Orange Naturals Iron Complex 20mg Gentle Iron Bisglycinate | 60 V-Caps
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 1 to 2 capsules (20-40 mg iron) per day with food - adults |
| Licensed Natural Health Product | NPN 80094846 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 20 MG GENTLE IRON BISGLYCINATE: Each vegetable capsule delivers 20 mg of elemental iron from Albion ferrous bis-glycinate chelate - a chelated form generally studied for easier digestive tolerance than ferrous sulfate or oxide.
- HELPS PREVENT IRON DEFICIENCY ANAEMIA: Natural Health Product NPN 80094846 - this product's own Health Canada-authorized use.
- 6 SUPPORTING COFACTORS IN ONE CAPSULE: Vitamin C, B6, B12, folic acid, magnesium and copper alongside iron - vitamin C supports iron absorption and copper is needed by the enzymes that move iron into circulation.
- REAL PEDIATRIC-SAFETY CAUTION - READ BEFORE USE: Keep out of reach of children. There is enough iron in this package to seriously harm a child.
- GENTLE VEGAN VEGETABLE CAPSULE: Non-medicinal ingredients: hypromellose (vegetable capsule), magnesium stearate. Vegan and non-GMO, with no gluten, dairy, soy, wheat or yeast.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Developed by naturopathic doctors and licensed under NPN 80094846. 60 vegetable capsules, a 30 to 60-day supply depending on dose.
Product Description
Iron Complex - Gentle Iron Bisglycinate with C, B6, B12, Folic Acid, Magnesium & Copper
Orange Naturals Iron Complex delivers 20 mg of gentle, highly-chelated iron (Albion ferrous bis-glycinate chelate) alongside vitamin C, B6, B12, folic acid, magnesium and copper in every vegetable capsule. Licensed under NPN 80094846 to help prevent iron deficiency anaemia, this vegan, naturopath-developed formula is free of gluten, dairy, soy, wheat and yeast, and made in Canada. Licensed Natural Health Product NPN 80094846.
Complexe de Fer d'Orange Naturals offre 20 mg de fer doux et hautement chélaté (chélate de bisglycinate ferreux Albion) accompagné de vitamine C, B6, B12, d'acide folique, de magnésium et de cuivre dans chaque capsule végétale. Homologué sous le NPN 80094846 pour aider à prévenir l'anémie ferriprive, cette formule végétalienne développée par des naturopathes est sans gluten, sans produits laitiers, sans soya, sans blé et sans levure, et fabriquée au Canada.
One Capsule. Real Ferrous Bisglycinate Iron.
20 mg Elemental Iron - Gentle, Chelated, with C, B6, B12, Folic Acid, Magnesium & Copper
20 mg Gentle Iron Bisglycinate Chelate
Each vegetable capsule delivers 20 mg of elemental iron from Albion ferrous bis-glycinate chelate, a chelated form generally studied for easier digestive tolerance.
Developed by Naturopathic Doctors
Orange Naturals formulas, including this Iron Complex, are developed by naturopathic doctors and made in Canada.
Advanced Ingredients, Superior Results
Iron bisglycinate chelation, vitamin C's role in enhancing iron absorption, and copper and B-vitamin cofactors in red blood cell formation have each been studied extensively. Here is what the wider research explores.
Iron (Albion Ferrous bis-glycinate chelate)
A gentle, chelated iron form generally studied for easier digestive tolerance than ferrous sulfate or oxide; this product's own authorized use is helping to prevent iron deficiency anaemia.
20 mg per vegetable capsuleVitamin C (ascorbic acid)
A reducing agent long studied for enhancing the absorption of non-heme iron from the diet and from supplements.
300 mg per vegetable capsuleVitamin B6 (Pyridoxal-5-phosphate)
The active coenzyme form of vitamin B6, involved alongside iron, B12 and folate in red blood cell formation.
25 mg per vegetable capsuleVitamin B12 (methylcobalamin)
A bioidentical, active form of vitamin B12 required for red blood cell formation and DNA synthesis.
400 mcg per vegetable capsule
Folic Acid (L-5-methyltetrahydrofolate)
The active, bioavailable folate form required alongside B12 and iron for healthy red blood cell formation.
400 mcg per vegetable capsuleMagnesium (Albion magnesium bis-glycinate chelate buffered)
A chelated magnesium form included in this complex's blend (magnesium bis-glycinate chelate, magnesium oxide).
42 mg per vegetable capsuleCopper (Albion copper bis-glycinate chelate)
An essential trace mineral required by copper-dependent ferroxidase enzymes (ceruloplasmin, hephaestin) that move iron out of storage and into circulation.
35 mcg per vegetable capsuleOrange Naturals Iron Complex: Supplement Facts
Each vegetable capsule contains:
- Vitamin C (ascorbic acid)300 mg
- Magnesium (Albion magnesium bis-glycinate chelate buffered)42 mg
- Vitamin B6 (Pyridoxal-5-phosphate)25 mg
- Iron (Albion Ferrous bis-glycinate chelate)20 mg
- Vitamin B12 (methylcobalamin)400 mcg
- Folic Acid (L-5-methyltetrahydrofolate)400 mcg
- Copper (Albion copper bis-glycinate chelate)35 mcg
Non-Medicinal Ingredients: Non-medicinal ingredients: Hypromellose (vegetable capsule), magnesium stearate.
Recommended Use or Purpose: Helps to prevent iron deficiency anaemia. Helps to prevent iron deficiency.
Recommended Dose (Adults): Take 1 to 2 capsules per day with food. Take a few hours before or after taking other medications.
Cautions and Warnings: Keep out of reach of children. There is enough iron in this package to seriously harm a child. Some people may experience constipation, diarrhea and/or vomiting. Stop use if hypersensitivity occurs. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule végétale contient :
- Vitamine C (acide ascorbique)300 mg
- Magnésium (chélate de bisglycinate de magnésium tamponné Albion)42 mg
- Vitamine B6 (Pyridoxal-5-phosphate)25 mg
- Fer (chélate de bisglycinate ferreux Albion)20 mg
- Vitamine B12 (méthylcobalamine)400 mcg
- Acide folique (L-5-méthyltétrahydrofolate)400 mcg
- Cuivre (chélate de bisglycinate de cuivre Albion)35 mcg
Ingrédients non médicinaux : Ingrédients non médicinaux : Hypromellose (capsule végétale), stéarate de magnésium.
Usage ou fins recommandés : Aide à prévenir l'anémie ferriprive. Aide à prévenir la carence en fer.
Posologie recommandée (adultes) : Prendre 1 à 2 capsules par jour avec de la nourriture. Prendre quelques heures avant ou après la prise d'autres médicaments.
Mises en garde : Garder hors de la portée des enfants. Cet emballage contient suffisamment de fer pour causer de graves dommages à un enfant. Certaines personnes peuvent ressentir de la constipation, de la diarrhée et/ou des vomissements. Cesser l'utilisation en cas d'hypersensibilité. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80094846
Helps prevent iron deficiency anaemia - in a gentle vegan capsule
Get Orange Naturals Iron Complex on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Iron Complex
20 mg gentle iron bisglycinate with vitamin C, B6, B12, folic acid, magnesium and copper - developed by naturopathic doctors, in one vegetable capsule.
20 mg Gentle Iron Bisglycinate
A full 20 mg dose of elemental iron from Albion ferrous bis-glycinate chelate, a form studied for easier digestive tolerance than ferrous sulfate or oxide.
Helps prevent iron deficiency anaemia
Licensed Natural Health Product, NPN 80094846.
6 supporting cofactors in one capsule
Vitamin C, B6, B12, folic acid, magnesium and copper alongside iron - no separate pills to track.
Developed by naturopathic doctors, made in Canada
Formulated by Orange Naturals and developed by naturopathic doctors. Vegan, gluten-free, dairy-free and soy-free.
Inside every capsule
20 mg of gentle, chelated iron (Albion ferrous bis-glycinate chelate) alongside vitamin C, B6, B12, folic acid, magnesium and copper - a vegan format with no gluten, dairy, soy, wheat or yeast.
How to use it
Take 1 to 2 capsules daily with food
Adults: take 1 to 2 capsules per day with food.
Space out from other medications
Take a few hours before or after taking other medications.
Keep well out of reach of children
There is enough iron in this package to seriously harm a child if swallowed accidentally.
Know what to expect
Some people may experience constipation, diarrhea and/or vomiting. Stop use if hypersensitivity occurs.
What the research says about iron bisglycinate and its cofactors
Educational summaries of published research on iron bisglycinate chelation, vitamin C, copper, B12 and folate generally - shared for education, not as claims about this finished product. Orange Naturals Iron Complex's own authorized use under NPN 80094846 is helping to prevent iron deficiency anaemia and helping to prevent iron deficiency.
A trial in pregnant women found ferrous bisglycinate had the most favourable digestive side-effect profile of three iron forms
Two randomized, double-blind studies in 482 pregnant women compared ferrous fumarate, ferrous bisglycinate and ferrous sulphate at equipotent low doses. Ferrous bisglycinate 25 mg iron/day had significantly fewer gastrointestinal complaints than ferrous fumarate 40 mg iron/day or ferrous sulphate 50 mg iron/day, and a lower frequency of black stools (8% vs 22% and 31%).
Human RCT (n=482)A trial in schoolchildren found iron bis-glycinate chelate produced a more sustained rise in iron stores than ferrous sulfate
200 schoolchildren with low iron stores but no anemia were randomized to 30 mg/day of elemental iron as ferrous sulfate or iron bis-glycinate chelate for 12 weeks. Ferritin rose in both groups; at 6 months after supplementation ended, ferritin remained higher in the bis-glycinate chelate group.
Human RCT (n=200)An honest mixed finding: in gastrectomized patients, ferrous sulfate outperformed ferrous glycinate chelate on some lab measures
In 18 patients with iron-deficiency anemia after stomach surgery, those given ferrous sulfate (80 mg/day elemental iron) showed larger improvements in corpuscular hemoglobin, serum iron and ferritin than those given ferrous glycinate chelate (50 mg/day elemental iron) over 4 months - a reminder that dose and individual absorption capacity, not just chelate form, affect real-world results.
Controlled trial (n=18)A pilot trial in anemic children found iron bisglycinate chelate more effective than polymaltose iron at rebuilding iron stores
Children aged 1 to 13 with iron-deficiency anemia were randomized to iron bisglycinate chelate or polymaltose iron (3 mg iron/kg/day for 45 days). Both treatments raised hemoglobin, but only the bisglycinate chelate group showed significant increases in ferritin and mean corpuscular hemoglobin, suggesting greater efficacy at rebuilding iron stores.
Human RCT (pilot)A community trial found iron bis-glycinate chelate and ferrous sulfate similarly effective at raising hemoglobin in anemic children
138 anemic schoolchildren in Brazil received either weekly ferrous sulfate or iron bis-glycinate chelate-enriched cookies for 8 weeks. Both groups showed significant hemoglobin increases (1.1 g/dL and 0.9 g/dL respectively), with no significant difference between the two approaches.
Randomized community trial (n=138)A trial in pregnant women with iron-deficiency anemia found ferrous asparto glycinate raised hemoglobin and ferritin more than ferrous ascorbate
73 pregnant women with iron-deficiency anemia were randomized to ferrous ascorbate or ferrous asparto glycinate for 28 days. At both day 14 and day 28, the glycinate group showed significantly higher hemoglobin and ferritin levels than the ascorbate group.
Human RCT (n=73)Classic human meal studies found about 50 mg of vitamin C per meal was desirable for optimal iron absorption
Studying 299 subjects across many different meals, ascorbic acid consistently enhanced non-heme iron absorption, with the effect most pronounced in meals containing absorption-inhibiting compounds like phytates and tannins. The authors concluded roughly 50 mg of vitamin C per main meal was desirable for optimum effect on iron absorption.
Human absorption studies (n=299)Adding vitamin-C-rich guava to a rice meal significantly increased non-heme iron absorption in adolescents
16 adolescents ate a standard rice-based meal with and without 100 g of guava (which raised the meal's vitamin C content twenty-fold). Iron absorption from the meal with guava was significantly greater in both girls (23.9% vs 9.7%) and boys (19.2% vs 8.6%) than the plain meal.
Human crossover study (n=16)A nuanced finding: copper alongside vitamin C enhanced iron absorption at moderate ratios but not at a higher copper ratio
In 14 adult women, adding copper plus ascorbic acid to a dose of iron increased non-heme iron absorption at 4:1 and 6:1 copper-to-iron molar ratios (57% and 64% vs 39% for iron alone), but this enhancement disappeared at an 8:1 ratio - showing the copper-vitamin C-iron relationship is dose-dependent rather than simply additive.
Human study (n=14)A meta-analysis found iron therapy meaningfully reduces fatigue in iron deficiency without anemia, though the picture is less clear cross-sectionally
Pooling 6 randomized controlled trials, iron supplementation showed a significant, robust benefit for fatigue in people with iron deficiency but no anemia. A separate pooling of 6 cross-sectional studies found no significant association between iron-deficiency-without-anemia and fatigue in the general population - an honest split between what treatment trials and population snapshots each show.
Meta-analysis (6 RCTs + 6 cross-sectional studies)An RCT found intravenous iron improved fatigue scores and running economy in iron-deficient, non-anemic active women
26 recreationally active women with iron deficiency but no anemia were randomized to intravenous iron or placebo. After 4 weeks, the iron group showed improved running economy and reduced fatigue scores compared with placebo, though peak oxygen consumption and hemoglobin mass were unchanged.
Human RCT (n=26)An 8-week trial combining iron supplementation with exercise training improved fatigue and proprioception in young women with iron-deficiency anemia
Young women with iron-deficiency anemia all received ferrous sulfate supplementation; those who additionally completed an 8-week Tabata-based training program showed greater improvements in hemoglobin, general and physical fatigue scores, and proprioceptive acuity than the untrained group.
Human RCT (n=38)A comparative trial found a lower-dose iron-plus-ascorbate formulation matched a higher-dose ferrous ascorbate for treating anemia in pregnancy
Pregnant women with iron-deficiency anemia in the second trimester received either emulsified microsomal ferric pyrophosphate (27 mg elemental iron) or ferrous ascorbate (100 mg elemental iron) for 4 weeks. Both groups showed similar improvements in hemoglobin (+2.63 vs +2.62 g/dL) and ferritin, with the lower-dose formulation showing fewer gastrointestinal side effects.
Human RCT (comparative)In pregnant women with persistent iron deficiency, oral iron corrected fewer women to non-anemic status than intravenous iron
201 pregnant women with iron deficiency persisting after routine oral iron were randomized to a single intravenous iron dose or continued oral iron (100 mg elemental iron daily). Over 18 weeks, 91% of the intravenous group remained non-anemic versus 73% of the oral iron group - oral iron remained effective for most, but was less complete than intravenous therapy in this persistent-deficiency population.
Human RCT (n=201)An umbrella review found inadequate iron and folic acid supplementation among the modifiable risk factors for anemia in pregnancy
Synthesizing 10 systematic reviews and meta-analyses, this umbrella review found inadequate iron/folic acid supplementation (adjusted odds ratio 1.38-1.82) among several modifiable risk factors for anemia in pregnancy, alongside low dietary diversity, intestinal parasites and malaria.
Umbrella reviewThe 2021 Global Burden of Disease study estimated 1.92 billion prevalent cases of anemia worldwide, with dietary iron deficiency the leading cause
Analyzing hemoglobin data across 204 countries, this study estimated the global prevalence of anemia at 24.3% across all ages in 2021 (1.92 billion cases), with dietary iron deficiency the single largest contributor to anemia-related years lived with disability, and children under 5, women, and people in sub-Saharan Africa and South Asia most affected.
Global Burden of Disease analysisA review of humanitarian nutrition surveys found anemia affecting roughly a quarter to nearly half of displaced women and children worldwide
Analyzing 380 nutrition surveys from 121 refugee settings in 24 countries (2013-2016), the median prevalence of anemia was 44% among young children and 28% among women of reproductive age, with the highest rates in West and Central Africa.
Multi-country survey analysisAn umbrella review estimated iron-deficiency anemia affects about 1 in 6 pregnant women and 1 in 5 young children in Iran
Pooling seven meta-analyses covering nearly 190,000 pregnant women and almost 6,000 children under six, this review estimated iron-deficiency anemia prevalence at 15.7% in pregnant women and 19.9% in young children, classifying Iran at a mild level of public-health severity by WHO criteria.
Umbrella systematic reviewMice lacking the copper-dependent enzymes hephaestin and ceruloplasmin developed severe systemic iron deficiency
Knockout mice missing both hephaestin and ceruloplasmin - two copper-dependent ferroxidase enzymes - developed severe anemia and significantly lower serum and spleen iron, despite iron building up in the liver, heart, kidney and gut lining, showing these copper-enzymes are essential for moving stored iron into circulation.
Animal knockout studyIn iron-deficient piglets, reduced copper-transporter activity was linked to lower levels of the iron-exporting protein ferroportin
In the duodenum of anemic piglets, researchers found iron deposits alongside reduced expression of ferroportin (the only known cellular iron exporter) and hephaestin, alongside decreased expression of a copper transporter - suggesting copper distribution within intestinal cells helps regulate how much iron is absorbed and exported.
Animal studyA human case and literature review describes macrocytic anemia as a hallmark presentation of copper deficiency
Reviewing copper deficiency (commonly caused by malabsorption after bariatric or bowel surgery) alongside a patient case, the authors describe hematologic disturbances including macrocytic anemia as a common early presentation, which typically corrects with copper repletion, alongside neurological symptoms that can be irreversible if untreated.
Case report and literature reviewA Cochrane review found vitamin B12 supplementation in children reduced deficiency but showed little to no effect on anemia in the trials pooled
Reviewing 16 trials in 4,083 children, vitamin B12 supplementation clearly reduced vitamin B12 deficiency and raised blood B12 concentrations compared to placebo (high-certainty evidence), but showed little to no difference in anemia, growth or cognitive function outcomes across the pooled trials - an honest, evidence-graded null finding for some outcomes even where the core deficiency-correction effect was clear.
Cochrane systematic review (16 RCTs, n=4,083)A clinical review describes how red-cell folate reflects folate status over several months and its role in preventing megaloblastic anemia
Reviewing laboratory methods for assessing folate status, the authors describe how folate is fixed in red blood cells during their formation, making red-cell folate a marker of status over roughly the preceding four months, and note that detecting and correcting folate deficiency prevents megaloblastic anemia.
Clinical laboratory reviewA review found the specific vitamin B12 form used in supplements, including methylcobalamin, makes little difference for most people
Reviewing the four commercially available B12 forms (methylcobalamin, adenosylcobalamin, hydroxycobalamin and cyanocobalamin), all are converted inside the body to the same active intracellular forms; for most of the population any bioidentical form - including the methylcobalamin used in this product - has similar bioavailability and effect.
ReviewFrequently asked questions
What is Orange Naturals Iron Complex and what does it do?
It's a vegetable capsule providing 20 mg of gentle iron (Albion ferrous bis-glycinate chelate) alongside vitamin C, B6, B12, folic acid, magnesium and copper. It helps to prevent iron deficiency anaemia and helps to prevent iron deficiency. It is a licensed Natural Health Product, NPN 80094846.
How much do I take?
Adults take 1 to 2 capsules per day with food, a few hours before or after taking other medications.
Why 'gentle' iron?
It uses iron bisglycinate chelate (Albion ferrous bis-glycinate chelate) rather than ferrous sulfate or oxide - a chelated form generally studied for easier digestive tolerance.
Why does it also contain vitamin C, B6, B12, folic acid, magnesium and copper?
Vitamin C is studied for enhancing the absorption of iron, copper is required by the enzymes that move iron into circulation, and B6, B12 and folic acid work alongside iron in red blood cell formation.
Is this safe to have around children?
Keep well out of reach of children. There is enough iron in this package to seriously harm a child - this is a real, serious caution required on all iron-containing products.
What side effects are possible?
Some people may experience constipation, diarrhea and/or vomiting. Stop use if hypersensitivity occurs.
Is it vegan and allergen-friendly?
Yes - the label states this product is vegan and non-GMO, free of gluten, dairy, soy, wheat and yeast.
Where do I buy it?
Use the orange button on this page - it takes you to the Orange Naturals listing on Amazon.ca for secure checkout and fast delivery.
Helps prevent iron deficiency anaemia - in a gentle vegan capsule
Get Orange Naturals Iron Complex on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80094846. Helps to prevent iron deficiency anaemia. Helps to prevent iron deficiency. Keep out of reach of children - there is enough iron in this package to seriously harm a child. The research summaries on this page concern iron bisglycinate, vitamin C, copper, B12 and folate generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Keep out of reach of children. There is enough iron in this package to seriously harm a child. Some people may experience constipation, diarrhea and/or vomiting. Stop use if hypersensitivity occurs. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: Helps to prevent iron deficiency anaemia. Helps to prevent iron deficiency.
Ingredients
Medicinal Ingredients (each vegetable capsule contains): Iron (Albion Ferrous bis-glycinate chelate), 20 mg. Vitamin C (ascorbic acid), 300 mg. Vitamin B6 (Pyridoxal-5-phosphate), 25 mg. Vitamin B12 (methylcobalamin), 400 mcg. Folic Acid (L-5-methyltetrahydrofolate), 400 mcg. Magnesium (Albion magnesium bis-glycinate chelate buffered - magnesium bis-glycinate chelate, magnesium oxide), 42 mg. Copper (Albion copper bis-glycinate chelate), 35 mcg. Non-medicinal ingredients: Hypromellose (vegetable capsule), magnesium stearate. Vegan. Non-GMO. Free of gluten, dairy, soy, wheat and yeast.
Directions
Recommended Dose (Adults): Take 1 to 2 capsules per day with food. Take a few hours before or after taking other medications.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.