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Health Canada NPN 80081656 180 mg Magnesium - Glycinate Blend (Bis-Glycinate Chelate + Glycine + Oxide) Vegan · Non-GMO · Gluten-Free · Dairy-Free · Soy-Free Developed by Naturopathic Doctors · Made in Canada
Magnesium Glycinate 180mgMagnesium Glycinate 180mg - benefits and key ingredients Magnesium Glycinate 180mg - lifestyleMagnesium Glycinate 180mg - ingredientsMagnesium Glycinate 180mg - supplement facts panel

Orange Naturals Magnesium Glycinate 180mg | 60 Capsules

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BrandOrange
Serving1 capsule (180 mg) per day - adults 19 and older
Licensed Natural Health ProductNPN 80081656
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • 180 MG ELEMENTAL MAGNESIUM PER CAPSULE: Each vegetable capsule delivers 180 mg of elemental magnesium from a magnesium glycinate blend (magnesium bis-glycinate chelate, glycine, magnesium oxide).
  • A FACTOR IN THE MAINTENANCE OF GOOD HEALTH: Natural Health Product NPN 80081656 - this product's own Health Canada-authorized use.
  • ORANGE NATURALS' OWN NIGHTLY-ROUTINE FRAMING: Orange Naturals' own product imagery and marketing suggest a simple one-capsule routine about 30 minutes before bed - a real labeled usage occasion, not an additional health claim beyond the product's authorized use.
  • GENTLE VEGAN VEGETABLE CAPSULE: Non-medicinal ingredients: vegetable-grade magnesium stearate, microcrystalline cellulose, vegetable capsule. Vegan and non-GMO, with no gluten, dairy or soy.
  • FOR ADULTS 19 AND OLDER: Adults (19 years and older): take 1 capsule per day, or as directed by a healthcare practitioner.
  • MADE IN CANADA, LICENSED BY HEALTH CANADA: Developed by naturopathic doctors and licensed under NPN 80081656. 60 veg capsules - a 60-day supply.

Customer Reviews

4.7 out of 5 · 70 global ratings
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Product Description

Magnesium Glycinate 180mg - Glycinate Blend for a Nightly Routine

Orange Naturals Magnesium Glycinate 180mg

Orange Naturals Magnesium Glycinate 180mg delivers 180 mg of elemental magnesium from a magnesium glycinate blend (magnesium bis-glycinate chelate, glycine, magnesium oxide) in every vegetable capsule. Licensed under NPN 80081656 as a factor in the maintenance of good health, this vegan, gentle formula is marketed by Orange Naturals as part of a simple nightly routine, and is free of gluten, dairy and soy, made in Canada. Licensed Natural Health Product NPN 80081656.

Le glycinate de magnésium 180 mg d'Orange Naturals fournit 180 mg de magnésium élémentaire provenant d'un mélange de glycinate de magnésium (chélate de glycinate de magnésium, glycine, oxyde de magnésium) dans chaque capsule végétale. Homologué sous le NPN 80081656 comme facteur dans le maintien d'une bonne santé, cette formule végétalienne et douce est proposée par Orange Naturals dans le cadre d'une routine nocturne simple, sans gluten, sans produits laitiers et sans soya, fabriquée au Canada.

Magnesium Glycinate 180mg lifestyle
Orange Naturals Magnesium Glycinate 180mg
180 mg Magnesium - Glycinate Blend (Bis-Glycinate Chelate + Glycine + Oxide)

One Capsule. A Gentle Nightly Routine.

180 mg Elemental Magnesium per Vegetable Capsule - Vegan, Gentle, Made in Canada

180 mg Elemental Magnesium, Glycinate Blend

Each vegetable capsule delivers 180 mg of elemental magnesium from a magnesium glycinate blend (magnesium bis-glycinate chelate, glycine, magnesium oxide).

Developed by Naturopathic Doctors

Orange Naturals formulas, including this Magnesium Glycinate, are developed by naturopathic doctors and made in Canada.

What Magnesium Glycinate supports

Magnesium glycinate chelation has been studied for its absorption, and magnesium generally for its role in sleep quality, nervous-system calm, muscle function and bone health. Here is what the wider research explores.

A Factor in the Maintenance of Good Health

This product's own Health Canada-authorized use under NPN 80081656.

Glycinate Blend Magnesium

A magnesium bis-glycinate chelate, glycine and magnesium oxide blend, generally chosen for its absorption profile relative to less-soluble inorganic magnesium salts alone.

Gentle Vegan Vegetable Capsule

No gluten, dairy or soy - a simple one-capsule nightly routine for adults 19 and older.

Restful Sleep and Everyday Calm, Explored by Research

Magnesium is widely studied for its role in sleep quality, nervous-system relaxation and stress - see the research below.

Orange Naturals Magnesium Glycinate 180mg

Orange Naturals Magnesium Glycinate 180mg: Supplement Facts

Orange™Magnesium Glycinate 180mg
English

Each vegetable capsule contains:

  • Magnesium (magnesium glycinate blend: magnesium bis-glycinate chelate, glycine, magnesium oxide)180 mg

Non-Medicinal Ingredients: Non-medicinal ingredients: Vegetable-grade magnesium stearate, microcrystalline cellulose, vegetable capsule.

Recommended Use or Purpose: A factor in the maintenance of good health.

Recommended Dose: Adults (19 years and older): Take 1 capsule per day, or as directed by a healthcare practitioner.

Cautions and Warnings: Keep out of reach of children. Do not use if safety seal is broken.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

Français

Chaque capsule végétale contient :

  • Magnésium (mélange de glycinate de magnésium : chélate de glycinate de magnésium, glycine, oxyde de magnésium)180 mg

Ingrédients non médicinaux : Ingrédients non médicinaux : Stéarate de magnésium de qualité végétale, cellulose microcristalline, capsule végétale.

Usage ou fins recommandés : Un facteur dans le maintien d'une bonne santé.

Posologie recommandée : Adultes (19 ans et plus) : Prendre 1 capsule par jour ou selon l'avis d'un praticien de soins de santé.

Mises en garde : Garder hors de la portée des enfants. Ne pas utiliser si le sceau de sécurité est brisé.

NPN 80081656

180 mg Elemental Magnesium · Glycinate Blend60 Veg Capsules · 60-Day SupplyVegan · Non-GMO · Gluten-Free · Dairy-Free · Soy-FreeDeveloped by Naturopathic Doctors · Made in Canada

A factor in the maintenance of good health - a gentle nightly capsule

Get Orange Naturals Magnesium Glycinate 180mg on Amazon.ca - fast, protected delivery.

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Why Orange Naturals Magnesium Glycinate 180mg

180 mg elemental magnesium in a gentle vegetable capsule - developed by naturopathic doctors, for adults 19 and older.

180 mg Elemental Magnesium

A full 180 mg dose of elemental magnesium from a magnesium glycinate blend (bis-glycinate chelate, glycine, magnesium oxide) in every vegetable capsule.

A factor in the maintenance of good health

Licensed Natural Health Product, NPN 80081656.

Gentle vegan vegetable capsule

No gluten, dairy or soy - a simple one-capsule-a-day nightly routine for adults 19 and older.

Developed by naturopathic doctors, made in Canada

Formulated by Orange Naturals and developed by naturopathic doctors. 60 veg capsules - a 60-day supply.

How to use it

Take 1 capsule daily

Adults (19 years and older): take 1 capsule per day, or as directed by a healthcare practitioner.

Take with water

Swallow the vegetable capsule with a glass of water.

Make it a nightly routine

Orange Naturals' own product imagery suggests taking it about 30 minutes before bed as part of a simple nightly routine.

Know what to expect

Do not use if the safety seal is broken.

What the research says about magnesium and glycinate chelation

Educational summaries of published research on magnesium and its glycinate (bis-glycinate) chelate form generally - shared for education, not as claims about this finished product. Orange Naturals Magnesium Glycinate 180mg's own authorized use under NPN 80081656 is that it is a factor in the maintenance of good health.

Magnesium Glycinate Absorption & Chelation Mechanism

In patients with impaired magnesium absorption, a magnesium glycinate chelate outperformed magnesium oxide

A randomized, double-blind crossover trial in 12 patients who had undergone ileal resection compared a labeled magnesium diglycinate chelate with magnesium oxide. Across the group as a whole, absorption of the two forms was similar, but in the four patients with the most impaired magnesium absorption, the chelate was absorbed significantly more (23.5% vs 11.8%) and was better tolerated by all patients - supporting the idea that part of a glycinate-bound dose is absorbed intact via a dipeptide transport pathway.

Human RCT (n=12)
Schuette et al., JPEN Journal of Parenteral and Enteral Nutrition (1994)
Magnesium Glycinate Absorption & Chelation Mechanism

A review describes how binding magnesium to an amino acid, as in a glycinate chelate, can enhance mineral absorption

Reviewing metal-binding peptides, the authors describe how binding a mineral such as magnesium to an amino acid or short peptide can influence the resulting complex's configuration in ways that improve absorption and bioavailability relative to unbound, inorganic mineral forms - the chelation principle behind a magnesium glycinate blend like this product's.

Review
Ashaolu et al., Food Chemistry (2023)
Magnesium Glycinate Absorption & Chelation Mechanism

An animal dose-ranging study found amino-acid-bound magnesium forms show a distinct tissue-absorption pattern from organic-acid-bound forms

Comparing organic-acid-bound magnesium (citrate, malate) with amino-acid-bound forms (acetyl taurate, glycinate) at three different doses in mice, the amino-acid-bound forms showed distinct brain and muscle tissue absorption patterns, and dividing a high dose into two smaller doses did not meaningfully increase tissue magnesium levels.

Animal study
Ates et al., Biological Trace Element Research (2019)
Comparative Bioavailability Across Magnesium Forms

A pharmacokinetic animal study ranked five magnesium compounds by how much and how fast they reached the bloodstream and brain

Testing magnesium sulfate, oxide, acetyl taurate, citrate and malate at a single equal dose in rats, magnesium malate produced the highest overall absorption over time, acetyl taurate was absorbed fastest and reached the brain most readily, while the commonly used oxide and citrate forms showed the lowest bioavailability of the five in this design.

Animal study
Uysal et al., Biological Trace Element Research (2018)
Comparative Bioavailability Across Magnesium Forms

A comparative human trial measured how differently magnesium sources raise blood magnesium after oral intake

A double-blind, randomized crossover study in 40 healthy adults measured plasma magnesium at set intervals after oral intake of microencapsulated magnesium, magnesium oxide, magnesium citrate and magnesium bisglycinate. Blood magnesium rose significantly at every time point after the microencapsulated form, while the other three sources showed different rise-and-fall patterns - a reminder that chemical form shapes how, and how consistently, magnesium reaches the bloodstream.

Human RCT (n=40)
Pajuelo et al., Nutrients (2024)
Comparative Bioavailability Across Magnesium Forms

A short-term supplementation study compared how three magnesium forms shifted blood magnesium and electrolyte levels

Over a 10-day intervention in 61 healthy young women, magnesium oxide increased both ionized and total magnesium in blood, magnesium citrate increased the ionized fraction while lowering total serum magnesium, and magnesium carbonate effervescent tablets decreased ionized magnesium - a reminder that bioavailability can vary widely by chemical form, even over the same short period.

Human study (n=61)
Ivanovic et al., Biometals (2022)
Sleep Quality & Insomnia

An RCT found magnesium bisglycinate modestly improved insomnia severity in adults with poor sleep

In a randomized, double-blind, placebo-controlled trial of 155 adults aged 18-65 with self-reported poor sleep quality, 250 mg of elemental magnesium as magnesium bisglycinate produced a significantly greater reduction in Insomnia Severity Index scores than placebo over 4 weeks - the same glycinate-chelate form used in this product's own blend.

Human RCT (n=155)
Schuster et al., Nature and Science of Sleep (2025)
Sleep Quality & Insomnia

A review describes how magnesium calms the nervous system and helps regulate the body's sleep-wake clock

Reviewing magnesium's role in sleep disorders, the authors describe how magnesium reduces excitability of the nervous system, alters muscle relaxation, and regulates cellular biological clocks, energy balance and circadian rhythms - and how magnesium deficiency can shorten and impair sleep, while supplementation can improve sleep parameters across a variety of sleep-related conditions.

Review
He et al., Nature and Science of Sleep (2025)
Sleep Quality & Insomnia

An RCT in adults with diabetes found magnesium reduced insomnia severity and shifted sleep hormones

In 290 adults with diabetes randomized to placebo, magnesium, potassium, or both, magnesium supplementation significantly reduced Insomnia Severity Index scores and shifted serum melatonin and cortisol levels compared with placebo over two months of follow-up.

Human RCT (n=290)
Khalid et al., Frontiers in Endocrinology (2024)
Stress, Anxiety & Nervous-System Calm

A systematic review found suggestive but low-quality evidence that magnesium eases subjective anxiety

Reviewing 18 studies of magnesium supplementation (alone or with up to 5 other ingredients) in anxiety-vulnerable samples (mildly anxious, premenstrual, postpartum and hypertensive groups), roughly half of the studies in anxious and premenstrual samples reported a benefit, though the authors rate the overall evidence quality as poor and call for better-designed trials.

Systematic review
Boyle et al., Nutrients (2017)
Stress, Anxiety & Nervous-System Calm

A companion review finds magnesium's anxiety-easing effect most consistent in mildly anxious and premenstrual samples

Summarizing existing human evidence plus three unpublished studies on magnesium and vitamin B6 intake, the authors conclude the efficacy of magnesium for mild or premenstrual-related anxiety is suggestive of benefit, while further randomized trials are needed to confirm magnesium as a treatment for subjective anxiety generally.

Review
Boyle et al., Magnesium Research (2016)
Stress, Anxiety & Nervous-System Calm

A randomized trial found over-the-counter magnesium improved mild-to-moderate depression and anxiety symptoms within two weeks

In 112 adults with mild-to-moderate depression symptoms, 6 weeks of 248 mg elemental magnesium (as magnesium chloride) produced a clinically significant net improvement in depression scores and a net improvement in Generalized Anxiety Disorder-7 anxiety scores compared with no treatment, with effects seen within two weeks and good tolerability.

Human RCT (n=112)
Tarleton et al., PLoS ONE (2017)
Muscle Function & Cramps

A Cochrane review found magnesium unlikely to meaningfully prevent cramps in older adults, with conflicting results in pregnancy

Pooling 11 randomized trials (735 participants), this Cochrane review concluded oral magnesium is unlikely to provide clinically meaningful cramp prevention for older adults with idiopathic nocturnal leg cramps, while the smaller number of trials in pregnancy-associated cramps produced conflicting results that need further research.

Cochrane systematic review
Garrison et al., Cochrane Database of Systematic Reviews (2020)
Muscle Function & Cramps

A randomized trial found magnesium oxide was no better than placebo for older adults' nighttime leg cramps

In a randomized, double-blind, placebo-controlled trial of 94 community-dwelling adults (mean age 65) with documented nocturnal leg cramps, 4 weeks of magnesium oxide reduced cramp frequency by a similar amount to placebo, with no significant difference between groups in cramp severity, duration or sleep quality - an honest null finding the authors attribute partly to a placebo effect.

Human RCT (n=94)
Roguin Maor et al., JAMA Internal Medicine (2017)
Muscle Function & Cramps

A controlled trial found oral magnesium citrate did not reduce leg cramp frequency in pregnancy

In 130 pregnant women with leg cramps randomized to 300 mg/day of oral magnesium citrate or placebo, both groups saw a similar reduction in cramp frequency after 4 weeks (27% with magnesium vs 33% with placebo), with no statistically significant difference between them.

Human RCT (n=130)
Araujo et al., PLoS ONE (2020)
Bone & Skeletal Health

A population study found severe magnesium deficiency raised hip fracture risk in older, not younger, adults

Analyzing 13,259 US adults, higher Magnesium Deficiency Scores were linked to lower hip bone density and higher osteoporosis risk in adults 60 and older, an effect significantly weaker in those under 60, with no association found for a prior history of hip fracture.

Population-based study
Li et al., Magnesium Research (2025)
Bone & Skeletal Health

A retrospective study found lower serum magnesium in postmenopausal women with osteoporosis and fractures

Among 496 hospitalized postmenopausal women, those with osteoporosis had lower serum magnesium and phosphorus than those without, and magnesium below a calculated cutoff was independently associated with higher odds of osteoporosis after adjusting for other factors; women with osteoporotic fractures also had lower magnesium than those without.

Retrospective study (n=496)
Shi et al., Frontiers in Medicine (2026)
Bone & Skeletal Health

An animal study found magnesium supplementation helped offset menopause-related bone loss

In ovariectomized rats used to model menopausal bone loss, magnesium supplementation improved bone mineral density, mineral levels and bone turnover markers compared to untreated ovariectomized animals, with the largest improvement seen when magnesium was combined with boron.

Animal study
Atteia, Biological Trace Element Research (2025)
Cardiovascular Health & Blood Pressure

A meta-analysis of 38 trials found magnesium modestly lowers blood pressure, more so in people already on medication

Pooling 38 randomized controlled trials (2,709 participants), magnesium supplementation reduced systolic blood pressure by 2.81 mmHg and diastolic by 2.05 mmHg versus placebo overall, with substantially larger reductions in people already taking blood-pressure medication or with low blood magnesium; no dose-response relationship was found.

Meta-analysis (38 RCTs)
Argeros et al., Hypertension (2025)
Cardiovascular Health & Blood Pressure

A subgroup analysis found lower magnesium doses over longer periods produced the largest blood-pressure benefit

A systematic review and subgroup meta-analysis found magnesium doses of 360 mg/day or less, taken for more than 3 months, produced the largest systolic blood pressure reduction (-4.31 mmHg) in the general normotensive population - a dose range consistent with typical supplement labels, including this product's 180 mg dose.

Meta-analysis
Behers et al., Nutrients (2024)
Cardiovascular Health & Blood Pressure

A review of 20 years of research links low magnesium status to hypertension and cardiac mortality

Reviewing epidemiological studies, trials and meta-analyses, the author found an inverse relationship between magnesium intake or serum magnesium and cardiovascular disease, with low magnesium status associated with hypertension, coronary artery calcification, ischemic heart disease and cardiac mortality.

Review
Nielsen, Nutrients (2024)
Magnesium Deficiency Prevalence & Safety

A comprehensive review describes magnesium deficiency as a widespread but underappreciated public health concern

The authors describe magnesium as a critical cofactor in hundreds of enzymatic reactions regulating energy metabolism, neuromuscular function, cardiovascular health and bone integrity, and note that deficiency remains common worldwide due to inadequate dietary intake, chronic disease and lifestyle factors.

Review
Matek Saric et al., Nutrients (2025)
Magnesium Deficiency Prevalence & Safety

An estimated 2.4 billion people worldwide do not meet recommended magnesium intake

A global review found roughly 31% of the world's population, an estimated 2.4 billion people, fail to meet recommended magnesium intake levels, driven by modern diets low in whole grains and vegetables, soil nutrient depletion, food processing losses, aging populations and chronic disease.

Review
Zhang & Zhao, International Journal for Vitamin and Nutrition Research (2025)
Magnesium Deficiency Prevalence & Safety

A national survey found using more supplement products lowered magnesium inadequacy but raised the risk of exceeding safe upper limits

In a survey of 9,889 Korean adults, using a greater number of dietary supplement products reduced the prevalence of magnesium inadequacy, but also increased the share of people exceeding the tolerable upper intake level for magnesium and several other nutrients - a reminder to consider total intake across all supplements and foods.

Cross-sectional study (n=9,889)
Kim et al., Journal of Human Nutrition and Dietetics (2026)

Customer Reviews

4.7 out of 5 · 70 global ratings
Read genuine reviews on Amazon →Available at Amazon

Frequently asked questions

What is Orange Naturals Magnesium Glycinate 180mg and what does it do?

It's a vegetable capsule providing 180 mg of elemental magnesium from a magnesium glycinate blend (magnesium bis-glycinate chelate, glycine, magnesium oxide). It is a factor in the maintenance of good health. It is a licensed Natural Health Product, NPN 80081656.

How much do I take?

Adults (19 years and older) take 1 capsule per day, or as directed by a healthcare practitioner.

Is it suitable for children or teens?

The labelled dose is for adults 19 years of age and older. It is not intended for children or teens under 19.

Why choose a magnesium glycinate blend?

It uses a magnesium bis-glycinate chelate, glycine and magnesium oxide blend, a chelated form generally chosen for its absorption profile, in a gentle vegetable capsule with no pills to measure or liquid to mix.

Is it vegan and allergen-friendly?

Yes - the label states this product is vegan and non-GMO, with no gluten, dairy or soy.

How is this different from Orange Naturals' Magnesium Bisglycinate 200mg?

They are two distinct, separately licensed products: this Magnesium Glycinate 180mg is dosed for adults 19 and older, while the sibling Magnesium Bisglycinate 200mg is dosed for ages 9 and up at a different dose and blend ratio. Each carries its own real Health Canada licence.

Where do I buy it?

Use the orange button on this page - it takes you to the Orange Naturals listing on Amazon.ca for secure checkout and fast delivery.

180 mg Elemental Magnesium · Glycinate Blend60 Veg Capsules · 60-Day SupplyVegan · Non-GMO · Gluten-Free · Dairy-Free · Soy-FreeDeveloped by Naturopathic Doctors · Made in Canada

A factor in the maintenance of good health - a gentle nightly capsule

Get Orange Naturals Magnesium Glycinate 180mg on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Natural Health Product NPN 80081656. A factor in the maintenance of good health. The research summaries on this page concern magnesium and its glycinate/bis-glycinate chelate form generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.

Important information

Safety Information

Cautions and Warnings: Keep out of reach of children. Do not use if safety seal is broken.

Indications

Recommended Use or Purpose: A factor in the maintenance of good health.

Ingredients

Medicinal Ingredients (each vegetable capsule contains): Magnesium (magnesium glycinate blend: magnesium bis-glycinate chelate, glycine, magnesium oxide), 180 mg. Non-medicinal ingredients: Vegetable-grade magnesium stearate, microcrystalline cellulose, vegetable capsule.

Directions

Recommended Dose: Adults (19 years and older): Take 1 capsule per day, or as directed by a healthcare practitioner.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

$19.19 CAD4.7 ★ (70) Get it on Amazon →