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Health Canada NPN 80030900 250 mg Astragalus (root, Astragalus membranaceus) per mL, 1:4 Extract Made in Canada · Naturopathic Tincture Used in Herbal Medicine to Help Maintain a Healthy Immune System
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Orange Naturals Astragalus Tincture | 100mL

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$23.96 CAD ($0.24 / mL)
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BrandOrange
Serving2 mL, 4 times per day
Licensed Natural Health ProductNPN 80030900
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • USED TRADITIONALLY FOR ENERGY: Used in Traditional Chinese Medicine to help support energy levels.
  • SUPPORTS A HEALTHY IMMUNE SYSTEM: Used in Herbal Medicine to help maintain a healthy immune system - this product's Health Canada-authorized use.
  • TRADITIONALLY USED FOR FREQUENT COLDS: Traditionally used in Chinese Medicine for those individuals who suffer from frequent colds.
  • ORGANIC ASTRAGALUS ROOT, 1:4 EXTRACT: Made from organic astragalus root (Astragalus membranaceus), extracted at a 1:4 ratio.
  • 250 MG PER ML, FAST-ABSORBING TINCTURE: Each mL delivers 250 mg of Astragalus root extract - take 2 mL, 4 times per day on an empty stomach.
  • MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated by Orange Naturals and licensed under NPN 80030900.

Product Description

Astragalus Tincture - Traditional Immune & Energy Support

Orange Naturals Astragalus Tincture

Orange Naturals Astragalus Tincture delivers 250 mg of organic Astragalus (root, Astragalus membranaceus) per mL, extracted at a 1:4 ratio in a base of grain alcohol and purified water. Used in Herbal Medicine to help maintain a healthy immune system, Astragalus is a long-standing Traditional Chinese Medicine root traditionally used to help support energy levels and for those who suffer from frequent colds. This 100 mL naturopathic tincture is licensed as a Natural Health Product. Licensed Natural Health Product NPN 80030900.

Teinture d'Astragale d'Orange Naturals offre 250 mg d'Astragale biologique (racine, Astragalus membranaceus) par mL, extrait selon un ratio de 1:4 dans une base d'alcool de grain et d'eau purifiée. Utilisée en phytothérapie pour aider à maintenir un système immunitaire sain, l'Astragale est une racine de longue date en médecine traditionnelle chinoise, traditionnellement utilisée pour aider à soutenir les niveaux d'énergie et chez les personnes sujettes aux rhumes fréquents. Cette teinture naturopathique de 100 mL est homologuée comme produit de santé naturel. NPN 80030900.

Astragalus Tincture lifestyle
Orange Naturals Astragalus Tincture
250 mg Astragalus (root, Astragalus membranaceus) per mL · 1:4 Extract

A Traditional Root, Modern Tincture Format

250 mg Astragalus (root, Astragalus membranaceus), 1:4 extract - fast-absorbing liquid format, 2 mL 4 times daily

250 mg Astragalus per mL

Each mL delivers a full 250 mg dose of organic Astragalus root (Astragalus membranaceus), extracted at a 1:4 ratio - take 2 mL, 4 times per day on an empty stomach.

Fast-Absorbing Tincture Format

As a liquid tincture, Astragalus can begin absorbing in the mouth, offering a fast-acting alternative to capsules or tablets.

Advanced Ingredients, Superior Results

Astragalus membranaceus (Huang Qi) is one of the most widely studied roots in Traditional Chinese Medicine, explored for its role in immune function, cardiovascular health, kidney health and general adaptogenic use. Here is what the wider research explores.

Astragalus (root, Astragalus membranaceus)

A traditional Chinese Medicine root long used as a qi tonic, studied for its role in immune function, cardiovascular health and general resistance to illness.

250 mg per mL, 1:4 extract

Orange Naturals Astragalus Tincture: Supplement Facts

Orange™Astragalus Tincture
English

Each mL contains:

  • Astragalus (root, Astragalus membranaceus), 1:4 extract250 mg

Non-Medicinal Ingredients: Non-medicinal ingredients: 40% grain alcohol, purified water.

Recommended Use or Purpose: Used in Herbal Medicine to help maintain a healthy immune system.

Recommended Dose (Adults): Take 2 mL, 4 times per day, preferably on an empty stomach.

Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if you have an auto-immune disorder. Keep out of reach of children.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.

Français

Chaque mL contient :

  • Astragale (racine, Astragalus membranaceus), extrait 1:4250 mg

Ingrédients non médicinaux : Ingrédients non médicinaux : Alcool de grain à 40 %, eau purifiée.

Usage ou fins recommandés : Utilisé en phytothérapie pour aider à maintenir un système immunitaire sain.

Posologie recommandée (adultes) : Prendre 2 mL, 4 fois par jour, de préférence à jeun.

Mises en garde : Consulter un praticien de la santé avant d'en faire l'usage si vous êtes enceinte ou allaitez, ou si vous souffrez d'un trouble auto-immun. Garder hors de la portée des enfants.

NPN 80030900

250 mg Astragalus (root, Astragalus membranaceus) per mL, 1:4 Extract100 mL (3.38 fl oz) Dropper BottleUsed in Herbal Medicine to Help Maintain a Healthy Immune SystemTraditionally Used in Chinese Medicine for Energy & Frequent Colds

Support your immune system with Astragalus

Get Orange Naturals Astragalus Tincture on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Why Orange Naturals Astragalus Tincture

250 mg of Astragalus (root, Astragalus membranaceus) per mL, 1:4 extract - a traditional Chinese Medicine root in a fast-absorbing tincture format.

250 mg Astragalus per mL

Each mL delivers a full 250 mg dose of organic Astragalus root (Astragalus membranaceus), extracted at a 1:4 ratio.

Supports a healthy immune system

Used in Herbal Medicine to help maintain a healthy immune system.

Fast-absorbing liquid tincture

Take 2 mL, 4 times per day on an empty stomach - a fast-acting alternative to capsules.

Made in Canada, Health Canada licensed

Formulated by Orange Naturals and licensed as a Natural Health Product. NPN 80030900.

Inside every mL

250 mg Astragalus (root, Astragalus membranaceus), 1:4 extract, per mL - take 2 mL, 4 times per day, preferably on an empty stomach. Non-medicinal ingredients: 40% grain alcohol and purified water.

Astragalus (root, Astragalus membranaceus) 250 mg per mL, 1:4 extract

How to use it

Take 2 mL, 4 times daily on an empty stomach

Adults: take 2 mL, 4 times per day, preferably on an empty stomach.

Use the dropper for accurate dosing

Each 100 mL bottle is designed for precise, drop-by-drop dosing directly into the mouth or in a small amount of water.

Consult a practitioner if pregnant, breastfeeding, or if you have an autoimmune disorder

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have an auto-immune disorder.

What the research says about Astragalus

Educational summaries of published research on Astragalus membranaceus generally; not product-specific claims. Orange Naturals Astragalus Tincture's own authorized use under NPN 80030900 is that it is used in Herbal Medicine to help maintain a healthy immune system.

Immune Function (Human Studies)

A randomized trial found Astragalus Membranaceus Root restored immune balance in elite rowers after strenuous training

In a double-blind, placebo-controlled study of 18 members of the Polish Rowing Team, 500 mg of Astragalus Membranaceus Root supplementation during a six-week intensive training camp helped sustain natural killer and T regulatory cell levels at baseline and shifted cytokine (IL-2/IL-10) response toward a more favourable balance during recovery from maximal exertion, compared with placebo.

Human RCT (n=18)
Latour et al., Journal of the International Society of Sports Nutrition (2021)
Immune Function (Human Studies)

A randomized trial found Radix Astragali improved symptoms and immune markers as an adjunct therapy in Graves disease

In 80 Graves disease patients randomized to methimazole alone or methimazole plus Radix Astragali, both groups improved thyroid function similarly, but symptoms such as heat intolerance, sweating and palpitations improved more in the Astragalus group, alongside a more pronounced reduction in inflammatory markers IL-1beta and TNF-alpha.

Human RCT (n=80)
Wu, Liu & Chen, Chinese Journal of Integrated Traditional and Western Medicine (2011)
Immune Function (Human Studies)

A randomized trial found a Compound Astragalus Recipe regulated lymphocyte subsets similarly to standard therapy in myasthenia gravis

In 60 myasthenia gravis patients randomized to a Compound Astragalus Recipe or prednisone for 3 months, both treatments produced comparable overall effective rates (80% vs 83.3%) and improved lymphocyte subset distribution and complement levels, with no adverse reactions observed in the Astragalus group versus transient liver-enzyme elevation in 5 prednisone patients.

Human RCT (n=60)
Niu, Sun & Zhang, Chinese Journal of Integrated Traditional and Western Medicine (2009)
Cardiovascular Health

A study found Astragalus Membranaceus Injection protected mitochondrial function in a chronic heart failure model

In a pressure-overload chronic heart failure mouse model, Astragalus Membranaceus Injection improved left ventricular ejection fraction, reduced cardiac hypertrophy and fibrosis, and restored mitophagy and mitochondrial homeostasis by inhibiting the AKT/mTOR signaling pathway.

Preclinical study
Li et al., Scientific Reports (2025)
Cardiovascular Health

A study found Astragalus Polyphenols protected heart cells against chemotherapy-induced cardiotoxicity

In cardiomyocyte models of doxorubicin-induced cardiotoxicity, Astragalus Polyphenols reversed reductions in cell viability and mitochondrial membrane potential, lowered reactive oxygen species, and reduced cardiac injury markers ANP and BNP by activating the PI3K/AKT/NRF2 signaling pathway.

Preclinical study
Bai et al., PLoS One (2025)
Cardiovascular Health

A review describes Astragalus membranaceus among traditional botanicals studied for ischemic heart disease and heart failure

Reviewing botanicals with cardiovascular therapeutic history, Astragalus membranaceus is described as a Chinese 'Qi tonifier' studied for benefit in ischemic heart disease, myocardial infarction, heart failure and anginal pain relief, with its in vitro antioxidant activity proposed as a mechanism for its cardioprotective effect.

Review
Miller, Alternative Medicine Review (1998)
Immunomodulatory Mechanism

A study found Astragalus polysaccharides trigger immune-activating cell death in melanoma via a gut-microbiota-dependent pathway

In a melanoma model, Astragalus polysaccharides suppressed tumor growth and prolonged survival by inducing immunogenic cell death through the cGAS-STING pathway; depleting the tumor's local microbiota blunted this effect, and administering a specific bacterial byproduct alone was enough to reactivate the pathway.

Preclinical study
Qiao et al., Cancer Medicine (2026)
Immunomodulatory Mechanism

A study found Astragalus polysaccharide reprograms tumor-associated macrophages toward an anti-tumor state in liver cancer

In a hepatocellular carcinoma model, Astragalus polysaccharide increased pro-inflammatory, anti-tumor macrophage populations within the tumor microenvironment by suppressing an enzyme (OGT) involved in macrophage polarization, enhancing immune cell infiltration and reducing signs of T-cell exhaustion.

Preclinical study
Lv et al., Immunological Investigations (2026)
Immunomodulatory Mechanism

A review describes how astragalosides activate T cells and regulate inflammation through the NF-kB pathway

Reviewing the immunoregulatory and anti-inflammatory activities of astragalosides (major active components of Astragalus), the review describes their role in T-cell activation, regulation of the effector/regulatory T-cell balance, enhancement of CD45 phosphatase activity, and inhibition of pro-inflammatory cytokines via the NF-kB pathway.

Review
Qi et al., The American Journal of Chinese Medicine (2017)
Respiratory Immune Support & Antiviral Adjuvant

A study found Astragalus membranaceus enhanced antibody response to a COVID-19 vaccine in mice

Orally administered Astragalus membranaceus water extract, combined with Coriolus versicolor, enhanced the antibody-binding activity of the BNT162b2 mRNA vaccine against ancestral and Delta SARS-CoV-2 spike proteins by 4.3 to 5.8-fold in mice, alongside increased antibody-neutralizing activity, likely via trained immunity of macrophages and dendritic cells.

Preclinical study
Chan et al., Journal of Leukocyte Biology (2024)
Respiratory Immune Support & Antiviral Adjuvant

A study found Astragalus polysaccharide acted as a persistent immune adjuvant for influenza and SARS-CoV-2 vaccines in mice

As an adjuvant to influenza and recombinant SARS-CoV-2 vaccines in mice, Astragalus polysaccharide increased antibody titers and improved survival and weight recovery after a lethal influenza challenge, with induced antibodies persisting at high levels for at least 20 weeks.

Preclinical study
Zhao et al., International Journal of Biological Macromolecules (2023)
Respiratory Immune Support & Antiviral Adjuvant

A study found astragaloside IV reduced inflammation in cigarette-smoke-exposed immune cells via autophagy

In macrophages exposed to cigarette smoke extract, astragaloside IV (a compound prescribed for upper respiratory tract infections) reduced pro-inflammatory cytokine release and rescued cell death by inducing autophagy through the TLR4/NF-kB signaling pathway.

Preclinical study
Ying et al., Biomedicine & Pharmacotherapy (2021)
Safety & Tolerability (Human Trials)

A Phase I trial found an Astragalus-containing herbal medicine was well tolerated up to 4800 mg per day in cancer patients

In an open-label, dose-escalation Phase I trial of 11 patients with solid cancers, SH003 (containing Astragalus membranaceus, Angelica gigas and Trichosanthes kirilowii) produced only grade 2 or lower adverse events at doses up to 4800 mg/day, with no dose-limiting toxicities observed.

Human Phase I trial (n=11)
Cheon & Ko, Integrative Cancer Therapies (2020)
Safety & Tolerability (Human Trials)

A Phase I trial found the same Astragalus-containing formula combined safely with a chemotherapy drug in breast and lung cancer patients

In 12 patients with advanced breast or lung cancer, SH003 combined with docetaxel chemotherapy was well tolerated up to 4800 mg/day with no dose-limiting toxicities attributed to SH003; the most common adverse events (neutropenia, mild skin reactions) were primarily linked to docetaxel.

Human Phase I trial (n=12)
Cheon et al., Integrative Cancer Therapies (2025)
Safety & Tolerability (Human Trials)

A randomized trial found an Astragalus and Angelica combination was safe and improved urinary symptoms in men with BPH

In 84 men with benign prostatic hyperplasia symptoms, 12 weeks of SHPro (an Astragalus and Angelica combination) significantly improved prostate symptom scores and erectile function versus control; only mild adverse events (gastrointestinal, skeletal, dermatologic) occurred, none judged related to the product.

Human RCT (n=84)
Lee et al., Investigative and Clinical Urology (2025)
Kidney & Renal Health

A meta-analysis of 66 trials found Astragalus membranaceus reduced albuminuria and improved kidney markers in diabetic kidney disease

Pooling 4,785 participants across 66 randomized trials, adding Astragalus membranaceus preparations to conventional therapy for diabetic kidney disease reduced albuminuria, proteinuria and serum creatinine more than conventional therapy alone, with a similar adverse-event profile between groups; the authors rated evidence quality as low and called for further high-quality trials.

Meta-analysis
Zhang et al., Journal of Ethnopharmacology (2019)
Kidney & Renal Health

A study found astragaloside IV protected kidney cells from diabetes-related damage by regulating iron-dependent cell death

In a diabetic rat model and high-glucose-exposed kidney cells, astragaloside IV (a primary bioactive compound of Astragalus root) improved kidney function and reduced oxidative stress and ferroptosis markers, restoring mitochondrial membrane potential and reducing lipid peroxidation in kidney tubule cells.

Preclinical study
Liu et al., International Immunopharmacology (2024)
Kidney & Renal Health

A study found formononetin, an Astragalus compound, improved kidney function in a chronic renal failure model

In an adenine-induced chronic renal failure rat model and human kidney tubule cells, formononetin (one of the main isoflavones isolated from Astragalus membranaceus) reduced serum creatinine and urine protein, improved kidney tissue injury and fibrosis, and inhibited the PI3K/AKT signaling pathway linked to inflammatory cytokine release.

Preclinical study
Luo et al., Journal of Ethnopharmacology (2024)
Diabetes & Glucose Metabolism

A randomized trial found an Astragalus-containing formula improved glucose and inflammatory markers in older adults with diabetic sarcopenia

In a 12-week randomized, double-blind, placebo-controlled trial of 90 older adults with diabetic sarcopenia, Shenqi paste (containing Astragalus membranaceus among 8 medicine-food ingredients) significantly improved handgrip strength, muscle mass index and function versus placebo, alongside a significant reduction in fasting blood glucose and C-reactive protein, with no serious adverse events.

Human RCT (n=90)
Hua et al., Journal of Ethnopharmacology (2026)
Diabetes & Glucose Metabolism

A study found an Astragalus and Rehmannia herb pair improved glucose and lipid metabolism in type 2 diabetic rats

Using network pharmacology and multi-omics analysis, a Rehmannia-Astragalus (Shengdihuang-Huangqi) herb pair significantly improved fasting blood glucose, dyslipidemia and tissue damage in type 2 diabetic rats, with formononetin (an Astragalus compound) identified among the key bioactive contributors acting on insulin resistance and lipid metabolism pathways.

Preclinical study
Cao et al., Phytomedicine (2026)
Diabetes & Glucose Metabolism

A study found fermented Astragalus membranaceus outperformed a plain water extract in a diabetic kidney model

Comparing fermented Astragalus membranaceus broth to its plain aqueous extract in diabetic rats, the fermented version produced greater improvements in body weight recovery, fasting blood glucose, kidney function markers and antioxidant capacity, suggesting fermentation improves the bioavailability of Astragalus's active compounds.

Preclinical study
Wu et al., Biomedical Chromatography (2026)
Traditional Use & Chemotherapy Adjuvant

An overview of 52 systematic reviews found an Astragalus-containing Chinese patent medicine improved outcomes as a cancer adjuvant therapy

Reviewing 52 systematic reviews of Aidi injection (containing Astragalus membranaceus, Panax ginseng and other herbs) used alongside chemotherapy or radiotherapy across lung, liver, colorectal and other cancers, the injection showed additional benefits on survival, tumor response, quality of life and reduction of chemo/radiotherapy side effects - though the authors rated the underlying review quality as generally weak and called for improvement.

Overview of systematic reviews
Yang et al., Journal of Ethnopharmacology (2021)
Traditional Use & Chemotherapy Adjuvant

A review describes Astragalus membranaceus (Huangqi) as a widely used traditional tonic with over 100 identified active compounds

Reviewing the botanical characteristics, phytochemistry and pharmacology of Astragalus membranaceus, the review describes its traditional use as an immune stimulant, tonic, antioxidant, hepatoprotectant, diuretic and antidiabetic, noting more than 100 identified compounds including flavonoids, saponins and polysaccharides.

Review
Fu et al., Phytotherapy Research (2014)
Traditional Use & Chemotherapy Adjuvant

A meta-analysis found Astragalus polysaccharide supplementation improved treatment outcomes and immune markers in cancer patients with a high safety profile

Pooling 2,648 participants across 31 randomized trials, adding Astragalus polysaccharide to cancer treatment improved objective response rate and CD3+/CD4+ T-cell counts versus control, with a low incidence of mild adverse reactions such as hand-foot numbness, supporting a favourable safety profile alongside standard cancer therapy.

Meta-analysis
Li et al., Naunyn-Schmiedeberg's Archives of Pharmacology (2025)

Frequently asked questions

What is Orange Naturals Astragalus Tincture and what does it do?

It's a liquid tincture providing 250 mg of Astragalus (root, Astragalus membranaceus), 1:4 extract, per mL. Used in Herbal Medicine to help maintain a healthy immune system.

How do I take it?

Adults take 2 mL, 4 times per day, preferably on an empty stomach.

Who should consult a healthcare practitioner before using it?

Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have an auto-immune disorder.

What is Astragalus traditionally used for?

In Traditional Chinese Medicine, Astragalus (Huang Qi) is traditionally used to help support energy levels and for those who suffer from frequent colds.

What are the non-medicinal ingredients?

40% grain alcohol and purified water.

How much is in one bottle?

Each bottle contains 100 mL (3.38 fl oz) of tincture.

Is this a Health Canada licensed product?

Yes - it is licensed as a Natural Health Product under NPN 80030900.

Where do I buy it?

Use the orange button on this page - it takes you to the listing on Amazon.ca for secure checkout and fast delivery.

250 mg Astragalus (root, Astragalus membranaceus) per mL, 1:4 Extract100 mL (3.38 fl oz) Dropper BottleUsed in Herbal Medicine to Help Maintain a Healthy Immune SystemTraditionally Used in Chinese Medicine for Energy & Frequent Colds

Support your immune system with Astragalus

Get Orange Naturals Astragalus Tincture on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Natural Health Product NPN 80030900. Used in Herbal Medicine to help maintain a healthy immune system. Consult a healthcare practitioner before use if you are pregnant or breastfeeding, or if you have an auto-immune disorder. The research summaries on this page concern astragalus generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Results may vary.

Important information

Safety Information

Cautions and Warnings: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if you have an auto-immune disorder. Keep out of reach of children.

Indications

Recommended Use or Purpose: Used in Herbal Medicine to help maintain a healthy immune system.

Ingredients

Medicinal Ingredients (each mL contains): Astragalus (root, Astragalus membranaceus), 1:4 extract, 250 mg. Non-medicinal Ingredients: 40% grain alcohol, purified water.

Directions

Recommended Dose (Adults): Take 2 mL, 4 times per day, preferably on an empty stomach.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.