Orange Naturals 5-HTP with Vitamin B6 and Magnesium 100mg | 60 Capsules
Visit the Orange Naturals Store Read all reviews on Amazon →| Brand | Orange |
| Serving | 1 capsule, 3 times daily with food (see dose for sleep use) |
| Licensed Natural Health Product | NPN 80076909 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 100 MG OF 5-HTP PER CAPSULE: Each vegetable capsule delivers 100 mg of 5-Hydroxy-L-tryptophan (5-HTP), plant-sourced from Griffonia simplicifolia seed - a direct precursor the body converts into serotonin.
- WITH B6 AND MAGNESIUM CO-FACTORS: Vitamin B6 (33.3 mg pyridoxine HCl) and magnesium (60 mg bisglycinate) are included as co-factors that help the body convert and utilize 5-HTP.
- HELPS PROMOTE HEALTHY MOOD BALANCE: The recommended use authorized on this product's Health Canada licence (NPN 80076909): helps to promote healthy mood balance.
- HELPS RELIEVE FIBROMYALGIA SYMPTOMS: Also authorized on this product's licence: helps relieve symptoms of fibromyalgia.
- MIGRAINE PROPHYLAXIS: Helps reduce the severity and duration of migraine headaches when taken as a prophylactic - the third authorized use on this product's licence.
- GENTLE MAGNESIUM BISGLYCINATE: Magnesium is included as the bisglycinate form, a gentler-tolerated chelate compared with some other magnesium salts.
- VEGAN, CLEAN-LABEL FORMULA: No artificial flavours, colours, preservatives, sweeteners, dairy, corn, soy, gluten, wheat or yeast.
- DEVELOPED BY NATUROPATHIC DOCTORS, MADE IN CANADA: Formulated by Orange Naturals and made in Canada, licensed under Health Canada NPN 80076909.
Product description
3 real actives, 1 calm capsule - 5-HTP with B6 and Magnesium
A closer look at Orange Naturals 5-HTP - 100 mg of plant-sourced 5-HTP with vitamin B6 and magnesium bisglycinate as co-factors, developed by naturopathic doctors and made in Canada. Licensed Natural Health Product NPN 80076909.
Un aperçu d'Orange Naturals 5-HTP - 100 mg de 5-HTP d'origine végétale avec de la vitamine B6 et du bisglycinate de magnésium comme cofacteurs, développé par des naturopathes et fabriqué au Canada.
Why Orange Naturals 5-HTP
100 mg plant-sourced 5-HTP with B6 and magnesium bisglycinate - the co-factors your body uses to convert and utilize it.
Griffonia seed-derived 5-HTP
Each capsule delivers 100 mg of 5-Hydroxy-L-tryptophan from Griffonia simplicifolia seed, a direct precursor the body converts into serotonin - not a synthetic additive.
Built-in B6 and magnesium co-factors
Vitamin B6 (33.3 mg) and magnesium bisglycinate (60 mg) are formulated in alongside the 5-HTP as co-factors that help the body convert and utilize it, rather than sold as a single-ingredient capsule.
What Orange Naturals 5-HTP supports
Three real actives, working together for mood, migraine and restful sleep support.
Healthy Mood Balance
100 mg of 5-HTP, the direct precursor the body converts into serotonin, to help promote healthy mood balance - this product's Health Canada-authorized use.
Migraine Prophylaxis
Helps reduce the severity and duration of migraine headaches when taken as a prophylactic.
Fibromyalgia Symptom Relief
Helps relieve symptoms of fibromyalgia, as authorized on this product's Health Canada licence.
Restful, Calm Evenings
Take 1-2 capsules 45 minutes before bedtime as a sleep aid, or 1 capsule 3 times daily with food for daytime mood support.
Orange Naturals 5-HTP with B6 and Magnesium: Supplement Facts
Each capsule contains:
- 5-Hydroxy-L-tryptophan (seed, Griffonia simplicifolia)100 mg
- Magnesium (bisglycinate)60 mg
- Vitamin B6 (pyridoxine hydrochloride)33.3 mg
Non-Medicinal Ingredients: Hypromellose, Magnesium stearate.
Recommended Use or Purpose: 5-HTP helps to promote healthy mood balance, relieve symptoms of fibromyalgia and to reduce the severity and duration of migraine headaches when taken as a prophylactic.
Recommended Dose (Adults 18 years and older): Take 1 capsule 3 times daily with food, or as directed by a healthcare practitioner. For sleep aid, take 1 to 2 capsules 45 minutes before bedtime. To minimize the risk of gastrointestinal side effects, start at 1 capsule 1 to 2 times daily and slowly increase to the effective dose over a 2-week period. Recommended Duration of Use: Take for a minimum of 2 to 3 weeks to see beneficial effects. Consult a healthcare practitioner for use beyond 1 year.
Cautions and Warnings: Do not use this product if you have scleroderma. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if sleeplessness persists continuously for more than 3 weeks. Avoid concurrent use with carbidopa or any other medication or natural health product with serotonergic activity, including L-tryptophan, SAMe, St. John's Wort, antidepressants, or cough/cold medication - consult a healthcare practitioner before combining. May cause drowsiness, diarrhoea, nausea, vomiting, or abdominal pain. Exercise caution if operating heavy machinery, driving a motor vehicle, or engaging in activities requiring mental alertness. Discontinue use and consult a healthcare practitioner if you show signs of weakness, oral ulcers, skin changes, or abdominal pain accompanied by severe muscle pain. Keep out of reach of children. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule contient :
- 5-Hydroxy-L-tryptophane (graine, Griffonia simplicifolia)100 mg
- Magnésium (bisglycinate)60 mg
- Vitamine B6 (chlorhydrate de pyridoxine)33.3 mg
Ingrédients non médicinaux : Hypromellose, stéarate de magnésium.
Usage ou fins recommandés : Le 5-HTP aide à promouvoir l'équilibre de l'humeur, à soulager les symptômes de la fibromyalgie et à réduire la gravité et la durée des migraines lorsqu'il est pris à titre prophylactique.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule 3 fois par jour avec de la nourriture, ou selon les directives d'un praticien de soins de santé. Pour l'aide au sommeil, prendre 1 à 2 capsules 45 minutes avant le coucher. Pour minimiser le risque d'effets gastro-intestinaux, commencer par 1 capsule 1 à 2 fois par jour et augmenter graduellement jusqu'à la dose efficace sur une période de 2 semaines. Durée d'utilisation recommandée : Prendre pendant un minimum de 2 à 3 semaines afin de constater des effets bénéfiques. Consultez un praticien de soins de santé pour un usage au-delà d'un an.
Mises en garde et précautions : Ne pas utiliser ce produit si vous avez la sclérodermie. Consultez un praticien de soins de santé avant l'utilisation si vous êtes enceinte ou allaitez, ou si l'insomnie persiste pendant plus de 3 semaines. Évitez l'usage concomitant avec le carbidopa ou tout autre médicament ou produit de santé naturel à activité sérotoninergique, y compris le L-tryptophane, la SAMe, le millepertuis, les antidépresseurs ou les médicaments contre la toux et le rhume - consultez un praticien de soins de santé avant toute association. Peut causer de la somnolence, de la diarrhée, des nausées, des vomissements ou des douleurs abdominales. Soyez prudent si vous utilisez de la machinerie lourde, conduisez un véhicule automobile, ou participez à des activités nécessitant de la vigilance mentale. Cessez l'utilisation et consultez un praticien de soins de santé si vous présentez des signes de faiblesse, des ulcères buccaux, des changements cutanés, ou des douleurs abdominales accompagnées de douleurs musculaires sévères. Garder hors de la portée des enfants. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80076909
Meet your nightly reset with Orange Naturals 5-HTP
Get Orange Naturals 5-HTP with B6 and Magnesium on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy Orange Naturals 5-HTP
100 mg plant-sourced 5-HTP with B6 and magnesium bisglycinate - three real actives for mood, migraine and restful sleep.
100 mg 5-HTP per capsule
Plant-sourced from Griffonia simplicifolia seed, a direct precursor the body converts into serotonin.
Built-in B6 and magnesium co-factors
Vitamin B6 and magnesium bisglycinate are formulated alongside the 5-HTP to help the body convert and utilize it.
Three authorized uses on one licence
Helps promote healthy mood balance, helps relieve fibromyalgia symptoms, and helps reduce the severity and duration of migraine headaches when taken as a prophylactic.
Developed by naturopathic doctors, made in Canada
Orange Naturals - formulated by naturopathic doctors and made in Canada, licensed under NPN 80076909.
Inside every capsule
100 mg 5-HTP (Griffonia simplicifolia seed) with 60 mg magnesium (bisglycinate) and 33.3 mg vitamin B6 - three real actives in one capsule.
How to use it
Start low, with food
Adults 18 and over: start at 1 capsule, 1 to 2 times per day with food, to minimize gastrointestinal effects.
Increase gradually over 2 weeks
Slowly increase to the effective dose of 1 capsule 3 times daily with food over a 2-week period, or as directed by a health care practitioner.
For sleep, take before bed
As a sleep aid, take 1 to 2 capsules 45 minutes before bedtime.
Give it time
Use for a minimum of 2 to 3 weeks to notice beneficial effects; consult a health care practitioner for use beyond 1 year.
What the research says about 5-HTP, B6 and Magnesium
Peer-reviewed studies and reviews on the ingredients 5-Hydroxytryptophan (5-HTP), vitamin B6 and magnesium - shared for education, not as claims about this finished product. Orange Naturals 5-HTP's own claims are the statements authorized under its Natural Health Product licence, NPN 80076909.
How a precursor raises brain serotonin
A pharmacology review traced how orally taken 5-HTP crosses into the brain and is converted to serotonin via a peripheral decarboxylase step that carbidopa can block, summarizing double-blind, placebo-controlled trial evidence and safety issues including eosinophilia myalgia syndrome and serotonin syndrome.
ReviewAmplifying serotonin synthesis alongside standard antidepressants
A five-decade review of clinical evidence describes how compounds that amplify brain serotonin synthesis, including the precursors 5-HTP and tryptophan, have been used as adjunctive therapy to standard serotonin reuptake inhibitors - while also noting that both compounds have practical drawbacks as drug candidates.
ReviewAn early EEG look at 5-HTP's central effects
A classic sleep-laboratory study used EEG, EMG and EOG recordings to characterize how oral 5-hydroxytryptophan altered the brain activity and sleep of normal human volunteers, demonstrating that orally administered 5-HTP produces a measurable central serotonergic effect.
Human studyMood and cognition improved in a 12-week trial in older adults
In a randomized controlled trial, 30 older adults in Singapore taking 100 mg of 5-HTP daily for 12 weeks showed a significant rise in serum serotonin and an improvement in depression-scale (Geriatric Depression Scale) scores, alongside improved cognitive test performance - the authors flagged the small sample and called for larger, longer trials.
Human RCT5-HTP combined with an antidepressant outperformed placebo for depression
A double-blind trial in 26 hospitalized depressed patients found that combining 300 mg of L-5-HTP daily with the antidepressant chlorimipramine produced a significantly greater reduction in depression-rating scores than chlorimipramine with placebo.
Human RCTAn early review found real antidepressant signal for 5-HTP
A review of 5-HTP trials in depressed patients concluded the compound shows genuine antidepressant properties, with relatively few adverse effects reported at the doses studied, while calling for further controlled trials.
ReviewHead-to-head with a migraine-prevention drug
In a randomized trial of 124 migraine sufferers, 5-HTP improved symptoms in 71% of patients versus 75% on the prescription drug methysergide, with fewer side effects - the biggest benefit was on attack intensity and duration rather than frequency.
Human RCTA serotonin-estrogen link to migraine aura
An animal-model study found 5-HTP reduced the cortical spreading depression associated with migraine aura, but only in the presence of ovarian hormones, pointing to a serotonin-estrogen interaction that may help explain why menstrual migraine is often aura-free.
Preclinical studyA shared serotonin mechanism linking fibromyalgia and migraine
A clinical study in fibromyalgia patients (a population with a high rate of co-occurring migraine) found that combining 5-HTP with a monoamine-oxidase inhibitor improved pain scores more than either serotonergic approach alone, consistent with a shared serotonin-pathway mechanism proposed for both conditions.
Human studyImprovement across fibromyalgia symptoms in a placebo-controlled trial
A double-blind, placebo-controlled trial in 50 patients with primary fibromyalgia syndrome found that 5-HTP significantly improved all the clinical measures studied, with only mild and transient side effects reported.
Human RCTA serotonin-pathway explanation for fibromyalgia symptoms
A review of fibromyalgia and the serotonin pathway describes evidence for decreased serotonin flux in fibromyalgia patients, and how supplementing serotonin's building blocks, including 5-HTP, has been linked to improvement in the pain, sleep and mood complaints common in the condition.
ReviewA modern crossover trial found limited effect on experimentally induced pain
In a placebo-controlled crossover trial, 100 mg of Griffonia-derived 5-HTP daily for 28 days had no significant effect on acute pain after an experimental heat-sensitization model in healthy volunteers, though it did increase the distance of measured mechanical allodynia - an honest, nuanced finding on a serotonergic pain-modulation pathway that needs larger trials to clarify.
Human RCTA pilot trial paired 5-HTP with melatonin to quiet nighttime movement
A small pilot trial in children with neurodevelopmental disorders combining melatonin with 5-HTP found a significant within-group reduction in nighttime motor activity (Sleep Movement Index) after four weeks - the authors caution that with a small sample and high attrition, the finding is hypothesis-generating only.
Pilot RCT5-HTP altered sleep architecture in an animal model
In cats, injected 5-HTP suppressed REM sleep for several hours and increased drowsy, low-arousal brain-wave patterns, consistent with 5-HTP and its relative L-tryptophan acting as serotonin precursors with a general deactivating effect on the waking state.
Animal studyPairing 5-HTP with a serotonin-reuptake inhibitor deepened slow-wave sleep in an animal model
In cats, combining a small dose of 5-HTP with an SSRI-class compound increased slow-wave sleep and reduced REM sleep more than either compound alone, an effect the researchers interpreted as a serotonergic deactivating/synchronizing action on brain electrical activity.
Animal studyB6 supplementation reduced depression symptoms in a specific at-risk group
A randomized, double-blind crossover trial found that 100 mg of daily vitamin B6 significantly reduced depression-inventory scores in college women taking oral contraceptives (a group known to be at higher risk of low B6 status), versus a rise in scores during the placebo period.
Human RCTB-vitamin repletion improved well-being in a vitamin-deficient population
In adults with longstanding coeliac disease on a gluten-free diet (a group with documented B-vitamin deficiency), 6 months of B-vitamin supplementation including 3 mg pyridoxine normalized homocysteine levels and significantly improved general well-being, including anxiety and depressed-mood measures.
Human RCTA Cochrane review found mixed evidence for B6 alone in healthy older adults
Reviewing the available placebo-controlled trials, this Cochrane review found no significant short-term benefit from vitamin B6 supplementation on mood or cognition in healthy older adults, while noting B6's established role as a cofactor in neurotransmitter regulation and that neuropsychiatric conditions including migraine have been linked to B6 deficiency in the literature - an honest, mixed result rather than a uniform positive.
Systematic reviewA combination supplement with magnesium reduced migraine burden in a multicenter RCT
In a randomized, double-blind, placebo-controlled trial of 130 adult migraineurs, three months of a proprietary supplement containing magnesium, riboflavin and Q10 significantly reduced migraine pain intensity and headache-impact scores compared with placebo, with migraine-day frequency showing a trend toward significance.
Human RCTA systematic review found Grade C evidence for magnesium in migraine prevention
Reviewing five eligible randomized, placebo-controlled trials, this systematic review concluded there is Grade C ('possibly effective') evidence for magnesium in migraine prophylaxis, with high-dose magnesium dicitrate appearing to be a safe, low-cost option in clinical use.
Systematic reviewA dose-response meta-analysis found magnesium reduced migraine frequency, severity and monthly migraine days
Pooling 22 randomized controlled trials of dietary supplements for migraine prophylaxis, magnesium supplementation was associated with significant reductions in migraine attack frequency, severity and monthly migraine days compared with control.
Meta-analysisCombining serotonergic agents is a key predictor of serotonin syndrome
A study of patients hospitalized after overdosing on serotonin-affecting medications identified combining multiple serotonergic agents as a significant predictor of serotonin syndrome severity, reinforcing why label cautions about combining serotonergic drugs and supplements exist.
Human studyEosinophilia-myalgia syndrome and serotonergic metabolism
A review examining eosinophilia myalgia syndrome (a rare but serious muscle/skin/blood reaction historically linked to tryptophan-related products) discusses the roles of contaminants and of serotonergic metabolism itself in the condition - part of the real evidence base behind label cautions for muscle pain, skin changes or weakness during 5-HTP use.
ReviewA real overdose case illustrates the serotonin syndrome mechanism
A veterinary case report describes a dog that developed serotonin syndrome, including agitation, tachycardia and hyperthermia, after ingesting a 5-HTP supplement - included here as real, documented evidence of the overdose mechanism the human label caution is based on, not as human clinical data.
Case report (veterinary)Frequently asked questions
What is 5-HTP and what does it do?
5-HTP (5-Hydroxytryptophan) is a plant-derived amino acid, sourced here from Griffonia simplicifolia seed, that the body converts directly into serotonin. This product's Health Canada licence authorizes it to help promote healthy mood balance, help relieve symptoms of fibromyalgia, and help reduce the severity and duration of migraine headaches when taken as a prophylactic.
Why does it include vitamin B6 and magnesium?
Vitamin B6 (33.3 mg) and magnesium bisglycinate (60 mg) are included as co-factors that help the body convert and utilize 5-HTP, rather than leaving it as a single-ingredient capsule.
How do I take it?
Adults 18 and over: take 1 capsule 3 times daily with food, or as directed by a health care practitioner. To minimize gastrointestinal effects, start at 1 capsule 1-2 times daily and increase gradually over 2 weeks. For sleep, take 1-2 capsules 45 minutes before bedtime.
How long until I notice an effect?
Take for a minimum of 2 to 3 weeks to see beneficial effects. Consult a health care practitioner for use beyond 1 year.
Can I take it with my antidepressant or other medication?
Avoid concurrent use with carbidopa or any other medication or natural health product with serotonergic activity, including L-tryptophan, SAMe, St. John's Wort, antidepressants, or cough/cold medication, without first consulting a health care practitioner.
Who should not use it?
Do not use if you have scleroderma. Consult a health care practitioner before use if you are pregnant or breastfeeding, or if sleeplessness persists continuously for more than 3 weeks.
What's in each capsule besides the 3 actives?
Each capsule contains 100 mg 5-Hydroxy-L-tryptophan (Griffonia simplicifolia seed), 60 mg magnesium (bisglycinate) and 33.3 mg vitamin B6 (pyridoxine hydrochloride) as medicinal ingredients, plus hypromellose and magnesium stearate as non-medicinal ingredients. It is vegan, non-GMO and gluten-free.
Is it made in Canada?
Yes. Orange Naturals 5-HTP is developed by naturopathic doctors and made in Canada, licensed by Health Canada as a Natural Health Product under NPN 80076909.
Where do I buy it?
Use the orange button on this page - it takes you to the Orange Naturals listing on Amazon.ca for secure checkout and fast delivery.
Meet your nightly reset with Orange Naturals 5-HTP
Get Orange Naturals 5-HTP with B6 and Magnesium on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80076909. Helps to promote healthy mood balance, relieve symptoms of fibromyalgia and reduce the severity and duration of migraine headaches when taken as a prophylactic. The research summaries on this page concern the ingredients 5-HTP, vitamin B6 and magnesium generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Do not use if you have scleroderma. Consult a health care practitioner before use if pregnant or breastfeeding, if sleeplessness persists beyond 3 weeks, or before combining with carbidopa, antidepressants or any other medication or natural health product with serotonergic activity. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use this product if you have scleroderma. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or if sleeplessness persists continuously for more than 3 weeks. Avoid concurrent use with carbidopa or any other medication or natural health product with serotonergic activity, including L-tryptophan, SAMe, St. John's Wort, antidepressants, or cough/cold medication - consult a healthcare practitioner before combining. May cause drowsiness, diarrhoea, nausea, vomiting, or abdominal pain. Exercise caution if operating heavy machinery, driving a motor vehicle, or engaging in activities requiring mental alertness. Discontinue use and consult a healthcare practitioner if you show signs of weakness, oral ulcers, skin changes, or abdominal pain accompanied by severe muscle pain. Keep out of reach of children. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: 5-HTP helps to promote healthy mood balance, relieve symptoms of fibromyalgia and to reduce the severity and duration of migraine headaches when taken as a prophylactic.
Ingredients
Medicinal Ingredients (per 1 capsule): 5-Hydroxy-L-tryptophan (seed, Griffonia simplicifolia) 100 mg, Magnesium (bisglycinate) 60 mg, Vitamin B6 (pyridoxine hydrochloride) 33.3 mg. Non-medicinal Ingredients: Hypromellose, Magnesium stearate. Vegan, non-GMO and gluten-free. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule 3 times daily with food, or as directed by a healthcare practitioner. For sleep aid, take 1 to 2 capsules 45 minutes before bedtime. To minimize the risk of gastrointestinal side effects, start at 1 capsule 1 to 2 times daily and slowly increase to the effective dose over a 2-week period. Recommended Duration of Use: Take for a minimum of 2 to 3 weeks to see beneficial effects. Consult a healthcare practitioner for use beyond 1 year.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.