Orange Naturals CoQ10 Ubiquinol 100mg (Kaneka) | 30 Softgels
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 1 softgel, 1-2 times per day |
| Licensed Natural Health Product | NPN 80112928 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 100 MG KANEKA UBIQUINOL PER SOFTGEL: Each softgel provides 100 mg of Ubiquinol (Kaneka Ubiquinol) - the active, reduced form of CoQ10 - take 1 softgel, 1-2 times per day.
- ANTIOXIDANT + CARDIOVASCULAR SUPPORT: An antioxidant. Helps to maintain and support cardiovascular health - this product's Health Canada-authorized use.
- HELPS REDUCE MIGRAINE FREQUENCY: Helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative.
- REAL CAUTIONS - READ BEFORE USE: Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding, or taking blood pressure medications or blood thinners.
- GMO-FREE FORMULA: No artificial flavours, colours, preservatives, sweeteners, dairy, soy, gluten, wheat or yeast.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals, developed by naturopathic doctors, and licensed under NPN 80112928.
Product Description
Ubiquinol 100mg - The Active Form of CoQ10 for Heart & Energy
Orange Naturals Ubiquinol delivers a full 100 mg dose of Kaneka Ubiquinol - the active, reduced form of Coenzyme Q10 - in every softgel. Developed by naturopathic doctors, this formula is an antioxidant, helps to maintain and support cardiovascular health, and helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative. GMO-free and licensed as a Natural Health Product - this product also carries real cautions around blood pressure medication and blood thinners, see below. Licensed Natural Health Product NPN 80112928.
Ubiquinol d'Orange Naturals offre une pleine dose de 100 mg d'Ubiquinol Kaneka - la forme active et réduite de la coenzyme Q10 - dans chaque capsule molle. Développée par des médecins naturopathes, cette formule est un antioxydant, aide à maintenir et à appuyer la santé cardiovasculaire, et aide à réduire la fréquence des migraines ainsi que les nausées et les vomissements qui les accompagnent lorsque pris à titre préventif. Sans OGM et homologuée comme produit de santé naturel - ce produit comporte aussi de réelles mises en garde sur les médicaments pour la pression artérielle et les anticoagulants, voir ci-dessous. NPN 80112928.
The Active, Reduced Form of CoQ10
100 mg Kaneka Ubiquinol - the bioavailable, ready-to-use form of Coenzyme Q10, developed by naturopathic doctors
100 mg Kaneka Ubiquinol per Softgel
Each softgel delivers a full 100 mg dose of Ubiquinol (Kaneka Ubiquinol) - the active, reduced form of CoQ10 that the body can use directly, without needing to convert it.
Developed by Naturopathic Doctors
Orange Naturals formulas, including this Ubiquinol, are developed by naturopathic doctors and made in Canada.
Advanced Ingredients, Superior Results
Ubiquinol is the reduced, directly bioavailable form of Coenzyme Q10 - studied for cardiovascular health, statin-related CoQ10 depletion, cellular energy production and migraine prevention. Here is what the wider research explores.
Ubiquinol (Kaneka Ubiquinol)
The active, reduced form of Coenzyme Q10 - the form the body can use directly without first having to convert it from ubiquinone. Studied for cellular energy production, antioxidant activity, cardiovascular health and statin-related CoQ10 depletion.
100 mg per softgel
Orange Naturals CoQ10 Ubiquinol 100mg: Supplement Facts
Each softgel contains:
- Ubiquinol (Kaneka Ubiquinol)100 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Medium chain triglycerides, ascorbyl palmitate, purified water, sunflower lecithin, annatto, sunflower oil, gelatin, glycerin, white beeswax.
Recommended Use or Purpose: An antioxidant. Helps to maintain and support cardiovascular health. Helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative.
Recommended Dose (Adults): Take 1 softgel, 1-2 times per day or as directed by a healthcare practitioner. Recommended Duration of Use: Use for a minimum of 3 months to see beneficial effects.
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding or if you are taking blood pressure medications or blood thinners. Consult a healthcare practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen. Do not use if the safety seal is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule molle contient :
- Ubiquinol (Ubiquinol Kaneka)100 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Triglycérides à chaîne moyenne, palmitate d'ascorbyle, eau purifiée, lécithine de tournesol, rocou, huile de tournesol, gélatine, glycérine, cire d'abeille blanche.
Usage ou fins recommandés : Un antioxydant. Aide à maintenir et à appuyer la santé cardiovasculaire. Aide à réduire la fréquence des migraines ainsi que les nausées et les vomissements qui les accompagnent lorsque pris à titre préventif.
Posologie recommandée (adultes) : Prendre 1 capsule molle, 1 à 2 fois par jour, ou selon les directives d'un praticien de la santé. Durée d'utilisation recommandée : Utiliser pendant un minimum de 3 mois pour observer les effets bénéfiques.
Mises en garde : Consulter un praticien de la santé avant d'en faire l'usage si vous êtes enceinte, allaitez ou si vous prenez des médicaments pour la pression artérielle ou des anticoagulants. Consulter un praticien de la santé si la fréquence des migraines augmente et que les nausées et vomissements associés persistent ou s'aggravent. Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.
NPN 80112928
Support your heart and energy with active Ubiquinol CoQ10
Get Orange Naturals Ubiquinol 100mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Ubiquinol
100 mg of Kaneka Ubiquinol - the active, reduced form of CoQ10 - per softgel, developed by naturopathic doctors, with real cautions you should read before use.
100 mg Kaneka Ubiquinol per softgel
Each softgel delivers a full 100 mg dose of Ubiquinol (Kaneka Ubiquinol), the active reduced form of CoQ10.
Supports cardiovascular health and reduces migraine frequency
An antioxidant. Helps to maintain and support cardiovascular health, and helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative.
Simple daily dose
Take 1 softgel, 1-2 times per day or as directed by a healthcare practitioner.
Real cautions, developed by naturopathic doctors
Formulated by Orange Naturals and developed by naturopathic doctors. Consult a healthcare practitioner before use if you are pregnant, breastfeeding, or taking blood pressure medications or blood thinners. NPN 80112928.
Inside every softgel
100 mg Ubiquinol (Kaneka Ubiquinol) per softgel - take 1 softgel, 1-2 times per day. Ubiquinol is the active, reduced form of CoQ10, in its most bioavailable state.
How to use it
Take 1 softgel, 1-2 times daily
Adults: take 1 softgel, 1-2 times per day or as directed by a healthcare practitioner.
A 30-day supply per bottle
Each bottle of 30 softgels provides a 30-day supply at the standard once-daily dose (or a 15-day supply at twice daily).
Give it at least 3 months
Use for a minimum of 3 months to see beneficial effects.
Read the cautions before you start
Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding, or taking blood pressure medications or blood thinners. Consult a healthcare practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen.
What the research says about Ubiquinol / Coenzyme Q10
Educational summaries of published research on Coenzyme Q10 and its active ubiquinol form generally; not product-specific claims. Orange Naturals Ubiquinol's own authorized use under NPN 80112928 is that it is an antioxidant, helps to maintain and support cardiovascular health, and helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative.
A meta-analysis of 33 trials found CoQ10 reduced mortality and hospitalization in heart failure without major adverse effects
Pooling randomized controlled trials of CoQ10 as an add-on therapy for heart failure, CoQ10 was associated with lower all-cause mortality, fewer heart-failure hospitalizations, improved NYHA functional class and brain natriuretic peptide levels, and better left ventricular ejection fraction and 6-minute walk distance than control, without major adverse effects.
Meta-analysis (33 RCTs)A crossover pilot study found ubiquinol improved peripheral endothelial function in heart failure with reduced ejection fraction
In 14 patients with stable HFrEF, 400 mg/day of ubiquinol for 3 months significantly improved a reactive-hyperemia measure of peripheral endothelial function compared with placebo, suggesting a possible vascular mechanism supporting cardiovascular benefit in heart failure.
Human RCT crossover (n=14)A European subgroup of the Q-SYMBIO trial confirmed CoQ10 reduced major adverse cardiovascular events in chronic heart failure
In the European sub-population of the multinational Q-SYMBIO randomized trial, CoQ10 300 mg daily added to standard heart-failure therapy significantly reduced major adverse cardiovascular events (9% vs 27% with placebo) along with improvements in all-cause and cardiovascular mortality, NYHA classification and ejection fraction.
Human RCT subgroup analysisA meta-analysis of 45 RCTs found CoQ10 significantly reduced systolic blood pressure in adults
Pooling 45 randomized controlled trials, CoQ10 supplementation significantly reduced systolic blood pressure (-3.44 mmHg) with no significant effect on diastolic blood pressure or heart rate; lower doses (under 200 mg/day) and longer treatment (over 8 weeks) produced greater systolic reductions.
Meta-analysis (45 RCTs)A dose-response meta-analysis found 100-200mg/day of CoQ10 gave the greatest systolic blood pressure benefit in cardiometabolic disease
Analyzing 26 studies (1,831 subjects) with a restricted cubic spline dose-response model, CoQ10 supplementation reduced systolic blood pressure in patients with cardiometabolic disorders, with a U-shaped dose-response relationship showing the greatest benefit at approximately 100-200 mg/day.
Dose-response meta-analysis (GRADE)An evidence-based review found CoQ10's effect on blood pressure inconsistent across complementary therapies for hypertension
Reviewing 23 publications on non-conventional hypertension therapies (magnesium, qigong, meditation, vitamin C, CoQ10 and others), the reviewers found CoQ10 specifically showed contradicting results - some studies found weak or no effect on blood pressure, while others found a significant reduction - an honest, mixed finding reported alongside more consistently positive therapies.
Evidence-based reviewA meta-analysis of 7 RCTs found CoQ10 supplementation significantly reduced muscle pain in statin-treated patients
Pooling 7 randomized controlled trials (389 patients, CoQ10 doses 100-600 mg/day for 30-90 days), CoQ10 supplementation produced a significant reduction in statin-associated muscle symptoms measured as pain intensity, though the reviewers noted more research is needed for firm evidence-based recommendations.
Meta-analysis (7 RCTs, n=389)A meta-analysis of placebo-controlled trials confirmed statin therapy significantly lowers plasma CoQ10 concentrations
Analyzing 8 placebo-controlled treatment arms, statin therapy (atorvastatin, simvastatin, rosuvastatin and pravastatin) was consistently associated with significantly reduced plasma CoQ10 concentrations regardless of statin type, lipophilicity, or treatment duration - the mechanistic basis for the interest in CoQ10 co-supplementation.
Meta-analysis (placebo-controlled)A randomized trial was designed to test whether CoQ10 reduces muscle pain intensity during statin treatment
This study protocol describes a crossover-confirmed randomized trial recruiting patients with a documented history of statin-related myalgia, testing 600 mg/day of CoQ10 against placebo alongside simvastatin, with muscle pain intensity tracked via the Brief Pain Inventory - illustrating the rigorous design needed to isolate a real CoQ10 effect from the mevalonate-depletion hypothesis.
Human RCT design/rationaleA 6-week RCT found ubiquinol supplementation improved mitochondrial oxidative phosphorylation efficiency in healthy men
In 54 healthy, recreationally active males randomized to 300 mg/day ubiquinol or placebo for 6 weeks, ubiquinol increased plasma CoQ concentration and lowered the inverse respiratory control ratio in skeletal muscle, suggestive of improved oxidative phosphorylation coupling efficiency, though it did not change exercise time-to-exhaustion in this trial.
Human RCT (n=54)Plasma CoQ10 was significantly lower in patients with chronic fatigue and linked to fatigue severity
Measuring plasma CoQ10 (an essential mitochondrial cofactor for ATP production) in 58 patients with myalgic encephalomyelitis/chronic fatigue syndrome versus 22 controls, CoQ10 was significantly lower in patients, and lower CoQ10 levels correlated with greater fatigue and autonomic symptom severity.
Human observational studyA state-of-the-art review describes CoQ10's central role in mitochondrial ATP production in heart tissue
Reviewing CoQ10's biology in heart failure, this review describes CoQ10's core function of facilitating ATP production in the mitochondria by participating in redox reactions within the electron transport chain, providing the mechanistic rationale for its study as a supportive therapy in energy-deprived states like heart failure.
ReviewA randomized trial found high-dose CoQ10 significantly reduced a marker of oxidative stress in hemodialysis patients
In 65 patients undergoing maintenance hemodialysis randomized to CoQ10 (600 or 1,200 mg/day) or placebo for 4 months, the 1,200 mg/day dose significantly reduced plasma F-isoprostane concentrations (a marker of oxidative stress) compared with placebo, with no treatment-related major adverse events.
Human RCT (n=65)A preclinical study found an esterified ubiquinol derivative showed stronger antioxidant and neuroprotective activity than standard CoQ10
Comparing ubiquinol diacetate to standard CoQ10 in neuronal cell and C. elegans models of Parkinson's disease, the ubiquinol derivative showed higher antioxidant activity and stronger neuroprotection against oxidative neurotoxin damage, illustrating the antioxidant mechanism underlying CoQ10/ubiquinol's proposed cellular protective effects.
Preclinical studyA randomized trial found an antioxidant-enriched multivitamin including CoQ10 raised systemic antioxidant levels and reduced pulmonary exacerbations in cystic fibrosis
In 73 patients with cystic fibrosis randomized to an antioxidant-enriched multivitamin (including CoQ10) or a standard multivitamin for 16 weeks, systemic antioxidant concentrations rose significantly in the treated group and the risk of a first pulmonary exacerbation requiring antibiotics was lower, with similar safety and tolerability between groups.
Human RCT (n=73)The original safety and bioavailability study of Kaneka's ubiquinol found significant absorption with no safety concerns at up to 300mg
In the first published safety and bioavailability study of Kaneka ubiquinol (Kaneka QH) in healthy volunteers, single doses of 150-300 mg and 4 weeks of daily dosing at 90-300 mg produced dose-dependent increases in plasma ubiquinol concentration with significant gastrointestinal absorption, and no clinically relevant changes on standard laboratory safety tests, vital signs or ECG.
Human clinical trialA crossover trial found a novel ubiquinol formulation achieved roughly 2 to 3 times higher blood levels than an ubiquinone formulation
In a randomized, double-blind, two-period crossover study of 12 healthy adults, a cocrystal ubiquinol softgel formulation showed substantially higher relative bioavailability than a reference ubiquinone formulation, with peak concentration and total drug exposure roughly 2 to 3 times higher for ubiquinol; no adverse events were reported for either formulation.
Human RCT crossover (n=12)A randomized trial found reduced CoQ10 (ubiquinol) supplementation increased both plasma and intracellular CoQ10 levels in burn patients
In a placebo-controlled trial of reduced CoQ10 (ubiquinol-10, 1,800 mg/day) in burn patients, whose baseline plasma CoQ10 was significantly lower than in healthy volunteers, supplementation significantly increased both plasma concentrations and intracellular CoQ10 content in peripheral blood mononuclear cells compared with placebo.
Human RCTA meta-analysis of 6 RCTs found CoQ10 reduced the frequency and duration of migraine attacks
Pooling 6 randomized controlled trials (371 participants), CoQ10 supplementation significantly reduced both the duration of headache attacks and the frequency of migraine headaches compared with control, though it did not significantly reduce headache severity in this analysis.
Meta-analysis (6 RCTs, n=371)A 2024 nutraceuticals review rated CoQ10 as Level C evidence for migraine prevention with minimal adverse events
Reviewing riboflavin, CoQ10, feverfew, magnesium, melatonin and butterbur for headache, this review assigns CoQ10 Level C evidence for migraine prevention with a low rate of adverse events, in contrast to butterbur (strong efficacy evidence but hepatotoxicity concern) and melatonin (very low certainty of efficacy).
ReviewA review describes CoQ10's proposed role in correcting the brain energy deficit implicated in migraine
Summarizing evidence that migraineurs show a measurable brain energy deficit and impaired mitochondrial function, this review discusses CoQ10 alongside riboflavin, magnesium, carnitine and other nutrients as candidates to support mitochondrial energy production and reduce oxidative stress as part of migraine prevention strategies.
ReviewA phase 2 trial of high-dose ubiquinol (1500mg/day) in 139 patients found it well-tolerated with comparable adverse event rates to placebo
In a multicentre, randomized, double-blind, placebo-controlled phase 2 trial of patients with multiple system atrophy, high-dose ubiquinol (1,500 mg/day) for 48 weeks was well tolerated, with adverse events potentially related to treatment reported in a similar proportion of the ubiquinol group (23.8%) and the placebo group (30.9%).
Human RCT (n=139, phase 2)A pilot study found add-on CoQ10-containing multivitamin therapy was generally well tolerated over 6 months
In 30 patients with intractable focal epilepsy given add-on multivitamin therapy including 100 mg/day of CoQ10 alongside B6, B9, D and E, most patients did not experience significant adverse events over 6 months of supplementation, supporting the therapy's tolerability profile alongside its exploratory efficacy findings.
Human pilot study (n=30)A phase I trial found 300mg/day of CoQ10 did not alter chemotherapy drug levels or cause added adverse events during breast cancer treatment
In a randomized, placebo-controlled, crossover, dose-finding phase I study in women receiving doxorubicin chemotherapy for breast cancer, 300 mg/day of CoQ10 raised serum CoQ10 levels as expected but caused no clinically significant change in doxorubicin pharmacokinetics and no difference in adverse events compared with placebo periods.
Human Phase I RCT crossoverFrequently asked questions
What is Orange Naturals Ubiquinol and what does it do?
It's a softgel providing 100 mg of Ubiquinol (Kaneka Ubiquinol) per softgel - the active, reduced form of CoQ10. It's an antioxidant that helps to maintain and support cardiovascular health, and helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative.
How is Ubiquinol different from regular CoQ10 (ubiquinone)?
Ubiquinol is the active, reduced form of Coenzyme Q10 - the form your body actually uses. Standard CoQ10 supplements are usually ubiquinone, the oxidized form, which the body must first convert to ubiquinol before it can be used.
How do I take it?
Adults take 1 softgel, 1-2 times per day or as directed by a healthcare practitioner. Use for a minimum of 3 months to see beneficial effects.
Who should consult a healthcare practitioner before using it?
Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding, or if you are taking blood pressure medications or blood thinners.
What if my migraines seem to get worse?
Consult a healthcare practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen.
How long does one bottle last?
Each bottle contains 30 softgels - a 30-day supply at the standard dose of 1 softgel per day, or a 15-day supply at 2 softgels per day.
Is it vegan and allergen-friendly?
It is GMO-free and free of artificial flavours, colours, preservatives, sweeteners, dairy, soy, gluten, wheat or yeast. Note that the softgel shell itself contains gelatin and beeswax, so this product is not vegan or vegetarian.
Where do I buy it?
Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.
Support your heart and energy with active Ubiquinol CoQ10
Get Orange Naturals Ubiquinol 100mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80112928. An antioxidant. Helps to maintain and support cardiovascular health. Helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative. Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding or if you are taking blood pressure medications or blood thinners. Consult a healthcare practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen. Use for a minimum of 3 months to see beneficial effects. The research summaries on this page concern Coenzyme Q10/ubiquinol generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding or if you are taking blood pressure medications or blood thinners. Consult a healthcare practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen. Do not use if the safety seal is broken. Keep out of reach of children.
Indications
Recommended Use or Purpose: An antioxidant. Helps to maintain and support cardiovascular health. Helps to reduce the frequency of migraine headaches and associated symptoms such as nausea and vomiting, when taken as a preventative.
Ingredients
Medicinal Ingredients (each softgel contains): Ubiquinol (Kaneka Ubiquinol), 100 mg. Non-medicinal Ingredients: Medium chain triglycerides, ascorbyl palmitate, purified water, sunflower lecithin, annatto, sunflower oil, gelatin, glycerin, white beeswax. GMO-free. No artificial flavours, colours, preservatives, sweeteners, dairy, soy, gluten, wheat or yeast. Note: this softgel contains gelatin and beeswax and is not vegan or vegetarian.
Directions
Recommended Dose (Adults): Take 1 softgel, 1-2 times per day or as directed by a healthcare practitioner. Recommended Duration of Use: Use for a minimum of 3 months to see beneficial effects.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.