Orange Naturals Glucosamine + NEM - Jointly Joint Support
Visit the Orange Naturals Store| Brand | Orange |
| Serving | 1 capsule, 2 times per day |
| Licensed Natural Health Product | NPN 80116683 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 750 MG GLUCOSAMINE HCL + 250 MG NEM PER CAPSULE: Each vegetable capsule combines glucosamine hydrochloride (from shrimp and crab exoskeleton) with NEM, partially hydrolysed natural eggshell membrane (Gallus gallus) - take 1 capsule, 2 times per day.
- STARTS WORKING IN AS LITTLE AS 1-5 DAYS: Starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days.
- NATURAL EGGSHELL MEMBRANE (NEM): Formulated with NEM, a partially hydrolysed natural eggshell membrane studied in clinical trials for joint comfort, flexibility and cartilage health.
- SUPPORTS JOINT FLEXIBILITY AND MOBILITY: Designed to support joint comfort and flexibility, helping maintain an active lifestyle.
- CONTAINS EGG AND SHELLFISH: Glucosamine HCl is sourced from shrimp and crab exoskeleton and NEM from egg (chicken eggshell membrane) - do not use if you have a known allergy to eggs, egg by-products or shellfish.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals, developed by naturopathic doctors, and licensed under NPN 80116683. Take 1 capsule, 2 times per day.
Product Description
Glucosamine + NEM - Fast-Acting Joint Support
Orange Naturals Glucosamine + NEM (labelled 'Jointly - Stiffness & Joint Pain' on the real product label) combines 750 mg Glucosamine HCl (from shrimp and crab exoskeleton) with 250 mg NEM (partially hydrolysed natural eggshell membrane) per vegetable capsule. Developed by naturopathic doctors and made in Canada, this formula starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days. Take 1 capsule, 2 times per day. NPN 80116683. Contains shellfish (glucosamine) and egg (NEM) - not suitable for those with shellfish or egg allergies. Licensed Natural Health Product NPN 80116683.
Glucosamine + NEM d'Orange Naturals (désigné « Articulations - Raideur et la douleur articulaire » sur l'étiquette réelle du produit) combine 750 mg de chlorhydrate de glucosamine (provenant de l'exosquelette de crevette et de crabe) et 250 mg de NEM (membrane de coquille d'oeuf naturelle partiellement hydrolysée) par capsule végétale. Développée par des médecins naturopathes et fabriquée au Canada, cette formule commence à réduire la douleur articulaire due à l'exercice aérobique d'intensité modérée en un seul jour et la raideur articulaire dès 5 jours. Prendre 1 capsule, 2 fois par jour. NPN 80116683. Contient des crustacés (glucosamine) et de l'oeuf (NEM) - ne convient pas aux personnes allergiques aux crustacés ou aux oeufs.
A Naturopathic-Developed, Fast-Acting Joint Formula
750 mg Glucosamine HCl + 250 mg NEM eggshell membrane per capsule - starts working on exercise-related joint pain in as little as 1 day
750 mg Glucosamine HCl + 250 mg NEM per Capsule
Each vegetable capsule combines glucosamine hydrochloride (from shrimp and crab exoskeleton) with NEM, a partially hydrolysed natural eggshell membrane - take 1 capsule, 2 times per day.
Developed by Naturopathic Doctors
Orange Naturals formulas, including Glucosamine + NEM, are developed by naturopathic doctors and made in Canada.
Glucosamine + NEM Synergy
Glucosamine and NEM (natural eggshell membrane) are two of the most-studied joint-health ingredients - reviewed together below, including where the evidence is strongest and where it is genuinely mixed.
750 mg Glucosamine HCl - Cartilage & Joint Support
Glucosamine is an amino sugar naturally found in cartilage; this capsule provides 750 mg from shrimp and crab exoskeleton. The research below takes an honest look at how the evidence differs between glucosamine's forms.
250 mg NEM - Fast-Acting Joint Pain & Stiffness Relief
NEM (partially hydrolysed natural eggshell membrane) is a clinically studied ingredient shown in multiple placebo-controlled trials to ease joint pain and stiffness within days, including after moderate exercise.
Simple Twice-Daily Dosing
Take 1 capsule, 2 times per day. Use for at least 1 month to see beneficial effects; ask a healthcare practitioner for use beyond 8 weeks.
Naturopathic-Developed, Made in Canada
Formulated by Orange Naturals, developed by naturopathic doctors, and licensed under NPN 80116683. Contains egg and shellfish - not suitable for those with egg or shellfish allergies.
Orange Naturals Glucosamine + NEM: Supplement Facts
Each capsule contains:
- Glucosamine HCl (exoskeleton, shrimp and crab)750 mg
- NEM Eggshell Membrane (egg shell, Gallus gallus, partially hydrolysed)250 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Hypromellose, magnesium stearate.
Uses: Starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days.
Directions (Adults 19 years and older): Take 1 capsule, 2 times per day. Use for at least 1 month to see beneficial effects. Ask a healthcare practitioner for use beyond 8 weeks.
Cautions and Warnings: Allergens: egg, shellfish. Do not use if you have a known allergy to eggs or egg by-products, or a known allergy to shellfish. Ask a healthcare practitioner prior to use if you are pregnant or if you are breastfeeding. Caution advised when taking any medication or if you have a medical condition. Ask a healthcare practitioner if symptoms persist or worsen. Do not use if safety seal is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule contient :
- Chlorhydrate de glucosamine (exosquelette, crabe et crevette)750 mg
- NEM Membrane de coquille d'oeuf (coquille d'oeuf, Gallus gallus, partiellement hydrolysée)250 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Hypromellose, stéarate de magnésium.
Usages : Commence à réduire la douleur articulaire due à l'exercice aérobique d'intensité modérée en un seul jour et la raideur articulaire dès 5 jours.
Mode d'emploi (adultes de 19 ans et plus) : Prendre 1 capsule, 2 fois par jour. Utiliser au moins 1 mois afin de constater des effets bénéfiques. Consulter un praticien de soins de santé pour un usage de plus de 8 semaines.
Mises en garde : Allergènes : oeufs, crustacés. Ne pas utiliser si vous avez une allergie connue aux oeufs, aux sous-produits des oeufs, ou une allergie connue aux crustacés. Consulter un praticien de soins de santé avant d'en faire l'usage si vous êtes enceinte ou si vous êtes allaitante. La prudence est de mise si vous prenez des médicaments ou si vous présentez un problème de santé. Consulter un praticien de soins de santé si les symptômes persistent ou s'aggravent. Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.
NPN 80116683
Start easing joint pain and stiffness in days, not weeks
Get Orange Naturals Glucosamine + NEM on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Glucosamine + NEM
750 mg Glucosamine HCl + 250 mg NEM per capsule - a fast-acting, naturopathic-developed joint formula that starts working in days, not weeks.
750 mg Glucosamine HCl + 250 mg NEM per capsule
Each vegetable capsule combines a full glucosamine hydrochloride dose with NEM (partially hydrolysed eggshell membrane) - take 1 capsule, 2 times per day.
Starts working in as little as 1-5 days
Starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days.
Backed by naturopathic formulation
Developed by naturopathic doctors, GMO-free, with no artificial flavours, colours, preservatives or sweeteners.
Made in Canada, licensed by Health Canada
Formulated by Orange Naturals and licensed under NPN 80116683. Contains egg and shellfish - not suitable for those with egg or shellfish allergies.
Inside every capsule
750 mg Glucosamine HCl + 250 mg NEM (partially hydrolysed eggshell membrane) - take 1 capsule, 2 times per day. Contains egg and shellfish.
How to use it
Take 1 capsule, 2 times daily
Adults (19 years and older): take 1 capsule, 2 times per day.
Give it at least 1 month
Use for at least 1 month to see beneficial effects.
Ask a practitioner before 8 weeks' continuous use
Ask a healthcare practitioner for use beyond 8 weeks.
A 30-day supply per bottle
Each bottle of 60 vegetable capsules provides a 30-day supply at the standard 2-capsule daily dose.
What the research says about Glucosamine + NEM
Educational summaries of published research on glucosamine and NEM (natural eggshell membrane) generally; not product-specific claims. Orange Naturals Glucosamine + NEM's own authorized use under NPN 80116683 is that it starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days.
A randomized trial found NEM reduced cartilage breakdown and rapidly eased pain and stiffness after moderate exercise in healthy postmenopausal women
In 60 healthy postmenopausal women performing a moderate stepping exercise regimen every other day, 500 mg NEM (natural eggshell membrane) daily for 2 weeks significantly reduced the cartilage-breakdown biomarker CTX-II versus placebo (-17.2% at 1 week, -9.9% at 2 weeks), and produced faster relief of exercise-induced joint stiffness (by day 7) and pain and stiffness during recovery (by days 4 and 8).
Human RCT (n=60)Two open-label studies found NEM reduced general joint pain and improved flexibility within days
Across a single-arm study (n=11) and a two-arm study (n=28), 500 mg NEM daily produced a 72.5% reduction in general pain and a 43.7% increase in flexibility by 30 days, with significant pain reduction already apparent at 7 days in both arms; no adverse events were reported in either study.
Human open-label studies (n=11, n=28)A placebo-controlled trial found eggshell membrane relieved knee pain starting within the first week of daily use
In 150 adults with knee osteoarthritis randomized to 300 mg eggshell membrane or placebo daily for 12 weeks, the eggshell membrane group showed significantly better KOOS pain and daily-life-function scores starting just 1 week after treatment began, with the improvement sustained through the full 12 weeks.
Human RCT (n=150)The original multicenter NEM trial found significant pain and stiffness relief within 10 days in knee osteoarthritis
In 67 patients with knee osteoarthritis randomized to 500 mg NEM or placebo daily for 8 weeks, NEM produced a statistically significant reduction in WOMAC pain (15.9%) and stiffness (12.8%) scores versus placebo after only 10 days, with the benefit sustained at 30 and 60 days and no serious adverse events reported.
Human multicenter RCT (n=67)A systematic review and meta-analysis of 7 trials found eggshell membrane significantly improved knee osteoarthritis pain and function
Pooling data from 7 randomized controlled trials of eggshell membrane supplementation for knee osteoarthritis, the meta-analysis found significant improvement in total WOMAC score and the WOMAC pain subscale versus placebo, supporting eggshell membrane as a safe adjunctive option, while noting further high-quality trials are needed to confirm long-term effects.
Systematic review and meta-analysis (7 RCTs)An animal model found eggshell membrane eased early inflammation and later protected cartilage in induced osteoarthritis
In a monosodium-iodoacetate-induced osteoarthritis model in mice and rats, oral eggshell membrane reduced pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) in the early stage of disease, and in the later stage reduced cartilage-degrading enzymes (MMP-3, MMP-13, ADAMTS-5) while preserving cartilage matrix components - a proposed two-phase mechanism demonstrated in animals, not yet confirmed in humans.
Preclinical study (mice and rats)A systematic review describes eggshell membrane's composition as chemically similar to human connective tissue and bone
Eggshell membrane is composed mainly of collagen type I, chondroitin sulfate, dermatan sulfate, hyaluronic acid and elastin - a composition described as similar to human bone and connective tissue - and the review links this composition to eggshell membrane's reported pain-reducing and anti-inflammatory effects, reporting improved calcium uptake and osteoblast activity in laboratory models.
Systematic reviewAn animal model of inflammatory arthritis found NEM reduced joint swelling, cartilage damage and biomarkers of cartilage breakdown
In rats with developing collagen-induced arthritis (a model of rheumatoid arthritis), daily NEM significantly reduced ankle swelling and ankle/knee histopathology scores (36-43% reduction) toward normal, and lowered serum biomarkers of cartilage breakdown and inflammation (CTX-II, COMP, alpha-2-macroglobulin) by 30-72% versus untreated controls.
Animal study (rats)A small human pilot study found eggshell membrane lowered a circulating inflammation marker in healthy elderly adults
Healthy home-dwelling adults over 70 who took 500 mg eggshell membrane daily for 4 weeks showed a significant reduction in the circulating inflammatory marker CRP versus placebo; companion experiments in aged mice fed eggshell membrane showed reduced inflammatory markers and attenuated markers of skeletal muscle aging.
Human pilot study + animal studyA 3-year randomized trial found glucosamine sulfate prevented joint-space narrowing and improved symptoms in knee osteoarthritis
In 212 patients with knee osteoarthritis randomized to 1500 mg glucosamine sulfate or placebo daily for 3 years, the placebo group showed progressive joint-space narrowing (-0.31 mm) while the glucosamine group showed no significant joint-space loss (-0.06 mm); WOMAC symptom scores also improved with glucosamine sulfate while worsening slightly on placebo, with no difference in safety between groups.
Human RCT (n=212, 3 years)A review describes how crystalline glucosamine sulfate inhibits an inflammatory joint-damage pathway at pharmacologically relevant doses
Crystalline glucosamine sulfate at the standard 1500 mg once-daily dose reaches plasma and synovial fluid concentrations sufficient to inhibit interleukin-1-driven gene expression involved in joint inflammation and tissue destruction; the review reports that long-term pivotal trials of this specific formulation showed significant improvement in pain and function, plus reduced radiographic joint-structure progression over up to 3 years.
ReviewAn umbrella review found high-certainty evidence that glucosamine sulfate improves joint-space width and slows osteoarthritis progression
Synthesizing 11 systematic reviews covering 37 randomized trials (3,949 participants, almost all using 1500 mg/day), glucosamine sulfate showed high-certainty benefit (GRADE) for the Lequesne index, joint space width change (including after 3 years), joint space narrowing and overall osteoarthritis progression, with no difference in adverse effects versus placebo.
Umbrella review (37 RCTs, n=3,949)A review found glucosamine hydrochloride preparations repeatedly failed to show a significant pain benefit, unlike the patented crystalline sulfate form
Comparing glucosamine formulations, the review found that only the patented, prescription-grade crystalline glucosamine sulfate reliably reached the plasma concentrations needed for a pharmacological effect and delivered a pain-reducing effect size greater than paracetamol; by contrast, randomized trials of non-crystalline glucosamine sulfate and glucosamine hydrochloride preparations - the forms most common in over-the-counter food supplements - repeatedly showed an effect size on pain of zero.
ReviewA review reiterates that only the patented crystalline sulfate form of glucosamine consistently controls osteoarthritis pain and slows progression
Reviewing the evidence base for glucosamine formulations in knee osteoarthritis, the authors conclude that patented crystalline glucosamine sulfate is the only form shown to reliably provide a moderate pain-reducing effect and disease-modifying benefit, while other glucosamine sulfate and glucosamine hydrochloride preparations vary substantially in formulation and have not shown the same reliable benefit.
ReviewA 2-year trial using glucosamine hydrochloride found no statistically significant pain benefit over placebo in knee osteoarthritis
In 662 patients with knee osteoarthritis continuing treatment from the NIH-sponsored GAIT trial, glucosamine hydrochloride (500 mg three times daily) did not achieve a statistically significant reduction in WOMAC pain versus placebo over 2 years, though it showed a non-significant favorable trend; this is the same salt form (glucosamine hydrochloride) used in many over-the-counter joint supplements, including this product - an honest, non-uniform result worth weighing against the positive crystalline-sulfate trials above.
Human RCT (n=662, 2 years)The GAIT trial found no significant difference in joint-space loss between glucosamine, chondroitin, celecoxib or placebo over 2 years
In 572 patients with knee osteoarthritis from the Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), no treatment group - glucosamine, chondroitin sulfate, the combination, celecoxib or placebo - showed a statistically significant difference in joint-space width loss over 2 years compared to placebo, though a trend toward benefit appeared in patients with earlier-stage (Kellgren/Lawrence grade 2) disease.
Human RCT (n=572, 2 years)A 12-month follow-up found crystalline glucosamine sulfate reduced pain but did not slow radiographic progression of knee osteoarthritis
In 111 patients with knee osteoarthritis followed for 12 months, those taking crystalline glucosamine sulfate (1500 mg/day) reported significantly lower pain intensity than those on standard NSAID therapy, but neither group showed a difference in the progression of radiographic joint damage (joint space width) over the study period.
Human prospective follow-up study (n=111)A systematic review of 15 trials found glucosamine reduced pain versus placebo but its benefit on stiffness and function was insufficient
Reviewing 15 randomized controlled trials, glucosamine significantly reduced global pain (VAS) versus placebo in knee osteoarthritis, and WOMAC scores confirmed some improvement in pain, stiffness and physical function, but the review characterizes these functional and stiffness effects as insufficient in magnitude; no serious adverse events or drug interactions were reported, and long-term use of glucosamine sulfate 1500 mg/day was considered well tolerated.
Systematic review (15 RCTs)A pharmacokinetic study from the GAIT trial found combining glucosamine with chondroitin lowered glucosamine's own plasma levels
Studying the pharmacokinetics of glucosamine and chondroitin sulfate taken alone or combined, the plasma concentration of glucosamine was significantly reduced when co-administered with chondroitin sulfate compared to glucosamine taken alone, suggesting any pain relief from the combination is not explained by higher circulating glucosamine levels, and that chondroitin's effects likely occur locally in the gut or liver rather than by reaching the joint space directly.
Human pharmacokinetic study (n=29 and n=28)An osteoarthritic rabbit model found oral glucosamine hydrochloride with chondroitin and hyaluronic acid modulated cartilage-repair genes
In rabbits with induced osteoarthritis, oral glucosamine hydrochloride combined with chondroitin sulfate and hyaluronic acid down-regulated genes encoding cartilage-degrading enzymes and up-regulated genes for cartilage matrix components (aggrecan, fibronectin, collagen type II) - a proposed mechanism for the combination's reported cartilage-protective effects in this animal model.
Preclinical study (rabbits)A review of two 3-year trials concluded crystalline glucosamine sulfate has both symptom- and joint-structure-modifying properties
Reviewing the pharmacology and clinical evidence for crystalline glucosamine sulfate, the compound is described as reversing interleukin-1's pro-inflammatory, joint-degrading effects by inhibiting its intracellular signaling pathway; two separate 3-year clinical trials of the 1500 mg once-daily crystalline formulation suggested a joint structure-modifying effect in addition to symptom relief.
ReviewA case report and FDA database review found glucosamine may interact with the blood thinner warfarin
Describing a patient whose INR rose from 2.3 to 4.7 after increasing his glucosamine-chondroitin dose while on long-term warfarin, the authors' review of the FDA MedWatch database found 20 reports of altered coagulation (increased INR, bleeding or bruising) in warfarin patients also taking glucosamine or glucosamine-chondroitin, including one serious bleeding event - supporting caution and medical consultation before combining glucosamine with anticoagulant medication.
Case report + pharmacovigilance database reviewA human study found 6 weeks of glucosamine at osteoarthritis-treatment doses worsened insulin resistance
In 38 volunteers without known blood-sugar problems, taking 1500 mg oral glucosamine daily for 6 weeks significantly increased a marker of insulin resistance (HOMA-IR, from 2.8 to 3.2), with the largest changes seen in those who already had poorer insulin sensitivity at baseline - an honest caution suggesting people with impaired glucose metabolism should discuss glucosamine use with a healthcare practitioner.
Human study (n=38)Real-world studies found crystalline glucosamine sulfate use was linked to fewer other medications and lower long-term healthcare costs
Reviewing real-life setting trials and surveys, patients using prescription-grade crystalline glucosamine sulfate needed less additional pain medication and fewer NSAIDs, with over 50% reductions in costs linked to other osteoarthritis medications and healthcare consultations over 12 months, and a reduced need for total joint replacement surgery for at least 5 years after 12 months of treatment.
Review of real-life studiesFrequently asked questions
What is Orange Naturals Glucosamine + NEM and what does it do?
It's a vegetable capsule combining 750 mg Glucosamine HCl with 250 mg NEM (partially hydrolysed natural eggshell membrane). It starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days.
How do I take it?
Adults (19 years and older) take 1 capsule, 2 times per day. Use for at least 1 month to see beneficial effects. Ask a healthcare practitioner for use beyond 8 weeks.
What is NEM?
NEM is a partially hydrolysed natural eggshell membrane ingredient studied in multiple clinical trials for joint pain, stiffness and flexibility.
Does this product contain shellfish or egg?
Yes. The Glucosamine HCl is sourced from shrimp and crab exoskeleton, and the NEM is sourced from chicken eggshell membrane. Do not use if you have a known allergy to eggs, egg by-products or shellfish.
Who should consult a healthcare practitioner before using it?
Ask a healthcare practitioner prior to use if you are pregnant or breastfeeding, if you are taking any medication, or if you have a medical condition.
How long does one bottle last?
Each bottle contains 60 vegetable capsules - a 30-day supply at the standard dose of 1 capsule, 2 times per day.
Is it vegan?
No - while the capsule shell itself is a vegetable (hypromellose) capsule, the formula's active ingredients are animal-derived: Glucosamine HCl from shrimp/crab exoskeleton and NEM from chicken eggshell membrane.
Is it GMO-free?
Yes - the label states GMO-free, with no artificial flavours, colours, preservatives, sweeteners, dairy, soy, gluten, wheat or yeast.
Where do I buy it?
Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.
Start easing joint pain and stiffness in days, not weeks
Get Orange Naturals Glucosamine + NEM on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80116683. Starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days. Contains egg and shellfish - do not use if you have a known allergy to eggs, egg by-products or shellfish. Ask a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if you are taking any medication or have a medical condition. The research summaries on this page concern glucosamine and NEM (natural eggshell membrane) generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Allergens: egg, shellfish. Do not use if you have a known allergy to eggs or egg by-products, or a known allergy to shellfish. Ask a healthcare practitioner prior to use if you are pregnant or if you are breastfeeding. Caution advised when taking any medication or if you have a medical condition. Ask a healthcare practitioner if symptoms persist or worsen. Do not use if safety seal is broken. Keep out of reach of children.
Indications
Uses: Starts to reduce joint pain due to moderate intensity aerobic exercise in as little as 1 day and joint stiffness as quickly as 5 days.
Ingredients
Medicinal Ingredients (each capsule contains): Glucosamine HCL (exoskeleton, shrimp and crab) 750 mg, NEM Eggshell Membrane (egg shell, Gallus gallus, partially hydrolysed chicken eggshell membrane) 250 mg. Non-medicinal Ingredients: Hypromellose, magnesium stearate. GMO free. No artificial flavours, colours, preservatives, sweeteners, dairy, soy, gluten, wheat or yeast.
Directions
Directions (Adults 19 years and older): Take 1 capsule, 2 times per day. Use for at least 1 month to see beneficial effects. Ask a healthcare practitioner for use beyond 8 weeks.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.