AOR NMN + Wheat Germ - Nicotinamide Mononucleotide with Spermidine | 30 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 capsule |
| Licensed Natural Health Product | NPN 80122939 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- TWO REAL, DOSED INGREDIENTS: 100 mg of nicotinamide mononucleotide (NMN) plus 100 mg of wheat germ extract standardized to 1 mg of spermidine - both declared medicinal ingredients on a Health Canada-licensed label (NPN 80122939).
- A DIRECT NAD+ PRECURSOR: NMN is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), the coenzyme every cell needs for energy metabolism. NMN helps maintain NAD+ levels in the body for the maintenance of good health.
- REAL, FOOD-DERIVED SPERMIDINE: The spermidine is enzymatically derived from wheat germ (Triticum aestivum), one of the richest natural dietary sources of this polyamine, rather than a synthetic isolate.
- SUPPORTS ENERGY METABOLISM & TISSUE FORMATION: As a source of vitamin B3, NMN supports biological functions that play a key role in the maintenance of good health, including energy metabolism and tissue formation.
- ONE CAPSULE, ONCE A DAY: Simple, once-daily dosing - take one capsule with or without food. A 30-capsule bottle is a 1-month supply.
- VEGAN, NON-GMO, GLUTEN-FREE: Formulated without animal-derived ingredients, non-GMO and gluten-free - though wheat is declared as the allergen source on the label.
- A FIRST FOR THE CANADIAN MARKET: AOR was the first to bring this specific NMN-plus-wheat-germ-spermidine combination to Canadian shelves, pairing both ingredients in a single daily capsule.
- TRUSTED CANADIAN MANUFACTURING: Made in Canada in a GMP-compliant facility by Advanced Orthomolecular Research (AOR), science-based formulations since 1991, licensed under Health Canada NPN 80122939.
Product description
NMN + Wheat Germ - Two Cellular-Aging Pathways, One Capsule
AOR NMN + Wheat Germ combines 100 mg of nicotinamide mononucleotide (NMN), a direct NAD+ precursor, with 100 mg of wheat germ extract naturally standardized to 1 mg of spermidine. Helps maintain NAD+ levels in the body for the maintenance of good health - one capsule a day, vegan and non-GMO. Licensed Natural Health Product NPN 80122939.
Why NMN + Wheat Germ
Two of the most-studied cellular-aging compounds, from a trusted Canadian orthomolecular brand.
A direct NAD+ precursor
NMN converts to NAD+ in a single metabolic step, helping maintain the NAD+ levels every cell needs for energy metabolism - levels that decline with age.
Real, food-derived spermidine
Wheat germ naturally contains one of the highest dietary concentrations of spermidine, the polyamine most studied for its role in autophagy, the cell's own renewal process.
Advanced Ingredients, Superior Results
Two distinct medicinal ingredients, each independently declared and dosed on the label.
Nicotinamide Mononucleotide (NMN)
A direct precursor to NAD+ (nicotinamide adenine dinucleotide), the coenzyme every cell needs for energy metabolism. NMN is a source of vitamin B3 and helps maintain NAD+ levels in the body, which decline over time with age.
100 mg per capsule
Wheat Germ Extract (1% Spermidine)
A natural, food-derived source of spermidine, an abundant polyamine studied for its role in autophagy - the cell's own internal cleanup and renewal process. Wheat germ is one of the richest natural dietary sources of spermidine.
100 mg per capsule (1 mg spermidine)AOR NMN + Wheat Germ: Supplement Facts
Serving Size: 1 Capsule
- Wheat Germ (from Triticum aestivum seed germ) standardized to 1% Spermidine100 mg (1 mg Spermidine)
- Nicotinamide Mononucleotide (NMN)100 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose. Contains 1 mg sodium. Allergen: Wheat.
Recommended Use or Purpose: NMN (a source of vitamin B3) is a factor in the maintenance of good health, normal growth and development. NMN supports biological functions that play a key role in the maintenance of good health, including helping in energy metabolism and tissue formation and helping maintain the body's ability to metabolize nutrients. Nicotinamide mononucleotide is a NAD+ precursor that helps maintain NAD+ levels in the blood and body - levels that decline over time with age - for the maintenance of good health. Spermidine, an abundant polyamine, is a factor in the maintenance of good health.
Recommended Dose (Adults 18 years and older): Take one capsule a day with or without food, or as directed by a health care practitioner. Do not open capsules, as this may compromise the integrity of the medicinal ingredients. Consult a health care practitioner if using beyond 3 months.
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant, trying to conceive, or breastfeeding. Consult a health care practitioner prior to use if you have a vitamin B12 deficiency or if you have diabetes. Consult a health care practitioner if you have malignant neoplasms, serious infections, cardiac failure, or myocardial infarction.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Portion : 1 capsule
- Germe de blé (de germe de graine de Triticum aestivum) normalisé à 1 % de spermidine100 mg (1 mg Spermidine)
- Mononucléotide de nicotinamide (NMN)100 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Cellulose microcristalline, stéaryl fumarate de sodium. Capsule : hypromellose. Contient 1 mg de sodium. Allergène : Blé.
Usage ou fins recommandés : Le NMN (source de vitamine B3) est un facteur de maintien d'une bonne santé, d'une croissance et d'un développement normaux. Le NMN favorise des fonctions biologiques qui jouent un rôle clé dans le maintien d'une bonne santé, notamment en contribuant au métabolisme énergétique et à la formation des tissus, et en aidant à maintenir la capacité de l'organisme à métaboliser les nutriments. Le mononucléotide de nicotinamide est un précurseur du NAD+ qui aide à maintenir les niveaux de NAD+ dans le sang et l'organisme - des niveaux qui diminuent avec l'âge - pour le maintien d'une bonne santé. La spermidine, une polyamine abondante, est un facteur de maintien d'une bonne santé.
Dose recommandée (Adultes de 18 ans et plus) : Prendre une capsule par jour, avec ou sans nourriture, ou selon les directives d'un praticien de la santé. Ne pas ouvrir les capsules, car cela pourrait compromettre l'intégrité des ingrédients médicinaux. Consulter un praticien de la santé en cas d'utilisation au-delà de 3 mois.
Mises en garde et précautions : Consulter un praticien de la santé avant l'usage si vous êtes enceinte, si vous essayez de concevoir ou si vous allaitez. Consulter un praticien de la santé avant l'usage si vous souffrez d'une carence en vitamine B12 ou si vous êtes diabétique. Consulter un praticien de la santé si vous présentez des néoplasmes malins, des infections graves, une insuffisance cardiaque ou un infarctus du myocarde.
NPN 80122939
Support NAD+ levels and cellular renewal the easy way
Get AOR NMN + Wheat Germ on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR NMN + Wheat Germ
One capsule, two independently-dosed, well-studied cellular-aging ingredients.
NAD+ Maintenance
NMN is a direct precursor to NAD+, the coenzyme every cell needs, helping maintain NAD+ levels that decline with age.
Cellular Renewal
Spermidine, naturally sourced from wheat germ, is studied for its role in autophagy - the cell's internal cleanup process.
Real, Declared Doses
100 mg NMN and 100 mg wheat germ extract (1 mg spermidine) per capsule - both medicinal ingredients, clearly declared on the label.
Trusted Canadian Manufacturing
Made in Canada by AOR since 1991 in a GMP-compliant facility, vegan, non-GMO and gluten-free, licensed under Health Canada NPN 80122939.
Inside every capsule
100 mg of NMN plus 100 mg of wheat germ extract (1 mg spermidine) - two declared medicinal ingredients in one daily capsule.
How to use
Take one capsule
One capsule a day, with or without food.
Any time of day
Take it at a time that fits your routine, or as directed by a health care practitioner.
Don't open the capsule
Swallow whole - opening the capsule may compromise the medicinal ingredients.
Stay consistent
One 30-capsule bottle is a 1-month supply at one capsule a day. Consult a health care practitioner if using beyond 3 months.
What the research says about NMN and spermidine
Peer-reviewed studies on nicotinamide mononucleotide (NMN) and spermidine - shared for education, not as claims about this finished product. AOR NMN + Wheat Germ's own claims are the statements authorized under its Natural Health Product licence, NPN 80122939. NMN and spermidine research are both active, still-developing fields, and findings continue to evolve.
NAD+ precursors reviewed
A widely-cited review examined the biology of NMN and nicotinamide riboside (NR) as NAD+ intermediates and their therapeutic potential for restoring NAD+ levels that decline with age.
ReviewAn immune-cell enzyme linked to NAD+ decline
Researchers found that the CD38 ecto-enzyme in immune cells is induced during aging and regulates both NAD+ and NMN levels in tissues.
Mouse studyNMN improved insulin sensitivity in a human trial
In a randomized, placebo-controlled trial, NMN supplementation increased muscle insulin sensitivity in prediabetic postmenopausal women - one of the earliest such human studies of NMN.
Human RCTThe foundational spermidine-autophagy finding
This landmark study first showed that spermidine induces autophagy - the cell's internal recycling process - and extends lifespan across yeast, flies and worms.
PreclinicalSpermidine as a physiological autophagy inducer
Researchers proposed spermidine as a naturally-occurring autophagy inducer with anti-aging potential in humans, building on its role as a caloric-restriction mimetic.
ReviewHow spermidine triggers autophagy
A mechanistic review detailed the molecular pathways by which spermidine induces autophagy and contributes to geroprotection - protection against age-related cellular decline.
ReviewLong-term NMN and age-related decline
Long-term NMN administration in mice mitigated multiple age-associated physiological declines over the study period.
Mouse studyNMN and mitochondrial function in senescent cells
NMN supplementation improved mitochondrial dysfunction and reduced markers of cellular senescence in mesenchymal stem cells via the NAD+/Sirt3 pathway.
Cell studyNAD+ support for mitochondrial stress response
In Alzheimer's disease models, the NAD+-boosting agent NMN improved the cellular mitochondrial stress response through an ATF4-dependent pathway.
PreclinicalNAD+ touches nearly every hallmark of aging
A recent review described how declining NAD+ affects essentially all recognized hallmarks of cellular aging, including its links to autophagy and mitochondrial quality control.
ReviewSpermidine's autophagy role, reviewed independently
A major review positioned spermidine's autophagy-inducing effects as a distinct, independently-studied mechanism of interest in aging research, separate from NAD+-precursor strategies like NMN.
ReviewNAD+ metabolism's broad reach in cell biology
This review described how NAD+ metabolism influences DNA repair, chromatin remodeling, cellular senescence and immune function - cellular processes that sit alongside, but are mechanistically distinct from, autophagy pathways.
ReviewHuman safety data on NMN, reviewed
An updated review of human clinical trials found NMN supplementation generally well-tolerated at studied doses, while noting that more long-term data is still needed.
ReviewA dose-ranging trial in healthy adults
A clinical trial evaluating NMN supplementation in healthy middle-aged adults reported on both efficacy signals and its safety and tolerability profile.
Human trialAn honest look at NMN's evidence gaps
Reviewers weighed NMN's promise as an anti-aging health product against real safety-evaluation gaps, noting only a small number of dedicated human safety studies existed at the time.
ReviewComparing the NAD+ precursor field
A review compared nicotinamide riboside, NMN and other NAD+ precursor candidates on bioavailability and potency, highlighting open questions researchers are still resolving.
ReviewNMN vs. NR as dietary NAD+ contributors
Researchers reviewed the comparative roles of NMN and nicotinamide riboside (NR) as precursors that both raise NAD+, noting NMN converts to NAD+ in fewer metabolic steps.
ReviewThe regulation challenges of targeting NAD+
A recent review outlined the biological regulation of NAD+ metabolism and the open scientific challenges in therapeutically targeting it, including via precursor supplementation.
ReviewWhy NAD+ and sirtuins matter for aging
A foundational review described how NAD+ serves as a coenzyme for the sirtuin family of proteins, and how NAD+ decline with age is linked to multiple age-related conditions.
ReviewWheat germ as a concentrated spermidine source
A quantitative analysis confirmed wheat germ as one of the richest natural sources of the polyamine spermidine, comparing multiple processed forms of the raw material.
Analytical studyWheat-germ-derived spermidine and autophagy in cells
Laboratory research found that spermidine extracted from wheat germ stimulated autophagy markers in human cell lines, supporting its proposed cellular-cleanup mechanism.
Cell studySurveying real human anti-aging trials
A 2024 review surveyed the landscape of human trials testing candidate anti-aging compounds, including NAD+ precursors and spermidine, and the doses and endpoints researchers have used.
ReviewDietary spermidine and cognitive function
A study reported that higher dietary spermidine intake was associated with improved cognitive function, adding to interest in modest, food-level spermidine doses.
Human studyA real-world daily dose studied for a year
In a 12-month randomized trial, older adults took a wheat-germ-derived spermidine supplement dosed at 0.9 mg per day - close to this product's 1 mg per capsule - with adverse events balanced between the supplement and placebo groups.
Human RCTFrequently asked questions
What is AOR NMN + Wheat Germ?
It's a Health Canada-licensed (NPN 80122939) natural health product combining 100 mg of nicotinamide mononucleotide (NMN), a direct NAD+ precursor, with 100 mg of wheat germ extract standardized to 1 mg of spermidine, a polyamine studied for its role in cellular renewal (autophagy). One capsule a day helps maintain NAD+ levels in the body for the maintenance of good health.
How is this different from AOR's standalone NMN capsule?
This product is a separately-licensed combination formula that adds 100 mg of wheat-germ-derived spermidine (1 mg) alongside 100 mg of NMN, under its own Health Canada NPN (80122939). AOR's standalone NMN product is a different, single-ingredient NMN formula under its own distinct NPN and dose. Always check the NPN and label on the specific bottle you're purchasing to confirm which product you have - they are two separate, independently-licensed formulas.
How do I take it?
Adults 18 years and older take one capsule a day with or without food, or as directed by a health care practitioner. Do not open the capsule. Consult a health care practitioner if using beyond 3 months.
What is spermidine and why is it derived from wheat germ?
Spermidine is a naturally-occurring polyamine studied for its role in autophagy, the cell's internal cleanup and renewal process. Wheat germ is one of the richest natural dietary sources of spermidine, and AOR's extract is standardized to a declared 1% spermidine content (1 mg per 100 mg of wheat germ).
Is it vegan, non-GMO and gluten-free?
Yes - the capsule and its ingredients are vegan, non-GMO and gluten-free. Because the spermidine is derived from wheat germ, the label also declares wheat as an allergen source, even though the product is formulated to be gluten-free.
Who should consult a health care practitioner before use?
Consult a health care practitioner prior to use if you are pregnant, trying to conceive, or breastfeeding; if you have a vitamin B12 deficiency or diabetes; or if you have malignant neoplasms, serious infections, cardiac failure, or myocardial infarction.
Is NMN or spermidine research settled science?
Both are active, still-developing areas of research. Human studies exist for each ingredient, but this is a relatively young field - the research summaries on this page are educational and describe the two ingredients generally, not claims about long-term outcomes from this specific product.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support NAD+ levels and cellular renewal the easy way
Get AOR NMN + Wheat Germ on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80122939. NMN helps maintain NAD+ levels in the body and supports energy metabolism and tissue formation; spermidine, from wheat germ, is a factor in the maintenance of good health. The research summaries below concern NMN and spermidine generally and are educational - they are not claims about this finished product. Read and follow the label. Consult a health-care practitioner prior to use if you are pregnant, trying to conceive, or breastfeeding, have a vitamin B12 deficiency, diabetes, or another condition noted below, or are taking other medications or supplements. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant, trying to conceive, or breastfeeding. Consult a health care practitioner prior to use if you have a vitamin B12 deficiency or if you have diabetes. Consult a health care practitioner if you have malignant neoplasms, serious infections, cardiac failure, or myocardial infarction.
Indications
Recommended Use or Purpose: NMN (a source of vitamin B3) is a factor in the maintenance of good health, normal growth and development. NMN supports biological functions that play a key role in the maintenance of good health, including helping in energy metabolism and tissue formation and helping maintain the body's ability to metabolize nutrients. Nicotinamide mononucleotide is a NAD+ precursor that helps maintain NAD+ levels in the blood and body - levels that decline over time with age - for the maintenance of good health. Spermidine, an abundant polyamine, is a factor in the maintenance of good health.
Ingredients
Medicinal ingredients (per capsule): Wheat Germ (from Triticum aestivum seed germ) 100 mg, standardized to 1% Spermidine (1 mg); Nicotinamide Mononucleotide (NMN) 100 mg. Contains 1 mg of sodium. Non-medicinal ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose. Allergen: Wheat. Vegan, Non-GMO and Gluten-Free. NMIs are subject to change - always read and follow the label for accurate ingredients, cautions and allergen information.
Directions
Recommended Dose (Adults 18 years and older): Take one capsule a day with or without food, or as directed by a health care practitioner. Do not open capsules, as this may compromise the integrity of the medicinal ingredients. Consult a health care practitioner if using beyond 3 months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.