Orange Naturals Hya Skin for Hydration - Hyaluronic Acid and Biotin | 30 Capsules
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 2 capsules per day, or as directed by a healthcare practitioner |
| Licensed Natural Health Product | NPN 80118359 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- HYALURONATE FOR HYDRATION: Each vegetable capsule provides 60 mg Sodium Hyaluronate (Hyabest) - take 2 capsules per day with food or as directed by a healthcare practitioner.
- HELPS INCREASE SKIN HYDRATION AND SUPPORTS COLLAGEN FORMATION: Hya Skin helps increase skin hydration and in collagen formation. Helps to maintain healthy hair, nails and skin.
- SILICON, L-LYSINE, VITAMIN C & BIOTIN: Each capsule also delivers 5 mg Silicon (LIVING SILICA methylsilanetriol), 250 mg L-Lysine, 75 mg Vitamin C (ascorbic acid) and 2.5 mg Biotin to round out the formula.
- BIOTIN CAUTION - READ BEFORE USE: This product provides biotin in amounts that may interfere with diagnostic laboratory tests - tell your healthcare practitioner and laboratory that you take this product before any blood test. Consult a healthcare practitioner for use beyond 4 weeks.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals and licensed under NPN 80118359. The label states this product is vegan, GMO-free, and free of dairy, soy, gluten, wheat and yeast, with no artificial flavours, colours, preservatives or sweeteners.
Product Description
Hya Skin for Hydration - Sodium Hyaluronate, Biotin, L-Lysine, Silicon & Vitamin C
Orange Naturals Hya Skin pairs 60 mg Sodium Hyaluronate (Hyabest) with Biotin, L-Lysine, Silicon (LIVING SILICA methylsilanetriol) and Vitamin C in every vegetable capsule. This formula helps increase skin hydration and in collagen formation, and helps to maintain healthy hair, nails and skin. This product also carries a real caution around biotin and lab test interference, and a 4-week use recommendation before consulting a healthcare practitioner, see below. Licensed Natural Health Product NPN 80118359.
Hya Peau pour l'hydratation d'Orange Naturals associe 60 mg d'hyaluronate de sodium (Hyabest) à de la biotine, de la L-lysine, du silicium (LIVING SILICA méthylsilanétriol) et de la vitamine C dans chaque capsule végétale. Cette formule aide à augmenter l'hydratation de la peau et participe à la formation du collagène, et aide à maintenir des cheveux, des ongles et une peau en santé. Ce produit comporte aussi une mise en garde réelle sur la biotine et les tests de laboratoire, ainsi qu'une recommandation d'un usage de 4 semaines avant de consulter un praticien de soins de santé, voir ci-dessous. NPN 80118359.
A Hydration & Collagen-Support Formula
60 mg Sodium Hyaluronate, plus Biotin, L-Lysine, Silicon and Vitamin C per capsule - 2 capsules daily
60 mg Sodium Hyaluronate (Hyabest) per Capsule
Each vegetable capsule delivers 60 mg of sodium hyaluronate, standardized as Hyabest, alongside biotin, L-lysine, silicon and vitamin C - take 2 capsules per day with food or as directed by a healthcare practitioner.
Helps Increase Skin Hydration and Supports Collagen Formation
Hya Skin helps increase skin hydration and in collagen formation, and helps to maintain healthy hair, nails and skin.
Advanced Ingredients, Superior Results
Sodium hyaluronate, biotin, L-lysine, silicon and vitamin C have each been studied for their role in skin hydration, collagen structure, and hair and nail health - and biotin carries a real, well-documented lab-test interference caution. Here is what the wider research explores.
Sodium Hyaluronate (Hyabest)
A low molecular weight form of hyaluronic acid, studied in oral form for improving skin hydration and elasticity and reducing wrinkle depth.
60 mg per capsuleBiotin
A B-vitamin studied for hair and nail health at this same 2.5 mg dose; this product provides biotin in amounts that may interfere with diagnostic laboratory tests.
2.5 mg per capsuleL-Lysine
An essential amino acid that supplies the lysine residues collagen protein needs, which are chemically modified to form the cross-links that give collagen its structure.
250 mg per capsule
Silicon (LIVING SILICA methylsilanetriol)
A bioavailable form of silicon studied for supporting collagen synthesis and skin, hair and nail strength.
5 mg per capsuleVitamin C (ascorbic acid)
An essential cofactor required for collagen synthesis in skin, and an antioxidant that helps protect against oxidative skin damage.
75 mg per capsuleOrange Naturals Hya Skin for Hydration: Supplement Facts
Each vegetable capsule contains:
- Sodium Hyaluronate (Hyabest)60 mg
- Biotin2.5 mg
- L-Lysine250 mg
- Silicon (LIVING SILICA methylsilanetriol)5 mg
- Vitamin C (ascorbic acid)75 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Vegetable-grade magnesium stearate, microcrystalline cellulose, acacia gum, vegetable capsule.
Recommended Use or Purpose: Hya Skin helps increase skin hydration and in collagen formation. Helps to maintain healthy hair, nails and skin.
Recommended Dose (Adults): Take 2 capsules per day or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 4 weeks.
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. This product provides biotin in amounts that may interfere with diagnostic laboratory tests. Consult a healthcare practitioner if symptoms persist or worsen. Do not use if the safety seal is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule végétale contient :
- Hyaluronate de sodium (Hyabest)60 mg
- Biotine2.5 mg
- L-Lysine250 mg
- Silicium (LIVING SILICA methylsilanetriol)5 mg
- Vitamine C (acide ascorbique)75 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Stéarate de magnésium de grade végétal, cellulose microcristalline, gomme arabique (acacia), capsule végétale.
Usage ou fins recommandés : Aide à augmenter l'hydratation de la peau et participe à la formation du collagène. Aide à maintenir des cheveux, des ongles et une peau en santé.
Posologie recommandée (adultes) : Prendre 2 capsules par jour ou selon l'avis d'un praticien de soins de santé. Consulter un praticien de soins de santé pour un usage de plus de 4 semaines.
Mises en garde : Consulter un praticien de soins de santé avant d'en faire l'usage si vous êtes enceinte ou allaitez. Ce produit fournit de la biotine dans des quantités qui pourraient fausser les tests diagnostiques de laboratoire. Consulter un praticien de soins de santé si les symptômes persistent ou s'aggravent. Ne pas utiliser si le sceau de sécurité est brisé. Tenir hors de la portée des enfants.
NPN 80118359
Lock in moisture and support collagen formation with Hya Skin
Get Orange Naturals Hya Skin for Hydration on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Hya Skin
60 mg Sodium Hyaluronate per capsule, plus Biotin, L-Lysine, Silicon and Vitamin C - with a real biotin lab-test caution and a 4-week use guidance you should read before use.
60 mg Sodium Hyaluronate (Hyabest) per Capsule
Each vegetable capsule delivers 60 mg of sodium hyaluronate, the same active studied in oral skin-hydration research.
Helps increase skin hydration and supports collagen formation
Hya Skin helps increase skin hydration and in collagen formation. Helps to maintain healthy hair, nails and skin.
Simple twice-daily capsule
Take 2 capsules per day or as directed by a healthcare practitioner.
Real cautions, made in Canada
This product provides biotin in amounts that may interfere with diagnostic laboratory tests - consult a healthcare practitioner for use beyond 4 weeks. NPN 80118359.
Inside every capsule
60 mg Sodium Hyaluronate (Hyabest), 2.5 mg Biotin, 250 mg L-Lysine, 5 mg Silicon (LIVING SILICA methylsilanetriol) and 75 mg Vitamin C (ascorbic acid) - take 2 capsules per day or as directed by a healthcare practitioner.
How to use it
Take 2 capsules daily
Adults: take 2 capsules per day or as directed by a healthcare practitioner.
Consult a practitioner beyond 4 weeks
Consult a healthcare practitioner for use beyond 4 weeks.
A 15-day supply per bottle
Each bottle of 30 veg capsules provides a 15-day supply at the standard 2-capsule daily dose.
Read the cautions before you start
Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. This product provides biotin in amounts that may interfere with diagnostic laboratory tests - tell your healthcare practitioner and laboratory before any blood test.
What the research says about this formula's ingredients
Educational summaries of published research on sodium hyaluronate, biotin, L-lysine, silicon and vitamin C generally; not product-specific claims. Orange Naturals Hya Skin's own authorized use under NPN 80118359 is that it helps increase skin hydration and in collagen formation, and helps to maintain healthy hair, nails and skin.
A 2025 trial using this formula's exact 60 mg daily dose found oral sodium hyaluronate significantly improved skin hydration and elasticity
In a randomized, double-blind, placebo-controlled trial of 150 healthy adults, 12 weeks of oral sodium hyaluronate at 60 mg/day or 120 mg/day both improved skin hydration and elasticity and reduced transepidermal water loss versus placebo, with the 60 mg dose showing similar but more modest benefits than the higher dose.
Human RCT (n=150)A 28-day RCT found oral hyaluronan measurably reduced wrinkle depth and increased skin hydration and elasticity
In a double-blind, randomized, placebo-controlled trial of 60 adult women with mild-to-moderate skin aging, 28 days of a full-spectrum oral hyaluronan supplement significantly improved all measured dermatological parameters versus placebo, including a 10.6% increase in hydration and reductions in wrinkle depth and volume.
Human RCT (n=60)A 2025 meta-analysis of 7 RCTs confirmed oral hyaluronic acid significantly improves skin hydration, elasticity and wrinkle depth
Pooling data from 7 randomized controlled trials of oral hyaluronic acid supplementation, this meta-analysis found statistically significant improvements in skin hydration, elasticity and wrinkle depth versus placebo, though the authors note more robust trials are still needed to confirm effects on skin firmness and transepidermal water loss.
Meta-analysis (7 RCTs)A 12-week RCT of a 60 mg/day hyaluronic acid matrix ingredient improved skin brightness, hydration and roughness
In a randomized, double-blind, placebo-controlled trial of 60 women aged 35-65 with signs of skin aging, 60 mg/day of an oral hyaluronic acid matrix ingredient significantly improved stratum corneum hydration, skin brightness, wrinkles and roughness compared to placebo over 12 weeks, with no serious adverse events.
Human RCT (n=60)An animal study found oral hyaluronic acid reduced UV-induced breakdown of the skin's own hyaluronic acid and collagen
In hairless mice repeatedly exposed to UVA and UVB radiation, oral hyaluronic acid supplementation reduced UV-induced degradation of the skin's hyaluronic acid and collagen and decreased the skin's inflammatory response, illustrating a mechanism by which dietary hyaluronic acid may support photoaged skin.
Preclinical study (animal model)A mouse study confirmed orally administered hyaluronic acid is absorbed and reaches the skin
After 7 days of oral dosing in mice, low molecular weight hyaluronic acid was detected at significantly increased levels in plasma and multiple tissues including the skin, demonstrating that dietary hyaluronic acid is absorbed across the gut and distributed to the skin rather than acting only when applied topically.
Preclinical study (animal model)A 20-week RCT of a bioavailable oral silicon compound improved skin surface roughness and reduced hair and nail brittleness
In a randomized, double-blind, placebo-controlled trial of 50 women with photodamaged skin, 20 weeks of 10 mg/day of choline-stabilized orthosilicic acid (a bioavailable silicon form) significantly improved skin microrelief and mechanical properties versus placebo, and significantly reduced self-reported hair and nail brittleness.
Human RCT (n=50)A review found orthosilicic acid is the most bioavailable form of silicon for skin, hair and nail support
Reviewing the different chemical forms of silicon supplements, the authors describe silicon as important for optimal collagen synthesis and skin strength and elasticity, and identify orthosilicic acid (OSA) as the most bioavailable form among the options studied, while noting that further clinical trials on efficacy are still needed.
ReviewA review found brittle nail syndrome responds to daily doses in the same range as this formula's own biotin and silicon content
Reviewing vitamins and minerals in nail health, the authors found no evidence supporting supplementation for already-healthy nails, but reported that brittle nail syndrome specifically appears to improve with a 2.5 mg daily dose of biotin or a 10 mg daily dose of silicon (as choline-stabilized orthosilicic acid).
ReviewA review describes how vitamin C drives collagen gene expression and maturation in skin
Reviewing ascorbic acid's role as a cosmeceutical, the authors describe how vitamin C promotes collagen gene expression and the maturation of collagen protein in skin, while also reducing the oxidative stress that contributes to skin aging.
ReviewA review confirms vitamin C is required for collagen synthesis and recommends adequate dietary intake for skin health
Reviewing vitamin C's roles in skin health, the authors describe its well-established function as a cofactor stimulating collagen synthesis in the dermis and its antioxidant protection against UV-induced damage, concluding that optimizing nutritional (dietary) vitamin C intake, not just topical use, is likely to benefit several skin properties.
ReviewA 2026 review groups vitamin C among the vitamins used systemically to support skin hydration and collagen synthesis
Reviewing the roles of vitamins in anti-aging skin care across topical, procedural and systemic approaches, the authors describe vitamin C's contribution to hydration and collagen biosynthesis as part of dietary supplement strategies aimed at supporting skin health from within.
ReviewA review explains how lysine residues in collagen must be chemically modified to form the cross-links that give skin its structure
Reviewing collagen's post-translational modifications, the authors describe how specific lysine residues in the collagen protein are hydroxylated and further modified through a sequential enzymatic process, ultimately forming the covalent cross-links that are critical to collagen's structural role in skin and connective tissue.
ReviewA study using lysyl hydroxylase-deficient cells showed what happens to collagen structure when lysine modification is disrupted
Using cells engineered to lack lysyl hydroxylase 2, the enzyme that hydroxylates specific lysine residues in collagen, researchers found the resulting collagen had smaller fibril diameter, impaired mineralization and was far more soluble than normal collagen, underscoring how essential proper lysine modification is to stable collagen structure.
Preclinical study (cell model)A study found a collagen-support formulation containing vitamin C increased expression of the enzymes that modify lysine into stable collagen cross-links
Testing a collagen-support formulation containing ascorbic acid and botanical extracts, researchers found it increased expression of prolyl 4-hydroxylase and lysyl hydroxylase, the enzymes responsible for modifying proline and lysine residues into the stable, cross-linked structure of mature collagen.
Laboratory study (cell assays)A 6-month RCT of an oral supplement containing biotin among its actives increased hair density in chronic hair-shedding and pattern hair loss
In 80 adults with chronic telogen effluvium or androgenetic alopecia randomized to a daily oral supplement (containing biotin alongside other micronutrients) or placebo, the supplement group's hair density increased significantly more than placebo at both 3 and 6 months, and was well tolerated with no moderate or severe adverse events.
Human RCT (n=80)A review situates biotin among the vitamins studied for their role in the normal hair follicle cycle
Reviewing the role of vitamins and minerals in hair loss, the authors describe biotin among the micronutrients that are major elements in normal hair follicle cycling and cellular turnover, while cautioning that large placebo-controlled trials are still needed to confirm supplementation benefits outside of deficiency states.
ReviewA systematic review found real evidence for biotin's hair benefit is mostly limited to deficiency and pathology states, an honest caveat worth reading
Systematically reviewing case reports and RCTs on biotin for hair and nail growth, the authors found 18 reported cases of clinical improvement with biotin supplementation, but in every case the patient had an underlying pathology causing poor hair or nail growth, concluding that evidence for biotin's benefit in already-healthy individuals remains limited.
Systematic reviewA review of brittle nail syndrome lists biotin among the oral supplements reported to be useful
Reviewing the causes and treatment of nail plate brittleness, a common complaint affecting up to 20% of the population, the authors report that oral supplementation with vitamins (especially biotin), trace elements and amino acids (especially cysteine) have been useful in idiopathic brittle nail syndrome.
ReviewA retrospective study found most patients with brittle nails improved on daily biotin supplementation
Reviewing 35 patients with brittle nails who took daily biotin supplementation, 63% showed clinical improvement in nail condition, consistent with an earlier Swiss study that found a 25% increase in nail plate thickness with biotin supplementation.
Retrospective study (n=35)A review names biotin among the oral supplements useful for treating brittle nails
Reviewing the causes and treatment of nail brittleness, a common complaint often linked to progressive dehydration of the nail plate, the authors recommend oral supplementation with vitamins (especially biotin), trace elements and amino acids as part of managing this condition, alongside preventive measures and cosmetic treatment.
ReviewA 2024 review names biotin among the assay interferences that can produce a falsely abnormal thyroid test
Reviewing interferences affecting thyroid function testing, the authors identify biotin (along with heterophile antibodies and certain other factors) as a cause of falsely abnormal thyroid immunoassay results in patients without any underlying thyroid dysfunction, recommending clinicians consider assay interference when lab results don't match the clinical picture.
ReviewA case report shows how high-dose biotin caused falsely elevated thyroid hormone results in a real patient
A 46-year-old man with Graves' disease on stable treatment showed his free T4 and free T3 results roughly double after starting a high-dose biotin supplement (72 mg/day), despite no clinical signs of relapse; his thyroid hormone levels returned to their prior range once the lab's assay was switched to a biotin-free method, confirming the abnormal results were an assay interference, not disease relapse.
Case reportA study measured how a single 10 mg biotin dose skewed real volunteers' thyroid blood tests within 2 hours
Testing thyroid function assays before and after volunteers took a 10 mg biotin supplement, researchers found significant interference in biotin-based assays (falsely elevated free T4, free T3 and total T3) within 2 hours of dosing, while non-biotin-based assays (TSH, total T4) were unaffected - illustrating exactly the kind of lab-test interference this product's own label warns about.
Human study + in vitroFrequently asked questions
What is Orange Naturals Hya Skin and what does it do?
It's a vegetable capsule providing 60 mg Sodium Hyaluronate (Hyabest) per capsule, along with Biotin, L-Lysine, Silicon and Vitamin C. It helps increase skin hydration and in collagen formation, and helps to maintain healthy hair, nails and skin.
How do I take it?
Adults take 2 capsules per day or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 4 weeks.
Why does this product carry a biotin caution?
This product provides biotin in amounts that may interfere with diagnostic laboratory tests (for example, some thyroid tests). Tell your healthcare practitioner and the laboratory that you take this product before any blood test.
Who should consult a healthcare practitioner before using it?
Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, and consult a healthcare practitioner for use beyond 4 weeks.
What are the medicinal ingredients?
Each vegetable capsule contains Sodium Hyaluronate (Hyabest) 60 mg, Biotin 2.5 mg, L-Lysine 250 mg, Silicon (LIVING SILICA methylsilanetriol) 5 mg, and Vitamin C (ascorbic acid) 75 mg.
How long does one bottle last?
Each bottle contains 30 veg capsules - a 15-day supply at the standard dose of 2 capsules per day.
Is it vegan and allergen-friendly?
Yes. The label states this product is vegan and free of dairy, soy, gluten, wheat and yeast, with no artificial flavours, colours, preservatives or sweeteners.
Where do I buy it?
Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.
Lock in moisture and support collagen formation with Hya Skin
Get Orange Naturals Hya Skin for Hydration on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80118359. Helps increase skin hydration and in collagen formation. Helps to maintain healthy hair, nails and skin. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. This product provides biotin in amounts that may interfere with diagnostic laboratory tests. Consult a healthcare practitioner for use beyond 4 weeks. The research summaries on this page concern the individual ingredients generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. This product provides biotin in amounts that may interfere with diagnostic laboratory tests. Consult a healthcare practitioner if symptoms persist or worsen. Do not use if the safety seal is broken. Keep out of reach of children.
Indications
Recommended Use or Purpose: Hya Skin helps increase skin hydration and in collagen formation. Helps to maintain healthy hair, nails and skin.
Ingredients
Medicinal Ingredients (each vegetable capsule contains): Sodium Hyaluronate (Hyabest), 60 mg. Biotin, 2.5 mg. L-Lysine, 250 mg. Silicon (LIVING SILICA methylsilanetriol), 5 mg. Vitamin C (ascorbic acid), 75 mg. Non-medicinal Ingredients: Vegetable-grade magnesium stearate, microcrystalline cellulose, acacia gum, vegetable capsule.
Directions
Recommended Dose (Adults): Take 2 capsules per day or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 4 weeks.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.