Orange Naturals Vitamin B12 Liquid Drops 500mcg | 15 mL, 300-Day Supply
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 1 to 2 drops per day (ages 1 and up) |
| Licensed Natural Health Product | NPN 80107631 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 500 MCG METHYLCOBALAMIN PER DROP: Each drop delivers 500 mcg of methylcobalamin, the bioactive form of vitamin B12, in a smooth, natural blueberry-flavoured liquid.
- HELPS PREVENT B12 DEFICIENCY & FORM RED BLOOD CELLS: Helps to prevent vitamin B12 deficiency and to form red blood cells - this product's Health Canada-authorized use.
- SUPPORTS METABOLISM & IMMUNE FUNCTION: Helps to maintain a healthy metabolism and normal function of the immune system.
- GENTLE LIQUID FORMAT, NO PILLS: A smooth liquid dropper format - no capsules or tablets to swallow, easy to add to food or drink or take directly under the tongue.
- FOR AGES 1 AND UP: Ages 1 and up: take 1 to 2 drops per day, or as directed by a healthcare practitioner.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Developed by naturopathic doctors and licensed under NPN 80107631. The label states this product is vegan and GMO-free, with no artificial flavours, colours, preservatives, sweeteners, dairy, soy, gluten, wheat or yeast.
Product Description
Vitamin B12 Liquid Drops - 500 mcg Methylcobalamin Per Drop
Orange Naturals Vitamin B12 Liquid Drops deliver 500 mcg of methylcobalamin, the bioactive form of vitamin B12, in a natural blueberry-flavoured liquid. Developed by naturopathic doctors, this formula helps to prevent vitamin B12 deficiency and to form red blood cells, and helps to maintain a healthy metabolism and normal function of the immune system. Ages 1 and up take 1 to 2 drops per day. Vegan, Non-GMO, gluten-free, dairy-free and soy-free, made in Canada. NPN 80107631. Licensed Natural Health Product NPN 80107631.
Les Gouttes de Vitamine B12 liquide d'Orange Naturals fournissent 500 mcg de méthylcobalamine, la forme bioactive de la vitamine B12, dans un liquide onctueux au goût naturel de bleuet. Développée par des médecins naturopathes, cette formule aide à prévenir une carence en vitamine B12 et à la formation des globules rouges, et aide à maintenir un métabolisme sain et le fonctionnement normal du système immunitaire. Dès l'âge de 1 an, prendre 1 à 2 gouttes par jour. Végétalien, sans OGM, sans gluten, sans produits laitiers et sans soya, fabriqué au Canada. NPN 80107631.
A Naturopathic-Developed Liquid Vitamin B12
500 mcg Methylcobalamin per Drop - Natural Blueberry Flavour, Vegan, Easy to Take
500 mcg Methylcobalamin, Natural Blueberry Flavour
Each drop delivers 500 mcg of methylcobalamin, the bioactive form of vitamin B12, in a smooth, natural blueberry-flavoured liquid.
Developed by Naturopathic Doctors
Orange Naturals formulas, including this Vitamin B12 Liquid Drops, are developed by naturopathic doctors and made in Canada.
What Vitamin B12 Liquid Drops supports
Vitamin B12 (methylcobalamin) is one of the most-studied nutrients for red blood cell formation, energy metabolism and nerve health, and its role in immune function and cognitive health is an active area of ongoing research. Here is what the wider research explores.
Prevents B12 Deficiency & Red Blood Cell Formation
Helps to prevent vitamin B12 deficiency and to form red blood cells - this product's own Health Canada-authorized use.
Healthy Metabolism
Helps to maintain a healthy metabolism - methylcobalamin is a cofactor in the body's energy-producing metabolic pathways.
Normal Immune System Function
Helps to maintain normal function of the immune system - this product's own Health Canada-authorized use.
Fast-Acting Liquid Format
A simple liquid dropper format designed for easy daily use - no capsules or tablets to swallow, in a natural blueberry flavour.
Orange Naturals Vitamin B12 Liquid Drops: Supplement Facts
Each drop contains:
- Vitamin B12 (methylcobalamin)500 mcg
Non-Medicinal Ingredients: Non-medicinal ingredients: Purified water, natural blueberry flavour, natural flavour, glycerin, potassium phosphate, potassium sorbate, disodium EDTA, stevia.
Recommended Use or Purpose: Helps to prevent vitamin B12 deficiency and to form red blood cells. Helps to maintain a healthy metabolism and normal function of the immune system.
Recommended Dose: Ages 1 and up: Take 1 to 2 drops per day, or as directed by a healthcare practitioner.
Cautions and Warnings: Keep out of reach of children. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque goutte contient :
- Vitamine B12 (méthylcobalamine)500 mcg
Ingrédients non médicinaux : Ingrédients non médicinaux : Eau purifiée, arôme naturel de bleuet, arôme naturel, glycérine, phosphate de potassium, sorbate de potassium, EDTA de sodium, stévia.
Usage ou fins recommandés : Aide à prévenir une carence en vitamine B12 et à la formation des globules rouges. Aide à maintenir un métabolisme sain et le fonctionnement normal du système immunitaire.
Posologie recommandée : Dès l'âge de 1 an : Prendre 1 à 2 gouttes par jour, ou selon l'avis d'un praticien de soins de santé.
Mises en garde : Garder hors de la portée des enfants. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80107631
Support energy metabolism, red blood cells and immune health with liquid B12
Get Orange Naturals Vitamin B12 Liquid Drops on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Vitamin B12 Liquid Drops
500 mcg methylcobalamin per drop in a natural blueberry-flavoured liquid - developed by naturopathic doctors, for ages 1 and up.
500 mcg Methylcobalamin
A full 500 mcg dose of methylcobalamin, the bioactive form of vitamin B12, in every drop.
Helps prevent B12 deficiency & form red blood cells
Helps to prevent vitamin B12 deficiency and to form red blood cells. Helps to maintain a healthy metabolism and normal function of the immune system.
Gentle liquid, natural blueberry flavour
A smooth, easy-to-take liquid - no capsules or tablets to swallow, in a natural blueberry flavour for ages 1 and up.
Developed by naturopathic doctors, made in Canada
Formulated by Orange Naturals and developed by naturopathic doctors. Vegan, Non-GMO, gluten-free, dairy-free and soy-free. NPN 80107631.
How to use it
Take 1 to 2 drops daily
Ages 1 and up: take 1 to 2 drops per day, or as directed by a healthcare practitioner.
Add to food or drink, or take directly
Add to a favourite food or beverage, or take the drops directly under the tongue.
A 300-day supply per bottle
Each 15 mL bottle provides approximately a 300-day supply at the standard dose of 1 drop daily.
Know what to expect
Do not use if the safety seal is broken. Keep out of reach of children.
What the research says about vitamin B12 and methylcobalamin
Educational summaries of published research on vitamin B12 and its methylcobalamin form generally - shared for education, not as claims about this finished product. Orange Naturals Vitamin B12 Liquid Drops' own authorized use under NPN 80107631 is that it helps to prevent vitamin B12 deficiency and to form red blood cells, and helps to maintain a healthy metabolism and normal function of the immune system.
A review maps how vitamin B12 moves from food to bloodstream through three transport proteins and their receptors
This review describes vitamin B12's multi-step absorption pathway: haptocorrin binds B12 released from food in the stomach, intrinsic factor takes over in the duodenum, and the cubilin-amnionless receptor complex in the distal ileum absorbs the intrinsic-factor-B12 complex before transcobalamin carries it into the bloodstream - with malabsorption able to occur at any of these steps.
ReviewA historical review traces decades of B12 research, from discovering intrinsic factor to mapping its ileal receptor
Reflecting on vitamin B12 (cobalamin) research since 1955, this historical review describes the original identification of gastric intrinsic factor and haptocorrin as B12-binding proteins, and how later work discovered the ileal receptor complex (cubam, formed by cubilin and amnionless) whose mutations cause Imerslund-Grasbeck syndrome, a rare inherited form of B12 malabsorption.
Historical reviewA meta-analysis of 16 studies found sublingual and oral B12 raised blood B12 levels and lowered homocysteine about as well as injections
Pooling 16 studies (6,098 participants) comparing B12 supplementation routes, oral and sublingual B12 produced comparable improvements in serum cobalamin (+402.6 pg/mL pooled) and homocysteine reduction (-4.83 micromol/L pooled) to intramuscular injections, with no statistically significant difference between routes - though the authors note substantial heterogeneity and call for further high-quality trials.
Systematic review & meta-analysis (16 studies, n=6,098)A New England Journal of Medicine clinical review outlines how B12 deficiency causes anemia and reversible nerve damage
This widely cited clinical practice review describes how vitamin B12 deficiency impairs DNA synthesis in developing red blood cells, producing megaloblastic anemia, and can separately cause neurological symptoms such as paresthesia and gait problems - emphasizing that oral high-dose B12 is generally as effective as injections for treatment, even in some causes of malabsorption.
Clinical practice reviewA Nature Reviews Disease Primers overview describes B12's essential role in red blood cell formation and estimates deficiency affects up to a quarter of the population
This comprehensive disease primer describes vitamin B12's role as a cofactor in DNA synthesis, methylation and mitochondrial metabolism, noting subclinical deficiency affects an estimated 2.5% to 26% of the general population depending on the definition used, with elderly individuals and those on restricted diets at particular risk.
ReviewA meta-analysis of 74 studies found anemia affects roughly a quarter of patients after gastric bypass surgery, closely tied to B12 status
Pooling 74 studies (12,262 patients), this meta-analysis found a 26% overall prevalence of anemia after Roux-en-Y gastric bypass, rising from 15% within the first year to 35% beyond five years, with vitamin B12 and iron deficiency identified as the strongest associated factors and higher anemia rates in studies with inadequate B12/iron/folic acid supplementation.
Systematic review & meta-analysis (74 studies, n=12,262)A 4.3-year randomized trial found long-term metformin use raised the risk of vitamin B12 deficiency in people with type 2 diabetes
In 390 insulin-treated type 2 diabetes patients randomized to metformin or placebo for 4.3 years, metformin lowered vitamin B12 concentrations by 19% on average and raised the absolute risk of B12 deficiency by 7.2 percentage points, with deficient patients showing meaningfully higher homocysteine levels - supporting periodic B12 monitoring during long-term metformin therapy.
Human RCT (n=390)A large case-control study found 2+ years of acid-reducing medication was linked to a higher risk of vitamin B12 deficiency
Comparing over 25,000 patients newly diagnosed with B12 deficiency to nearly 185,000 without it, two or more years of proton pump inhibitor use was associated with a 65% higher risk of B12 deficiency, and two or more years of H2-receptor antagonist use with a 25% higher risk - with higher PPI doses showing a stronger association.
Case-control study (n=210,155)A meta-analysis of 17 studies found adults on vegan diets show lower B12 status and higher homocysteine than omnivores, even on a full biomarker panel
Analyzing a full panel of B12 biomarkers rather than serum B12 alone, this meta-analysis found vegan adults had significantly lower serum B12 and elevated homocysteine compared with omnivores, indicating functional B12 deficiency risk - but B12 supplement use among vegans significantly improved all biomarkers measured.
Systematic review & meta-analysis (17-19 studies)A review details how vitamin B12 acts as a cofactor for two enzymes central to cellular energy production and methylation
This biochemistry review explains that vitamin B12 (cobalamin) is required by methylmalonyl-CoA mutase for mitochondrial energy metabolism from certain amino acids, and by methionine synthase for the methionine cycle that generates S-adenosylmethionine, the body's principal methyl donor - disruption of either pathway has wide-ranging metabolic consequences.
ReviewA 28-day randomized trial found a B-vitamin complex including B12 improved exercise endurance and reduced fatigue markers
In a randomized double-blind crossover trial of 32 healthy adults, 28 days of a vitamin B complex (B1, B2, B6 and B12) increased running time to exhaustion by 1.26-fold and significantly reduced blood lactate and ammonia - biochemical markers of fatigue - during and after exercise, compared with placebo.
Human RCT, crossover (n=32)An ongoing clinical trial is testing whether B1, B6 and B12 supplementation eases fatigue in long COVID - a question not yet answered
This registered trial protocol describes a randomized, placebo-controlled study testing B-vitamin supplementation (including 500 mcg daily B12) against fatigue, cognitive difficulty and other persistent symptoms in adults with post-COVID-19 syndrome; the pilot phase confirmed the study design was feasible, but effectiveness results were not yet available as of this publication - an honest research-in-progress finding, not a completed result.
Registered RCT protocol (feasibility confirmed, results pending)A clinical study found B12 replacement therapy restored several markers of immune function in B12-deficient pernicious anemia patients
In patients with pernicious anemia, vitamin B12 deficiency was associated with reduced CD8+ lymphocyte counts, an altered CD4/CD8 ratio and depressed natural killer cell activity; after cyanocobalamin treatment, these immune markers - along with complement C3/C4 and immunoglobulin levels - moved back toward normal.
Clinical trial (prospective)A randomized trial in elderly adults found a B12-containing nutritional formula raised natural killer cell activity and cut reported infections
In 60 healthy adults aged 70 and older, four months of a nutritional formula supplying vitamin B12, folic acid, vitamin E and probiotics increased natural killer cell activity (which declined in the unsupplemented group) and was associated with significantly fewer reported infections over the study period.
Human RCT (n=60)A UK nutrition review lists vitamin B12 among the micronutrients essential for the immune system's normal function
Reviewing modifiable nutritional risk factors, the authors describe vitamin D, vitamin A, the B vitamins (including B12), vitamin C and several minerals as all contributing to the normal function of the immune system, and note that correcting suboptimal intakes in at-risk groups may help support immune resilience - while cautioning that no single nutrient prevents or cures any specific infection.
ReviewA study of young adult vegetarians found marginal-to-deficient B12 status was linked to measurably reduced hand dexterity
In 38 healthy vegetarians and vegans aged 19-40, 26% showed deficient or marginal B12 status, and those with adequate B12 scored 10-20% higher on standardized hand-dexterity tests than those with marginal-to-deficient status - early, objective evidence that peripheral nerve function can be affected before overt neuropathy is diagnosed.
Cross-sectional feasibility study (n=38)A review identifies B12 as one of the primary B-vitamins causally linked to peripheral neuropathy worldwide
This review of nutritional peripheral neuropathies discusses vitamin B12 alongside B1, B2, B3 and B6 as vitamins with an established causal link to nerve damage, tracing historical endemic outbreaks tied to dietary shortages and describing modern risk factors including vegan/vegetarian diets and bariatric surgery.
ReviewA case report found small-nerve-fiber dysfunction from B12 deficiency measurably improved after 21 months of B12 replacement
In a 49-year-old man with B12 deficiency from autoimmune gastric disease, specialized nerve tests detected dysfunction in thin-myelinated pain-sensing fibers; after 21 months of intramuscular B12 supplementation, these abnormalities normalized alongside improvement in standard nerve conduction studies.
Case reportA meta-analysis of 30 trials found folic acid supplementation modestly lowered stroke risk but not coronary heart disease risk
Pooling 30 randomized trials (82,334 participants), folic acid supplementation was associated with a 10% lower risk of stroke and a 4% lower risk of overall cardiovascular disease, with the benefit most pronounced in people with lower baseline folate and no pre-existing cardiovascular disease - but no significant effect was found on coronary heart disease specifically.
Meta-analysis (30 RCTs, n=82,334)A meta-analysis found B-vitamin supplementation cut recurrent stroke risk by 29% in high-risk patients not taking antiplatelet drugs
Combining three major trials (VISP, VITATOPS, HOPE-2) in 4,643 people at high vascular risk who were not on antiplatelet therapy, homocysteine-lowering B-vitamin supplementation was associated with a 29% reduction in recurrent stroke risk - a benefit the authors note was attenuated in prior analyses that did not separate out antiplatelet users.
Meta-analysis (3 RCTs, n=4,643)A meta-analysis of 11 trials found combined folic acid, B12 and B6 lowered stroke risk by 14% but had no effect on heart attacks
Pooling 11 randomized trials (26,395 patients), combined folic acid/B12/B6 supplementation reduced homocysteine and lowered stroke incidence by 14%, with the benefit growing over longer follow-up - but showed no significant effect on overall cardiovascular events or myocardial infarction specifically, an honest mixed finding for a combination that includes this product's own nutrient.
Meta-analysis (11 RCTs, n=26,395)A high-certainty meta-analysis of 17 trials found B-vitamin supplementation produces a small but real improvement in older adults' cognitive function
After removing statistical outliers and lower-quality single-blind studies, this meta-analysis of 5,275 older adults found B6, B9 (folate) or B12 supplementation for 26+ weeks produced a small, high-certainty improvement in global cognitive function, though the effect size did not differ by baseline cognitive status (intact, mild impairment or dementia).
Systematic review & meta-analysis (17 RCTs, n=5,275)A 2-year trial in older adults with high homocysteine found B12 and folic acid did not reduce depressive symptoms, though it modestly helped quality of life
In 2,919 adults aged 65 and older with elevated homocysteine, two years of 500 mcg B12 plus 400 mcg folic acid lowered homocysteine more than placebo but produced no significant difference in depressive symptom scores - an honest null result - though one of four quality-of-life measures declined less in the supplemented group.
Human RCT (n=2,919)A study of over 4,500 older adults found low B12 status was linked to higher odds of cognitive dysfunction, especially in a genetically at-risk subgroup
In the TUDA cohort of community-dwelling older adults, lower vitamin B12 status was independently associated with 30% higher odds of cognitive dysfunction, an association that was significantly stronger in carriers of the ApoE e4 genetic variant - a well-known Alzheimer's risk factor - suggesting B12 status may matter most in genetically susceptible individuals.
Observational cohort study (n=4,553)Frequently asked questions
What is Orange Naturals Vitamin B12 Liquid Drops and what does it do?
It's a liquid drop supplement providing 500 mcg of methylcobalamin (the bioactive form of vitamin B12) per drop, in a natural blueberry-flavoured liquid. It helps to prevent vitamin B12 deficiency and to form red blood cells, and helps to maintain a healthy metabolism and normal function of the immune system. It is a licensed Natural Health Product, NPN 80107631.
How much do I take?
Ages 1 and up: take 1 to 2 drops per day, or as directed by a healthcare practitioner.
What form of B12 does it use?
Methylcobalamin - a bioactive, ready-to-use form of vitamin B12, rather than cyanocobalamin.
How do I take the drops?
Add the drops to a favourite food or drink, or take them directly under the tongue - no capsules or tablets to swallow.
Is it suitable for young children?
The labelled dose is for ages 1 and up, at 1 to 2 drops per day. It is not intended for infants under 1 year of age.
Is it vegan and allergen-friendly?
Yes - the label states this product is vegan and GMO-free, with no artificial flavours, colours, preservatives, sweeteners, dairy, soy, gluten, wheat or yeast.
How long does one bottle last?
Each 15 mL bottle provides approximately a 300-day supply at the labelled dose of 1 drop daily, or about 150 days at 2 drops daily.
Where do I buy it?
Use the orange button on this page - it takes you to the Orange Naturals listing on Amazon.ca for secure checkout and fast delivery.
Support energy metabolism, red blood cells and immune health with liquid B12
Get Orange Naturals Vitamin B12 Liquid Drops on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80107631. Helps to prevent vitamin B12 deficiency and to form red blood cells. Helps to maintain a healthy metabolism and normal function of the immune system. The research summaries on this page concern vitamin B12 and methylcobalamin generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Keep out of reach of children. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: Helps to prevent vitamin B12 deficiency and to form red blood cells. Helps to maintain a healthy metabolism and normal function of the immune system.
Ingredients
Medicinal Ingredients (each drop contains): Vitamin B12 (methylcobalamin), 500 mcg. Non-medicinal ingredients: Purified water, natural blueberry flavour, natural flavour, glycerin, potassium phosphate, potassium sorbate, disodium EDTA, stevia.
Directions
Recommended Dose: Ages 1 and up: Take 1 to 2 drops per day, or as directed by a healthcare practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.