Orange Naturals Devil's Claw Tincture | 100mL
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 2 mL, 3 times per day |
| Licensed Natural Health Product | NPN 80031253 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- HELPS STIMULATE THE APPETITE: Traditionally used in Herbal Medicine as a bitter to help stimulate appetite.
- RELIEVES DIGESTIVE DISTURBANCES: Traditionally used in Herbal Medicine to help relieve digestive disturbances such as dyspepsia.
- HELPS RELIEVE JOINT PAIN ASSOCIATED WITH OSTEOARTHRITIS: Used in Herbal Medicine to help relieve joint pain associated with osteoarthritis - use for a minimum of 2 to 3 months to see beneficial effects.
- NATURAL ANTI-INFLAMMATORY: Devil's claw's traditional anti-inflammatory and pain-relieving properties can be helpful for arthritic and rheumatic conditions.
- MADE FROM ORGANIC AND WILD CRAFTED HERBS: Made from organic devil's claw secondary root tuber (Harpagophytum procumbens), 1:4 extract.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals and licensed under NPN 80031253.
Product Description
Devil's Claw Tincture - Traditional Joint Comfort & Digestive Support
Orange Naturals Devil's Claw Tincture delivers 250 mg of organic Devil's Claw (secondary root tuber, Harpagophytum procumbens) per mL, extracted at a 1:4 ratio in a base of grain alcohol and purified water. Used in Herbal Medicine to help relieve joint pain associated with osteoarthritis, Devil's Claw is also traditionally used in Herbal Medicine as a bitter to help stimulate appetite and to help relieve digestive disturbances such as dyspepsia. It can take 2 to 3 months of regular use to begin feeling the joint-comfort benefits. This 100 mL naturopathic tincture is licensed as a Natural Health Product. Licensed Natural Health Product NPN 80031253.
Teinture de Griffe du Diable d'Orange Naturals offre 250 mg de Griffe du diable biologique (tubercule de racine secondaire, Harpagophytum procumbens) par mL, extrait selon un ratio de 1:4 dans une base d'alcool de grain et d'eau purifiée. Utilisée en phytothérapie pour aider à soulager la douleur articulaire associée à l'arthrose, la Griffe du diable est également utilisée traditionnellement en phytothérapie comme amer pour aider à stimuler l'appétit et pour aider à soulager les troubles digestifs tels que la dyspepsie. Il peut falloir de 2 à 3 mois d'usage régulier avant de ressentir les bienfaits sur le confort articulaire. Cette teinture naturopathique de 100 mL est homologuée comme produit de santé naturel. NPN 80031253.
A Traditional Root, Modern Tincture Format
250 mg Devil's Claw (secondary root tuber, Harpagophytum procumbens), 1:4 extract - fast-absorbing liquid format, 2 mL 3 times daily
250 mg Devil's Claw per mL
Each mL delivers a full 250 mg dose of organic Devil's Claw secondary root tuber (Harpagophytum procumbens), extracted at a 1:4 ratio - take 2 mL, 3 times per day on an empty stomach.
Fast-Absorbing Tincture Format
As a liquid tincture, Devil's Claw can begin absorbing in the mouth, offering a fast-acting alternative to capsules or tablets.
Advanced Ingredients, Superior Results
Harpagophytum procumbens (Devil's Claw) is one of the most widely studied roots in traditional herbal medicine for joint comfort, explored for its role in osteoarthritis symptom relief, low back pain, and anti-inflammatory activity. Here is what the wider research explores.
Devil's Claw (secondary root tuber, Harpagophytum procumbens)
A traditional South African root long used for joint comfort and digestive bitterness, studied for its role in osteoarthritis symptom relief, low back pain and anti-inflammatory activity.
250 mg per mL, 1:4 extract
Orange Naturals Devil's Claw Tincture: Supplement Facts
Each mL contains:
- Devil's Claw (secondary root tuber, Harpagophytum procumbens), 1:4 extract250 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: 40% grain alcohol, purified water.
Recommended Use or Purpose: Traditionally used in Herbal Medicine as a bitter to help stimulate appetite. Traditionally used in Herbal Medicine to help relieve digestive disturbances such as dyspepsia. Used in Herbal Medicine to help relieve joint pain associated with osteoarthritis; use for a minimum of 2 to 3 months to see beneficial effects.
Recommended Dose (Adults): Take 2 mL, 3 times per day on an empty stomach.
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. Consult a healthcare practitioner if symptoms persist. Consult a healthcare practitioner if symptoms worsen. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque mL contient :
- Griffe du diable (tubercule de racine secondaire, Harpagophytum procumbens), extrait 1:4250 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Alcool de grain à 40 %, eau purifiée.
Usage ou fins recommandés : Utilisé traditionnellement en phytothérapie comme amer pour aider à stimuler l'appétit. Utilisé traditionnellement en phytothérapie pour aider à soulager les troubles digestifs tels que la dyspepsie. Utilisé en phytothérapie pour aider à soulager la douleur articulaire associée à l'arthrose; utiliser pendant un minimum de 2 à 3 mois pour observer les bienfaits.
Posologie recommandée (adultes) : Prendre 2 mL, 3 fois par jour sur un estomac vide.
Mises en garde : Consulter un praticien de la santé avant d'en faire l'usage si vous êtes enceinte ou allaitez. Consulter un praticien de la santé si les symptômes persistent. Consulter un praticien de la santé si les symptômes s'aggravent. Garder hors de la portée des enfants.
NPN 80031253
Support joint comfort with Devil's Claw
Get Orange Naturals Devil's Claw Tincture on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Devil's Claw Tincture
250 mg of Devil's Claw (secondary root tuber, Harpagophytum procumbens) per mL, 1:4 extract - a traditional root in a fast-absorbing tincture format.
250 mg Devil's Claw per mL
Each mL delivers a full 250 mg dose of organic Devil's Claw secondary root tuber (Harpagophytum procumbens), extracted at a 1:4 ratio.
Used for joint pain associated with osteoarthritis
Used in Herbal Medicine to help relieve joint pain associated with osteoarthritis - use for a minimum of 2 to 3 months to see beneficial effects.
Fast-absorbing liquid tincture
Take 2 mL, 3 times per day on an empty stomach - a fast-acting alternative to capsules.
Made in Canada, Health Canada licensed
Formulated by Orange Naturals and licensed as a Natural Health Product. NPN 80031253.
Inside every mL
250 mg Devil's Claw (secondary root tuber, Harpagophytum procumbens), 1:4 extract, per mL - take 2 mL, 3 times per day on an empty stomach. Non-medicinal ingredients: 40% grain alcohol and purified water.
How to use it
Take 2 mL, 3 times daily on an empty stomach
Adults: take 2 mL, 3 times per day on an empty stomach.
Use consistently for 2 to 3 months
For joint pain associated with osteoarthritis, use for a minimum of 2 to 3 months to see beneficial effects.
Consult a practitioner if pregnant, breastfeeding, or if symptoms persist
Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if your symptoms persist or worsen.
What the research says about Devil's Claw
Educational summaries of published research on Harpagophytum procumbens generally; not product-specific claims. Orange Naturals Devil's Claw Tincture's own authorized use under NPN 80031253 is that it is used in Herbal Medicine to help relieve joint pain associated with osteoarthritis, and traditionally used as a bitter to help stimulate appetite and relieve digestive disturbances such as dyspepsia.
A 4-month clinical trial found devil's claw as effective as a standard osteoarthritis drug, with fewer side effects
In a double-blind, randomized trial, 122 patients with hip or knee osteoarthritis took either a devil's claw preparation (2.6 g powdered root per day) or the prescription drug diacerhein for 4 months. Both groups saw significant, similar improvements in pain and the Lequesne functional index. Patients taking devil's claw also used significantly less rescue medication (NSAIDs and analgesics), and reported meaningfully fewer adverse events than the diacerhein group, with the most common side effect being mild diarrhea.
Human RCT (n=122)A companion analysis of the same 4-month trial confirmed devil's claw reduced reliance on anti-inflammatory painkillers
Reporting on the same 122-patient, multicenter, double-blind trial comparing devil's claw (2,610 mg per day) with diacerhein for hip and knee osteoarthritis, this analysis confirmed no significant difference in pain, functional disability, or the Lequesne severity score between the two treatments after 4 months. Use of acetaminophen-caffeine and the NSAID diclofenac was significantly lower in the devil's claw group, which also had a significantly lower rate of adverse events overall.
Human RCT (n=122)A 12-week surveillance study found a devil's claw extract meaningfully reduced pain and stiffness in real-world osteoarthritis patients
In an open, 12-week multicenter study of 75 patients with hip or knee osteoarthritis taking an aqueous devil's claw extract standardized to 50 mg harpagoside per day, standard WOMAC osteoarthritis scores improved substantially: pain fell by 23.8%, stiffness by 22.2%, and physical function difficulty by 23.1%. Physicians also recorded improvements in pain on palpation, joint mobility, and joint crepitus. Only two patients reported possible mild adverse drug reactions.
Human Trial (n=75)An updated Cochrane review found devil's claw reduces low back pain more than placebo
This update of a Cochrane systematic review of 14 randomized controlled trials (2,050 participants) on herbal medicines for non-specific low back pain found that, alongside cayenne, devil's claw (Harpagophytum procumbens), white willow bark, comfrey, Brazilian arnica, and lavender oil each appeared to reduce pain more than placebo, though the certainty of evidence for these substances was rated moderate at best. No significant adverse events were reported across the included trials.
Systematic Review (Cochrane, 14 RCTs)An earlier Cochrane review found two high-quality trials showing devil's claw matched a prescription painkiller for short-term back pain relief
Reviewing 10 randomized controlled trials of herbal medicines for low back pain, this Cochrane analysis identified two high-quality trials of devil's claw, standardized to 50 mg or 100 mg harpagoside per day, showing strong evidence for short-term improvements in pain and reduced need for rescue medication versus placebo. A separate high-quality trial found devil's claw performed comparably to 12.5 mg per day of the prescription NSAID rofecoxib.
Systematic Review (Cochrane, 10 RCTs)A clinical review concluded a minimum harpagoside dose of 50 mg per day is needed for devil's claw to relieve pain effectively
This clinical review compared devil's claw preparations by their harpagoside content, noting that a water-extracted preparation delivers roughly double the harpagoside of preparations extracted with 60% ethanol at the same dose. Drawing on the evidence base for low back and arthritic pain, the author concluded that only preparations with at least 50 mg of harpagoside in the daily dose have demonstrated effectiveness, and that devil's claw extract carries a lower risk of adverse events than synthetic analgesics.
ReviewA 2026 review positioned devil's claw as a complementary option to NSAIDs, not a general replacement
This structured narrative review examined devil's claw's pharmacological mechanisms, clinical efficacy, safety, and comparative role relative to NSAIDs, whose long-term use can be limited by gastrointestinal, cardiovascular, and renal side effects. While devil's claw preparations were generally well tolerated and showed symptomatic benefit for some osteoarthritis and low back pain patients, the authors noted the clinical evidence base remains smaller and less certain than that for NSAIDs, concluding devil's claw is better suited as a complementary or selective option - particularly for patients with NSAID intolerance - than a general replacement.
ReviewA 2025 review found clinical trials of standardized devil's claw extracts caused fewer GI side effects than NSAIDs
This review of harpagoside - the key active compound in devil's claw - traced its effects on multiple inflammatory signaling pathways (including NF-kB, AP-1, and Nrf2/HO-1) and summarized clinical trials using standardized extracts (50-100 mg harpagoside per day, or 2.6 g per day of powdered root), which reported significant improvements in osteoarthritis and chronic low back pain with fewer gastrointestinal adverse effects than NSAIDs. The authors also flagged harpagoside's naturally poor oral absorption as an ongoing formulation challenge.
ReviewA review of 14 clinical trials found devil's claw appeared to relieve osteoarthritis pain with less risk than NSAIDs
This review assessed 14 published clinical studies of devil's claw for osteoarthritis - 8 observational studies, 2 comparator trials, and 4 double-blind placebo-controlled RCTs. While many trials had methodological limitations, the higher-quality studies suggested devil's claw was effective at reducing pain, the main clinical symptom of osteoarthritis, and appeared to carry minor risk relative to NSAIDs, though the authors called for a definitive, methodologically rigorous trial to settle the question conclusively.
Review (14 clinical trials)Lab research found harpagoside blocks a key inflammation switch that drives pain and swelling
In human liver and mouse macrophage cell lines exposed to a bacterial toxin (LPS), harpagoside - a major compound in devil's claw - inhibited the production of two inflammatory enzymes, COX-2 and inducible nitric oxide synthase. This effect was traced to harpagoside blocking activation of NF-kB, a master switch for inflammatory gene activity, suggesting a specific cellular mechanism behind devil's claw's traditional anti-inflammatory and pain-relieving reputation.
Preclinical Study (in vitro)A devil's claw extract blocked a key inflammatory messenger in human immune cells
Human monocytes (immune cells) exposed to a bacterial toxin were treated with a devil's claw extract after bacterial contaminants were removed. The extract dose-dependently prevented the release of tumour necrosis factor-alpha (TNF-alpha), a central inflammatory messenger, from these cells. Interestingly, two individual devil's claw compounds tested alone (harpagide and harpagoside) had no effect on their own, suggesting the whole extract's anti-inflammatory activity depends on more than a single isolated compound.
Preclinical Study (human cell line)A mouse study found a devil's claw extract reduced pain behavior partly through the body's own opioid system
Mice given an oral devil's claw extract before a standard pain-response test (formalin injection) showed significantly less pain-related licking and biting behavior in a dose-dependent way. This pain-relieving effect was significantly blunted by naloxone, a drug that blocks opioid receptors, suggesting the body's own opioid signaling pathways play a role in how devil's claw dampens pain, distinct from the mechanism of two other herbal extracts tested in the same study.
Preclinical Study (mouse)A systematic review of 28 clinical trials found devil's claw was no less safe than placebo
This systematic review searched three major databases back to 1985 and identified 28 clinical trials of devil's claw for osteoarthritic and low back pain, of which 20 reported on adverse events. In none of the double-blind studies was the rate of adverse events during devil's claw treatment higher than during placebo treatment; minor gastrointestinal complaints occurred in about 3% of patients. The authors found reports of acute toxicity but none of chronic toxicity, and called for more long-term safety data given that most studies used doses at the lower end of the therapeutic range.
Systematic Review (28 trials)A Brazilian meta-analysis found devil's claw alone did not outperform control treatment for osteoarthritis, unlike some other herbal medicines
This systematic review and meta-analysis of 16 studies (1,741 patients) on herbal medicines marketed in Brazil for osteoarthritis found that, of the six herbs with enough data for meta-analysis, Boswellia serrata outperformed both placebo and a comparator drug, and ginger improved pain versus placebo - but devil's claw, turmeric and cat's claw showed no significant difference from control in the pooled data. The authors judged the overall evidence quality for all the herbs studied, including devil's claw, to be low.
Systematic Review & Meta-AnalysisA Cochrane review found no significant adverse events from devil's claw across the low back pain trials it examined
This Cochrane systematic review of 14 randomized trials for non-specific low back pain found that daily doses of devil's claw standardized to 50 mg or 100 mg harpagoside showed low-to-moderate quality evidence of better short-term pain relief than placebo and reduced use of rescue medication, with one trial showing relative equivalence to 12.5 mg per day of the prescription drug rofecoxib. Across all the herbal medicines and trials included in the review, no significant adverse events were noted.
Systematic Review (Cochrane)A review traced devil's claw's traditional uses across southern Africa to its iridoid glycoside compounds
This review of the ethnobotany, phytochemistry, and biological activity of Harpagophytum procumbens, a traditional medicine of the Kalahari region, documented ethnomedicinal uses spanning arthritis, pain, fever, dyspepsia, and skin ailments. Its analgesic and anti-inflammatory activity has largely been attributed to iridoid glycosides, especially harpagoside and harpagide, with hydrolyzed forms of these compounds showing more pronounced anti-inflammatory activity than their unhydrolyzed forms in the studies reviewed.
ReviewA bibliographic review spanning two centuries traced devil's claw's path from African bush medicine to modern phytopharmaceutical
This bibliographic review compiled nearly 700 sources - including peer-reviewed papers and grey literature such as theses and government reports - published on devil's claw over roughly 200 years. The author traced its historical development into a modern herbal medicine with a well-documented mode of action and a strong clinical safety record, while identifying open questions, including how the two closely related Harpagophytum species compare in safety and effectiveness when used interchangeably in commercial products.
Bibliographic Review (~700 sources)A review of animal, clinical and lab studies found devil's claw consistently acted as an anti-inflammatory and pain reliever
This review examined the biological and therapeutic actions of devil's claw across animal, clinical, and in vitro/ex vivo studies. The majority of animal studies indicated devil's claw was an effective anti-inflammatory and analgesic agent for acute and subacute inflammation, and clinical trials supported its benefit for pain relief and improved mobility in various musculoskeletal conditions, though the authors noted the precise mechanism by which it reduces inflammation was not yet fully elucidated at the time of the review.
ReviewA review of joint-health medicinal plants included devil's claw among the few with real human clinical evidence
This review surveyed medicinal plants studied in human trials for joint disorders like osteoarthritis and rheumatoid arthritis, conditions marked by chronic inflammation and oxidative stress. Devil's claw was included among the small group of joint-supportive herbs with actual human clinical data (as opposed to only animal or lab studies), reflecting a broader pattern in which conventional joint medications are potent but carry serious side-effect risks, while herbal options like devil's claw offer a generally lower rate of adverse events.
ReviewAn evidence-based systematic review traced devil's claw's use from African folklore to modern herbal pharmacotherapy
This evidence-based systematic review by the Natural Standard Research Collaboration compiled the scientific literature, expert opinion, folkloric precedent, history, pharmacology, and dosing information on devil's claw, consolidating decades of traditional use in southern Africa alongside its modern clinical evidence base for osteoarthritis and low back pain into a single structured reference.
Systematic ReviewA review of herbal immunomodulators listed devil's claw among plants shown to alter immune-signaling cytokines
This review of medicinal plants that modulate cytokine secretion - informational molecules central to immune and inflammatory activity - surveyed primary research on whole or standardized botanical extracts. Devil's claw was included among 17 plants, alongside herbs like turmeric, echinacea, and ginseng, shown across in vitro, ex vivo, or in vivo studies to modulate the activity of key cytokines such as IL-1, IL-6, and TNF, offering one possible explanation for its long traditional use in inflammatory conditions.
ReviewA veterinary trial found a multi-herb natural health product containing devil's claw improved mobility in dogs with osteoarthritis
In privately-owned dogs with naturally occurring osteoarthritis, a natural health product combining several medicinal herbs including devil's claw significantly increased peak vertical force (a validated objective measure of limb loading and comfort) after 8 weeks compared to baseline and to untreated control dogs, and also increased daily locomotor activity measured by accelerometer. As a multi-ingredient formula, the improvement cannot be attributed to devil's claw alone, but the trial adds real-world veterinary evidence for this class of herbal joint-support product.
Veterinary RCT (n=27 dogs)A 12-week human trial found a rosehip, nettle and devil's claw combination significantly reduced knee osteoarthritis pain
In a randomized, placebo-controlled, double-blind trial, 92 patients with knee osteoarthritis took a daily combination of rosehip, nettle leaf, and devil's claw root extract (plus vitamin D) or placebo for 12 weeks. The combination significantly outperformed placebo on the WOMAC pain score and all other WOMAC subscores, improved physical and mental quality of life, and trended toward reduced use of rescue analgesics, with physicians and patients both rating it superior to placebo and well tolerated. As a multi-herb formula, results reflect the combination rather than devil's claw in isolation.
Human RCT (n=92)A 2024 trial found a boswellia and devil's claw supplement added extra benefit to physical therapy for knee osteoarthritis
Eighty-eight knee osteoarthritis patients across 4 sites were divided into three groups receiving physical therapy plus a supplement containing boswellic acid and harpagoside (from devil's claw), physical therapy alone, or physical therapy plus placebo. The supplement group showed functional improvement roughly twice as large as the other groups partway through treatment, and patients taking the supplement were about three times as likely to reach a clinically meaningful quality-of-life improvement. As a combination formula, the findings support boswellic acid plus harpagoside together, not devil's claw alone.
Human RCT (n=88)Frequently asked questions
What is Orange Naturals Devil's Claw Tincture and what does it do?
It's a liquid tincture providing 250 mg of Devil's Claw (secondary root tuber, Harpagophytum procumbens), 1:4 extract, per mL. Used in Herbal Medicine to help relieve joint pain associated with osteoarthritis, and traditionally used as a bitter to help stimulate appetite and relieve digestive disturbances such as dyspepsia.
How do I take it?
Adults take 2 mL, 3 times per day on an empty stomach. For joint pain associated with osteoarthritis, use for a minimum of 2 to 3 months to see beneficial effects.
Who should consult a healthcare practitioner before using it?
Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if your symptoms persist or worsen.
What is Devil's Claw traditionally used for?
Devil's Claw root is used in Herbal Medicine to help relieve joint pain associated with osteoarthritis, and traditionally used as a bitter to help stimulate appetite and relieve digestive disturbances such as dyspepsia.
What are the non-medicinal ingredients?
40% grain alcohol and purified water.
How much is in one bottle?
Each bottle contains 100 mL (3.38 fl oz) of tincture.
Is this a Health Canada licensed product?
Yes - it is licensed as a Natural Health Product under NPN 80031253.
Where do I buy it?
Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.
Support joint comfort with Devil's Claw
Get Orange Naturals Devil's Claw Tincture on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80031253. Used in Herbal Medicine to help relieve joint pain associated with osteoarthritis; use for a minimum of 2 to 3 months to see beneficial effects. Traditionally used in Herbal Medicine as a bitter to help stimulate appetite and to help relieve digestive disturbances such as dyspepsia. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if symptoms persist or worsen. The research summaries on this page concern devil's claw generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. Consult a healthcare practitioner if symptoms persist. Consult a healthcare practitioner if symptoms worsen. Keep out of reach of children.
Indications
Recommended Use or Purpose: Traditionally used in Herbal Medicine as a bitter to help stimulate appetite. Traditionally used in Herbal Medicine to help relieve digestive disturbances such as dyspepsia. Used in Herbal Medicine to help relieve joint pain associated with osteoarthritis; use for a minimum of 2 to 3 months to see beneficial effects.
Ingredients
Medicinal Ingredients (each mL contains): Devil's Claw (secondary root tuber, Harpagophytum procumbens), 1:4 extract, 250 mg (0.25 g DHE). Non-medicinal Ingredients: 40% grain alcohol, purified water.
Directions
Recommended Dose (Adults): Take 2 mL, 3 times per day on an empty stomach.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.