Orange Naturals D3+K2 Drops 250IU/30mcg | 15mL Liquid
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 4 drops daily (adults) |
| Licensed Natural Health Product | NPN 80037537 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 250 IU D3 + 30 MCG K2 PER DROP: Each drop provides 250 IU Vitamin D3 (cholecalciferol) and 30 mcg Vitamin K2 (menaquinone-7), suspended in MCT oil - adults take 4 drops daily.
- HELPS DEVELOP & MAINTAIN BONES: Helps in the development and maintenance of bones - this product's Health Canada-authorized use.
- MCT OIL FOR ENHANCED ABSORPTION: Suspended in medium chain triglycerides (MCT oil) to help support the uptake of these fat-soluble vitamins.
- REAL CAUTIONS - READ BEFORE USE: Consult a healthcare practitioner prior to use if you are taking any medication, including blood thinners, or if you have a medical condition. Allergens: soy.
- NATURAL ORANGE FLAVOUR, EASY DROPPER FORMAT: A pleasant-tasting liquid format that can be added to juice or water, or taken straight on the tongue - no pills to swallow.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals, developed by naturopathic doctors, and licensed under NPN 80037537.
Product Description
D3+K2 Drops - Bone Support in One Easy Drop
Orange Naturals D3+K2 Drops deliver 250 IU of Vitamin D3 (cholecalciferol) and 30 mcg of Vitamin K2 (menaquinone-7) in every drop, suspended in MCT oil for enhanced absorption. Developed by naturopathic doctors, this natural orange-flavoured liquid helps in the development and maintenance of bones. Adults take 4 drops daily - added to juice or water, or straight on the tongue. This product carries real cautions around blood thinners and medical conditions, see below. Licensed Natural Health Product NPN 80037537.
Les gouttes D3+K2 d'Orange Naturals offrent 250 UI de vitamine D3 (cholécalciférol) et 30 mcg de vitamine K2 (ménaquinone-7) dans chaque goutte, en suspension dans une huile TCM (triglycérides à chaîne moyenne) pour une absorption améliorée. Développées par des médecins naturopathes, cette formule liquide au goût naturel d'orange aide au développement et au maintien des os. Les adultes prennent 4 gouttes par jour - ajoutées à du jus ou de l'eau, ou directement sur la langue. Ce produit comporte de réelles mises en garde concernant les anticoagulants et les états médicaux, voir ci-dessous. NPN 80037537.
A Naturopathic-Developed Bone Health Formula
250 IU D3 + 30 mcg K2 (MK-7) per drop, in MCT oil - simple 4-drop daily dosing, developed by naturopathic doctors
250 IU D3 + 30 mcg K2 per Drop
Each drop delivers a precise, naturopath-developed dose of Vitamin D3 (cholecalciferol) and Vitamin K2 (menaquinone-7) - adults take 4 drops daily.
MCT Oil Base for Absorption
Suspended in medium chain triglycerides (MCT oil), supporting the uptake of these fat-soluble vitamins versus a dry tablet.
Advanced Ingredients, Superior Results
Vitamin D3 and vitamin K2 are two of the most-studied nutrients for bone health and calcium metabolism - each with a distinct, well-documented role. Here is what the wider research explores.
Vitamin D3 (cholecalciferol)
The active form of vitamin D your body makes from sunlight - supports calcium absorption and helps in the development and maintenance of bones.
250 IU (6.25 mcg) per drop
Vitamin K2 (menaquinone-7, MK-7)
A long-chain form of vitamin K2 studied for its role in directing calcium metabolism, working alongside vitamin D3 in bone health.
30 mcg per dropOrange Naturals D3+K2 Drops: Supplement Facts
Each drop contains:
- Vitamin D3 (cholecalciferol)250 IU (6.25 mcg)
- Vitamin K2 (menaquinone-7)30 mcg
Non-Medicinal Ingredients: Non-medicinal ingredients: Medium chain triglycerides, natural orange flavour, d-alpha tocopherol. Contains soy.
Recommended Use or Purpose: Helps in the development and maintenance of bones.
Recommended Dose (Adults 19 years and older): Take 4 drops daily, added to juice or water, or straight on the tongue.
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are taking any medication, including blood thinners, or if you have a medical condition. Allergens: Soy. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque goutte contient :
- Vitamine D3 (cholécalciférol)250 IU (6.25 mcg)
- Vitamine K2 (ménaquinone-7)30 mcg
Ingrédients non médicinaux : Ingrédients non médicinaux : Triglycérides à chaîne moyenne, arôme naturel d'orange, d-alpha tocophérol. Contient du soya.
Usage ou fins recommandés : Aide au développement et au maintien des os.
Posologie recommandée (adultes de 19 ans et plus) : Prendre 4 gouttes par jour, ajoutées à du jus ou de l'eau, ou directement sur la langue.
Mises en garde : Consulter un praticien de soins de santé avant l'usage si vous prenez des médicaments, y compris des anticoagulants, ou si vous souffrez d'un état médical. Allergènes : Soya. Garder hors de la portée des enfants.
NPN 80037537
Support strong bones with D3+K2 Drops
Get Orange Naturals D3+K2 Drops on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals D3+K2 Drops
250 IU Vitamin D3 + 30 mcg Vitamin K2 (MK-7) per drop, in MCT oil - developed by naturopathic doctors, with real cautions you should read before use.
250 IU D3 + 30 mcg K2 per drop
Each drop delivers a precise dose of Vitamin D3 (cholecalciferol) and Vitamin K2 (menaquinone-7).
Helps develop and maintain bones
Helps in the development and maintenance of bones - this product's Health Canada-authorized use.
Easy 4-drop daily dose
Add to juice or water, or take straight on the tongue - no pills to swallow, natural orange flavour.
Real cautions, developed by naturopathic doctors
Formulated by Orange Naturals and developed by naturopathic doctors. Consult a healthcare practitioner before use if you take blood thinners or have a medical condition. NPN 80037537.
Inside every drop
250 IU Vitamin D3 (cholecalciferol) + 30 mcg Vitamin K2 (menaquinone-7) per drop, suspended in MCT oil - adults take 4 drops daily. Consult a healthcare practitioner before use if you are taking any medication including blood thinners or have a medical condition.
How to use it
Take 4 drops daily
Adults: take 4 drops daily, added to juice or water, or straight on the tongue.
A 75-day supply per bottle
Each 15 ml bottle provides approximately a 75-day supply at the standard 4-drop daily dose.
Use the dropper for a precise daily serving
The easy-to-use dropper helps ensure a consistent, hassle-free dose every day.
Read the cautions before you start
Consult a healthcare practitioner prior to use if you are taking any medication, including blood thinners, or if you have a medical condition. Allergens: soy.
What the research says about Vitamin D3 and Vitamin K2
Educational summaries of published research on vitamin D3 and vitamin K2 generally; not product-specific claims. Orange Naturals D3+K2 Drops' own authorized use under NPN 80037537 is that it helps in the development and maintenance of bones.
A dose-response trial found vitamin D3 increases calcium absorption with no maximum threshold
In a placebo-controlled trial of 76 healthy postmenopausal women given 800, 2000 or 4000 IU of vitamin D3 daily for 8 weeks, calcium absorption increased in a statistically significant linear trend with dose, with a 6.7% absolute increase in the highest-dose group and no evidence of a plateau across the tested range.
Human RCT (n=76)A major review found 800 IU/day of vitamin D3 with calcium can reduce fracture incidence by about 20%
Analyzing randomized controlled trials on optimal vitamin D status, the review found that maintaining serum 25-hydroxyvitamin D above 20 ng/mL through around 800 IU/day of vitamin D3 normalizes calcium and bone homeostasis, and that this dose combined with calcium reduces fracture incidence by roughly 20% in postmenopausal women.
Review of RCTsA controlled trial found vitamin D3 raised blood calcium and vitamin D levels in children with arthritis but did not improve bone mass accrual
In 18 children with juvenile arthritis given vitamin D3 (2,000 IU/day), calcium, both, or placebo in rotation, vitamin D3 increased serum 25-hydroxyvitamin D and calcium levels as expected, but neither vitamin D3 nor calcium supplementation improved bone mineral content accrual over the study period - an honest null result for bone mass specifically in this population.
Human RCT (n=18)A meta-analysis found high-dose vitamin D reduced hospital stay and ICU admission in COVID-19 patients, but not mortality
Pooling 13 randomized controlled trials, high-dose vitamin D supplementation showed potential benefits in reducing length of hospital stay and ICU admission rates in COVID-19 patients, but the overall effect on mortality did not reach statistical significance - the authors cautioned that heterogeneity between the included studies was high.
Meta-analysis (13 RCTs)A meta-analysis found high-dose vitamin D reduced influenza, cough and fever in young children but not overall respiratory infections
Reviewing seven randomized trials in 5,748 children under 5, daily vitamin D supplementation above 1,000 IU was linked to a 57% reduction in influenza/cold, 56% reduction in cough, and 59% reduction in fever incidence, but showed no significant effect on overall upper respiratory tract infection incidence - a nuanced, outcome-specific finding.
Meta-analysis (7 RCTs, n=5,748)A systematic review found no conclusive evidence that vitamin D supplementation reduces respiratory infections in dark-skinned populations
Reviewing 18 studies (7 RCTs, 11 observational) in non-white ethnic groups, the review found an inverse association between vitamin D status and inflammatory markers in some studies, but supplementation itself showed no significant effect on acute respiratory tract infection incidence in ethnic minority, African American, or Asian/Pacific subgroups - an honest null result highlighting a research gap.
Systematic review & meta-analysisA 12-month trial found 7,000 IU/day of vitamin D3 was safe in children and young adults, with no serious adverse events
In 58 HIV-infected children and young adults (ages 9-24.9) randomized to 7,000 IU/day vitamin D3 or placebo for 12 months, no subject experienced a serious safety event and there were no clinically significant changes in blood, liver, kidney, metabolic, lipid, or inflammatory markers - vitamin D status improved as expected with no safety signal.
Human RCT (n=58)A year-long trial found 10,000 IU/day of vitamin D3 was well tolerated in adults with Crohn's disease
In a randomized, double-blind trial comparing 10,000 IU/day to 1,000 IU/day of vitamin D3 for 12 months in adults with Crohn's disease in remission, the higher dose significantly raised serum 25-hydroxyvitamin D levels and was associated with a good safety profile and improved mood scores in both groups.
Human RCTA phase II/III trial found weekly high-dose vitamin D had a comparable safety profile to placebo
In 276 patients with severe vitamin D deficiency randomized to weekly calcifediol (100 or 125 mcg) or placebo, over 90% of treated patients reached adequate vitamin D levels by week 16 versus 7.3% on placebo, and the incidence of adverse events was comparable across all three groups.
Phase II/III RCT (n=276)A 3-year trial found low-dose MK-7 supplementation helped slow bone loss in healthy postmenopausal women
In 244 healthy postmenopausal women given 180 mcg/day of MK-7 or placebo for 3 years, MK-7 improved vitamin K status and significantly decreased the age-related decline in bone mineral density and bone mineral content at the lumbar spine and femoral neck, and favorably affected bone strength indices.
Human RCT (n=244)A trial found MK-7 preserved trabecular bone microarchitecture at the tibia in postmenopausal women with osteopenia
In 148 postmenopausal women with osteopenia (all also supplemented with calcium and vitamin D), 375 mcg/day of MK-7 for 12 months preserved trabecular number, spacing and thickness at the tibia, versus measurable age-related deterioration of these same measures in the placebo group.
Human RCT (n=148)A trial found MK-7 (as natto) improved vitamin K status but did not slow bone loss in early menopausal women
In 334 healthy Norwegian women 1-5 years post-menopause, 360 mcg/day of MK-7 (delivered as natto capsules) for 12 months significantly improved carboxylated osteocalcin status but produced no measurable difference in bone loss rates at the hip, spine or total body compared with placebo - an honest null result in this population.
Human RCT (n=334)A trial in kidney transplant recipients found vitamin K2 slowed arterial stiffness progression but did not change calcification propensity
In 40 vitamin K-deficient kidney transplant recipients randomized to MK-7 (360 mcg/day) or placebo for 12 weeks, vitamin K2 had no effect on serum calcification propensity but did prevent progression of arterial pulse wave velocity, a measure of arterial stiffness, versus placebo - a mixed but real finding pointing to a specific vascular mechanism.
Human RCT (n=40)An 18-month hemodialysis trial found vitamin K2 improved vitamin K status but did not slow coronary artery calcification
In 178 hemodialysis patients randomized to MK-7 (360 mcg 3x/week) or control for 18 months, coronary artery calcification scores did not differ significantly between groups, though vitamin K2 supplementation did significantly reduce dephosphorylated-uncarboxylated MGP, a marker of vitamin K status - an honest null on the primary outcome.
Human RCT (n=178)A post-hoc analysis found six months of vitamin K supplementation did not change a functional marker of arterial calcification in type 2 diabetes
In 68 adults with type 2 diabetes randomized to MK-7 (360 mcg/day) or placebo for 6 months, serum calcification propensity time did not differ significantly between groups, and did not correlate with imaging-based arterial calcification measures - the authors called for further research on both vitamin K's cardiovascular role and this marker.
Human RCT (n=68)A review describes vitamin K2's cardiovascular role through activation of the anti-calcification protein matrix Gla protein
Summarizing vitamin K2's cardiovascular biology, the review describes how vitamin K activates matrix Gla protein (MGP), an inhibitor of vascular calcification, and links inactive MGP to arterial stiffness, vascular and valvular calcification, and increased cardiovascular mortality - while noting that direct trial evidence on slowing calcification progression is still being established.
Narrative reviewA large Danish trial is testing whether 3 years of MK-7 slows coronary artery calcification in an aging general population
The InterVitaminK trial protocol describes a randomized, double-blind, placebo-controlled study of 450 adults aged 52-82 with detectable coronary artery calcification, testing MK-7 (333 mcg/day) for 3 years against progression of coronary calcification, bone mineral density and metabolic markers - the authors note oral MK-7 is considered safe with no severe adverse events reported to date.
Trial protocol (n=450, planned)A trial protocol is testing whether MK-7 slows arterial stiffness progression in peritoneal dialysis patients
The VIKIPEDIA trial protocol describes a randomized, placebo-controlled study of 44 peritoneal dialysis patients testing high-dose MK-7 (1,000 mcg/day) for 1.5 years against pulse wave velocity and cardiovascular event outcomes, building on evidence that vitamin K deficiency is common in this population and linked to elevated markers of vascular calcification.
Trial protocol (n=44, planned)A review describes vitamin K2's role in calcium metabolism alongside vitamin D in supporting bone and cardiovascular health after menopause
Reviewing nutrients relevant to peri- and postmenopausal health, vitamin K2 is described as affecting calcium metabolism such that higher bone calcium levels are associated with lower vascular calcification and lower cardiovascular risk, alongside vitamin K2's established role in bone homeostasis - positioning combined vitamin D and K2 intake as relevant to both bone and vascular health in this life stage.
ReviewA 2-year dialysis trial testing MK-7 alongside standard calcium and vitamin D care found site-specific, mixed effects on bone density
In 123 dialysis patients randomized to MK-7 (360 mcg/day) or placebo for 2 years, lumbar spine bone density loss seen in the placebo group was prevented by MK-7, while bone density at the distal radius unexpectedly declined faster in the MK-7 group - the authors concluded the evidence does not support MK-7 for preserving bone broadly in this population, an honest mixed result.
Human RCT (n=123)A nutrition review positions calcium and vitamin D as the primary bone-health micronutrients, with vitamin K among the supporting nutrients
Reviewing micronutrients for osteoporosis prevention, the review identifies calcium and vitamin D as the micronutrients of greatest importance for bone mass at all ages, notes vitamin D doses of 800-1,000 IU/day may be needed for optimal bone health in older adults, and lists vitamin K among the additional nutrients supportive of bone health via a healthy diet.
ReviewA crossover study found co-ingesting fat-soluble vitamins, including D3 and MK-7, with non-fat fermented milk increased their blood levels versus water
In 20 healthy men given a fat-soluble vitamin solution (including cholecalciferol and menaquinone-7) together with either water or non-fat fermented milk, blood levels of vitamin D3 and MK-7 (among other fat-soluble vitamins) were significantly higher over 8 hours when co-ingested with the fermented milk - suggesting the food matrix, not fat content alone, can meaningfully affect fat-soluble vitamin uptake.
Human crossover study (n=20)A study found MK-7 is well absorbed into the bloodstream, while the related compound MK-4 was not detectable after oral intake
In healthy women given single and repeated doses of MK-4 or MK-7, MK-7 was well absorbed, reaching peak serum levels around 6 hours and remaining detectable up to 48 hours, and repeated dosing raised serum MK-7 levels significantly - while MK-4 was not detectable in serum at any timepoint under either dosing schedule, showing the two vitamin K2 forms behave very differently once ingested.
Human RCT (comparative)A trial found high-dose vitamin D3 already dissolved in an oily solution absorbed equally well whether taken fasting or with a high-fat meal
In 88 adults randomized to a single 50,000 IU dose of vitamin D3 taken fasting or with a standardized high-fat breakfast, 25-hydroxyvitamin D levels rose significantly and similarly in both conditions with no significant difference between fed and fasted absorption - indicating that once vitamin D3 is solubilized in an oily vehicle, meal-fat timing does not meaningfully change its uptake.
Human RCT (n=88)Frequently asked questions
What is Orange Naturals D3+K2 Drops and what does it do?
It's a liquid drop supplement providing 250 IU of Vitamin D3 (cholecalciferol) and 30 mcg of Vitamin K2 (menaquinone-7, MK-7) per drop, suspended in MCT oil. It helps in the development and maintenance of bones.
How do I take it?
Adults take 4 drops daily, added to juice or water, or straight on the tongue.
Why is it suspended in MCT oil?
Vitamin D3 and vitamin K2 are fat-soluble nutrients, so they are suspended in medium chain triglycerides (MCT oil) to support their absorption, rather than delivered as a dry tablet.
Who should consult a healthcare practitioner before using it?
Consult a healthcare practitioner prior to use if you are taking any medication, including blood thinners, or if you have a medical condition.
What allergens does it contain?
This product contains soy.
How long does one bottle last?
Each 15 ml bottle provides approximately a 75-day supply at the standard dose of 4 drops daily.
What form of vitamin K2 does it use?
Vitamin K2 as menaquinone-7 (MK-7), a long-chain form of vitamin K2.
Is it flavoured?
Yes - it has a natural orange flavour designed to make daily use easy for the whole family.
Where do I buy it?
Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.
Support strong bones with D3+K2 Drops
Get Orange Naturals D3+K2 Drops on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80037537. Helps in the development and maintenance of bones. Consult a healthcare practitioner prior to use if you are taking any medication including blood thinners, or if you have a medical condition. Allergens: soy. The research summaries on this page concern vitamin D3 and vitamin K2 generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are taking any medication, including blood thinners, or if you have a medical condition. Allergens: Soy. Keep out of reach of children.
Indications
Recommended Use or Purpose: Helps in the development and maintenance of bones.
Ingredients
Medicinal Ingredients (each drop contains): Vitamin D3 (cholecalciferol), 250 IU (6.25 mcg). Vitamin K2 (menaquinone-7), 30 mcg. Non-medicinal Ingredients: Medium chain triglycerides, natural orange flavour, d-alpha tocopherol. Contains soy.
Directions
Recommended Dose (Adults 19 years and older): Take 4 drops daily, added to juice or water, or straight on the tongue.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.