Orange Naturals Magnesium Sleep with GABA & Melatonin | 90 Veg Capsules
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 1-2 capsules before bedtime |
| Licensed Natural Health Product | NPN 80077289 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 3 ACTIVES IN ONE NIGHTLY CAPSULE: Each vegetable capsule delivers 125 mg of magnesium (Albion magnesium bis-glycinate chelate), 100 mg of GABA (gamma-aminobutyric acid) and 2.5 mg of melatonin.
- HELPS REDUCE TIME TO FALL ASLEEP: Helps to reduce the time it takes to fall asleep (sleep onset latency aspect of sleep quality) in people with delayed sleep phase disorder.
- HELPS RESET THE SLEEP-WAKE CYCLE: Helps re-set the body's sleep-wake cycle, an aspect of the circadian rhythm, and helps to temporarily promote relaxation.
- BISGLYCINATE CHELATED MAGNESIUM: Uses a magnesium bis-glycinate chelate form, generally chosen for its gentler digestive profile and absorption relative to less-soluble inorganic magnesium salts.
- SIMPLE BEDTIME DOSE: Adults take 1 to 2 capsules before bedtime, or as directed by a healthcare practitioner - do not drive or use machinery for 5 hours after taking melatonin.
- CLEAN VEGAN FORMULA, MADE IN CANADA: Non-medicinal ingredients: hypromellose, magnesium stearate. Vegan and non-GMO, with no gluten, dairy or soy. 90 veg capsules - a 90-day supply.
Product Description
Magnesium Sleep with GABA & Melatonin - 3 Actives, One Nightly Capsule
Orange Naturals Magnesium Sleep with GABA & Melatonin combines 125 mg of magnesium (Albion magnesium bis-glycinate chelate), 100 mg of GABA and 2.5 mg of melatonin in every vegetable capsule. Licensed under NPN 80077289, it helps reduce the time it takes to fall asleep in people with delayed sleep phase disorder, helps re-set the body's sleep-wake cycle, and helps temporarily promote relaxation - a vegan formula free of gluten, dairy and soy, made in Canada. Licensed Natural Health Product NPN 80077289.
Magnésium Sommeil avec GABA et mélatonine d'Orange Naturals combine 125 mg de magnésium (chélate de bisglycinate de magnésium Albion), 100 mg de GABA et 2,5 mg de mélatonine dans chaque capsule végétale. Homologué sous le NPN 80077289, il aide à réduire le temps nécessaire pour s'endormir chez les personnes souffrant du syndrome de retard de phase du sommeil, aide à rééquilibrer le cycle veille-sommeil du corps, et aide à promouvoir temporairement la relaxation - une formule végétalienne sans gluten, sans produits laitiers et sans soya, fabriquée au Canada.
3 Actives, One Capsule, Before Bedtime
Magnesium Bisglycinate + GABA & Melatonin - Vegan, Non-GMO, Gluten-Free
125 mg Magnesium, Albion Bis-Glycinate Chelate
A gentle, amino-acid-chelated form of magnesium in every vegetable capsule, generally chosen for its digestive tolerability.
Plus 100 mg GABA and 2.5 mg Melatonin
GABA and melatonin round out this nightly formula to help you fall asleep faster and support your sleep-wake cycle.
What Magnesium, GABA & Melatonin Support
Magnesium, GABA and melatonin have each been studied for their own role in sleep, relaxation and the body's circadian rhythm. Here is what the wider research explores about this formula's three real actives.
Helps Reduce Time to Fall Asleep
This product's own Health Canada-authorized use: helps reduce the time it takes to fall asleep in people with delayed sleep phase disorder.
Helps Reset the Sleep-Wake Cycle
Helps re-set the body's sleep-wake cycle, an aspect of the circadian rhythm.
Temporarily Promotes Relaxation
Helps to temporarily promote relaxation as part of a gentle nightly routine.
Bisglycinate Chelated Magnesium
Albion magnesium bis-glycinate chelate, chosen for gentle digestive tolerability relative to less-soluble inorganic magnesium salts.
GABA for Calm
GABA, the body's principal inhibitory neurotransmitter, included to support relaxation before bed.
3 Real Actives, Vegan Formula
Magnesium, GABA and melatonin combined in one vegan vegetable capsule, free of gluten, dairy and soy.
Orange Naturals Magnesium Sleep with GABA & Melatonin: Supplement Facts
Each vegetable capsule contains:
- Magnesium (Albion magnesium bis-glycinate chelate: magnesium bis-glycinate, magnesium oxide)125 mg
- GABA (gamma-aminobutyric acid)100 mg
- Melatonin2.5 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Hypromellose, magnesium stearate.
Recommended Use or Purpose: Helps to reduce the time needed to fall asleep in people with delayed sleep phase disorder. Helps reset the body's sleep-wake cycle (aspect of the circadian rhythm). Helps to temporarily promote relaxation.
Recommended Dose (Adults): Take 1 to 2 capsules before bedtime, or as directed by a healthcare practitioner.
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if you are taking anticoagulant, anticonvulsant, steroid, or blood pressure/immunosuppressive/sedative/hypnotic/psychotropic medications, or if you have asthma, depression, diabetes/hypoglycemia, migraine, hormonal/seizure disorders, or cardiovascular/chronic kidney/immune system/liver disease. Consumption with alcohol or medications/natural health products with sedative properties is not recommended. Do not drive or use machinery for 5 hours after taking melatonin. Consult a healthcare practitioner for use beyond 4 weeks or if symptoms of chronic insomnia worsen or persist continuously for more than 4 weeks. Stop use if allergy occurs or if you experience headache, confusion or nausea. Do not use if the safety seal under the cap is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule végétale contient :
- Magnésium (chélate de bisglycinate de magnésium Albion : bisglycinate de magnésium, oxyde de magnésium)125 mg
- GABA (acide gamma-aminobutyrique)100 mg
- Mélatonine2.5 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Hypromellose, stéarate de magnésium.
Usage ou fins recommandés : Aide à réduire le temps nécessaire pour s'endormir chez les personnes souffrant du syndrome de retard de phase du sommeil. Aide à rééquilibrer le cycle veille-sommeil du corps (aspect du rythme circadien). Aide à promouvoir temporairement la relaxation.
Posologie recommandée (adultes) : Prendre 1 à 2 capsules avant le coucher, ou selon l'avis d'un praticien de soins de santé.
Mises en garde et avertissements : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Consulter un praticien de soins de santé avant l'usage si vous prenez des anticoagulants, des anticonvulsifs, des stéroïdes, ou des médicaments pour la tension artérielle, immunosuppresseurs, sédatifs, hypnotiques ou psychotropes, ou si vous souffrez d'asthme, de dépression, de diabète/hypoglycémie, de migraines, de troubles hormonaux ou convulsifs, ou de maladies cardiovasculaires, rénales chroniques, du système immunitaire ou du foie. La consommation avec de l'alcool ou des médicaments/produits de santé naturels ayant des propriétés sédatives n'est pas recommandée. Ne pas conduire ou utiliser de machinerie pendant 5 heures après la prise de mélatonine. Consulter un praticien de soins de santé pour un usage de plus de 4 semaines ou si des symptômes d'insomnie chronique s'aggravent ou persistent pendant plus de 4 semaines. Cesser l'utilisation en cas d'allergie ou si vous ressentez des maux de tête, de la confusion ou des nausées. Ne pas utiliser si le sceau de sécurité sous le bouchon est brisé. Garder hors de la portée des enfants.
NPN 80077289
Quiet a racing mind - a gentle nightly capsule
Get Orange Naturals Magnesium Sleep with GABA & Melatonin on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Magnesium Sleep with GABA & Melatonin
125 mg magnesium bisglycinate, 100 mg GABA and 2.5 mg melatonin in one gentle vegetable capsule, developed by naturopathic doctors.
125 mg Magnesium Bisglycinate
A full 125 mg dose of magnesium from an Albion magnesium bis-glycinate chelate, in every vegetable capsule.
100 mg GABA + 2.5 mg Melatonin
Helps reduce the time it takes to fall asleep in people with delayed sleep phase disorder and helps re-set the body's sleep-wake cycle.
Gentle vegan vegetable capsule
No gluten, dairy or soy - a simple one-to-two-capsule nightly routine.
Developed by naturopathic doctors, made in Canada
Formulated by Orange Naturals and developed by naturopathic doctors. 90 veg capsules - a 90-day supply.
Inside every capsule
125 mg of magnesium (Albion magnesium bis-glycinate chelate), 100 mg of GABA and 2.5 mg of melatonin in every vegetable capsule - a gentle nightly formula, vegan with no gluten, dairy or soy.
How to use it
Take 1-2 capsules before bedtime
Adults: take 1 to 2 capsules before bedtime, or as directed by a healthcare practitioner.
Avoid driving after taking melatonin
Do not drive or use machinery for 5 hours after taking melatonin.
Check in beyond 4 weeks
Consult a healthcare practitioner for use beyond 4 weeks, or if symptoms of chronic insomnia worsen or persist continuously for more than 4 weeks.
Keep the seal intact
Do not use if the safety seal under the cap is broken. Keep out of reach of children.
What the research says about magnesium, GABA and melatonin
Educational summaries of published research on magnesium, GABA (gamma-aminobutyric acid) and melatonin generally - shared for education, not as claims about this finished product. Orange Naturals Magnesium Sleep with GABA & Melatonin's own authorized use under NPN 80077289 is that it helps reduce the time it takes to fall asleep in people with delayed sleep phase disorder, helps re-set the body's sleep-wake cycle, and helps temporarily promote relaxation.
An RCT found magnesium bisglycinate modestly reduced insomnia severity in adults with poor sleep
A randomized, double-blind, placebo-controlled trial in 155 adults aged 18-65 with self-reported poor sleep quality found that 250 mg of elemental magnesium as magnesium bisglycinate produced a significantly greater reduction in Insomnia Severity Index scores than placebo over 4 weeks, with the largest improvements seen in participants with lower baseline dietary magnesium intake.
Human RCT (n=155)A large NHANES study found magnesium deficiency linked to sleep apnea, but not insomnia
Analyzing 20,585 US adults, a higher renal magnesium depletion score was associated with significantly higher odds of sleep apnea, but showed no significant association with restless legs, insomnia or insufficient sleep - a reminder that magnesium's sleep-related associations can vary by the specific sleep problem studied.
Population-based study (n=20,585)A national nutrition survey found short sleepers consistently under-consume magnesium
Analyzing NHANES data on 26,211 US adults, participants reporting short sleep duration (under 7 hours) had lower usual intake of calcium, magnesium and vitamin D than longer sleepers, with a higher share falling below the estimated average requirement across several nutrients.
Population-based study (n=26,211)In patients with impaired magnesium absorption, a magnesium glycinate chelate outperformed magnesium oxide
A randomized, double-blind crossover trial in 12 patients who had undergone ileal resection compared a labeled magnesium diglycinate chelate with magnesium oxide. Absorption was similar across the group as a whole, but in the four patients with the most impaired magnesium absorption, the chelate was absorbed significantly more (23.5% vs 11.8%) and was better tolerated by all patients.
Human RCT (n=12)A review describes how binding magnesium to an amino acid, as in a bis-glycinate chelate, can enhance mineral absorption
Reviewing metal-binding peptides, the authors describe how binding a mineral such as magnesium to an amino acid or short peptide can influence the resulting complex's configuration in ways that improve absorption and bioavailability relative to unbound, inorganic mineral forms - the chelation principle behind this product's Albion magnesium bis-glycinate chelate.
ReviewA pharmacokinetic animal study ranked five magnesium compounds by how much and how fast they reached the bloodstream and brain
Testing magnesium sulfate, oxide, acetyl taurate, citrate and malate at a single equal dose in rats, magnesium malate produced the highest overall absorption over time and acetyl taurate was absorbed fastest and reached the brain most readily, while the commonly used oxide and citrate forms showed the lowest bioavailability of the five in this design.
Animal studyA systematic review found suggestive but low-quality evidence that magnesium eases subjective anxiety
Reviewing 18 studies of magnesium supplementation (alone or with up to 5 other ingredients) in anxiety-vulnerable samples (mildly anxious, premenstrual, postpartum and hypertensive groups), roughly half of the studies in anxious and premenstrual samples reported a benefit, though the authors rate the overall evidence quality as poor and call for better-designed trials.
Systematic reviewA herbal supplement combining magnesium and chromium improved mood, anxiety and sleep in stressed adults over 15 days
A randomized, double-blind, placebo-controlled crossover trial in stressed adults gave a herbal supplement containing magnesium and chromium alongside hawthorn and skullcap extracts. Chronic supplementation improved mood and anxiety, reducing total mood disturbance, anger/hostility and Trait anxiety scores, with well-being and sleep also measured across the 15-day treatment period and no serious adverse effects reported.
Human RCTA magnesium and B-vitamin combination increased relaxed brain activity and reduced subjective stress under acute stress
A randomized, double-blind, placebo-controlled trial in 100 moderately stressed adults found that a combination of magnesium, B vitamins, green tea and rhodiola extracts significantly increased resting-state EEG theta activity - considered indicative of a relaxed, alert state - and reduced subjective stress, anxiety and mood disturbance after an acute stress test.
Human RCT (n=100)Oral GABA increased relaxation-linked brain waves and reduced anxiety within an hour
In a human study, oral GABA intake significantly increased alpha brain waves and decreased beta waves on EEG within 60 minutes compared with water or L-theanine. In a second study, GABA intake also increased salivary immunoglobulin A (a marker suppressed by stress) in volunteers crossing a suspended bridge as a stressful task, while a placebo group's levels fell.
Human trialCombined GABA and L-theanine improved sleep quality and sleep recovery over 4 weeks
An exploratory study in adults with sleep problems found that combined daily intake of GABA (700 mg) and L-theanine (200 mg) for 4 weeks significantly improved total Pittsburgh Sleep Quality Index scores, wearable-tracked sleep recovery scores, and reduced heart rate during sleep in the first week of intake.
Human trialGABA supplementation improved sleep efficiency, mood and heart-rate variability over 90 days
A randomized, double-blind, placebo-controlled trial in sedentary women with overweight or obesity undergoing physical exercise found that 200 mg of daily GABA supplementation for 90 days improved habitual sleep efficiency (lower Pittsburgh Sleep Quality Index scores), reduced negative affect and depression scores, and increased heart-rate variability indicating greater parasympathetic (calming) nervous-system activity.
Human RCT (n=30)GABA is the body's major inhibitory neurotransmitter, with several proposed mechanisms for easing insomnia
Reviewing GABA and its receptors, the authors describe gamma-aminobutyric acid as the major inhibitory neurotransmitter in the central nervous system, and outline several mechanisms by which it may ease insomnia - including GABA-A and GABA-B receptor modulation, reducing neuroinflammation, and interacting with the circadian hormone melatonin.
ReviewA review of the GABAergic system's role in insomnia describes how raising GABA activity can improve sleep symptoms
Summarizing mechanisms of GABAergic regulation in insomnia, the authors describe how enhancing GABA levels and GABAergic neural signal transmission - including activating GABA receptor expression and regulating the hypothalamic-pituitary-adrenal stress axis - can help improve insomnia symptoms alongside circadian rhythm regulation.
ReviewA review describes how magnesium and GABA-related amino acids jointly support sleep through overlapping pathways
Synthesizing research on nutritional modulators of sleep, the authors describe how magnesium modulates neuronal excitability and enhances GABAergic tone, while inhibitory amino acids like glycine and GABA increase central nervous system inhibition to facilitate sleep onset and architecture.
ReviewA meta-analysis found melatonin meaningfully advances sleep timing in delayed sleep phase disorder
Pooling 5 trials in 91 adults and 4 trials in 226 children with delayed sleep phase disorder, melatonin treatment advanced the mean endogenous melatonin onset by 1.18 hours and clock hour of sleep onset by 0.67 hours, and decreased sleep-onset latency by 23.27 minutes compared with placebo.
Meta-analysisA meta-analysis found melatonin's sleep-onset benefit was far larger in delayed sleep phase syndrome than in general insomnia
Reviewing randomized controlled trials of exogenous melatonin, sleep onset latency decreased by an average of 11.7 minutes overall, but the effect was much larger in people with delayed sleep phase syndrome (a 38.8 minute decrease) than in people with general insomnia (7.2 minutes), with no evidence of adverse effects on short-term use.
Meta-analysisA meta-analysis confirmed melatonin improves sleep onset latency in adults with delayed sleep phase disorder
Reviewing 34 randomized controlled trials across children/adolescents and adults with sleep or mental health disorders, melatonin significantly improved sleep onset latency (by diary) and total sleep time (by polysomnography) in adults with delayed sleep phase disorder, with no significant tolerability differences versus placebo.
Meta-analysis (34 RCTs)The brain's master body clock relies on GABA and melatonin-responsive signaling to keep the sleep-wake cycle on schedule
A review of clinical chronobiology describes the suprachiasmatic nucleus - the hypothalamus's master circadian clock - as synchronizing the body's peripheral clocks primarily through GABA and vasoactive intestinal polypeptide signaling, with melatonin and melatonin agonists among the standard treatments used to help realign a disrupted sleep-wake rhythm.
ReviewA study of patients with no circulating melatonin still maintained a 24-hour sleep-wake cycle, but reported more daytime sleep complaints
Studying 17 people whose pineal gland was removed and who had confirmed absence of circulating melatonin, all participants maintained a 24-hour sleep/wake cycle and none met criteria for a circadian sleep-wake disorder, though mild nocturnal sleep symptoms and frequent daytime complaints were reported - suggesting other synchronizing mechanisms besides melatonin help anchor the circadian clock, even as melatonin's absence was still felt.
Human study (n=17)A review describes melatonin as a chronobiotic that can shift the timing of the body clock when carefully dosed
Reviewing circadian disruption and jet lag, the authors describe melatonin as a chronobiotic capable of realigning the circadian clock, but note its effect follows a phase-response curve - meaning the direction and size of the shift depends on precise timing and dosage, alongside light exposure as the strongest realigning stimulus.
ReviewA meta-analysis found a good overall safety profile for higher-dose melatonin
A systematic review and meta-analysis of 79 randomized trials (3861 adult participants) found that higher-dose melatonin (10 mg or more) did not increase serious adverse events or study withdrawals compared with placebo, though it modestly increased milder effects such as drowsiness, headache and dizziness.
Meta-analysis (79 RCTs)Perioperative melatonin reduced postoperative delirium risk in a meta-analysis, especially at higher doses
Pooling 16 randomized controlled trials (1981 patients), perioperative melatonin or melatonin agonists lowered the incidence of postoperative delirium overall, with a larger benefit from higher-dose melatonin and in the early postoperative period, without an increase in severe adverse events.
Meta-analysis (16 RCTs)A preclinical study found a cannabis-derived compound can raise melatonin blood levels via a shared metabolic enzyme
Because melatonin is chiefly broken down by the liver enzyme CYP1A2, the authors tested whether cannabinol (CBN), a minor cannabinoid increasingly sold combined with melatonin in sleep products, could inhibit that same enzyme. CBN potently inhibited CYP1A2-mediated metabolism of melatonin and increased melatonin's bioavailability four-fold in mice - a reminder that substances sharing melatonin's metabolic pathway can meaningfully change how much melatonin reaches the bloodstream.
Preclinical studyFrequently asked questions
What is Orange Naturals Magnesium Sleep with GABA & Melatonin and what does it do?
It's a vegetable capsule combining 125 mg of magnesium (Albion magnesium bis-glycinate chelate), 100 mg of GABA and 2.5 mg of melatonin. It helps reduce the time it takes to fall asleep in people with delayed sleep phase disorder, helps re-set the body's sleep-wake cycle, and helps temporarily promote relaxation. It is a licensed Natural Health Product, NPN 80077289.
How do I take it?
Adults take 1 to 2 capsules before bedtime, or as directed by a healthcare practitioner. Do not drive or use machinery for 5 hours after taking melatonin.
Can I take it if I'm pregnant, breastfeeding, or have a health condition?
Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner before use if you are taking anticoagulant, anticonvulsant, steroid, or blood pressure/immunosuppressive/sedative/hypnotic/psychotropic medications, or if you have asthma, depression, diabetes/hypoglycemia, migraine, hormonal/seizure disorders, or cardiovascular/chronic kidney/immune system/liver disease.
Is it safe to use long-term?
Consult a healthcare practitioner for use beyond 4 weeks, or if symptoms of chronic insomnia worsen or persist continuously for more than 4 weeks.
How is this different from Orange Naturals' other magnesium products?
This is the only Orange Naturals magnesium product that combines magnesium with both GABA and melatonin as co-equal active ingredients, under its own separate Health Canada licence. The brand's other magnesium products are single-ingredient magnesium formulas (in capsule, liquid, powder or effervescent form) or pair magnesium with a different single active such as L-theanine or 5-HTP, each with its own distinct dose and licence.
Why choose a magnesium bisglycinate chelate form?
It uses an Albion magnesium bis-glycinate chelate, a chelated form generally chosen for its gentler digestive tolerability relative to less-soluble inorganic magnesium salts like magnesium oxide.
Is it vegan and allergen-friendly?
Yes - the label states this product is vegan and non-GMO, with no gluten, dairy or soy.
Where do I buy it?
Use the orange button on this page - it takes you to the Orange Naturals listing on Amazon.ca for secure checkout and fast delivery.
Quiet a racing mind - a gentle nightly capsule
Get Orange Naturals Magnesium Sleep with GABA & Melatonin on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80077289. Helps to reduce the time it takes to fall asleep in people with delayed sleep phase disorder. Helps re-set the body's sleep-wake cycle. Helps to temporarily promote relaxation. The research summaries on this page concern magnesium, GABA and melatonin generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Do not use if you are pregnant or breastfeeding. Do not drive or use machinery for 5 hours after taking melatonin. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if you are taking anticoagulant, anticonvulsant, steroid, or blood pressure/immunosuppressive/sedative/hypnotic/psychotropic medications, or if you have asthma, depression, diabetes/hypoglycemia, migraine, hormonal/seizure disorders, or cardiovascular/chronic kidney/immune system/liver disease. Consumption with alcohol or medications/natural health products with sedative properties is not recommended. Do not drive or use machinery for 5 hours after taking melatonin. Consult a healthcare practitioner for use beyond 4 weeks or if symptoms of chronic insomnia worsen or persist continuously for more than 4 weeks. Stop use if allergy occurs or if you experience headache, confusion or nausea. Do not use if the safety seal under the cap is broken. Keep out of reach of children.
Indications
Recommended Use or Purpose: Helps to reduce the time needed to fall asleep in people with delayed sleep phase disorder. Helps reset the body's sleep-wake cycle (aspect of the circadian rhythm). Helps to temporarily promote relaxation.
Ingredients
Medicinal Ingredients (each vegetable capsule contains): Magnesium (Albion magnesium bis-glycinate chelate: magnesium bis-glycinate, magnesium oxide), 125 mg. GABA (gamma-aminobutyric acid), 100 mg. Melatonin, 2.5 mg. Non-medicinal ingredients: Hypromellose, magnesium stearate.
Directions
Recommended Dose (Adults): Take 1 to 2 capsules before bedtime, or as directed by a healthcare practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.