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Health Canada NPN 80034760 6 Real Actives - Vitex, I3C, Black Cohosh & More Vegan · Non-GMO · Gluten-Free · Dairy-Free Real Contraindications - Read Before Use
Hormone HeroHormone Hero - benefits and key ingredients Hormone Hero - lifestyleHormone Hero - ingredientsHormone Hero - supplement facts panel

Orange Naturals Hormone Hero | 60 V-Caps, NPN 80034760

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BrandOrange
Serving2 capsules per day with food
Licensed Natural Health ProductNPN 80034760
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • 6-INGREDIENT HORMONE-SUPPORT FORMULA: Indole-3-Carbinol (200 mg), Chasteberry extract (200 mg), Magnesium (75 mg), Vitamin B6 (25 mg), Black cohosh extract (20 mg) and Vitamin D3 (500 IU) in each vegetable capsule.
  • HERBAL REMEDY FOR PREMENSTRUAL SYMPTOM RELIEF: Used in Herbal Medicine to help relieve premenstrual symptoms and as a hormone normaliser to help stabilise menstrual cycle irregularities - this product's Health Canada-authorized use.
  • SIMPLE TWICE-DAILY DOSE: Adult women: take 2 capsules per day with food, for a minimum of 3 months, or as directed by a healthcare practitioner.
  • REAL CONTRAINDICATIONS - READ BEFORE USE: Do not use if pregnant or breastfeeding. May decrease the efficacy of birth control pills. Consult a healthcare practitioner if taking hormone medications or Parkinson's medication, or if you have a liver disorder.
  • VEGAN, NON-GMO, ALLERGEN-FRIENDLY: Free of dairy, corn, soy, gluten, wheat and yeast, in a vegan vegetable capsule.
  • MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals, developed by naturopathic doctors, and licensed under NPN 80034760.

Customer Reviews

4.7 out of 5 · 5 global ratings
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Product Description

Hormone Hero - 6-Ingredient Formula for Premenstrual Symptom Relief

Orange Naturals Hormone Hero

Orange Naturals Hormone Hero combines 6 real actives - Indole-3-Carbinol, Chasteberry (Vitex agnus-castus), Black Cohosh, Magnesium, Vitamin B6 and Vitamin D3 - in every vegan vegetable capsule. Developed by naturopathic doctors, this formula is used in Herbal Medicine to help relieve premenstrual symptoms and as a hormone normaliser to help stabilise menstrual cycle irregularities. Vegan, non-GMO and licensed as a Natural Health Product - this product also carries a real, important contraindication, see below. NPN 80034760. Licensed Natural Health Product NPN 80034760.

Héro hormonal d'Orange Naturals combine 6 ingrédients réels - indole-3-carbinol, vitex (gattilier), actée à grappes noires, magnésium, vitamine B6 et vitamine D3 - dans chaque capsule végétale vegane. Développée par des médecins naturopathes, cette formule est utilisée en phytothérapie pour aider à soulager les symptômes prémenstruels et comme normalisateur hormonal pour aider à stabiliser les irrégularités du cycle menstruel. Végétalienne, sans OGM et homologuée comme produit de santé naturel - ce produit comporte aussi une réelle contre-indication importante, voir ci-dessous. NPN 80034760.

Hormone Hero lifestyle
Orange Naturals Hormone Hero
6 Real Actives - Vitex, I3C, Black Cohosh & More

A Naturopathic-Developed Hormone-Support Formula

6 real actives including Vitex and Indole-3-Carbinol - simple twice-daily dosing, developed by naturopathic doctors

6 Real Actives in Every Capsule

Indole-3-Carbinol, Chasteberry (Vitex agnus-castus), Black Cohosh, Magnesium, Vitamin B6 and Vitamin D3 - take 2 capsules daily with food.

Developed by Naturopathic Doctors

Orange Naturals formulas, including Hormone Hero, are developed by naturopathic doctors and made in Canada.

Advanced Ingredients, Superior Results

Vitex (chasteberry) and black cohosh are among the most-studied botanicals for premenstrual and menopausal symptom relief - alongside indole-3-carbinol's role in estrogen metabolism and magnesium/B6's studied effects on premenstrual mood and fluid retention. Here is what the wider research explores.

Indole-3-Carbinol (I3C)

A natural compound found in cruciferous vegetables such as broccoli, kale and Brussels sprouts, studied for its role in supporting the liver's processing of estrogen and shifting estrogen metabolism pathways.

200 mg per vegetable capsule

Chasteberry extract (Vitex agnus-castus)

A traditional herbal remedy for premenstrual symptoms, studied for its dopaminergic effects on prolactin release from the pituitary gland and its hormone-normalizing action.

200 mg (fruit, 4:1 extract) per vegetable capsule

Magnesium (magnesium bisglycinate)

A highly bioavailable chelated form of magnesium, studied for its effects on premenstrual fluid retention and anxiety-related symptoms.

75 mg per vegetable capsule

Vitamin B6 (pyridoxine HCl)

An essential cofactor in neurotransmitter synthesis and one of the most-studied nutrients for premenstrual symptom relief, often paired with magnesium.

25 mg per vegetable capsule

Black cohosh extract (Actaea racemosa)

A traditional root extract studied for menopausal vasomotor and mood symptoms, with an established real-label caution for liver disorders.

20 mg (root, 3:1 extract) per vegetable capsule

Vitamin D3 (cholecalciferol)

A fat-soluble vitamin studied for its association with premenstrual symptom severity and mood regulation.

500 IU (12.5 mcg) per vegetable capsule

Orange Naturals Hormone Hero: Supplement Facts

Orange™Hormone Hero
English

Each vegetable capsule contains:

  • Indole-3-Carbinol (I3C)200 mg
  • Chasteberry extract (Vitex agnus-castus, fruit, 4:1)200 mg
  • Magnesium (magnesium bisglycinate)75 mg
  • Vitamin B6 (pyridoxine HCl)25 mg
  • Black cohosh extract (Actaea racemosa, root, 3:1)20 mg
  • Vitamin D3 (cholecalciferol)500 IU (12.5 mcg)

Non-Medicinal Ingredients: Non-medicinal ingredients: Hypromellose (vegetable capsule), magnesium stearate, maltodextrin, microcrystalline cellulose, silica. Vegan, non-GMO. Free of dairy, corn, soy, gluten, wheat and yeast.

Recommended Use or Purpose: Used in Herbal Medicine to help relieve premenstrual symptoms. Used in Herbal Medicine as a hormone normaliser to help stabilise menstrual cycle irregularities.

Recommended Dose (Adult women): Take 2 capsules per day with food, or as directed by a healthcare practitioner. For optimal results, take for a minimum of 3 months. Periodic intervals of abstinence (2-week breaks before continuing) are recommended for long-term use.

Cautions and Warnings: Contraindications: Do not use if you are pregnant or breastfeeding. Use of this product may decrease the efficacy of birth control pills. Cautions: Consult a healthcare practitioner on the use of this product, especially if you are taking any medication, including hormone-containing medications such as progesterone preparations, oral contraceptives, or hormone replacement therapy, or Parkinson's disease medications, or if you have a medical condition including a liver disorder or develop symptoms of liver trouble, or if symptoms persist or worsen. Consult a healthcare practitioner prior to use if you have or develop low estrogen or symptoms of low estrogen. Consult a healthcare practitioner prior to use if you are attempting to conceive. Do not use if the safety seal under the cap is broken. Keep out of reach of children.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

Français

Chaque capsule végétale contient :

  • Indole-3-carbinol (I3C)200 mg
  • Extrait de vitex (Vitex agnus-castus, fruit, 4:1)200 mg
  • Magnésium (bisglycinate de magnésium)75 mg
  • Vitamine B6 (chlorhydrate de pyridoxine)25 mg
  • Extrait d'actée à grappes noires (Actaea racemosa, racine, 3:1)20 mg
  • Vitamine D3 (cholécalciférol)500 IU (12.5 mcg)

Ingrédients non médicinaux : Ingrédients non médicinaux : Hypromellose (capsule végétale), stéarate de magnésium, maltodextrine, cellulose microcristalline, silice. Convient aux végétaliens, sans OGM. Sans produits laitiers, sans maïs, sans soya, sans gluten, sans blé ni levure.

Usage ou fins recommandés : Utilisé en phytothérapie pour aider à soulager les symptômes prémenstruels. Utilisé en phytothérapie comme normalisateur hormonal pour aider à stabiliser les irrégularités du cycle menstruel.

Posologie recommandée (femmes adultes) : Prendre 2 capsules par jour avec de la nourriture, ou selon les directives d'un praticien de la santé. Pour des résultats optimaux, prendre pendant au moins 3 mois. Des intervalles périodiques d'abstinence (2 semaines de pause avant de continuer) sont recommandés pour une utilisation à long terme.

Mises en garde : Contre-indications : Ne pas utiliser ce produit si vous êtes enceinte ou si vous allaitez. L'utilisation de ce produit pourrait réduire l'efficacité des contraceptifs oraux. Mises en garde : Consulter un praticien de soins de santé concernant l'utilisation de ce produit, surtout si vous prenez tout médicament, y compris des médicaments contenant des hormones tels que des préparations de progestérone, des contraceptifs oraux ou une hormonothérapie substitutive, ou des médicaments pour la maladie de Parkinson, ou si vous souffrez d'un état médical dont un trouble du foie, ou si vous manifestez des symptômes de troubles du foie, ou si les symptômes persistent ou s'aggravent. Consulter un praticien de soins de santé avant l'usage si vous avez ou développez de faibles taux d'œstrogène ou des symptômes de faibles taux d'œstrogène. Consulter un praticien de soins de santé avant l'usage si vous tentez de devenir enceinte. Ne pas utiliser si le sceau de sécurité sous le capuchon est brisé. Tenir hors de la portée des enfants.

NPN 80034760

6 Real Actives - Vitex, I3C, Black Cohosh & More60 Vegetable Capsules · 30-Day SupplyVegan · Non-GMO · Gluten-Free · Dairy-Free · Soy-FreeDeveloped by Naturopathic Doctors · Made in Canada

Help relieve premenstrual symptoms with a 6-ingredient hormone-support formula

Get Orange Naturals Hormone Hero on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Why Orange Naturals Hormone Hero

6 real actives in every vegetable capsule - developed by naturopathic doctors, with a real contraindication you should read before use.

6 real actives per capsule

Indole-3-Carbinol, Chasteberry (Vitex agnus-castus), Black Cohosh, Magnesium, Vitamin B6 and Vitamin D3.

Helps relieve premenstrual symptoms

Used in Herbal Medicine to help relieve premenstrual symptoms and as a hormone normaliser to help stabilise menstrual cycle irregularities.

Simple twice-daily dose

Take 2 capsules per day with food, or as directed by a healthcare practitioner.

Real contraindications, developed by naturopathic doctors

Formulated by Orange Naturals and developed by naturopathic doctors. This product carries a real contraindication for pregnancy/breastfeeding and a birth-control interaction caution - read the label. NPN 80034760.

Inside every capsule

A 6-ingredient hormone-support blend - Indole-3-Carbinol, Chasteberry (Vitex agnus-castus), Magnesium, Vitamin B6, Black Cohosh and Vitamin D3 - take 2 capsules per day with food. This formula carries a real contraindication for pregnancy/breastfeeding and an interaction caution for birth control pills - consult a healthcare practitioner before use.

Indole-3-Carbinol (I3C) 200 mg per vegetable capsuleChasteberry extract (Vitex agnus-castus) 200 mg (fruit, 4:1 extract) per vegetable capsuleMagnesium (magnesium bisglycinate) 75 mg per vegetable capsuleVitamin B6 (pyridoxine HCl) 25 mg per vegetable capsuleBlack cohosh extract (Actaea racemosa) 20 mg (root, 3:1 extract) per vegetable capsuleVitamin D3 (cholecalciferol) 500 IU (12.5 mcg) per vegetable capsule

How to use it

Take 2 capsules daily with food

Adult women: take 2 capsules per day with food, or as directed by a healthcare practitioner.

A 30-day supply per bottle

Each bottle of 60 vegetable capsules provides a 30-day supply at the standard 2-capsule daily dose.

Use for a minimum of 3 months

For optimal results, take for a minimum of 3 months. Periodic intervals of abstinence (2-week breaks before continuing) are recommended for long-term use.

Read the contraindications before you start

Do not use if pregnant or breastfeeding. May decrease the efficacy of birth control pills. Consult a healthcare practitioner if taking hormone medications or Parkinson's medication, or if you have a liver disorder.

What the research says about this formula's ingredients

Educational summaries of published research on Vitex (chasteberry), black cohosh, indole-3-carbinol, magnesium, vitamin B6 and vitamin D generally; not product-specific claims. Orange Naturals Hormone Hero's own authorized use under NPN 80034760 is that it is used in Herbal Medicine to help relieve premenstrual symptoms and as a hormone normaliser to help stabilise menstrual cycle irregularities.

Vitex (Chasteberry) - Premenstrual Symptom Relief (Human Trials)

A multicenter dose-finding trial identified 20 mg as the effective daily dose of a Vitex agnus-castus extract for PMS

In 162 women with PMS randomized to placebo or 8, 20 or 30 mg of the Vitex extract Ze 440 over three menstrual cycles, the 20 mg dose produced significantly greater improvement in total symptom score than placebo or the 8 mg dose, while the higher 30 mg dose showed no added benefit - supporting 20 mg as the preferred daily dose.

Human RCT (n=162)
Schellenberg, Zimmermann, Drewe, Hoexter & Zahner, Phytomedicine (2012)
Vitex (Chasteberry) - Premenstrual Symptom Relief (Human Trials)

A systematic review and meta-analysis found a large pooled effect of Vitex agnus-castus for PMS, but flagged high risk of bias

Pooling 14 of 17 identified randomized controlled trials, Vitex agnus-castus showed a large effect on premenstrual syndrome symptoms compared with placebo (Hedges g -1.21), but the authors cautioned that high heterogeneity, high risk of bias and evidence of publication bias mean the true treatment effect is likely smaller than this pooled estimate suggests.

Systematic review & meta-analysis
Verkaik, Kamperman, van Westrhenen & Schulte, American Journal of Obstetrics and Gynecology (2017)
Vitex (Chasteberry) - Premenstrual Symptom Relief (Human Trials)

A placebo-controlled trial in Chinese women found Vitex agnus-castus significantly reduced moderate-to-severe PMS symptoms

In 67 Chinese women with moderate-to-severe PMS, a daily Vitex agnus-castus tablet (BNO 1095) produced a significantly greater reduction in premenstrual syndrome diary scores than placebo by the third treatment cycle, with the largest improvements seen in negative affect and water retention.

Human RCT (n=67)
Ma, Lin, Chen & Wang, Gynecological Endocrinology (2010)
Vitex - Mechanism of Action & Comparative Trials

A laboratory study found Vitex agnus-castus extracts inhibit prolactin secretion via a dopaminergic mechanism

Testing extracts of Vitex agnus-castus on rat pituitary cells in culture, the extracts significantly inhibited both basal and TRH-stimulated prolactin secretion, similar to the synthetic dopamine agonist lisuride, and this inhibition could be blocked by a dopamine receptor blocker - identifying a dopaminergic mechanism behind the plant's traditional use for mild hyperprolactinemia.

Preclinical study
Sliutz, Speiser, Schultz, Spona & Zeillinger, Hormone and Metabolic Research (1993)
Vitex - Mechanism of Action & Comparative Trials

A controlled trial found Vitex agnus-castus more effective than pyridoxine (vitamin B6) for premenstrual tension syndrome

In a randomized, controlled trial of 175 women with premenstrual tension syndrome, both a Vitex agnus-castus capsule formulation and pyridoxine (vitamin B6) produced similar overall score reductions on the PMTS scale, but Vitex caused considerably more marked relief of specific complaints (breast tenderness, edema, inner tension, headache, constipation and depression), and was rated 'excellent' by investigators nearly twice as often as pyridoxine.

Human RCT (n=175)
Lauritzen, Reuter, Repges, Bohnert & Schmidt, Phytomedicine (1997)
Vitex - Mechanism of Action & Comparative Trials

A 2025 narrative review catalogued Vitex agnus-castus's multiple mechanisms across the hypothalamic-pituitary-ovarian axis

Reviewing three decades of research, this paper describes Vitex agnus-castus and its constituents (isoflavones, essential oils) as acting on female reproduction via hypothalamic, pituitary and ovarian hormone pathways and dopamine receptors, supporting its traditional use for menstrual disorders, premenstrual syndrome, cyclic mastalgia and corpus luteum insufficiency, while noting further high-quality studies are still needed.

Review
Sirotkin, Phytotherapy Research (2025)
Black Cohosh - Menopausal Symptom Relief (Human Trials)

A randomized trial found black cohosh significantly improved early menopausal symptom scores over 8 weeks

In 84 early postmenopausal women given 6.5 mg of dried black cohosh root extract daily or placebo, the treatment group showed significantly greater improvement in total Greene Climacteric Scale scores - including vasomotor, psychiatric, physical and sexual symptom subscales - at both 4 and 8 weeks, with no side effects reported.

Human RCT (n=84)
Mohammad-Alizadeh-Charandabi, Shahnazi, Nahaee & Bayatipayan, Chinese Medicine (2013)
Black Cohosh - Menopausal Symptom Relief (Human Trials)

A 6-month trial found black cohosh improved objective, polysomnography-measured sleep in postmenopausal women

In 42 postmenopausal women with sleep complaints who completed this randomized, placebo-controlled trial, black cohosh significantly increased sleep efficiency and reduced wake-after-sleep-onset duration on polysomnography compared with placebo, and improved vasomotor and physical quality-of-life domains, with no adverse events attributed to treatment.

Human RCT (n=42)
Jiang, Jin, Huang, Feng, Hou, Du, Zheng & Li, Climacteric (2015)
Black Cohosh - Menopausal Symptom Relief (Human Trials)

A Cochrane review found insufficient evidence that black cohosh reduces hot flush frequency compared with placebo

Reviewing 16 randomized controlled trials in 2,027 women, this Cochrane review found no significant difference between black cohosh and placebo in daily hot flush frequency or overall menopausal symptom scores, while hormone therapy significantly outperformed black cohosh - an honest, mixed finding the reviewers attributed partly to high heterogeneity and inconsistent trial quality, concluding there is currently insufficient evidence to support black cohosh for menopausal symptoms.

Cochrane systematic review (n=2,027)
Leach & Moore, Cochrane Database of Systematic Reviews (2012)
Black Cohosh - Liver Safety Literature

A meta-analysis of 5 randomized trials found no evidence that isopropanolic black cohosh extract affects liver function

Pooling raw liver-enzyme data (AST, ALT) from 1,020 women across five randomized, double-blind, controlled trials of isopropanolic black cohosh extract, this meta-analysis found no significant effect on aspartate aminotransferase or alanine aminotransferase compared with reference groups, providing reassurance against black cohosh hepatotoxicity claims from this dataset.

Meta-analysis (n=1,020)
Naser, Schnitker, Minkin, de Arriba, Nolte & Osmers, Menopause (2011)
Black Cohosh - Liver Safety Literature

A critical review of 69 suspected black cohosh liver-injury cases found major data-quality problems undermining causality claims

Analyzing 69 published and spontaneously reported cases of suspected black cohosh-induced liver disease, this review found serious inconsistencies, confounding variables (alcohol use, co-medication, comorbidity, uncertain product identity) and poor case-data quality throughout, concluding the presented data do not support a confirmed causal relationship between black cohosh and the liver injuries described.

Critical review (69 cases)
Teschke, Menopause (2010)
Black Cohosh - Liver Safety Literature

A real case report describes acute liver injury following combined use of black cohosh and thuja supplements

A 40-year-old woman developed acute liver injury after taking black cohosh (Cimicifuga racemosa) together with thuja (Thuja occidentalis) for fertility purposes; causality assessment implicated the combined herbal use, and her liver function fully recovered after both supplements were discontinued - an honest reminder that herb-induced liver injury, while uncommon and hard to attribute to a single herb, is a real documented risk worth monitoring for.

Case report
Patel, Alavi, Ortega & Matela, Case Reports in Gastrointestinal Medicine (2021)
Indole-3-Carbinol - Estrogen Metabolism

A human trial found indole-3-carbinol increased protective estrogen 2-hydroxylation in overweight women

In five overweight, premenopausal women given 400 mg per day of purified indole-3-carbinol for two months, the ratio of the protective estrogen metabolite 2-hydroxyestrone to estriol was significantly increased, indicating induction of 2-hydroxylation similar to responses previously seen in non-obese women.

Human clinical trial (n=5)
Michnovicz, International Journal of Obesity and Related Metabolic Disorders (1998)
Indole-3-Carbinol - Estrogen Metabolism

A review described indole-3-carbinol's multiple mechanisms as an estrogen-metabolism modulator and antitumor agent

This review describes how indole-3-carbinol induces CYP1A1 (increasing protective 2-hydroxylation of estrogens) while decreasing CYP1B1 (reducing the carcinogenic 4-hydroxylation pathway), alongside direct effects on apoptosis and cell-cycle regulators, and notes documented antitumor activity against HPV-mediated tumors in human patients.

Review
Bradlow, Sepkovic, Telang & Osborne, Annals of the New York Academy of Sciences (1999)
Indole-3-Carbinol - Estrogen Metabolism

A laboratory study found factors secreted by fat cells can suppress the same estrogen 2-hydroxylation pathway indole-3-carbinol promotes

Using conditioned media from cultured adipocytes, this study found substances released by fat cells substantially inhibited 2-hydroxylation of estradiol in breast cancer cells - an effect partially reversed by adding indole-3-carbinol, a potent inducer of 2-hydroxylation - suggesting a mechanism connecting body fat, estrogen metabolism and indole-3-carbinol's studied role.

In vitro study
Bradlow, Sepkovic, Telang & Tiwari, In Vivo (2011)
Magnesium - Premenstrual Symptoms & Mood

A crossover trial found magnesium supplementation reduced premenstrual fluid-retention symptoms in the second treatment cycle

In 38 women given 200 mg of magnesium (as magnesium oxide) or placebo daily for two menstrual cycles, magnesium produced a significantly greater reduction in premenstrual fluid-retention symptoms (weight gain, swelling, breast tenderness, bloating) than placebo in the second cycle of use, though no effect was seen in the first month.

Human RCT, crossover (n=38)
Walker, De Souza, Vickers, Abeyasekera, Collins & Trinca, Journal of Women's Health (1998)
Magnesium - Premenstrual Symptoms & Mood

A crossover trial found a combination of magnesium plus vitamin B6 had a synergistic effect on anxiety-related premenstrual symptoms

In 44 women randomly assigned to daily magnesium (200 mg), vitamin B6 (50 mg), the combination, or placebo across four menstrual cycles, the combined magnesium-plus-B6 treatment - not either nutrient alone - produced a statistically significant reduction in anxiety-related premenstrual symptoms (nervous tension, mood swings, irritability), consistent with this formula's own pairing of the two nutrients, though the authors noted the effect was modest and called for further study.

Human RCT, crossover (n=44)
De Souza, Walker, Robinson & Bolland, Journal of Women's Health & Gender-Based Medicine (2000)
Magnesium - Premenstrual Symptoms & Mood

A systematic review found suggestive but inconsistent evidence for magnesium's effect on premenstrual anxiety

Reviewing 18 studies of magnesium supplementation in anxiety-vulnerable populations, only 4 of 7 studies in PMS samples reported a positive effect of magnesium on subjective anxiety outcomes, and magnesium had no effect in postpartum samples - an honest, mixed picture the authors attributed to generally poor study quality, calling for better-designed trials.

Systematic review (18 studies)
Boyle, Lawton & Dye, Nutrients (2017)
Vitamin B6 - Premenstrual Symptom Relief

A systematic review of 9 trials found vitamin B6 roughly doubled the odds of overall premenstrual symptom improvement over placebo

Pooling 9 randomized, placebo-controlled trials in 940 women, this systematic review found an odds ratio of 2.32 for overall premenstrual symptom improvement and 1.69 for depressive symptom improvement with vitamin B6 (doses up to 100 mg/day) versus placebo, while cautioning that conclusions are limited by the generally low quality of the included trials.

Systematic review (n=940)
Wyatt, Dimmock, Jones & Shaughn O'Brien, BMJ (1999)
Vitamin B6 - Premenstrual Symptom Relief

A controlled study found vitamin B6 improved some but not all premenstrual symptoms, with a caution about high-dose use

In 55 women with moderate-to-severe premenstrual mood changes given 150 mg/day of vitamin B6 or placebo for two months, B6 improved autonomic and behavioral symptoms (dizziness, vomiting, poor performance) but a substantial amount of physical and affective symptomatology remained - an honest mixed result, with the authors also flagging then-recent reports of toxicity from low-dose long-term B6 use as reason for caution.

Human RCT (n=55)
Kendall & Schnurr, Obstetrics and Gynecology (1987)
Vitamin B6 - Premenstrual Symptom Relief

A trial found pyridoxine (vitamin B6) significantly reduced premenstrual symptom scores, with a higher response rate than bromocriptine

In 60 women with PMS assigned to placebo, bromocriptine, or pyridoxine (100 mg/day) for three months, both active treatments significantly reduced premenstrual symptom scores versus placebo, with pyridoxine showing a significantly higher response rate and fewer side effects than bromocriptine.

Human RCT (n=60)
Sharma, Kulshreshtha, Singh & Bhagoliwal, Indian Journal of Physiology and Pharmacology (2007)
Vitamin D3 - Levels, Mood & Premenstrual Symptoms

A trial found vitamin D supplementation improved PMS-related mood symptoms in adolescents with severe vitamin D deficiency

In 158 young women (15-21 years) with severe hypovitaminosis D and PMS-related mood symptoms, 4 months of vitamin D supplementation (normalizing blood levels) produced significant reductions in anxiety, irritability, sadness and disturbed-relationship scores compared with placebo, with adverse-event rates similar between groups.

Human RCT (n=158)
Tartagni, Cicinelli, Tartagni, Alrasheed, Matteo, Baldini, De Salvia & Loverro, Journal of Pediatric and Adolescent Gynecology (2016)
Vitamin D3 - Levels, Mood & Premenstrual Symptoms

A large cross-sectional study found inadequate vitamin D status was associated with some, but not all, premenstrual symptoms

In 998 women aged 20-29, those with inadequate vitamin D status (plasma 25-hydroxyvitamin D under 20 ng/mL) had significantly higher odds of several moderate-to-severe premenstrual symptoms (cramps, fatigue, anxiety, confusion), but vitamin D status was not associated with other symptoms including bloating, mood swings, headache or insomnia - a nuanced, partial finding.

Cross-sectional study (n=998)
Jarosz & El-Sohemy, Journal of the Academy of Nutrition and Dietetics (2018)
Vitamin D3 - Levels, Mood & Premenstrual Symptoms

A case-control study found no significant association between serum vitamin D levels and premenstrual syndrome

Comparing luteal-phase serum vitamin D levels between women with and without PMS (82 total participants), this study found a high rate of vitamin D deficiency in both groups but no statistically significant difference in vitamin D levels between women with PMS and those without - an honest null result alongside the mixed findings from other vitamin D studies.

Case-control study (n=82)
Rajaei, Akbari Sene, Norouzi, Berangi, Arabian, Lak & Dabbagh, International Journal of Reproductive Biomedicine (2016)

Customer Reviews

4.7 out of 5 · 5 global ratings
Read genuine reviews on Amazon →Available at Amazon

Frequently asked questions

What is Orange Naturals Hormone Hero and what does it do?

It's a vegan vegetable capsule combining 6 real actives - Indole-3-Carbinol, Chasteberry (Vitex agnus-castus), Black Cohosh, Magnesium, Vitamin B6 and Vitamin D3. It is used in Herbal Medicine to help relieve premenstrual symptoms and as a hormone normaliser to help stabilise menstrual cycle irregularities.

How do I take it?

Adult women take 2 capsules per day with food, or as directed by a healthcare practitioner, for a minimum of 3 months.

How long does one bottle last?

Each bottle contains 60 vegetable capsules - a 30-day supply at the standard dose of 2 capsules per day.

Who should NOT use this product?

Do not use this product if you are pregnant or breastfeeding.

Does it interact with birth control?

Use of this product may decrease the efficacy of birth control pills - consult a healthcare practitioner if you use hormonal contraception.

Who should consult a healthcare practitioner before using it?

Consult a healthcare practitioner especially if you are taking any medication, including hormone medications (progesterone preparations, oral contraceptives, hormone replacement therapy) or Parkinson's disease medications, or if you have a medical condition including a liver disorder, or if you are attempting to conceive or have low estrogen or symptoms of low estrogen.

What if I develop symptoms while using it?

Consult a healthcare practitioner if you develop symptoms of liver trouble, or if symptoms persist or worsen.

Is it vegan and allergen-friendly?

Yes - it is vegan, non-GMO, and free of dairy, corn, soy, gluten, wheat and yeast.

Where do I buy it?

Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.

6 Real Actives - Vitex, I3C, Black Cohosh & More60 Vegetable Capsules · 30-Day SupplyVegan · Non-GMO · Gluten-Free · Dairy-Free · Soy-FreeDeveloped by Naturopathic Doctors · Made in Canada

Help relieve premenstrual symptoms with a 6-ingredient hormone-support formula

Get Orange Naturals Hormone Hero on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Natural Health Product NPN 80034760. Used in Herbal Medicine to help relieve premenstrual symptoms and as a hormone normaliser to help stabilise menstrual cycle irregularities. Do not use if you are pregnant or breastfeeding. Use of this product may decrease the efficacy of birth control pills. Consult a healthcare practitioner on the use of this product, especially if you are taking any medication, including hormone medications such as progesterone preparations, oral contraceptives or hormone replacement therapy, or Parkinson's disease medications, or if you have a medical condition including a liver disorder, or if you develop symptoms of liver trouble, or if you have or develop low estrogen or symptoms of low estrogen, or are attempting to conceive. The research summaries on this page concern this formula's individual ingredients generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.

Important information

Safety Information

Cautions and Warnings: Contraindications: Do not use if you are pregnant or breastfeeding. Use of this product may decrease the efficacy of birth control pills. Cautions: Consult a healthcare practitioner on the use of this product, especially if you are taking any medication, including hormone-containing medications such as progesterone preparations, oral contraceptives, or hormone replacement therapy, or Parkinson's disease medications, or if you have a medical condition including a liver disorder or develop symptoms of liver trouble, or if symptoms persist or worsen. Consult a healthcare practitioner prior to use if you have or develop low estrogen or symptoms of low estrogen. Consult a healthcare practitioner prior to use if you are attempting to conceive. Do not use if the safety seal under the cap is broken. Keep out of reach of children.

Indications

Recommended Use or Purpose: Used in Herbal Medicine to help relieve premenstrual symptoms. Used in Herbal Medicine as a hormone normaliser to help stabilise menstrual cycle irregularities.

Ingredients

Medicinal Ingredients (each vegetable capsule contains): Indole-3-Carbinol (I3C), 200 mg. Chasteberry extract (Vitex agnus-castus, fruit, 4:1), 200 mg. Magnesium (magnesium bisglycinate), 75 mg. Vitamin B6 (pyridoxine HCl), 25 mg. Black cohosh extract (Actaea racemosa, root, 3:1), 20 mg. Vitamin D3 (cholecalciferol), 500 IU (12.5 mcg). Non-medicinal Ingredients: Hypromellose (vegetable capsule), magnesium stearate, maltodextrin, microcrystalline cellulose, silica. Vegan. Non-GMO. Free of dairy, corn, soy, gluten, wheat and yeast.

Directions

Recommended Dose (Adult women): Take 2 capsules per day with food, or as directed by a healthcare practitioner. For optimal results, take for a minimum of 3 months. Periodic intervals of abstinence (2-week breaks before continuing) are recommended for long-term use.

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