps support vaginal health

Source of probiotics. Helps restore and maintain healthy vaginal flora.

Plus cranberry for urinary health

200mg cranberry (Vaccinium macrocarpon) extract, used in Herbal Medicine to help prevent urinary tract infections (UTIs).

Real cautions, formulated in Canada

Do not use if immune-compromised. Ask a healthcare practitioner if taking blood thinners or with a history of kidney stones. NPN 80116764.

Inside every capsule

Lactobacillus acidophilus La-14 (8 billion CFU) and Lacticaseibacillus rhamnosus HN001 (2 billion CFU) - 10 billion active cells in total - plus 200mg cranberry (Vaccinium macrocarpon) extract 50:1 - take 1 capsule per day, at least 2-3 hours before or after antibiotics.

Lactobacillus acidophilus La-14 8 billion CFU per capsuleLacticaseibacillus rhamnosus HN001 2 billion CFU per capsuleCranberry (Vaccinium macrocarpon) Extract 50:1 200mg per capsule (equivalent to 10,000mg dry fruit)

How to use it

Take 1 capsule daily

Women 19 years of age and older: take 1 capsule per day.

Time it around antibiotics

Take at least 2-3 hours before or after taking antibiotics.

Give it at least 4 weeks

Use for at least 4 weeks to see beneficial effects, as directed.

Read the cautions before you start

Do not use if you have an immune-compromised condition (e.g. AIDS, lymphoma) or are undergoing long-term corticosteroid treatment. Ask a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea, severe abdominal pain, are taking blood thinners, or have a history of kidney stones. Stop use and consult a healthcare practitioner if digestive upset occurs, worsens or persists beyond 3 days.

The Research Behind This Formula's Strains and Cranberry Extract

Women's Everyday Probiotic combines two documented probiotic strains and a cranberry extract, each with a body of published research behind it. The summaries below are educational background on these strains, related published strains, and cranberry generally - they describe what published studies found, not additional claims for this specific product beyond its Health Canada-authorized use: source of probiotics that helps support vaginal health, helps restore and maintain healthy vaginal flora, with cranberry used in Herbal Medicine to help prevent urinary tract infections (UTIs).

This Formula's Own Two Strains (La-14 + HN001)

This Formula's Exact Two Strains Inhibit a Toxic Shock Toxin in the Lab

A laboratory study tested this formula's own two named strains - Lactobacillus acidophilus La-14 and Lacticaseibacillus rhamnosus HN001 - against toxic-shock-syndrome-toxin-1-producing Staphylococcus aureus using human vaginal epithelial cells. La-14 was bactericidal against the S. aureus strain and blocked toxin production, while HN001 also inhibited toxin production, largely through acid production; neither strain triggered inflammatory signaling on its own. This is a direct test of this product's own two named strains, not a different published strain.

In vitro laboratory study
Schlievert et al., Microbiology Spectrum (2023)
This Formula's Own Two Strains (La-14 + HN001)

A Randomized Trial of This Formula's Own Strains Found a Stable, Healthy Microbiota - and an Honest Null Result

In a randomised, placebo-controlled, triple-blind trial of 50 healthy women, two weeks of oral La-14 and HN001 - this product's own two named strains - did not colonize the vagina above the study's detection limit. However, the vaginal microbiota remained lactobacilli-dominant and vaginal pH stayed in the healthy range throughout, with no safety concerns raised. An honest result: not every study finds vaginal colonization, even for the strains a product actually contains.

Human RCT (n=50)
Lyra et al., Microorganisms (2023)
This Formula's Own Two Strains (La-14 + HN001)

A Pilot Study Found This Formula's Own Strains Detectable in the Vagina After Oral Intake

In a randomised pilot study of 40 healthy women, twice-daily oral intake of L. acidophilus La-14 and L. rhamnosus HN001 - alongside bovine lactoferrin, an ingredient this product does not contain - led to a significant, detectable increase in vaginal levels of both organisms, persisting for at least a week after supplementation stopped. This is the original proof-of-concept that these two orally-taken strains can reach the vagina, though the result contrasts with a later, more rigorous trial (above) that did not detect colonization above its stricter assay threshold.

Human RCT (pilot, n=40)
De Alberti et al., Archives of Gynecology and Obstetrics (2015)
Lactobacillus acidophilus (La-14 Strain Family)

In Mice, This Formula's Own Acidophilus and Rhamnosus Strains Calmed a Gardnerella-Induced Vaginal Infection

In a mouse model of bacterial vaginosis induced by Gardnerella vaginalis, oral or intravaginal administration of HN001 and La-14 - individually or combined - significantly reduced markers of vaginal inflammation and inhibited the pathogen's ability to adhere to cervical cells, while shifting the immune response toward a more regulatory profile. Animal data, not a human trial, but a detailed mechanistic look at this formula's own two strains.

Animal model study
Jang et al., Nutrients (2017)
Lactobacillus acidophilus (La-14 Strain Family)

In the Lab, This Formula's Own Strain Combination Fought Four Different Vaginal Pathogens

A laboratory co-culture study tested Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus GLA-14 - the same named strains as this formula's own HN001 and La-14 - against four organisms responsible for bacterial vaginosis and aerobic vaginitis: Gardnerella vaginalis, Atopobium vaginae, Staphylococcus aureus and Escherichia coli. The combination showed antimicrobial activity against all four, though the degree of effect varied by pathogen.

In vitro laboratory study
Bertuccini et al., International Journal of Immunopathology and Pharmacology (2017)
Lactobacillus acidophilus (La-14 Strain Family)

A Randomized Trial Found This Strain Combination Cut Recurrent Yeast Infections by Two-Thirds

In a randomized trial of 48 women with a documented history of recurrent vulvovaginal candidiasis, adding oral Lactobacillus acidophilus GLA-14, Lactobacillus rhamnosus HN001 and bovine lactoferrin (an ingredient this product does not contain) to standard antifungal treatment cut six-month recurrence to 29.2%, versus 100% recurrence on placebo. This trial used the GLA-14 strain code rather than this formula's own La-14 label; both are believed to be the same commercial strain marketed under different supplier codes, though independent genetic confirmation of that equivalence was not part of this research.

Human RCT (n=48)
Russo et al., Mycoses (2019)
Lacticaseibacillus rhamnosus HN001 (This Formula's Own Strain)

In Pregnant Women, This Formula's Own HN001 Strain Was Linked to Fewer Potentially Harmful Vaginal Bacteria

In a randomized trial of overweight and obese pregnant women, those given Lacticaseibacillus rhamnosus HN001 (combined with a Bifidobacterium strain this product does not contain) showed a lower abundance of several potential pathobionts, including Ureaplasma and Prevotella species, in vaginal microbiota sequencing compared to placebo. HN001 is the same named strain used in this product.

Human RCT sub-analysis (n=112-116)
Houttu et al., Biomedicine & Pharmacotherapy (2022)
Lacticaseibacillus rhamnosus HN001 (This Formula's Own Strain)

An Honest Limit: HN001 Didn't Change Every Inflammatory Marker Measured in Pregnancy

A companion randomized trial from the same pregnancy cohort found that HN001 supplementation itself had no significant direct effect on several serum and vaginal inflammatory proteins measured during pregnancy, although obesity and gestational diabetes status appeared to modify some of the markers. A useful reminder that a real, well-studied strain does not move every biomarker researchers measure.

Human RCT (n=112, mixed/null result)
Houttu et al., Biomolecules (2020)
Lacticaseibacillus rhamnosus HN001 (This Formula's Own Strain)

A Major Trial Was Designed Specifically to Test HN001 for Vaginal and Maternal Health in Pregnancy

The Probiotics in Pregnancy Study is a two-centre, randomized, placebo-controlled trial that enrolled 400 pregnant women to test whether Lactobacillus rhamnosus HN001 - this product's own named strain - taken from early pregnancy through breastfeeding, could reduce rates of bacterial vaginosis, Group B Streptococcus vaginal colonization, and gestational diabetes, alongside infant eczema outcomes. This is the trial's published protocol and rationale, describing what the study set out to measure.

Registered RCT protocol (planned n=400)
Barthow et al., BMC Pregnancy and Childbirth (2016)
Combined Probiotic Therapy for Vaginal Dysbiosis

Adding This Strain Pairing to Standard BV Treatment Improved Recurrence Rates

In a double-blind randomized trial of 48 women with recurrent bacterial vaginosis, adding oral Lactobacillus acidophilus GLA-14 and Lactobacillus rhamnosus HN001 (plus bovine lactoferrin, not an ingredient in this product) to standard metronidazole treatment significantly improved Nugent score normalization, symptom remission and six-month recurrence rates compared to metronidazole plus placebo.

Human RCT (n=48)
Russo et al., Beneficial Microbes (2018)
Combined Probiotic Therapy for Vaginal Dysbiosis

The Same Strain Pairing Restored a Normal Nugent Score in Women With Borderline Vaginal Microbiota

In women with 'intermediate' (borderline abnormal) vaginal microbiota, 15 days of oral Lactobacillus acidophilus GLA-14 and Lactobacillus rhamnosus HN001 (with bovine lactoferrin) led to confirmed vaginal colonization by the ingested strains and a significant improvement in Nugent score and symptoms of abnormal discharge and itching, versus placebo.

Human RCT
Russo et al., Archives of Gynecology and Obstetrics (2018)
Combined Probiotic Therapy for Vaginal Dysbiosis

A Different Rhamnosus Strain Also Restored Vaginal pH and Reduced Pathogenic Bacteria

In a randomized controlled trial of 80 women with signs of vaginal dysbiosis, 10 days of oral Lacticaseibacillus rhamnosus TOM 22.8 (DSM 33500) - a different named rhamnosus strain than this product's own HN001 - restored physiological vaginal pH, reduced potentially pathogenic bacteria, and improved symptoms and quality of life versus no treatment. Included here as evidence that rhamnosus strains as a class can support vaginal microbiota restoration, not as a claim about this exact strain.

Human RCT (n=80)
Vaccalluzzo et al., Journal of Applied Microbiology (2024)
Cranberry Extract & Urinary Tract Infection Prevention

An Honest Starting Point: The 2012 Cochrane Review Found No Significant Overall Benefit

The 2012 update of the Cochrane review on cranberry for UTI prevention pooled 24 studies (4,473 participants) and found that cranberry products did not significantly reduce symptomatic UTIs overall, including in women with recurrent UTIs specifically, concluding that cranberry juice 'cannot currently be recommended.' The reviewers also noted many products didn't report their actual proanthocyanidin content, potentially explaining inconsistent results.

Cochrane systematic review & meta-analysis (24 trials, n=4,473)
Jepson, Williams & Craig, Cochrane Database of Systematic Reviews (2012)
Cranberry Extract & Urinary Tract Infection Prevention

The Current 2023 Cochrane Update Reversed Course: Real Benefit in Recurrent-UTI Women and Children

The most recent Cochrane update added 26 new studies (50 total, 8,857 participants) and found, with moderate-certainty evidence, that cranberry products reduced UTI risk in women with recurrent UTIs, in children, and in people made susceptible by a medical intervention. In a direct three-study comparison, cranberry products reduced UTIs more than probiotics did. The evidence still does not support use in pregnant women, the elderly, or people with bladder-emptying problems - an important, specific limitation.

Cochrane systematic review & meta-analysis (50 trials, n=8,857)
Williams et al., Cochrane Database of Systematic Reviews (2023)
Cranberry Extract & Urinary Tract Infection Prevention

A Separate Meta-Analysis Found the Strongest Cranberry Effect in Women With Recurrent UTIs

A meta-analysis of 13 trials (1,616 participants) found cranberry-containing products were associated with a protective effect against UTIs overall, with the largest benefit seen specifically in women with recurrent UTIs and in children - closely matching the population and framing of this product's own real label claim for cranberry.

Meta-analysis (13 trials, n=1,616)
Wang et al., Archives of Internal Medicine (2012)
Probiotics & the Broader Vaginal Microbiota Field

A 2025 Review of 16 Trials Found Real, Strain-Dependent Evidence for Probiotics in Bacterial Vaginosis

A systematic review of 16 randomized trials (2014-2024) on probiotics for bacterial vaginosis found that a Lacticaseibacillus rhamnosus strain (a different named strain than this product's own HN001) at a specific high dose was the most effective option identified, with several other strains and species also showing therapeutic potential at varying doses, and only mild, self-limiting side effects reported overall.

Systematic review (16 RCTs)
Udjianto et al., Narra Journal (2025)
Probiotics & the Broader Vaginal Microbiota Field

An Honest Null Finding: A Different Multi-Strain Probiotic Didn't Prevent Recurrent Infections in Pregnancy

A multicentre, double-blind randomized trial gave pregnant women who had recovered from a vaginal infection a different multi-strain oral probiotic (not this product's own La-14/HN001 combination) or placebo. There was no significant difference in the rate of recurrent vaginal infections between groups, and none of the women showed vaginal colonization by the ingested probiotic strains - a useful reminder that oral probiotic vaginal colonization and clinical benefit are not guaranteed for every strain combination.

Human RCT (n=47, null result)
Nachum et al., Nutrients (2025)
Probiotics & the Broader Vaginal Microbiota Field

Restoring a Lactobacillus-Dominant Vaginal Microbiota Is an Active Area of Clinical Research

A phase 2 randomized trial in South Africa tested an investigational vaginal live biotherapeutic containing Lactobacillus crispatus - a different Lactobacillus species and product class than this product's oral La-14/HN001 capsule - after antibiotic treatment for bacterial vaginosis. It significantly increased Lactobacillus-dominant vaginal microbiomes at 4 weeks versus placebo, illustrating the wider clinical interest in restoring protective vaginal Lactobacillus populations, using a different delivery route and organism than this product.

Human RCT, phase 2 (n=45)
Hemmerling et al., The Lancet Microbe (2025)
General Probiotic Principles: Strain-Specificity & Antibiotic Timing

Choosing the Right Strain Matters More Than the Number of Strains

A systematic review comparing single-strain probiotics to multi-strain mixtures across 65 randomized trials and eight disease indications found that, in most cases, single strains performed just as well as multi-strain blends for the same condition. The author concluded that choosing an appropriate probiotic should be based on evidence for that specific strain, not simply on how many strains a product contains - the same strain-specific reasoning behind this product's use of two named, individually studied strains.

Systematic review (65 RCTs, 8 disease indications)
McFarland, Digestive Diseases and Sciences (2020)
General Probiotic Principles: Strain-Specificity & Antibiotic Timing

An Evidence-Based Guide Confirms: Probiotic Efficacy Is Both Strain-Specific and Condition-Specific

A practical, evidence-based review of 249 trials across 22 different probiotic types found that efficacy varies by the exact strain and the specific condition being addressed, and recommended matching a product's named strain(s) to good trial evidence for the intended use, rather than assuming any probiotic works for any purpose.

Evidence-based review (249 trials, 22 probiotic types)
Sniffen et al., PLOS ONE (2018)
General Probiotic Principles: Strain-Specificity & Antibiotic Timing

Taking a Probiotic Closer to Your First Antibiotic Dose Makes It More Effective

A meta-regression analysis of 19 randomized trials (6,261 hospitalized adults) found that probiotics reduced the risk of Clostridioides difficile infection during antibiotic treatment by over 50% overall, and that starting the probiotic within 2 days of the first antibiotic dose nearly doubled the protective effect compared to starting later. This general timing principle - not a study of this product specifically - is the same reasoning behind this label's own direction to take this product 2-3 hours before or after antibiotics.

Meta-regression analysis (19 RCTs, n=6,261)
Shen et al., Gastroenterology (2017)
Probiotic Safety in Immunocompromised Individuals (Substantiates This Product's Own Caution)

A Real Case of Lactobacillus acidophilus Bacteremia in a Patient With AIDS

A case report and literature review describes Lactobacillus acidophilus bacteremia (bacteria entering the bloodstream) in a patient with AIDS, temporally linked to heavy consumption of probiotic-enriched yogurt. This is the same species as this product's own La-14 strain (a different specific strain) and directly substantiates this product's own label caution against use in immune-compromised conditions such as AIDS.

Case report + literature review
Haghighat & Crum-Cianflone, International Journal of STD & AIDS (2015)
Probiotic Safety in Immunocompromised Individuals (Substantiates This Product's Own Caution)

A Real Case of Lactobacillus Bacteremia in a Patient on Corticosteroids

A case report describes Lactobacillus bacteremia in a 17-year-old with ulcerative colitis being treated with systemic corticosteroids and infliximab, one week after starting a Lactobacillus rhamnosus GG probiotic. Genetic sequencing matched the organism in his blood to the strain in his probiotic capsule with 99.78% identity. Lactobacillus rhamnosus GG is a different named strain than this product's own HN001, but the same species - and the corticosteroid context directly matches this product's own label caution against use during long-term corticosteroid treatment.

Case report
Vahabnezhad et al., Journal of Clinical Gastroenterology (2013)
Probiotic Safety in Immunocompromised Individuals (Substantiates This Product's Own Caution)

Genetic Testing Has Directly Confirmed Probiotic-to-Bloodstream Transmission in ICU Patients

A case study describes two intensive-care patients who developed bacteremia caused by Lacticaseibacillus rhamnosus. Genetic fingerprinting (pulsed-field gel electrophoresis) confirmed the bloodstream bacteria were an identical match to the commercially available probiotic product each patient had been taking, providing direct laboratory proof that an orally-taken probiotic strain can, rarely, reach the bloodstream in a vulnerable patient - the same species as this product's own HN001 (a different strain), reinforcing why this product's label restricts use in immune-compromised conditions.

Case study with genetic strain matching (n=2)
Mikucka et al., Pathogens (2022)

Customer Reviews

4.3 out of 5 · 34 global ratings
Read genuine reviews on Amazon →Available at Amazon

Frequently asked questions

What is Orange Naturals Women's Everyday Probiotic and what does it do?

It's a vegetable capsule delivering 10 billion active cells across two targeted Lactobacillus strains, plus 200mg cranberry extract. It's a source of probiotics that helps support vaginal health and helps restore and maintain healthy vaginal flora, while cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs).

How do I take it?

Women 19 years and older take 1 capsule per day, at least 2-3 hours before or after antibiotics. Use for at least 4 weeks to see beneficial effects.

What are the two probiotic strains?

Lactobacillus acidophilus La-14 (8 billion CFU) and Lacticaseibacillus rhamnosus HN001 (2 billion CFU) - 10 billion active cells in total.

Why does it contain cranberry?

Each capsule contains a 200mg, 50:1 cranberry (Vaccinium macrocarpon) fruit extract, equivalent to 10,000mg of dry fruit. Cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs).

Who should NOT use this product, or should consult a healthcare practitioner first?

Do not use if you have an immune-compromised condition such as AIDS or lymphoma, or if you are undergoing long-term corticosteroid treatment. Ask a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea, severe abdominal pain, are taking blood thinners, or have a history of kidney stones.

Is this the same as Orange Naturals' other probiotics?

No - this is a distinct, separately licensed formula. It uses two targeted Lactobacillus strains plus cranberry extract and is focused on vaginal health and UTI prevention, unlike this brand's other probiotic formulas, which use different strain counts and ingredients and are focused on general digestive health.

Is it gluten-free, dairy-free and soy-free?

Yes - the real label confirms this product is gluten-free, dairy-free, soy-free, GMO-free, wheat-free and yeast-free, with no artificial flavours, colours or preservatives.

How long does one bottle last?

Each bottle contains 30 vegetable capsules - a 30-day supply at the standard dose of 1 capsule per day.

Where do I buy it?

Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.

10 Billion Active Cells · 2 Targeted Lactobacillus Strains30 Vegetable Capsules · 30-Day Supply · Plus 200mg CranberryGluten-Free · Dairy-Free · Soy-Free · GMO-FreeNot for Immune-Compromised Conditions - Read Before Use

Help support vaginal health and healthy vaginal flora with Women's Everyday Probiotic

Get Orange Naturals Women's Everyday Probiotic on Amazon.ca - fast, protected delivery.

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Natural Health Product NPN 80116764. Source of probiotics. Helps support vaginal health. Helps restore and maintain healthy vaginal flora. Cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs). Do not use if you have an immune-compromised condition (e.g. AIDS, lymphoma) or are undergoing long-term corticosteroid treatment. Ask a healthcare practitioner prior to use if you are taking blood thinners or have a history of kidney stones. The research summaries on this page concern the individual ingredients generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.

Important information

Safety Information

Cautions and Warnings: Do not use this product if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). Ask a healthcare practitioner prior to use if you have a fever, you have vomiting, you have bloody diarrhea, you have severe abdominal pain, you are taking blood thinners, or you have a history of kidney stones. Stop use and consult a healthcare practitioner if symptoms persist or worsen, or if symptoms of digestive upset (e.g. diarrhea) occur, worsen and/or persist beyond 3 days. Do not use if the safety seal is broken. Keep out of reach of children.

Indications

Recommended Use or Purpose: Source of probiotics. Helps support vaginal health. Helps restore and maintain healthy vaginal flora. Cranberry is used in Herbal Medicine to help prevent urinary tract infections (UTIs).

Ingredients

Medicinal Ingredients (each vegetable capsule contains): Lactobacillus acidophilus (La-14), 8 billion CFU. Lacticaseibacillus rhamnosus (HN001), 2 billion CFU. Cranberry (fruit, Vaccinium macrocarpon) extract 50:1, equivalent to 10,000mg of dry fruit, 200mg. Non-medicinal Ingredients: Acacia (Fibregum), ascorbic acid, dipotassium phosphate, hypromellose, magnesium stearate, monopotassium phosphate, sodium chloride, sugars (sucrose), trehalose.

Directions

Recommended Dose (Women 19 years of age and older): Take 1 capsule per day. Take at least 2-3 hours before or after antibiotics. Use for at least 4 weeks to see beneficial effects.

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