Orange Naturals Berberine 500mg | 60 Capsules
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 1 capsule, 2 times per day at the beginning of each meal |
| Licensed Natural Health Product | NPN 80128242 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 500 MG BERBERINE PER CAPSULE: Each vegetable capsule provides 500 mg of Berberine (root, Berberis aquifolium) - take 1 capsule, 2 times per day at the beginning of each meal.
- SUPPORTS HEALTHY GLUCOSE LEVELS: Helps support healthy glucose levels - this product's Health Canada-authorized use.
- CARDIOVASCULAR & CHOLESTEROL SUPPORT: Helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL).
- REAL DRUG-INTERACTION CAUTIONS - READ BEFORE USE: Berberine is known to affect the metabolism of numerous drugs. Consult a healthcare practitioner before use if you are taking any medication or natural health product, or if you have diabetes, gall stones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease.
- VEGAN, GMO-FREE FORMULA: No artificial flavours, colours, preservatives, sweeteners, dairy, corn, soy, gluten, wheat or yeast.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals, developed by naturopathic doctors, and licensed under NPN 80128242.
Product Description
Berberine 500mg - Glucose, Cholesterol & Cardiovascular Support
Orange Naturals Berberine delivers a full 500 mg dose of Berberine (root, Berberis aquifolium) in every vegetable capsule. Developed by naturopathic doctors, this formula helps support healthy glucose levels and helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL). Vegan, GMO-free and licensed as a Natural Health Product - this product also carries real, serious cautions around drug interactions, see below. Licensed Natural Health Product NPN 80128242.
Berbérine d'Orange Naturals offre une pleine dose de 500 mg de Berbérine (racine, Berberis aquifolium) dans chaque capsule végétale. Développée par des médecins naturopathes, cette formule aide à maintenir des taux sains de glucose et aide à soutenir la santé cardiovasculaire et des taux sains de cholestérol (triglycérides sériques, total et LDL). Végétalien, sans OGM et homologué comme produit de santé naturel - ce produit comporte aussi de réelles mises en garde sur les interactions médicamenteuses, voir ci-dessous. NPN 80128242.
A Naturopathic-Developed Metabolic Formula
500 mg Berberine (root, Berberis aquifolium) - simple twice-daily dosing, developed by naturopathic doctors
500 mg Berberine per Capsule
Each vegetable capsule delivers a full, potent dose of Berberine (root, Berberis aquifolium) - take 1 capsule, 2 times per day at the beginning of each meal.
Developed by Naturopathic Doctors
Orange Naturals formulas, including this Berberine, are developed by naturopathic doctors and made in Canada.
Advanced Ingredients, Superior Results
Berberine is one of the most-studied plant alkaloids for glucose and lipid metabolism - and one with real, well-documented drug-interaction considerations. Here is what the wider research explores.
Berberine (root, Berberis aquifolium)
The primary active alkaloid of the barberry family, studied for its role in glucose metabolism, lipid regulation and gut microbiota - and known to inhibit several CYP450 liver enzymes that metabolize many prescription drugs.
500 mg per vegetable capsule
Orange Naturals Berberine 500mg: Supplement Facts
Each vegetable capsule contains:
- Berberine (root, Berberis aquifolium)500 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Hypromellose, magnesium stearate, microcrystalline cellulose, silicon dioxide.
Recommended Use or Purpose: Helps support healthy glucose levels. Helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL).
Recommended Dose (Adults 18 years and older): Take 1 capsule, 2 times per day at the beginning of each meal. Recommended Duration of Use: For use beyond 3 months, consult a healthcare practitioner.
Cautions and Warnings: Contraindications: Do not use this product if you are pregnant or breastfeeding. Cautions: Consult a healthcare practitioner prior to use if you have diabetes, gall stones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease. Consult a healthcare practitioner if you are taking any medication or natural health products, as berberine is known to affect the metabolism of numerous drugs. Stop use and consult a healthcare practitioner if you experience symptoms of hypoglycemia such as feelings of anxiety, dizziness, tremor, sweating, nausea, headache, paleness, chills or confusion. Known Adverse Reactions: May cause gastrointestinal discomfort such as constipation, vomiting, abdominal pain or diarrhea; if this occurs, discontinue use and consult a healthcare practitioner. Do not use if the safety seal is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule végétale contient :
- Berbérine (racine, Berberis aquifolium)500 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Cellulose microcristalline, dioxyde de silicium, stéarate de magnésium, hypromellose.
Usage ou fins recommandés : Aide à maintenir des taux sains de glucose. Aide à soutenir la santé cardiovasculaire et des taux sains de cholestérol (triglycérides sériques, total et LDL).
Posologie recommandée (adultes de 18 ans et plus) : Prendre 1 capsule, 2 fois par jour, au début de chaque repas. Durée d'utilisation recommandée : Consulter un praticien de soins de santé pour un usage de plus de 3 mois.
Mises en garde : Contre-indications : Ne pas utiliser ce produit si vous êtes enceinte ou allaitez. Mises en garde : Consulter un praticien de la santé avant d'en faire l'usage si vous avez le diabète, des calculs biliaires, de l'hypoglycémie, de l'hypertension, un trouble du foie ou une maladie cardiovasculaire. Consulter un praticien de la santé avant d'en faire l'usage si vous prenez des médicaments ou d'autres produits de santé naturels, car la berbérine est connue pour nuire au métabolisme de nombreux médicaments. Cesser l'utilisation et consulter un praticien de santé si vous éprouvez des symptômes d'hypoglycémie, tels que sentiment d'anxiété, étourdissements, transpiration, nausées, maux de tête, pâleur, frissons ou confusion. Réactions indésirables connues : Peut causer un inconfort gastro-intestinal tel que constipation, vomissements, douleurs abdominales ou diarrhée; le cas échéant, cesser l'utilisation et consulter un praticien de santé. Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.
NPN 80128242
Support healthy glucose and cholesterol levels with Berberine
Get Orange Naturals Berberine 500mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals Berberine
500 mg of Berberine (root, Berberis aquifolium) per vegetable capsule - developed by naturopathic doctors, with real drug-interaction cautions you should read before use.
500 mg Berberine per capsule
Each vegetable capsule delivers a full 500 mg dose of Berberine (root, Berberis aquifolium).
Supports glucose, cholesterol & cardiovascular health
Helps support healthy glucose levels and helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL).
Simple twice-daily dose
Take 1 capsule, 2 times per day at the beginning of each meal.
Real cautions, developed by naturopathic doctors
Formulated by Orange Naturals and developed by naturopathic doctors. This product carries real, serious cautions around drug interactions - read the label. NPN 80128242.
Inside every capsule
500 mg Berberine (root, Berberis aquifolium) per vegetable capsule - take 1 capsule, 2 times per day at the beginning of each meal. Berberine is known to affect the metabolism of numerous drugs - consult a healthcare practitioner before use if you take any medication or other natural health product.
How to use it
Take 1 capsule, 2 times daily with meals
Adults (18 years and older): take 1 capsule, 2 times per day at the beginning of each meal.
A 30-day supply per bottle
Each bottle of 60 vegetable capsules provides a 30-day supply at the standard 2-capsule daily dose.
Ask a practitioner before 3 months' continuous use
For use beyond 3 months, consult a healthcare practitioner.
Read the cautions before you start
Do not use if pregnant or breastfeeding. Consult a healthcare practitioner if you have diabetes, gall stones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease, or if you are taking any medication or natural health product - berberine is known to affect the metabolism of numerous drugs.
What the research says about Berberine
Educational summaries of published research on berberine generally; not product-specific claims. Orange Naturals Berberine's own authorized use under NPN 80128242 is that it helps support healthy glucose levels and helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL).
A phase 2 trial found a berberine-based compound significantly reduced HbA1c in type 2 diabetes
In a 12-week, double-blind, placebo-controlled trial of 113 adults with type 2 diabetes, berberine ursodeoxycholate (HTD1801) produced dose-dependent HbA1c reductions of -0.4% (500mg twice daily) and -0.7% (1000mg twice daily) versus placebo, alongside improved fasting glucose, lipids and liver markers; the compound was safe and well tolerated, with 97% of patients completing the study.
Human RCT (n=113)A 12-week trial found berberine plus cinnamon lowered blood sugar and LDL cholesterol in diabetes
In a double-blind, placebo-controlled trial, patients with type 2 diabetes taking 1,200mg berberine plus 600mg cinnamon daily saw significant reductions in fasting blood sugar, HbA1c and LDL cholesterol compared to placebo, with no significant difference in total cholesterol, HDL or triglycerides.
Human RCTAn 8-week trial found berberine added no significant benefit to an exercise program for prediabetic men
In 54 middle-aged men with overweight/obesity and prediabetes, two models of home-based high-intensity interval training both significantly reduced fasting glucose, insulin resistance and inflammatory markers versus non-exercising controls, but adding roughly 1,000mg/day of berberine to the exercise programs did not produce additional benefits - an honest null result for berberine as an add-on to exercise in this trial.
Human RCT (n=54)A meta-analysis of 16 trials found berberine improved cholesterol and triglycerides with a good safety profile
Pooling 2,147 participants across 16 randomized trials, berberine significantly reduced total cholesterol, LDL cholesterol and triglycerides while increasing HDL cholesterol when used alone, with no significant difference in adverse events versus control and no severe adverse effects reported in either group.
Meta-analysisA network meta-analysis of 131 trials ranked berberine among several effective LDL-lowering nutraceuticals
Comparing artichoke, berberine, bergamot, garlic, green tea extract, plant sterols, red yeast rice and other nutraceuticals across 13,062 participants, nearly all analyzed options (except policosanols) significantly lowered LDL cholesterol and total cholesterol versus placebo, with bergamot and red yeast rice ranking most effective overall.
Network meta-analysisA Bayesian network meta-analysis found berberine could lower blood glucose and regulate blood lipids in type 2 diabetes
Comparing curcumin, resveratrol, silymarin and berberine across 17 studies (1,337 participants) with type 2 diabetes, each phytochemical showed a distinct clinical advantage - berberine for lowering blood glucose and regulating lipids, resveratrol for blood pressure and lipids broadly, and silymarin for glucose control specifically.
Bayesian network meta-analysisA 297-patient trial found berberine changed gut microbiota structure while lowering blood glucose
In an 18-week, multi-center, double-blind trial, berberine (alone or combined with Bifidobacterium) significantly reduced fasting and post-meal blood glucose versus placebo, and the berberine groups showed more changes in gut microbiota composition from baseline than the Bifidobacterium-alone or placebo groups.
Human RCT (n=297)A review describes how berberine and related compounds may manage type 2 diabetes by targeting the gut microbiome
Reviewing traditional Chinese medicine compounds including berberine, baicalin and resveratrol, the gut microbiota is identified as a key determinant of host metabolism in type 2 diabetes - though the review notes most supporting evidence remains limited to animal models and early clinical trials, calling for larger human studies.
ReviewA meta-analysis of animal studies found alkaloids like berberine reduced atherosclerotic plaque via gut microbiota changes
Analyzing mouse models of atherosclerosis, phytochemicals and probiotics (including the alkaloid class that contains berberine) reduced atherosclerotic plaque and modulated gut microbial composition by reducing the Firmicutes/Bacteroidetes ratio, with a more pronounced effect observed in male animals.
Meta-analysis (animal studies)A review describes berberine's proposed role in regulating blood pressure and heart rate
Summarizing berberine's therapeutic properties, the review describes proposed mechanisms including upregulating hepatic LDL receptors, enhancing insulin secretion, inhibiting hepatic gluconeogenesis, and regulating blood pressure and heart rate, alongside its established use for cardiovascular disorders and hypercholesterolemia.
ReviewA systematic review found the evidence for berberine lowering blood pressure is limited and inconclusive
Reviewing 5 randomized and 2 non-randomized controlled trials (614 participants), berberine showed a significant blood-pressure reduction compared to metformin in one trial, but no significant added benefit when combined with amlodipine versus amlodipine alone; the reviewers concluded the overall evidence is low quality and insufficient to establish effectiveness for hypertension - an honest, mixed finding.
Systematic reviewA review notes berberine improved heart failure symptoms and cardiac function when added to standard therapy
Surveying natural compounds used in Traditional Chinese Medicine for cardiovascular disease, the alkaloid berberine is highlighted alongside the multi-herb formula Qili Qiangxin as having improved heart failure symptoms and cardiac function in clinical trials when added to standard cardiovascular therapy.
ReviewA systematic review found berberine affects gut microbiota diversity and multiple obesity-related pathways
Reviewing preclinical and human studies, berberine reduced gut microbial diversity at preclinical doses starting around 100mg/kg/day, inhibited hepatic gluconeogenesis via PEPCK, G6Pase and AMPK, and reduced adipocyte differentiation; in humans, berberine modulated gut microbe diversity at a 500mg/day dose and improved cholesterol-absorption gene regulation at 300mg/day.
Systematic reviewA combination of anti-adipogenic phytonutrients including berberine reduced weight gain in an obesity model
Testing nine phytonutrients including berberine, resveratrol and curcumin, the combination suppressed fat-cell formation in human preadipocytes more potently than any single compound, and in a diet-induced obesity mouse model improved glucose tolerance while reducing weight gain, liver fat, and circulating triglycerides and LDL cholesterol.
Preclinical studyA review lists berberine among dietary supplements shown to support weight reduction in obesity
Reviewing dietary supplements used for excess body weight, berberine is described as improving lipid metabolism and reducing blood glucose levels, alongside capsaicin, bitter orange, green coffee and probiotics, as part of a broader non-pharmacological approach to managing obesity and its complications.
ReviewA review describes berberine acting through AMPK and related pathways across multiple organ systems
Reviewing berberine's regulation of ferroptosis (an iron-dependent form of cell death), the compound is described as acting through NRF2, p53, AMPK, PI3K/Akt and MAPK signaling pathways, inhibiting this process in cardiovascular, metabolic and neurological tissue while showing the opposite effect in some other tissue types.
ReviewA rat study found a berberine-rich herbal extract improved glucose and lipid metabolism via the AMPK pathway
In rats with dexamethasone- and fructose-induced metabolic disorder, Coptidis Rhizome (in which berberine was the most abundant identified compound) improved fasting glucose, insulin sensitivity and lipid levels, with hepatic transcriptomics and protein analysis pointing to activation of the HO-1 and AMPK signaling pathways as the underlying mechanism.
Preclinical studyA meta-analysis of 42 trials with molecular docking found berberine binds directly to the SIRT1/AMPK pathway
Analyzing 3,247 patients across 42 randomized trials of a berberine-containing herbal formula for insulin resistance, molecular docking showed berberine and related compounds bind with strong affinity to SIRT1 and AMPK proteins, providing a proposed mechanistic basis for the formula's significant improvements in insulin resistance, fasting glucose and HbA1c.
Meta-analysis with molecular dockingA pharmacology review identifies berberine's inhibition of CYP3A4 and CYP2D6 as its most important drug-interaction risk
Reviewing berberine's effects on 12 major human CYP450 liver enzymes, the compound was found to influence CYP3A4/5, CYP2D6, CYP2C9, CYP2E1, CYP1A1/2 and most CYP2B isoforms; the review concludes that because CYP2D6 and CYP3A4 metabolize so many commonly used drugs, berberine's inhibitory effect on these two enzymes specifically is the most clinically important interaction risk to consider.
ReviewBerberine significantly increased blood levels of the cholesterol drug atorvastatin in rats
In hyperlipidemic and normal rats, co-administering berberine significantly increased plasma exposure of atorvastatin (a CYP3A4 and P-glycoprotein substrate), enhancing its lipid-lowering effect but raising the concern of drug over-exposure - the authors concluded that clinical attention should be paid to plasma levels when combining the two to avoid adverse reactions.
Preclinical studyA pharmacokinetic model predicted high-dose berberine could meaningfully raise blood levels of a real leukemia drug
Using physiologically based pharmacokinetic modeling built on real clinical data for CYP3A and P-glycoprotein substrates (including midazolam, cyclosporine and digoxin), a high dose of berberine (300mg three times daily) was predicted to raise systemic exposure of the cancer drug bosutinib by about 30%, illustrating a concrete, quantified real-world drug-interaction pathway from CYP3A inhibition.
Pharmacokinetic modeling studyA phase I trial found berberine combined with a standard IBD drug was generally well tolerated
In a double-blind phase I trial of Chinese adults with ulcerative colitis, 900mg/day of berberine alongside mesalamine was well tolerated over 3 months; among 12 participants on berberine, one had a grade 3 liver-enzyme (transaminase) elevation and one had grade 1 nausea, versus none of these events among 4 on placebo.
Human Phase I trialA meta-analysis of 25 trials found no significant difference in adverse events between berberine and control for dyslipidemia
Pooling 3,042 participants across 25 randomized trials, berberine (alone or with lipid-lowering drugs) significantly reduced total cholesterol, triglycerides and LDL cholesterol while raising HDL cholesterol, with no statistically significant difference in adverse-event incidence versus control and no severe adverse effects reported in any trial.
Meta-analysisA meta-analysis of 46 trials confirmed berberine's efficacy and safety for type 2 diabetes as an adjunct therapy
Reviewing 46 randomized trials, berberine (alone or added to standard diabetes therapy) significantly improved HbA1c, fasting glucose, insulin resistance and lipid profiles; serum creatinine, blood urea nitrogen and adverse events were also tracked as safety measures, supporting berberine's clinical safety profile as an adjunctive treatment.
Meta-analysisFrequently asked questions
What is Orange Naturals Berberine and what does it do?
It's a vegetable capsule providing 500 mg of Berberine (root, Berberis aquifolium) per capsule. It helps support healthy glucose levels and helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL).
How do I take it?
Adults (18 years and older) take 1 capsule, 2 times per day at the beginning of each meal. For use beyond 3 months, consult a healthcare practitioner.
Why does this product have so many cautions?
Berberine is known to affect the metabolism of numerous drugs, and it can influence blood glucose and blood pressure. Because of this, it carries real, important cautions for anyone with certain health conditions or taking medication - see the full list below and on the label before use.
Who should NOT use this product?
Do not use this product if you are pregnant or breastfeeding.
Who should consult a healthcare practitioner before using it?
Consult a healthcare practitioner prior to use if you have diabetes, gall stones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease, or if you are taking any medication or other natural health products, as berberine is known to affect the metabolism of numerous drugs.
What side effects are possible?
May cause gastrointestinal discomfort such as constipation, vomiting, abdominal pain or diarrhea - if this occurs, discontinue use and consult a healthcare practitioner. Stop use and consult a healthcare practitioner if you experience symptoms of hypoglycemia such as feelings of anxiety, dizziness, tremor, sweating, nausea, headache, paleness, chills or confusion.
How long does one bottle last?
Each bottle contains 60 vegetable capsules - a 30-day supply at the standard dose of 1 capsule, 2 times per day.
Is it vegan and allergen-friendly?
Yes - it is vegan, GMO-free, and free of artificial flavours, colours, preservatives, sweeteners, dairy, corn, soy, gluten, wheat or yeast.
Where do I buy it?
Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.
Support healthy glucose and cholesterol levels with Berberine
Get Orange Naturals Berberine 500mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80128242. Helps support healthy glucose levels. Helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL). Do not use this product if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if you have diabetes, gall stones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease, or if you are taking any medication or natural health products, as berberine is known to affect the metabolism of numerous drugs. The research summaries on this page concern berberine generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. For use beyond 3 months, consult a healthcare practitioner. Results may vary.
Important information
Safety Information
Cautions and Warnings: Contraindications: Do not use this product if you are pregnant or breastfeeding. Cautions: Consult a healthcare practitioner prior to use if you have diabetes, gall stones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease. Consult a healthcare practitioner if you are taking any medication or natural health products, as berberine is known to affect the metabolism of numerous drugs. Stop use and consult a healthcare practitioner if you experience symptoms of hypoglycemia such as feelings of anxiety, dizziness, tremor, sweating, nausea, headache, paleness, chills or confusion. Known Adverse Reactions: May cause gastrointestinal discomfort such as constipation, vomiting, abdominal pain or diarrhea; if this occurs, discontinue use and consult a healthcare practitioner. Do not use if the safety seal is broken. Keep out of reach of children.
Indications
Recommended Use or Purpose: Helps support healthy glucose levels. Helps to support cardiovascular health and healthy cholesterol levels (serum triglyceride, total, and LDL).
Ingredients
Medicinal Ingredients (each vegetable capsule contains): Berberine (root, Berberis aquifolium), 500 mg. Non-medicinal Ingredients: Hypromellose, magnesium stearate, microcrystalline cellulose, silicon dioxide. Vegan. GMO-free. No artificial flavours, colours, preservatives, sweeteners, dairy, corn, soy, gluten, wheat or yeast.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule, 2 times per day at the beginning of each meal. Recommended Duration of Use: For use beyond 3 months, consult a healthcare practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.