Available at Amazon
Health Canada NPN 80076912 400 mg EPA + 200 mg DHA per Softgel Wild-Sourced · Dairy-Free · Gluten-Free Cardiovascular Health Support
Omega 3 Fish OilOmega 3 Fish Oil - benefits and key ingredients Omega 3 Fish Oil - lifestyleOmega 3 Fish Oil - ingredientsOmega 3 Fish Oil - supplement facts panel

Orange Naturals Omega 3 Fish Oil 90 Softgels, 30-90 Day Supply for Brain & Heart, Wild-Sourced EPA 400mg DHA 200mg Essential Fatty Acids

Visit the Orange Naturals Store
4.6 ★★★★☆ (14)
Read all reviews on Amazon →

$27.89 CAD ($0.31 / softgel)
Get it on Amazon.ca
BrandOrange
Serving1 to 3 softgels per day, with food
Licensed Natural Health ProductNPN 80076912
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • 400 MG EPA + 200 MG DHA PER SOFTGEL: Each softgel provides 1000 mg of wild-sourced fish oil, delivering 400 mg EPA and 200 mg DHA (600 mg total omega-3 fatty acids) - take up to 3 softgels per day, with food.
  • WILD-SOURCED FROM ANCHOVY, SARDINE & MACKEREL: Sourced from wild-caught anchovy, sardine and mackerel - not farmed fish.
  • HELPS SUPPORT CARDIOVASCULAR HEALTH: Helps support cardiovascular health - this product's Health Canada-authorized use.
  • EASY TO SWALLOW FORMULA: Formulated with no artificial flavours, colours or preservatives, and no dairy, corn, gluten, wheat or yeast.
  • REAL CAUTIONS - READ BEFORE USE: Contains fish and soy allergens. Do not use if the safety seal is broken. Keep out of reach of children.
  • MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals and licensed under NPN 80076912.

Customer Reviews

4.6 out of 5 · 14 global ratings
Read genuine reviews on Amazon →Available at Amazon

Product Description

Omega 3 Fish Oil - Wild-Sourced EPA & DHA for Heart and Mind

Orange Naturals Omega 3 Fish Oil

Orange Naturals Omega 3 Fish Oil delivers 1000 mg of wild-sourced fish oil per softgel - from anchovy, sardine and mackerel - providing 400 mg EPA and 200 mg DHA (600 mg total omega-3 fatty acids). Developed by naturopathic doctors, this formula helps support cardiovascular health. Take up to 3 softgels per day, with food. Dairy-free, gluten-free and corn-free with no artificial flavours, colours or preservatives - contains fish and soy allergens, see cautions below. Licensed Natural Health Product NPN 80076912.

Oméga 3 Huile de poisson d'Orange Naturals offre 1000 mg d'huile de poisson sauvage par capsule molle - provenant d'anchois, de sardines et de maquereaux - fournissant 400 mg d'AEP et 200 mg d'ADH (600 mg d'acides gras oméga-3 au total). Développée par des médecins naturopathes, cette formule aide à soutenir la santé cardiovasculaire. Prendre jusqu'à 3 capsules molles par jour, avec un repas. Sans produits laitiers, sans gluten et sans maïs, sans arômes artificiels, colorants ni agents de conservation - contient des allergènes de poisson et de soya, voir les mises en garde ci-dessous. NPN 80076912.

Omega 3 Fish Oil lifestyle
Orange Naturals Omega 3 Fish Oil
400 mg EPA + 200 mg DHA per Softgel

Wild-Sourced, Not Farmed

1000 mg fish oil from wild-caught anchovy, sardine and mackerel - 400 mg EPA + 200 mg DHA per softgel, developed by naturopathic doctors

400 mg EPA + 200 mg DHA per Softgel

Each softgel delivers 1000 mg of wild-sourced fish oil, providing 400 mg EPA and 200 mg DHA (600 mg total omega-3s) to help support cardiovascular health.

Wild-Sourced, Developed by Naturopathic Doctors

Sourced from wild-caught anchovy, sardine and mackerel - not farmed fish - and developed by naturopathic doctors, made in Canada.

Advanced Ingredients, Superior Results

Omega-3 fatty acids EPA and DHA from fish oil are among the most studied nutrients in nutrition research - explored for cardiovascular health, blood pressure, cognitive function and mood. Here is what the wider research explores.

Fish Oil (Anchovy, Sardine, Mackerel)

Wild-sourced fish oil providing 400 mg EPA (eicosapentaenoic acid) and 200 mg DHA (docosahexaenoic acid) - 600 mg total omega-3 fatty acids per softgel. Studied for cardiovascular health, blood pressure, cognitive function and mood support.

1000 mg per softgel

Orange Naturals Omega 3 Fish Oil: Supplement Facts

Orange™Omega 3 Fish Oil
English

Each softgel contains:

  • Fish Oil (Anchovy, Sardine, Mackerel)1000 mg
  • EPA (eicosapentaenoic acid, 40%)400 mg
  • DHA (docosahexaenoic acid, 20%)200 mg

Non-Medicinal Ingredients: Non-medicinal ingredients: D-alpha-tocopherol (soy), gelatin, glycerin, purified water. Allergens: fish, soy.

Recommended Use or Purpose: Helps support cardiovascular health.

Recommended Dose (Adults 19 years and older): Take up to 3 softgels per day. Take with food or as directed by a healthcare practitioner.

Cautions and Warnings: Allergens: fish, soy. Keep out of reach of children. Do not use if the safety seal is broken.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

Français

Chaque capsule molle contient :

  • Huile de poisson (Anchois, sardines et maquereaux)1000 mg
  • AEP (acide eicosapentaénoïque, 40%)400 mg
  • ADH (acide docosahexaénoïque, 20%)200 mg

Ingrédients non médicinaux : Ingrédients non médicinaux : D-alpha tocophérol (soya), eau purifiée, gélatine, glycérine. Allergènes : poisson, soya.

Usage ou fins recommandés : Aide à soutenir la santé cardiovasculaire.

Posologie recommandée (adultes de 19 ans et plus) : Prendre jusqu'à 3 capsules molles par jour. Prendre avec un repas ou selon l'avis d'un praticien de soins de santé.

Mises en garde : Allergènes : poisson, soya. Garder hors de la portée des enfants. Ne pas utiliser si le sceau de sécurité est brisé.

NPN 80076912

400 mg EPA + 200 mg DHA per Softgel90 Softgels · 30-90 Day SupplyDairy-Free · Gluten-Free · Corn-Free · Wild-SourcedCardiovascular Health Support

Support your heart with wild-sourced Omega 3 fish oil

Get Orange Naturals Omega 3 Fish Oil on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Why Orange Naturals Omega 3 Fish Oil

1000 mg of wild-sourced fish oil - 400 mg EPA + 200 mg DHA per softgel - developed by naturopathic doctors, with real allergen cautions you should read before use.

400 mg EPA + 200 mg DHA per softgel

Each softgel delivers 1000 mg of wild-sourced fish oil (anchovy, sardine, mackerel), providing 400 mg EPA and 200 mg DHA.

Helps support cardiovascular health

This product's Health Canada-authorized use under NPN 80076912.

Simple daily dose

Take up to 3 softgels per day, with food, or as directed by a healthcare practitioner.

Real cautions, developed by naturopathic doctors

Formulated by Orange Naturals. Contains fish and soy allergens. Do not use if the safety seal is broken. Keep out of reach of children. NPN 80076912.

Inside every softgel

1000 mg of wild-sourced fish oil (anchovy, sardine, mackerel) providing 400 mg EPA + 200 mg DHA - take up to 3 softgels per day, with food.

Fish Oil (Anchovy, Sardine, Mackerel) 1000 mg per softgel

How to use it

Take up to 3 softgels daily, with food

Adults (19 years and older): take up to 3 softgels per day. Take with food or as directed by a healthcare practitioner.

A 30 to 90 day supply per bottle

Each bottle of 90 softgels provides a 30-day supply at 3 softgels/day, up to a 90-day supply at 1 softgel/day.

Keep the seal intact

Do not use if the safety seal is broken.

Check the allergens first

Contains fish and soy allergens. Keep out of reach of children.

What the research says about Omega-3 Fish Oil (EPA/DHA)

Educational summaries of published research on fish oil and its omega-3 fatty acids (EPA/DHA) generally; not product-specific claims. Orange Naturals Omega 3 Fish Oil's own authorized use under NPN 80076912 is that it helps support cardiovascular health. This research includes some large trials with null or mixed findings, represented honestly, and a section on bleeding-risk research that is educational only - it is NOT a caution printed on this product's own label (see the ingredients panel above for this product's actual warnings).

Cardiovascular Health

The VITAL trial found 1 g/day of marine omega-3 did not significantly reduce major cardiovascular events overall, though it lowered heart attack risk

In a randomized trial of 25,871 U.S. adults given 1 g/day of marine omega-3 fatty acids or placebo for a median of 5.3 years, the omega-3 group did not have a significantly lower rate of the primary composite cardiovascular endpoint compared with placebo, though myocardial infarction incidence was significantly reduced, with the largest benefits seen in participants with low dietary fish intake.

Human RCT (n=25,871)
Manson et al., New England Journal of Medicine (2019)
Cardiovascular Health

A Cochrane review of 86 trials found high-certainty evidence that EPA and DHA supplementation has little or no effect on most cardiovascular outcomes

Pooling 86 randomized controlled trials in over 162,000 participants, this Cochrane systematic review found that increasing EPA and DHA intake through supplements probably has little or no effect on cardiovascular mortality, coronary heart disease events, stroke, or arrhythmia - an honest, high-certainty null finding for this broader outcome set, even though some individual trials show benefit.

Cochrane systematic review (86 RCTs)
Abdelhamid et al., Cochrane Database of Systematic Reviews (2020)
Cardiovascular Health

A 2021 review outlines the cardiovascular mechanisms and overall risk profile of omega-3 fatty acids

Reviewing the evidence on omega-3 polyunsaturated fatty acids and cardiovascular health, this update describes proposed mechanisms including triglyceride lowering, anti-arrhythmic and anti-inflammatory effects, and modest blood pressure reduction, while noting that outcome trials have produced mixed results depending on dose, formulation and the population studied.

Review
Elagizi et al., Nutrients (2021)
Large-Scale EPA/DHA Outcome Trials

The REDUCE-IT trial found a purified, prescription-strength EPA formulation reduced cardiovascular events by 25% in statin-treated patients with elevated triglycerides

In 8,179 statin-treated patients with elevated triglycerides and established cardiovascular disease or diabetes, 4 g/day of icosapent ethyl (a highly purified, prescription-only EPA ethyl ester - not an over-the-counter fish oil softgel like this product) significantly reduced the composite of cardiovascular death, heart attack, stroke, revascularization or unstable angina compared with placebo, alongside a small increase in atrial fibrillation and a non-significant increase in serious bleeding.

Human RCT (n=8,179, prescription drug)
Bhatt et al., New England Journal of Medicine (2019)
Large-Scale EPA/DHA Outcome Trials

The STRENGTH trial found a high-dose EPA+DHA combination showed no cardiovascular benefit and was stopped early

In 13,078 statin-treated patients at high cardiovascular risk with hypertriglyceridemia, 4 g/day of an omega-3 carboxylic acid formulation (EPA and DHA combined, prescription-strength) showed no significant difference in major adverse cardiovascular events compared with a corn oil comparator, and the trial was halted early for a low probability of benefit - an important contrast to trials of purified EPA alone.

Human RCT (n=13,078, prescription drug)
Nicholls et al., JAMA (2020)
Large-Scale EPA/DHA Outcome Trials

A cardiology review discusses why the REDUCE-IT result diverged from earlier omega-3 outcome trials

Reviewing REDUCE-IT alongside prior placebo-controlled trials of niacin, fibrates and omega-3 fatty acids that failed to show cardiovascular benefit on top of statins, this review discusses possible explanations for icosapent ethyl's positive result, including its purified EPA-only composition and higher achieved blood EPA levels, versus mixed EPA+DHA formulations like the one tested in STRENGTH.

Review
Boden et al., European Heart Journal (2020)
Blood Pressure

A dose-response meta-analysis found omega-3 intake reduced blood pressure, with a non-linear relationship to dose

Analyzing randomized controlled trials of omega-3 fatty acid intake and blood pressure, this dose-response meta-analysis found that omega-3 supplementation significantly reduced both systolic and diastolic blood pressure, with the relationship to dose following a non-linear pattern rather than a simple more-is-better curve.

Dose-response meta-analysis
Zhang et al., Journal of the American Heart Association (2022)
Blood Pressure

An umbrella meta-analysis confirmed omega-3 fatty acids help control blood pressure across multiple prior meta-analyses

Synthesizing multiple existing meta-analyses of randomized controlled trials, this umbrella review concluded that omega-3 polyunsaturated fatty acid supplementation has a beneficial, consistent effect on lowering both systolic and diastolic blood pressure.

Umbrella meta-analysis
Musazadeh et al., Frontiers in Nutrition (2022)
Blood Pressure

A meta-analysis in patients with metabolic syndrome found omega-3 supplementation improved blood pressure and serum lipids

Pooling randomized controlled trials in patients with metabolic syndrome, this systematic review and meta-analysis found that omega-3 fatty acid supplementation was associated with improvements in both blood pressure and serum lipid profile measures compared with control.

Systematic review & meta-analysis
Liu et al., Foods (2023)
Bioavailability & Absorption

A classic absorption study found fish oil in natural triglyceride form was absorbed far better than the ethyl ester form

In healthy men given a single dose of fish oil fatty acids as triacylglycerols, free fatty acids, or ethyl esters, the natural triacylglycerol (triglyceride) form was absorbed roughly 57-68% as well as free fatty acids, while the ethyl ester form was absorbed only about 20-21% as well - a substantial real-world absorption gap tied to the chemical form of the oil.

Human study (n=8)
Lawson & Hughes, Biochemical and Biophysical Research Communications (1988)
Bioavailability & Absorption

A human trial found a pre-digested monoacylglycerol form of omega-3s absorbed significantly better than the ethyl ester form

Comparing high therapeutic doses of omega-3s in different chemical forms in humans, a monoacylglycerol structure showed significantly greater absorption than the commonly used ethyl ester form, with a comparable profile to free fatty acid forms - illustrating that chemical form, not just dose, meaningfully affects how much omega-3 is actually absorbed.

Human study
Cuenoud et al., Nutrients (2020)
Bioavailability & Absorption

A pharmacology review found omega-3 carboxylic acid absorption can be up to four times greater than the ethyl ester form

Reviewing prescription omega-3 fatty acid formulations for hypertriglyceridemia, this review notes that unlike ethyl ester forms - whose absorption depends heavily on pancreatic lipase activity and co-ingested dietary fat - free fatty acid (carboxylic acid) formulations are absorbed up to four-fold better and do not require lipase-mediated hydrolysis first.

Review
Backes et al., Lipids in Health and Disease (2016)
Cognitive Function & Brain Health

The MIDAS trial found 900mg/day of DHA improved learning and memory scores in older adults with age-related cognitive decline

In a 24-week randomized, double-blind, placebo-controlled trial of 485 healthy adults aged 55 and older with mild age-related cognitive decline, 900 mg/day of DHA significantly improved performance on a visuospatial learning and episodic memory test, along with improved verbal recognition memory, and was well tolerated with no serious treatment-related adverse events.

Human RCT (n=485)
Yurko-Mauro et al., Alzheimer's & Dementia (2010)
Cognitive Function & Brain Health

A randomized trial found omega-3, carotenoid and vitamin E supplementation improved working memory in older adults

In a randomized clinical trial of older adults, a combined supplement of omega-3 fatty acids, carotenoids and vitamin E significantly improved working memory performance compared with placebo, suggesting a role for these nutrients together in supporting cognitive function with aging.

Human RCT
Power et al., Clinical Nutrition (2021)
Cognitive Function & Brain Health

A dose-response meta-analysis found n-3 fatty acids modestly influence cognitive function in people without dementia

Analyzing the dose-response relationship between n-3 polyunsaturated fatty acid intake and cognitive function in individuals without dementia, this systematic review and meta-analysis found a measurable, though modest, association between higher omega-3 intake and better cognitive performance across the pooled trials.

Dose-response meta-analysis
Suh et al., BMC Medicine (2024)
Mood & Depression

A meta-analysis found only a small, non-significant benefit of omega-3s for depression once publication bias was accounted for

Pooling 13 randomized placebo-controlled trials of omega-3 fatty acids for major depressive disorder (731 participants), this meta-analysis found no significant overall benefit compared with placebo, and nearly all of the apparent treatment effect in the published literature was attributable to publication bias once statistically corrected for - an important honest caveat on this research area.

Meta-analysis (13 RCTs, n=731)
Bloch & Hannestad, Molecular Psychiatry (2011)
Mood & Depression

A meta-analysis found omega-3 supplements only helped depression when they were EPA-dominant

Pooling 15 trials (916 participants), this meta-analysis found that omega-3 supplements containing at least 60% EPA relative to total EPA+DHA showed a significant benefit on depression scores, while supplements with less than 60% EPA showed no benefit - pointing to EPA proportion, not just total omega-3 dose, as the key variable.

Meta-analysis (15 RCTs, n=916)
Sublette et al., Journal of Clinical Psychiatry (2011)
Mood & Depression

A 2023 meta-analysis found EPA helped depression at moderate doses but not at higher doses

Pooling 10 randomized controlled trials (1,426 participants), this meta-analysis found EPA-enriched supplements (at least 60% of total EPA+DHA) significantly reduced depression severity at doses of 1 to under 2 g/day of EPA, but doses of 2 g/day or more were not associated with a significant benefit - a nuanced, non-linear dose relationship rather than simply more-is-better.

Meta-analysis (10 RCTs, n=1,426)
Kelaiditis et al., Prostaglandins, Leukotrienes and Essential Fatty Acids (2023)
Safety & Tolerability

A meta-analysis of 21 trials in over 24,000 people found prescription-strength omega-3 products were generally safe and well tolerated

Pooling 21 randomized controlled trials with over 24,000 total participants, this systematic review found no definite evidence of any serious adverse event tied to prescription omega-3 fatty acid products, though treatment-related fishy taste, mild skin reactions, and small changes in some lab values (like fasting blood sugar) were more common than with control.

Meta-analysis (21 RCTs, n=24,460)
Chang et al., Prostaglandins, Leukotrienes and Essential Fatty Acids (2018)
Safety & Tolerability

A 4-year trial of high-dose DHA found limited safety risks, with occasional gastrointestinal symptoms

In a 4-year randomized trial of high-dose DHA (30 mg/kg/day) in patients with X-linked retinitis pigmentosa, long-term supplementation was associated with limited safety risks overall, though gastrointestinal symptoms occurred in some participants and should be monitored, especially in those with a personal or family history of GI disturbances.

Human RCT (4-year, n=60)
Hughbanks-Wheaton et al., Investigative Ophthalmology & Visual Science (2014)
Safety & Tolerability

A safety review found no evidence of health risk from polyunsaturated fatty acid intake below the recommended ceiling

Reviewing the safety literature on n-6 and n-3 polyunsaturated fatty acids, including effects on lipid peroxidation, cholesterol, glucose metabolism and hemostasis, this review concluded that below a daily intake ceiling of about 10% of total energy, there is little evidence that high dietary intake of these fatty acids poses a health risk.

Review
Eritsland, American Journal of Clinical Nutrition (2000)
Bleeding Risk & Anticoagulant Interaction

A study in patients on chronic warfarin found fish oil supplementation did not significantly change anticoagulation status

In patients stabilized on chronic warfarin therapy randomized to placebo or 3-6 g/day of fish oil for 4 weeks, there was no statistically significant difference in International Normalized Ratio (INR) between groups, and no major bleeding events occurred - though this was a small study (16 patients) and individual monitoring is still advisable when combining any supplement with an anticoagulant.

Human RCT (n=16)
Bender et al., Journal of Thrombosis and Thrombolysis (1998)
Bleeding Risk & Anticoagulant Interaction

A large perioperative trial found fish oil did not increase bleeding risk in cardiac surgery patients

In a multinational, placebo-controlled trial of 1,516 patients undergoing cardiac surgery, perioperative fish oil supplementation (EPA+DHA, higher pre-operative loading doses tapering to 2 g/day) did not increase major bleeding risk compared with placebo, and was associated with fewer blood transfusions and lower bleeding risk at higher achieved blood omega-3 levels.

Human RCT (n=1,516)
Akintoye et al., Circulation: Cardiovascular Quality and Outcomes (2018)
Bleeding Risk & Anticoagulant Interaction

A randomized trial found omega-3 supplementation before prostate surgery did not increase perioperative bleeding

In 130 patients with prostate cancer randomized to a long-chain omega-3 supplement (3 g/day) or placebo for 4 to 10 weeks before radical prostatectomy, there was no clinically significant difference in perioperative bleeding, blood counts, or postoperative complications between groups, supporting the supplement's safety in this surgical population.

Human RCT (n=130)
Fradet et al., Clinical Nutrition ESPEN (2021)

Customer Reviews

4.6 out of 5 · 14 global ratings
Read genuine reviews on Amazon →Available at Amazon

Frequently asked questions

What is Orange Naturals Omega 3 Fish Oil and what does it do?

It's a softgel providing 1000 mg of wild-sourced fish oil (anchovy, sardine, mackerel) per softgel, delivering 400 mg EPA and 200 mg DHA. It helps support cardiovascular health - this product's Health Canada-authorized use.

How much EPA and DHA does it provide?

Each softgel provides 400 mg EPA (eicosapentaenoic acid) and 200 mg DHA (docosahexaenoic acid) - 600 mg of total omega-3 fatty acids from 1000 mg of fish oil.

How do I take it?

Adults (19 years and older): take up to 3 softgels per day, with food, or as directed by a healthcare practitioner.

Where does the fish oil come from?

It's sourced from wild-caught anchovy, sardine and mackerel - not farmed fish.

Is it vegan or vegetarian?

No. The softgel shell contains gelatin, so this product is not vegan or vegetarian.

Are there any allergens?

Yes - this product contains fish and soy (from the D-alpha-tocopherol). Keep out of reach of children, and do not use if the safety seal is broken.

How long does one bottle last?

Each bottle contains 90 softgels - a 30-day supply at 3 softgels per day, up to a 90-day supply at 1 softgel per day.

Where do I buy it?

Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.

400 mg EPA + 200 mg DHA per Softgel90 Softgels · 30-90 Day SupplyDairy-Free · Gluten-Free · Corn-Free · Wild-SourcedCardiovascular Health Support

Support your heart with wild-sourced Omega 3 fish oil

Get Orange Naturals Omega 3 Fish Oil on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Natural Health Product NPN 80076912. Helps support cardiovascular health. Allergens: fish, soy. Keep out of reach of children. Do not use if the safety seal is broken. The research summaries on this page concern fish oil and its omega-3 fatty acids (EPA/DHA) generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.

Important information

Safety Information

Cautions and Warnings: Allergens: fish, soy. Keep out of reach of children. Do not use if the safety seal is broken.

Indications

Recommended Use or Purpose: Helps support cardiovascular health.

Ingredients

Medicinal Ingredients (each softgel contains): Fish oil (anchovy, sardine, mackerel), 1000 mg, providing Omega-3 Fatty Acids: EPA (eicosapentaenoic acid) 400 mg (40%), DHA (docosahexaenoic acid) 200 mg (20%). Non-medicinal Ingredients: D-alpha-tocopherol (soy), gelatin, glycerin, purified water. Allergens: fish, soy. No artificial flavours, colours, preservatives, sweeteners, dairy, corn, gluten, wheat or yeast. Note: this softgel contains gelatin and is not vegan or vegetarian.

Directions

Recommended Dose (Adults 19 years and older): Take up to 3 softgels per day. Take with food or as directed by a healthcare practitioner.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

$27.89 CAD4.6 ★ (14) Get it on Amazon →