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Health Canada NPN 80107957 50 Billion CFU · 14 Specialized Probiotic Strains Soy-Free · Gluten-Free Not for Immune-Compromised Conditions - Read Before Use
Rapid Restore Probiotic 50B CFURapid Restore Probiotic 50B CFU - benefits and key ingredients Rapid Restore Probiotic 50B CFU - lifestyleRapid Restore Probiotic 50B CFU - ingredientsRapid Restore Probiotic 50B CFU - supplement facts panel

Orange Naturals Rapid Restore Probiotic 50 Billion CFU | 60 Capsules

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$50.08 CAD ($0.83 / capsule)
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BrandOrange
Serving1 capsule per day
Licensed Natural Health ProductNPN 80107957
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • 50 BILLION CFU ACROSS 14 PROBIOTIC STRAINS: Each capsule delivers 50 billion CFU across 14 specialized Bifidobacterium, Lactobacillus, Lactococcus and Pediococcus strains - take 1 capsule per day, at least 2-3 hours before or after antibiotics.
  • HELPS SUPPORT GUT FLORA AND IMMUNE FUNCTION: Helps support gut flora and intestinal health. Helps with immune function.
  • PLUS 20 MG VITAMIN C: Each capsule also delivers 20 mg Vitamin C (ascorbic acid) alongside the 14-strain probiotic blend.
  • REAL CAUTION - READ BEFORE USE: Consult a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea or severe abdominal pain. Do not use this product if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment).
  • MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals and licensed under NPN 80107957. The label states this product is soy-free and gluten-free. Refrigerate after opening.

Customer Reviews

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Product Description

Rapid Restore Probiotic 50B - 50 Billion CFU, 14 Strains + Vitamin C

Orange Naturals Rapid Restore Probiotic 50B CFU

Orange Naturals Rapid Restore Probiotic packs 50 billion CFU across 14 specialized probiotic strains - Bifidobacterium, Lactobacillus, Lactococcus and Pediococcus species - plus 20 mg Vitamin C into every vegetable capsule. This formula helps support gut flora and intestinal health and helps with immune function, and is directed to be taken at least 2-3 hours before or after antibiotics. This product also carries a real caution around immune-compromised conditions, see below. Licensed Natural Health Product NPN 80107957.

Rapid Restore Probiotic 50B d'Orange Naturals renferme 50 milliards d'UFC répartis sur 14 souches probiotiques spécialisées - des espèces Bifidobacterium, Lactobacillus, Lactococcus et Pediococcus - ainsi que 20 mg de vitamine C dans chaque capsule végétale. Cette formule aide à soutenir la flore intestinale et la santé intestinale et aide à la fonction immunitaire; elle doit être prise au moins 2 à 3 heures avant ou après la prise d'antibiotiques. Ce produit comporte aussi une mise en garde réelle concernant les conditions d'immunodéficience, voir ci-dessous. NPN 80107957.

Rapid Restore Probiotic 50B CFU lifestyle
Orange Naturals Rapid Restore Probiotic 50B CFU
50 Billion CFU · 14 Strains + Vitamin C

A 14-Strain, 50 Billion CFU Probiotic Formula

50 billion CFU across 14 specialized strains plus 20 mg Vitamin C - one vegetable capsule daily, timed around antibiotics, formulated in Canada

50 Billion CFU Across 14 Probiotic Strains

Each capsule delivers 14 specialized Bifidobacterium, Lactobacillus, Lactococcus and Pediococcus strains totaling 50 billion CFU, plus 20 mg Vitamin C - take 1 capsule per day, at least 2-3 hours before or after antibiotics.

Formulated in Canada, NPN Licensed

Orange Naturals Rapid Restore Probiotic is formulated in Canada and licensed under NPN 80107957.

Advanced Ingredients, Superior Results

This formula's own 14 probiotic strains and added Vitamin C have each been studied, individually or in related published strains, for their role in gut microbiota, antibiotic-associated recovery and immune function - and probiotic use in immune-compromised individuals carries a real, well-documented safety caution. Here is what the wider research explores.

Bifidobacterium animalis subsp. lactis BI-07

One of four distinct Bifidobacterium animalis lactis substrains in this formula, a species studied for supporting gut microbiota balance.

2.5 billion CFU per capsule

Bifidobacterium animalis subsp. lactis DSM 15954 (Bb-12)

A widely studied Bifidobacterium animalis lactis substrain (Bb-12), included in this formula's Bifidobacterium blend.

2.5 billion CFU per capsule

Bifidobacterium animalis subsp. lactis BL-04

The highest-dosed single strain in this formula, a Bifidobacterium animalis lactis substrain studied for gut microbiota effects.

6 billion CFU per capsule

Bifidobacterium bifidum Bb-06

A Bifidobacterium bifidum strain, a species studied for gut and immune health support.

2.5 billion CFU per capsule

Bifidobacterium longum subsp. longum BL-05

A Bifidobacterium longum strain; this species is among the most common gut bifidobacteria found in healthy people across the lifespan.

0.5 billion CFU per capsule

Lactobacillus acidophilus La-14

A well-studied Lactobacillus acidophilus strain, part of this formula's multi-species probiotic blend.

5 billion CFU per capsule

Lactobacillus casei Lc-11

A Lactobacillus casei strain, studied alongside L. rhamnosus and L. acidophilus for gut and metabolic support.

5 billion CFU per capsule

Lactobacillus paracasei Lpc-37

A Lactobacillus paracasei strain; related published strains of this species have been studied for immune function in older adults.

5 billion CFU per capsule

Lactobacillus plantarum Lp-115

A Lactobacillus plantarum strain; related published strains of this species have been studied for innate immune signaling.

5 billion CFU per capsule

Lactobacillus rhamnosus GG

One of the most extensively studied probiotic strains worldwide, researched for antibiotic-associated diarrhea, gut microbiota and immune-related outcomes.

3 billion CFU per capsule

Lactobacillus salivarius Ls-33

A Lactobacillus salivarius strain included in this formula's multi-species probiotic blend.

5 billion CFU per capsule

Lactococcus lactis LL-23

A Lactococcus lactis strain, a lactic acid bacterium species used in fermented foods and probiotic blends.

7 billion CFU per capsule

Lactococcus lactis MJC18

A second Lactococcus lactis strain in this formula, rounding out its multi-species blend.

0.5 billion CFU per capsule

Pediococcus acidilactici UL5

A Pediococcus acidilactici strain; related published strains of this species have been studied for gut microbiota interactions.

0.5 billion CFU per capsule

Vitamin C (ascorbic acid)

An essential vitamin studied for supporting immune cell function, added alongside this formula's 14-strain probiotic blend.

20 mg per capsule

Orange Naturals Rapid Restore Probiotic 50B CFU: Supplement Facts

Orange™Rapid Restore Probiotic 50B CFU
English

Each vegetable capsule contains:

  • Bifidobacterium animalis subsp. lactis BI-072.5 billion CFU
  • Bifidobacterium animalis subsp. lactis DSM 15954 (Bb-12)2.5 billion CFU
  • Bifidobacterium animalis subsp. lactis BL-046 billion CFU
  • Bifidobacterium bifidum Bb-062.5 billion CFU
  • Bifidobacterium longum subsp. longum BL-050.5 billion CFU
  • Lactobacillus acidophilus La-145 billion CFU
  • Lactobacillus casei Lc-115 billion CFU
  • Lactobacillus paracasei Lpc-375 billion CFU
  • Lactobacillus plantarum Lp-1155 billion CFU
  • Lactobacillus rhamnosus GG3 billion CFU
  • Lactobacillus salivarius Ls-335 billion CFU
  • Lactococcus lactis LL-237 billion CFU
  • Lactococcus lactis MJC180.5 billion CFU
  • Pediococcus acidilactici UL50.5 billion CFU
  • Vitamin C (ascorbic acid)20 mg

Non-Medicinal Ingredients: Non-medicinal ingredients: Acacia (Fibregum), sodium chloride, vegetable-grade magnesium stearate, monopotassium phosphate, dipotassium phosphate, trehalose, sucrose, vegetable capsule.

Recommended Use or Purpose: Helps support gut flora and intestinal health. Helps with immune function. Source of probiotics (14 bacterial strains, 50 billion CFU) and Vitamin C.

Recommended Dose (Adults 18 years and older): Take 1 capsule per day, at least 2-3 hours before or after antibiotics, or as directed by a healthcare practitioner. Refrigerate after opening.

Cautions and Warnings: Consult a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea or severe abdominal pain. Stop use and consult a healthcare practitioner if symptoms of digestive upset (e.g. diarrhea) occur, worsen and/or persist beyond 3 days. Do not use this product if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). Do not use if the safety seal is broken. Keep out of reach of children.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

Français

Chaque capsule végétale contient :

  • Bifidobacterium animalis sous-espèce lactis BI-072.5 billion CFU
  • Bifidobacterium animalis sous-espèce lactis DSM 15954 (Bb-12)2.5 billion CFU
  • Bifidobacterium animalis sous-espèce lactis BL-046 billion CFU
  • Bifidobacterium bifidum Bb-062.5 billion CFU
  • Bifidobacterium longum sous-espèce longum BL-050.5 billion CFU
  • Lactobacillus acidophilus La-145 billion CFU
  • Lactobacillus casei Lc-115 billion CFU
  • Lactobacillus paracasei Lpc-375 billion CFU
  • Lactobacillus plantarum Lp-1155 billion CFU
  • Lactobacillus rhamnosus GG3 billion CFU
  • Lactobacillus salivarius Ls-335 billion CFU
  • Lactococcus lactis LL-237 billion CFU
  • Lactococcus lactis MJC180.5 billion CFU
  • Pediococcus acidilactici UL50.5 billion CFU
  • Vitamine C (acide ascorbique)20 mg

Ingrédients non médicinaux : Ingrédients non médicinaux : Acacia (Fibregum), chlorure de sodium, stéarate de magnésium de qualité végétale, phosphate monopotassique, phosphate dipotassique, tréhalose, sucrose, capsule végétale.

Usage ou fins recommandés : Aide à soutenir la flore intestinale et la santé intestinale. Aide à la fonction immunitaire. Source de probiotiques (14 souches bactériennes, 50 milliards d'UFC) et de vitamine C.

Posologie recommandée (adultes de 18 ans et plus) : Prendre 1 capsule par jour, au moins 2 à 3 heures avant ou après la prise d'antibiotiques, ou selon les directives d'un praticien de la santé. Réfrigérer après ouverture.

Mises en garde : Consulter un praticien de la santé avant l'usage si vous avez de la fièvre, des vomissements, des selles sanglantes ou de fortes douleurs abdominales. Cesser l'utilisation et consulter un praticien de la santé si des symptômes de trouble digestif (par ex. diarrhée) surviennent, s'aggravent ou persistent au-delà de 3 jours. Ne pas utiliser ce produit si vous présentez une condition d'immunodéficience (par ex. SIDA, lymphome, patients sous traitement prolongé aux corticostéroïdes). Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.

NPN 80107957

50 Billion CFU · 14 Specialized Probiotic Strains60 Vegetable Capsules · 60-Day SupplySoy-Free · Gluten-FreeNot for Immune-Compromised Conditions - Read Before Use

Help restore your gut flora and support immune function with Rapid Restore Probiotic

Get Orange Naturals Rapid Restore Probiotic 50B on Amazon.ca - fast, protected delivery.

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Why Orange Naturals Rapid Restore Probiotic

50 billion CFU across 14 probiotic strains plus 20 mg Vitamin C per capsule - formulated in Canada, timed around antibiotics, with a real immune-compromised caution you should read before use.

50 Billion CFU Across 14 Probiotic Strains

Each capsule delivers 14 specialized Bifidobacterium, Lactobacillus, Lactococcus and Pediococcus strains totaling 50 billion CFU.

Helps support gut flora and immune function

Helps support gut flora and intestinal health. Helps with immune function.

Simple once-daily capsule, timed around antibiotics

Take 1 capsule per day, at least 2-3 hours before or after antibiotics or as directed by a healthcare practitioner.

Real cautions, formulated in Canada

Do not use if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment) - read the label. NPN 80107957.

Inside every capsule

50 billion CFU across 14 probiotic strains (Bifidobacterium, Lactobacillus, Lactococcus and Pediococcus species) plus 20 mg Vitamin C - take 1 capsule per day, at least 2-3 hours before or after antibiotics.

Bifidobacterium animalis subsp. lactis BI-07 2.5 billion CFU per capsuleBifidobacterium animalis subsp. lactis DSM 15954 (Bb-12) 2.5 billion CFU per capsuleBifidobacterium animalis subsp. lactis BL-04 6 billion CFU per capsuleBifidobacterium bifidum Bb-06 2.5 billion CFU per capsuleBifidobacterium longum subsp. longum BL-05 0.5 billion CFU per capsuleLactobacillus acidophilus La-14 5 billion CFU per capsuleLactobacillus casei Lc-11 5 billion CFU per capsuleLactobacillus paracasei Lpc-37 5 billion CFU per capsuleLactobacillus plantarum Lp-115 5 billion CFU per capsuleLactobacillus rhamnosus GG 3 billion CFU per capsuleLactobacillus salivarius Ls-33 5 billion CFU per capsuleLactococcus lactis LL-23 7 billion CFU per capsuleLactococcus lactis MJC18 0.5 billion CFU per capsulePediococcus acidilactici UL5 0.5 billion CFU per capsuleVitamin C (ascorbic acid) 20 mg per capsule

How to use it

Take 1 capsule daily, timed around antibiotics

Adults: take 1 capsule per day, at least 2-3 hours before or after antibiotics, or as directed by a healthcare practitioner.

Refrigerate after opening

Keep the bottle refrigerated once opened to help protect the live probiotic strains.

A 60-day supply per bottle

Each bottle of 60 vegetable capsules provides a 60-day supply at the standard 1-capsule daily dose.

Read the cautions before you start

Consult a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea or severe abdominal pain. Do not use if you have an immune-compromised condition. Stop use and consult a healthcare practitioner if digestive upset occurs, worsens or persists beyond 3 days.

What the research says about this formula's strains and Vitamin C

Educational summaries of published research on this formula's own probiotic strains (or, where noted, related published strains of the same species), antibiotic-associated recovery, and Vitamin C generally; not product-specific claims. Orange Naturals Rapid Restore Probiotic's own authorized use under NPN 80107957 is that it helps support gut flora and intestinal health and helps with immune function.

Multi-Strain Probiotic Formulas & Gut Microbiome (This Formula's Own Design)

A 2026 randomized trial found a multi-strain probiotic sustained symptom relief by remodeling the gut microbiome and metabolome

In a randomized, double-blind, placebo-controlled trial of 120 patients, adding a multi-strain probiotic to standard therapy produced a significantly larger reduction in symptom scores after 12 weeks than standard therapy alone, alongside shifts in gut bacteria and beneficial metabolites (including short-chain fatty acids) - illustrating how a multi-strain probiotic blend, the same format as this formula's 14-strain design, can reshape the gut ecosystem.

Human RCT (n=120)
Li et al., mSystems (2026)
Multi-Strain Probiotic Formulas & Gut Microbiome (This Formula's Own Design)

A trial found the combination of Lactobacillus rhamnosus GG with Bifidobacterium lactis Bb-12 - two of this formula's own strains - measurably shifted infant gut microbiota

In a randomized trial of 68 preterm neonates, direct oral administration of Lactobacillus rhamnosus GG combined with Bifidobacterium animalis subsp. lactis Bb-12 significantly increased the relative abundance of Bifidobacterium and Lactobacillales in the gut within 7 days, compared to other administration routes or placebo - both of these exact named strains are part of this formula's own 14-strain blend.

Human RCT (n=68)
Rahkola et al., Pediatric Research (2023)
Multi-Strain Probiotic Formulas & Gut Microbiome (This Formula's Own Design)

A 2025 methods study validated detection of this formula's own named strains (Bl-04, Lpc-37) in human clinical trial samples

Comparing two PCR-based detection methods for tracking multi-strain probiotic consumption in a human clinical trial, researchers validated species-specific assays for Bifidobacterium animalis subsp. lactis Bl-04 and Lactobacillus paracasei Lpc-37 - the same two named commercial strains used in this formula - confirming these strains can be reliably distinguished from background gut bacteria in fecal samples.

Methods validation study (human clinical trial samples)
Yeung & Ouwehand, Frontiers in Microbiology (2025)
Probiotics & Antibiotic-Associated Recovery (Matches This Product's Own Directions)

A systematic overview found high-dose probiotics significantly help prevent antibiotic-associated diarrhea in children

Reviewing 20 systematic reviews on probiotics for antibiotic-associated diarrhea (AAD) in children, the authors found that high doses (5-40 billion CFU per day - in the same range as this formula's 50 billion CFU) had a significant preventive effect, though they caution that the quality of underlying evidence varies and conclusions should be treated with appropriate caution.

Overview of systematic reviews
Yang et al., Frontiers in Pharmacology (2023)
Probiotics & Antibiotic-Associated Recovery (Matches This Product's Own Directions)

A meta-analysis found starting probiotics early, alongside antibiotics, reduced antibiotic-associated diarrhea in older adults

Pooling 8 randomized trials in 4,691 elderly participants, this meta-analysis found that probiotics given within two days of starting antibiotic treatment produced a lower rate of antibiotic-associated diarrhea, while starting probiotics late (48 hours after the first antibiotic dose) showed no benefit - supporting the practice of timing probiotic use around a course of antibiotics.

Meta-analysis (8 RCTs, n=4,691)
Zhang et al., BMC Geriatrics (2022)
Probiotics & Antibiotic-Associated Recovery (Matches This Product's Own Directions)

A 2024 review named Lactobacillus rhamnosus GG - this formula's own strain - among the probiotics with the strongest evidence for antibiotic-associated dysbiosis

Reviewing systematic reviews and meta-analyses of clinical trials, the authors concluded that timely, adequately dosed probiotics - specifically naming Lactobacillus rhamnosus GG alongside the yeast Saccharomyces boulardii - can help prevent or resolve antibiotic-associated diarrhea and support the gut microbiota's return to its pre-antibiotic state when taken at the start of antibiotic treatment or within 48 hours.

Review
Waitzberg et al., Advances in Therapy (2024)
Lactobacillus rhamnosus GG (This Formula's Own Strain)

A randomized trial found Lactobacillus rhamnosus GG reduced illness symptoms after household COVID-19 exposure

In a randomized, double-blind, placebo-controlled trial of 182 people with household exposure to COVID-19, those given oral Lactobacillus rhamnosus GG for 28 days developed illness symptoms significantly less often than the placebo group (26.4% vs 42.9%), with gut microbiome changes also observed - though overall COVID-19 diagnosis rates did not differ significantly between groups.

Human RCT (n=182)
Wischmeyer et al., Clinical Nutrition (2023)
Lactobacillus rhamnosus GG (This Formula's Own Strain)

A trial found 8 weeks of Lactobacillus rhamnosus GG increased protective mucin gene expression in adults with type 2 diabetes

In a randomized, placebo-controlled trial of 34 women with type 2 diabetes, 8 weeks of Lactobacillus rhamnosus GG (ATCC 53103) supplementation increased expression of the MUC2 and MUC3A mucin genes - which help protect the intestinal barrier - by more than ninefold, though no significant difference in blood sugar control was seen versus placebo in this small study.

Human RCT (n=34)
Eliuz Tipici et al., European Journal of Nutrition (2023)
Lactobacillus rhamnosus GG (This Formula's Own Strain)

A trial combining Lactobacillus rhamnosus GG with two other strains in this formula improved appetite and body weight in underweight adults

In an 8-week randomized trial of 95 underweight adults, a probiotic supplement combining Lactobacillus rhamnosus GG, Lactobacillus acidophilus and Lactobacillus casei - three of the exact species used in this formula - alongside a weight-gain diet produced significantly greater increases in body weight, appetite and caloric intake than diet alone, along with softer, more regular stools.

Human RCT (n=95)
Hatami et al., Journal of Dietary Supplements (2025)
Bifidobacterium Strains & Gut/Immune Health (This Formula's Bifido Actives)

A trial using Bifidobacterium animalis subsp. lactis BB-12 - this formula's own strain - shortened respiratory infections in children

In a randomized, double-blind, placebo-controlled trial of 94 healthy children, 3 months of lactoferrin combined with Bifidobacterium animalis subsp. lactis BB-12 (the same strain used in this formula) significantly reduced both the severity and average duration of respiratory tract infections compared to placebo, while also restructuring gut microbiota diversity, with no serious adverse events.

Human RCT (n=94)
Shi et al., Frontiers in Pediatrics (2026)
Bifidobacterium Strains & Gut/Immune Health (This Formula's Bifido Actives)

A trial found a Bifidobacterium bifidum strain improved markers of gut barrier integrity and inflammation in adults with excess body fat

In a randomized, double-blind, placebo-controlled trial of 58 adults, 8 weeks of Bifidobacterium bifidum BGN4 significantly improved circulating zonulin (a marker of intestinal permeability), TNF-alpha and fasting insulin versus placebo, with no adverse effects on liver enzymes, blood pressure or digestive symptoms - a different published strain of the same species used in this formula's own Bifidobacterium bifidum Bb-06.

Human RCT (n=58)
Choi et al., Nutrition & Metabolism (2026)
Bifidobacterium Strains & Gut/Immune Health (This Formula's Bifido Actives)

A study identified Bifidobacterium longum subsp. longum - this formula's own species - as the most common gut bifidobacterium in healthy elderly people

Analyzing gut-associated bifidobacteria across the human lifespan, researchers found Bifidobacterium longum subsp. longum - the same species used in this formula - was the most prevalent bifidobacterium in healthy elderly individuals and centenarians, and lab testing of strains isolated from elderly donors showed a reduction in inflammation-related gene expression in host immune cells.

Genomic + in vitro study
Longhi et al., Beneficial Microbes (2024)
Digestive Regularity & IBS Symptom Relief

A major 2023 meta-analysis of 82 trials found some probiotic strains ease global IBS symptoms, though certainty in the evidence is generally low

Pooling 82 randomized trials in over 10,000 IBS patients, this meta-analysis found moderate-to-low certainty evidence that certain probiotic strains and combinations improve global symptoms, abdominal pain or bloating versus placebo, while confirming probiotics were not associated with a significantly higher rate of adverse events across more than 7,000 patients.

Meta-analysis (82 RCTs, n=10,332)
Goodoory et al., Gastroenterology (2023)
Digestive Regularity & IBS Symptom Relief

A study found a multi-strain probiotic shifted gut bacteria differently in IBS patients who responded to treatment versus those who did not

Analyzing stool samples from IBS patients before and after 8 weeks of a multi-strain probiotic (a different Lactobacillus/Bifidobacterium/Pediococcus/Lactococcus blend than this formula's own), several genera increased significantly more in treatment responders than non-responders, suggesting gut microbiome composition may help explain why probiotics work better for some IBS patients than others.

Post hoc analysis of an RCT
Shin et al., Journal of Neurogastroenterology and Motility (2022)
Digestive Regularity & IBS Symptom Relief

A trial of a Lactobacillus rhamnosus strain improved bowel movement frequency and stool consistency in children with constipation

In a 4-week randomized, double-blind, placebo-controlled trial of 154 young children with functional constipation, Lacticaseibacillus rhamnosus MP108 - a different published strain of the same species used in this formula's own Lactobacillus rhamnosus GG - significantly increased treatment success (83.1% vs 63.6%), weekly bowel movement frequency and stool softness versus placebo.

Human RCT (n=154)
Peng et al., Pediatric Research (2026)
Immune Function & Probiotics (Matches This Product's Own Immune-Function Use)

A trial of a Lactobacillus paracasei strain found no overall immune benefit in the elderly, but a possible effect in the oldest old - an honest, mixed finding

In a randomized, double-blind, placebo-controlled trial of 42 nursing-home residents aged 65+, six weeks of heat-killed Lactobacillus paracasei MCC1849 - a different strain of the same species used in this formula's own Lactobacillus paracasei Lpc-37 - showed no significant overall effect on antibody responses to influenza vaccination, though a subgroup of residents aged 85+ showed improved antibody responses versus placebo.

Human RCT (n=42)
Maruyama et al., International Journal of Food Sciences and Nutrition (2015)
Immune Function & Probiotics (Matches This Product's Own Immune-Function Use)

A trial found Lactobacillus plantarum - this formula's own species - boosted innate immune signaling linked to antiviral defense

In a single-arm trial of 18 healthy volunteers, daily intake of a Lactobacillus plantarum strain (a different published strain of the same species used in this formula's own Lactobacillus plantarum Lp-115) significantly increased an innate cytokine index linked to early antiviral immune responses and enhanced natural killer cell activity compared to baseline.

Human trial (n=18)
Kageyama et al., Experimental and Therapeutic Medicine (2021)
Immune Function & Probiotics (Matches This Product's Own Immune-Function Use)

A 2026 trial combining Bifidobacterium animalis lactis and Lactobacillus plantarum strains reduced recurrent respiratory infections in children

In a randomized, double-blind, placebo-controlled trial of 120 children with recurrent respiratory tract infections, three months of a probiotic combining Bifidobacterium animalis subsp. lactis and Lactobacillus plantarum strains (different published strains of two species used in this formula) significantly improved clinical outcomes (76.7% vs 56.7% by intention-to-treat) and produced a more balanced immune antibody response than placebo, with no adverse events.

Human RCT (n=120)
Chen et al., European Journal of Nutrition (2026)
Vitamin C & Immune Support (This Formula's Added Active)

A Cochrane review found regular vitamin C shortens common colds, though it does not prevent them in the general population

Pooling 29 trial comparisons in over 11,000 participants, this Cochrane review found that regular vitamin C supplementation did not reduce the incidence of colds in the general population, but did shorten cold duration by 8% in adults and 14% in children, and reduced cold severity - with a much larger preventive effect (52% fewer colds) seen specifically in people under brief periods of severe physical stress, such as marathon runners and soldiers.

Cochrane systematic review + meta-analysis (29 trial comparisons, n=11,306)
Hemila & Chalker, Cochrane Database of Systematic Reviews (2013)
Vitamin C & Immune Support (This Formula's Added Active)

A systematic review found vitamin C measurably supports neutrophil immune cell function in several human trials

Reviewing 16 randomized controlled trials testing vitamin C's effects on neutrophils (a key first-response immune cell), the authors found that 44% of the trials showed a measurable benefit - including improved cell migration toward infection sites, increased oxidative burst activity in athletes after exercise, and reduced programmed cell death in septic surgical patients given intravenous vitamin C.

Systematic review of human RCTs
Liugan & Carr, Nutrients (2019)
Vitamin C & Immune Support (This Formula's Added Active)

A review of real clinical cases shows how severe, prolonged vitamin C deficiency directly impairs immune and tissue health - and reverses quickly with supplementation

Reviewing nine published case reports of scurvy (severe vitamin C deficiency) occurring alongside restrictive eating disorders, the authors describe how vitamin C deficiency produces immune, gastrointestinal, psychiatric and skin symptoms including fatigue, gum bleeding and joint pain - and that vitamin C supplementation typically produced rapid symptom improvement once the deficiency was corrected.

Systematic review of case reports
Cui, Frontiers in Nutrition (2024)
Probiotic Safety in Immunocompromised Populations (Substantiates This Product's Own Caution)

A real case shows why this product's own label warns against use with immune-compromised conditions like AIDS

Reporting a case of Lactobacillus acidophilus bacteremia (bacteria entering the bloodstream) in a patient with AIDS following heavy consumption of probiotic-enriched yogurt, the authors reviewed the wider literature on Lactobacillus infections in HIV-infected people - directly substantiating this product's own label caution against use in immune-compromised conditions such as AIDS.

Case report + literature review
Haghighat & Crum-Cianflone, International Journal of STD & AIDS (2015)
Probiotic Safety in Immunocompromised Populations (Substantiates This Product's Own Caution)

A systematic review found probiotics may rarely cause serious infection in people with cancer, an immunocompromised population

Reviewing 17 studies (1,530 participants) on probiotic safety in people with cancer, the authors identified 5 case reports of probiotic-related bloodstream infection, concluding that while probiotics may reduce chemotherapy- and antibiotic-associated diarrhea, they can rarely cause sepsis in this immunocompromised population - the same population this product's own label advises against use for.

Systematic review + meta-analysis
Redman et al., Annals of Oncology (2014)
Probiotic Safety in Immunocompromised Populations (Substantiates This Product's Own Caution)

A safety survey found Lactobacillus rhamnosus GG - this formula's own strain - among the most-reported causes of rare Lactobacillus infections, almost always in vulnerable patients

Surveying published infection case reports from 2019-2021, researchers found Lactobacillus rhamnosus GG (the strain used in this formula, among others) was the most frequently implicated strain in rare cases of Lactobacillus bacteremia and endocarditis, occurring almost exclusively in diabetic or immunocompromised patients with additional risk factors such as prosthetic heart valves - reinforcing why this product's own label restricts use in immune-compromised conditions.

Case report survey (2019-2021)
Rossi et al., Nutrients (2022)

Customer Reviews

4.3 out of 5 · 34 global ratings
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Frequently asked questions

What is Orange Naturals Rapid Restore Probiotic and what does it do?

It's a vegetable capsule providing 50 billion CFU across 14 specialized probiotic strains plus 20 mg Vitamin C. It helps support gut flora and intestinal health and helps with immune function.

How do I take it?

Adults take 1 capsule per day, at least 2-3 hours before or after antibiotics, or as directed by a healthcare practitioner. Refrigerate after opening.

Why is it timed around antibiotics?

Antibiotics can disrupt gut bacteria, including probiotic strains. Taking this product 2-3 hours apart from an antibiotic dose helps the live strains reach the gut without being directly exposed to the antibiotic.

Who should NOT use this product, or should consult a healthcare practitioner first?

Consult a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea or severe abdominal pain. Do not use this product if you have an immune-compromised condition (for example AIDS, lymphoma, or if you are undergoing long-term corticosteroid treatment).

What are the medicinal ingredients?

Each capsule contains 14 probiotic strains (Bifidobacterium animalis subsp. lactis BI-07, DSM 15954/Bb-12 and BL-04; Bifidobacterium bifidum Bb-06; Bifidobacterium longum subsp. longum BL-05; Lactobacillus acidophilus La-14; Lactobacillus casei Lc-11; Lactobacillus paracasei Lpc-37; Lactobacillus plantarum Lp-115; Lactobacillus rhamnosus GG; Lactobacillus salivarius Ls-33; Lactococcus lactis LL-23 and MJC18; Pediococcus acidilactici UL5) totaling 50 billion CFU, plus Vitamin C (ascorbic acid) 20 mg.

How long does one bottle last?

Each bottle contains 60 vegetable capsules - a 60-day supply at the standard dose of 1 capsule per day.

Is it vegan and allergen-friendly?

The capsule shell is a vegetable capsule (not gelatin), and the ingredient list contains no dairy or gluten sources. The real label and independent retailers confirm this product is soy-free and gluten-free.

Where do I buy it?

Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.

50 Billion CFU · 14 Specialized Probiotic Strains60 Vegetable Capsules · 60-Day SupplySoy-Free · Gluten-FreeNot for Immune-Compromised Conditions - Read Before Use

Help restore your gut flora and support immune function with Rapid Restore Probiotic

Get Orange Naturals Rapid Restore Probiotic 50B on Amazon.ca - fast, protected delivery.

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Natural Health Product NPN 80107957. Helps support gut flora and intestinal health. Helps with immune function. Consult a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea or severe abdominal pain, or if you have an immune-compromised condition. The research summaries on this page concern the individual ingredients generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.

Important information

Safety Information

Cautions and Warnings: Consult a healthcare practitioner prior to use if you have a fever, vomiting, bloody diarrhea or severe abdominal pain. Stop use and consult a healthcare practitioner if symptoms of digestive upset (e.g. diarrhea) occur, worsen and/or persist beyond 3 days. Do not use this product if you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). Do not use if the safety seal is broken. Keep out of reach of children.

Indications

Recommended Use or Purpose: Helps support gut flora and intestinal health. Helps with immune function. Source of probiotics (14 bacterial strains, 50 billion CFU) and Vitamin C.

Ingredients

Medicinal Ingredients (each vegetable capsule contains): Bifidobacterium animalis subsp. lactis BI-07, 2.5 billion CFU. Bifidobacterium animalis subsp. lactis DSM 15954 (Bb-12), 2.5 billion CFU. Bifidobacterium animalis subsp. lactis BL-04, 6 billion CFU. Bifidobacterium bifidum Bb-06, 2.5 billion CFU. Bifidobacterium longum subsp. longum BL-05, 0.5 billion CFU. Lactobacillus acidophilus La-14, 5 billion CFU. Lactobacillus casei Lc-11, 5 billion CFU. Lactobacillus paracasei Lpc-37, 5 billion CFU. Lactobacillus plantarum Lp-115, 5 billion CFU. Lactobacillus rhamnosus GG, 3 billion CFU. Lactobacillus salivarius Ls-33, 5 billion CFU. Lactococcus lactis LL-23, 7 billion CFU. Lactococcus lactis MJC18, 0.5 billion CFU. Pediococcus acidilactici UL5, 0.5 billion CFU. Vitamin C (ascorbic acid), 20 mg. Non-medicinal Ingredients: Acacia (Fibregum), sodium chloride, vegetable-grade magnesium stearate, monopotassium phosphate, dipotassium phosphate, trehalose, sucrose, vegetable capsule.

Directions

Recommended Dose (Adults 18 years and older): Take 1 capsule per day, at least 2-3 hours before or after antibiotics, or as directed by a healthcare practitioner. Refrigerate after opening.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

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