Orange Naturals Estro Calm with I-3-C 200mg | 60 Veg Capsules
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 1 to 2 capsules per day |
| Licensed Natural Health Product | NPN 80076977 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- THERAPEUTIC 200 MG DOSE OF INDOLE-3-CARBINOL: Each vegan vegetable capsule provides 200 mg of pure Indole-3-Carbinol (I3C) - take 1 to 2 capsules per day, or as directed by a healthcare practitioner.
- HELPS PROMOTE HEALTHY ESTROGEN BALANCE: I3C is a natural compound found in cruciferous vegetables that helps to promote healthy estrogen balance - this product's Health Canada-authorized use.
- SUPPORTS THE LIVER'S ROLE IN ESTROGEN PROCESSING: Supports the liver's natural function in processing excess estrogen as part of its ordinary detoxification role.
- VEGAN, GLUTEN-FREE, ALLERGEN-FRIENDLY: Free from dairy, corn, gluten, nuts and soy, in a vegan vegetable capsule.
- REAL CAUTIONS - READ BEFORE USE: Do not use if pregnant or breastfeeding. Consult a healthcare practitioner prior to use to exclude a serious cause of hormonal imbalance, or if you are taking medication, attempting to conceive, or have low estrogen, symptoms of low estrogen, or a liver disorder.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals, developed by naturopathic doctors, and licensed under NPN 80076977.
Product Description
Estro Calm with I-3-C - Indole-3-Carbinol for Healthy Estrogen Balance
Orange Naturals Estro Calm with I-3-C delivers a full 200 mg dose of pure Indole-3-Carbinol (I3C) - a natural compound found in cruciferous vegetables like broccoli, kale and Brussels sprouts - in every vegan vegetable capsule. Developed by naturopathic doctors, this formula helps to promote healthy estrogen balance by supporting the liver's role in processing excess estrogen. Vegan, gluten-free and licensed as a Natural Health Product - this product also carries real, important cautions, see below. NPN 80076977. Licensed Natural Health Product NPN 80076977.
Estro Calm avec I-3-C d'Orange Naturals offre une pleine dose de 200 mg d'indole-3-carbinol (I3C) - un composé naturel présent dans les légumes crucifères comme le brocoli, le chou frisé et les choux de Bruxelles - dans chaque capsule végétale vegane. Développée par des médecins naturopathes, cette formule aide à promouvoir un équilibre sain des œstrogènes en soutenant le rôle du foie dans le traitement de l'excès d'œstrogènes. Végétalien, sans gluten et homologué comme produit de santé naturel - ce produit comporte aussi de réelles mises en garde importantes, voir ci-dessous. NPN 80076977.
A Naturopathic-Developed Estrogen Metabolism Formula
200 mg Indole-3-Carbinol (I3C) - simple once or twice-daily dosing, developed by naturopathic doctors
200 mg Indole-3-Carbinol per Capsule
Each vegan vegetable capsule delivers a full 200 mg dose of pure Indole-3-Carbinol (I3C) - take 1 to 2 capsules per day, or as directed by a healthcare practitioner.
Developed by Naturopathic Doctors
Orange Naturals formulas, including Estro Calm with I-3-C, are developed by naturopathic doctors and made in Canada.
Advanced Ingredients, Superior Results
Indole-3-Carbinol is one of the most-studied compounds from cruciferous vegetables for its role in estrogen metabolism - and one with real, well-documented cautions for certain groups. Here is what the wider research explores.
Indole-3-Carbinol (I3C)
A natural compound found in cruciferous vegetables such as broccoli, kale, cabbage and Brussels sprouts, studied for its role in supporting the liver's processing of estrogen and shifting estrogen metabolism pathways.
200 mg per vegetable capsule
Orange Naturals Estro Calm with I-3-C: Supplement Facts
Each vegetable capsule contains:
- Indole-3-Carbinol (I3C)200 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Hypromellose (vegetable capsule), magnesium carbonate. Vegan, dairy-free, corn-free, gluten-free, nut-free and soy-free.
Recommended Use or Purpose: Helps to promote healthy estrogen balance.
Recommended Dose (Adults): Take 1 to 2 capsules per day, or as directed by a healthcare practitioner.
Cautions and Warnings: Contraindications: Do not use if you are pregnant or breastfeeding. Cautions: Consult a healthcare practitioner prior to use to exclude the diagnosis of a serious cause of hormonal imbalance; and if you are taking any medication, attempting to conceive, or if you have low estrogen, symptoms of low estrogen, or other medical condition including a liver disorder. Known Adverse Reactions: Consult a healthcare practitioner if you develop liver-related symptoms, such as abdominal pain, jaundice, or dark urine. Do not use if the safety seal is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule végétale contient :
- Indole-3-carbinol (I3C)200 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Hypromellose (capsule végétale), carbonate de magnésium. Convient aux végétaliens; sans produits laitiers, sans maïs, sans gluten, sans noix et sans soya.
Usage ou fins recommandés : Aide à promouvoir un équilibre sain des œstrogènes.
Posologie recommandée (adultes) : Prendre 1 à 2 capsules par jour, ou selon les directives d'un praticien de la santé.
Mises en garde : Contre-indications : Ne pas utiliser ce produit si vous êtes enceinte ou si vous allaitez. Mises en garde : Consulter un praticien de la santé avant l'usage afin d'exclure le diagnostic d'une cause sérieuse de déséquilibre hormonal; et si vous prenez des médicaments, si vous essayez de concevoir, ou si vous avez de faibles taux d'œstrogène, des symptômes de faibles taux d'œstrogène, ou tout autre problème de santé, y compris un trouble du foie. Réactions indésirables connues : Consulter un praticien de la santé si vous développez des symptômes hépatiques, tels que douleur abdominale, jaunisse ou urine foncée. Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.
NPN 80076977
Help promote healthy estrogen balance with Indole-3-Carbinol
Get Orange Naturals Estro Calm with I-3-C on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Estro Calm with I-3-C
200 mg of Indole-3-Carbinol (I3C) per vegetable capsule - developed by naturopathic doctors, with real cautions you should read before use.
200 mg Indole-3-Carbinol per capsule
Each vegan vegetable capsule delivers a full 200 mg dose of pure I3C.
Helps promote healthy estrogen balance
Supports the liver's role in processing excess estrogen as part of its natural detoxification functions.
Simple once or twice-daily dose
Take 1 to 2 capsules per day, or as directed by a healthcare practitioner.
Real cautions, developed by naturopathic doctors
Formulated by Orange Naturals and developed by naturopathic doctors. This product carries real, important cautions for certain groups - read the label. NPN 80076977.
Inside every capsule
200 mg of pure Indole-3-Carbinol (I3C) in a vegan vegetable capsule - take 1 to 2 capsules per day to help promote healthy estrogen balance.
How to use it
Take 1 to 2 capsules daily
Adults: take 1 to 2 capsules per day, or as directed by a healthcare practitioner.
A 30 to 60-day supply per bottle
Each bottle of 60 vegetable capsules provides a 60-day supply at 1 capsule per day, or a 30-day supply at 2 capsules per day.
Rule out a serious cause first
Consult a healthcare practitioner prior to use to exclude the diagnosis of a serious cause of hormonal imbalance.
Read the cautions before you start
Do not use if pregnant or breastfeeding. Consult a healthcare practitioner if you are taking any medication, attempting to conceive, or if you have low estrogen, symptoms of low estrogen, or a liver disorder.
What the research says about Indole-3-Carbinol (I3C)
Educational summaries of published research on indole-3-carbinol and its metabolite DIM generally (estrogen metabolism, cruciferous-vegetable epidemiology, liver detoxification pathways); not product-specific claims. Orange Naturals Estro Calm with I-3-C's own authorized use under NPN 80076977 is that it helps to promote healthy estrogen balance.
Early lab research identified indole-3-carbinol as a shifter of estrogen down the protective 2-hydroxylation pathway
Using an MCF-7 breast cell assay, this study found several pesticides increased the ratio of the growth-promoting 16-alpha-hydroxyestrone metabolite relative to the antiproliferative 2-hydroxyestrone metabolite, while indole-3-carbinol did the opposite - increasing 2-hydroxyestrone formation and yielding a ratio about one-third of that seen in untreated cells.
In vitro studyA study linked estradiol 16-alpha-hydroxylation to HPV-related tissue growth and found indole-3-carbinol blocked the effect
Examining estrogen metabolism in laryngeal tissue, the researchers found that estradiol and 16-alpha-hydroxyestrone stimulated cell proliferation while 2-hydroxyestrone did not; indole-3-carbinol, which shifts metabolism toward 2-hydroxylation, blocked estradiol's proliferative effect and reduced papilloma formation in an animal model of HPV-11 infected tissue.
Laboratory & animal studyA rat liver study found indole-3-carbinol and its metabolite DIM alter the metabolism of an estrogen precursor hormone
Indole-3-carbinol and its gut-conversion product diindolylmethane (DIM) both altered how female rat liver microsomes metabolized 4-androstenedione, a precursor hormone that can be aromatized into estrone; the authors proposed this as a further route by which indole-3-carbinol compounds may reduce the formation of 16-alpha-hydroxyestrone.
Preclinical studyA 5-day human trial found 400 mg per day of indole-3-carbinol significantly raised the protective estrogen metabolite ratio in women
In women with the wild-type CYP1A1 gene, five days of indole-3-carbinol at 400 mg per day significantly increased the urinary 2-hydroxyestrone to 16-alpha-hydroxyestrone ratio, from 1.35 to 2.39 on average; women carrying a specific CYP1A1 gene variant did not show this same increase, suggesting genetics may influence individual response.
Human clinical trialA randomized, placebo-controlled crossover trial found an indole-3-carbinol and green tea catechin product raised the urinary estrogen metabolite ratio in premenopausal women
In 148 premenopausal women, 12 weeks of a daily supplement containing indole-3-carbinol and green tea catechins produced a significantly higher urinary 2-hydroxyestrone to 16-alpha-hydroxyestrone ratio compared to placebo - a metabolite ratio that has been studied as a marker of estrogen metabolism.
Human RCT, crossover (n=148)A 12-month randomized trial found DIM, indole-3-carbinol's main metabolite, favourably shifted estrogen metabolism markers in women taking tamoxifen
In 98 women completing this placebo-controlled trial, 300 mg per day of diindolylmethane (DIM, a bioactive metabolite of indole-3-carbinol) significantly increased the urinary 2/16-alpha-hydroxyestrone ratio and serum sex hormone-binding globulin compared to placebo, with minimal adverse events reported in either group over the 12-month study.
Human RCT (n=98, 12 months)A 30-year study of over 182,000 women found higher fruit and vegetable intake, especially cruciferous vegetables, was linked to lower breast cancer risk
In the Nurses' Health Study and Nurses' Health Study II, women with the highest fruit and vegetable intake (especially cruciferous and yellow/orange vegetables) had an 11% lower risk of invasive breast cancer compared to those with the lowest intake, with the strongest associations seen for more aggressive tumor subtypes.
Prospective cohort (n=182,145, 30-year follow-up)A Japanese prospective study found cruciferous vegetable intake was associated with lower premenopausal breast cancer risk
Following 47,289 Japanese women for an average of 10.2 years, higher cruciferous vegetable intake was associated with a statistically significant 36% lower risk of breast cancer among premenopausal women, and a marginal inverse association with estrogen/progesterone-receptor-positive tumors.
Prospective cohort (n=47,289)The Black Women's Health Study found cruciferous vegetable intake trended toward lower breast cancer risk over 12 years
Among 51,928 women followed for 12 years, total vegetable intake was associated with a significantly lower risk of estrogen/progesterone-receptor-negative breast cancer, with cruciferous vegetable intake specifically showing a favorable trend for breast cancer risk overall.
Prospective cohort (n=51,928)Foundational research identified the acid-conversion products of indole-3-carbinol as the compounds that activate liver detoxification enzymes
Indole-3-carbinol converts in the stomach's acidic environment into condensation products, including indolo[3,2-b]carbazole (ICZ); this study found ICZ binds strongly to the aromatic hydrocarbon receptor and induces cytochrome P450 1A1, the same detoxification-enzyme pathway responsible for indole-3-carbinol's effects on liver metabolism.
Preclinical studyA rat study found indole-3-carbinol was the most potent tested inducer of a Phase II liver detoxification enzyme
Testing several dietary cancer-chemopreventive agents, indole-3-carbinol produced the largest increase (6.2-fold) in hepatic glutathione S-transferase T1-1, a Phase II liver enzyme involved in detoxifying certain reactive compounds, in male rats specifically.
Preclinical studyA mouse study measured indole-3-carbinol's dose-dependent effects on liver detoxification enzymes and established a toxicity threshold
Ten days of indole-3-carbinol at 50 mg/kg body weight produced modest increases in several hepatic detoxification enzymes (cytochrome P450, glutathione S-transferase, UDP-glucuronosyl transferase) and a four-fold increase in quinone reductase in mice; the study also found dose-dependent toxicity emerging above 100 mg/kg body weight, informing safe dosing margins for this compound.
Preclinical studyResearch identified DIM, indole-3-carbinol's gut metabolite, as a receptor-mediated modulator of estrogen signaling
Diindolylmethane (DIM), formed from indole-3-carbinol under stomach acid conditions, was found to bind the aryl hydrocarbon receptor and inhibit estradiol-induced cell proliferation and estrogen-responsive gene activity in breast cells, as well as reduce nuclear estrogen receptor levels.
Preclinical studyA cell study found indole-3-carbinol and its metabolite DIM reduced estrogen receptor alpha expression
Treating breast cells with indole-3-carbinol reduced estrogen receptor alpha mRNA by about 60%; its metabolite DIM was considerably more potent at the same effect, at a twentieth of the concentration, suggesting DIM may be the primary active form responsible for indole-3-carbinol's effects on estrogen receptor signaling.
In vitro studyA study found DIM combined with soy genistein shifted estrogen metabolism toward the 2-hydroxylation pathway in prostate cells
In prostate cancer cell lines, diindolylmethane (I3C's metabolite) and genistein together increased expression of the 2-hydroxylation enzyme CYP1A1 and reduced levels of 16-alpha-hydroxyestrone while increasing 2-hydroxyestrogen, consistent with a shift the researchers describe as reduced estrogenic activity.
In vitro studyA liver-cell study compared several plant compounds, including indole-3-carbinol, for their ability to activate the body's own antioxidant defense pathway
Testing sulforaphane, allyl isothiocyanate, indole-3-carbinol and parthenolide in human liver cells, the study found each compound could activate the Nrf2 antioxidant-response pathway to varying degrees, with indole-3-carbinol producing a more modest activation than sulforaphane in this particular assay.
In vitro studyA colon-cell study found dietary indoles, including a metabolite of indole-3-carbinol, helped protect against DNA damage from a genotoxic agent
Pretreating human colon cells with dietary indoles (including ICZ, a condensation product of indole-3-carbinol) and isothiocyanates reduced single-strand DNA breaks from the carcinogen benzo(a)pyrene to less than 20% of the level seen without pretreatment, alongside measurable increases in the detoxification enzyme CYP1A1.
In vitro studyA mouse-genetics study showed the Nrf2 pathway that indole-3-carbinol helps activate is essential for the body's own antioxidant enzyme induction
Using mice with the Nrf2 gene knocked out, this study demonstrated that Nrf2 is required for both baseline and diet-induced expression of intestinal antioxidant and detoxification enzymes; several dietary compounds tested, including indole-3-carbinol, lost much of their enzyme-inducing effect in the Nrf2-deficient animals, confirming this pathway's central role.
Preclinical study (gene-knockout model)A comprehensive review catalogued indole-3-carbinol's molecular targets, including hormone receptors and liver detoxification pathways
Reviewing the accumulated laboratory and early clinical evidence, this paper describes indole-3-carbinol's effects on cell-cycle regulators, its ability to modulate estrogen receptor and androgen receptor activity, its induction of 2-hydroxylation of estradiol, and notes 'numerous studies' pointing to a strong hepatoprotective activity against various compounds in animal models.
ReviewA historical review traced indole-3-carbinol research from early cruciferous-vegetable feeding studies to its mechanisms as a micronutrient
This review traces how early animal studies linking cruciferous vegetable consumption to reduced chemically induced tumors led to the identification of indole-3-carbinol and its reaction products as agents that induce liver detoxification enzymes via the aryl hydrocarbon receptor, and describes additional proposed mechanisms including free-radical and electrophile scavenging.
ReviewA review of indole compounds from cruciferous vegetables highlighted two cell-signaling pathways underlying their studied effects
Surveying the literature on indole-3-carbinol and related indole derivatives from vegetables such as broccoli, cauliflower and Brussels sprouts, this review identifies the PI3K/Akt/mTOR signaling pathway and the aryl hydrocarbon receptor as two of the main mechanisms researchers have proposed to explain these compounds' studied cellular effects.
ReviewA placebo-controlled human dose-ranging study of indole-3-carbinol found no significant toxicity across a range of doses
In 57 women completing this 4-week, double-blind study, doses of indole-3-carbinol ranging from 50 to 400 mg per day were tested against placebo, with no significant toxicity effects reported at any dose; a dose of 300 mg per day or more produced the clearest shift in the urinary estrogen metabolite ratio used as the study's marker.
Human RCT, dose-ranging (n=57)A rat study found dietary indole-3-carbinol protected the liver against a hepatotoxic drug without blunting the drug's intended effect
Rats fed indole-3-carbinol for 6 days before receiving a hepatotoxic experimental antitumor drug showed almost complete protection from the drug's liver-damaging effects (elevated bilirubin, liver enzymes and bile-duct cell injury), and indole-3-carbinol did not interfere with the drug's activity against mammary tumors in the same animals.
Preclinical studyA rat study offers an honest caution: in liver tissue already injured by a carcinogen, indole-3-carbinol increased oxidative stress markers rather than protecting
In rats whose livers had already been initiated with the carcinogen diethylnitrosamine, subsequently feeding indole-3-carbinol increased markers of oxidative stress and the number of precancerous liver cell lesions, in contrast to the protective effects seen in other toxin-exposure models - a reminder that this research is context-dependent, and part of why real product labels advise consulting a healthcare practitioner about any existing liver disorder.
Preclinical study (honest mixed finding)Frequently asked questions
What is Orange Naturals Estro Calm with I-3-C and what does it do?
It's a vegan vegetable capsule providing 200 mg of Indole-3-Carbinol (I3C) per capsule. It helps to promote healthy estrogen balance by supporting the liver's role in processing excess estrogen.
How do I take it?
Adults take 1 to 2 capsules per day, or as directed by a healthcare practitioner.
How long does one bottle last?
Each bottle contains 60 vegetable capsules - a 60-day supply at 1 capsule per day, or a 30-day supply at 2 capsules per day.
Who should NOT use this product?
Do not use this product if you are pregnant or breastfeeding.
Who should consult a healthcare practitioner before using it?
Consult a healthcare practitioner prior to use to exclude the diagnosis of a serious cause of hormonal imbalance, and if you are taking any medication, attempting to conceive, or if you have low estrogen, symptoms of low estrogen, or other medical condition including a liver disorder.
What if I develop symptoms while using it?
Consult a healthcare practitioner if you develop liver-related symptoms such as abdominal pain, jaundice, or dark urine.
What is Indole-3-Carbinol (I3C)?
I3C is a natural compound found in cruciferous vegetables such as broccoli, kale, cabbage and Brussels sprouts.
Is it vegan and allergen-friendly?
Yes - it is vegan, and free of dairy, corn, gluten, nuts and soy.
Where do I buy it?
Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.
Help promote healthy estrogen balance with Indole-3-Carbinol
Get Orange Naturals Estro Calm with I-3-C on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80076977. Helps to promote healthy estrogen balance. Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use to exclude the diagnosis of a serious cause of hormonal imbalance, and if you are taking any medication, attempting to conceive, or if you have low estrogen, symptoms of low estrogen, or other medical condition including a liver disorder, or if you develop liver-related symptoms such as abdominal pain, jaundice, or dark urine. The research summaries on this page concern Indole-3-Carbinol and cruciferous-vegetable compounds generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Contraindications: Do not use if you are pregnant or breastfeeding. Cautions: Consult a healthcare practitioner prior to use to exclude the diagnosis of a serious cause of hormonal imbalance; and if you are taking any medication, attempting to conceive, or if you have low estrogen, symptoms of low estrogen, or other medical condition including a liver disorder. Known Adverse Reactions: Consult a healthcare practitioner if you develop liver-related symptoms, such as abdominal pain, jaundice, or dark urine. Do not use if the safety seal is broken. Keep out of reach of children.
Indications
Recommended Use or Purpose: Helps to promote healthy estrogen balance.
Ingredients
Medicinal Ingredients (each vegetable capsule contains): Indole-3-Carbinol (I3C), 200 mg. Non-medicinal Ingredients: Hypromellose (vegetable capsule), magnesium carbonate. Vegan. Dairy-free, corn-free, gluten-free, nut-free and soy-free.
Directions
Recommended Dose (Adults): Take 1 to 2 capsules per day, or as directed by a healthcare practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.