AOR Niacin No-Flush 550mg with Inositol - Vitamin B3 Supplement | 90-180 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 capsule daily |
| Licensed Natural Health Product | NPN 80015111 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- NO-FLUSH NIACIN FORMULA: 550 mg of inositol hexanicotinate per capsule - niacin (vitamin B3) chemically bound to inositol so it has not been associated with the itchy, burning-skin "flush" reaction of regular niacin.
- PROVIDES NIACIN (VITAMIN B3): Delivers 500 mg of niacin per capsule; niacin is a factor in the maintenance of good health, normal growth and development.
- PLUS 121 MG OF INOSITOL: Also provides 121 mg of inositol per capsule, a naturally occurring compound independently studied in its own right.
- GENTLE ON COMFORT: Formulated specifically so you can get niacin without the warmth, redness and itching that regular nicotinic acid can cause.
- SIMPLE ONE-CAPSULE DOSE: One capsule daily, with or without food - no titration schedule to manage.
- VEGAN, NON-GMO, GLUTEN-FREE: Vegan hypromellose capsules with just two non-medicinal ingredients (microcrystalline cellulose, sodium stearyl fumarate) - no unnecessary fillers.
- TRUSTED CANADIAN QUALITY: Manufactured in a GMP-compliant Canadian facility by Advanced Orthomolecular Research (AOR), a licensed Natural Health Product, NPN 80015111.
Product description
AOR Niacin No-Flush - Vitamin B3 with Inositol
A closer look at AOR Niacin No-Flush - 550 mg of inositol hexanicotinate per capsule, providing 500 mg of niacin (vitamin B3) and 121 mg of inositol, in the no-flush ester form that has not been associated with the skin-flushing reaction of regular niacin. Licensed Natural Health Product, NPN 80015111. Licensed Natural Health Product NPN 80015111.
Un regard plus approfondi sur Niacine Sans Rougeur d'AOR - 550 mg d'hexanicotinate d'inositol par capsule, fournissant 500 mg de niacine (vitamine B3) et 121 mg d'inositol, sous la forme d'ester sans rougeur qui n'a pas été associée à la réaction de rougeur cutanée de la niacine ordinaire. Produit de santé naturel homologué, NPN 80015111.
Why Inositol Hexanicotinate
One real ester compound, delivering niacin and inositol together without the flush of regular niacin.
Backed by science
Niacin's classic role in cholesterol and cardiovascular research, and the specific bioavailability and comfort trade-offs of the no-flush inositol hexanicotinate form, are each summarized in the research below.
The AOR difference
550 mg of inositol hexanicotinate per capsule (500 mg niacin + 121 mg inositol) - vegan, non-GMO, gluten-free and made in Canada, with just two non-medicinal ingredients.
Advanced Ingredients, Superior Results
Inositol hexanicotinate provides two real, distinct nutrients - niacin (vitamin B3) and inositol - in one no-flush ester compound.
Inositol Hexanicotinate
The no-flush ester form of niacin - six niacin (nicotinic acid) molecules bound to one inositol molecule - used specifically because it has not been associated with the flushing reaction of regular niacin.
550 mg per capsuleNiacin (Vitamin B3)
An essential B-vitamin and a factor in the maintenance of good health, normal growth and development, provided here in its no-flush inositol-bound form rather than as free nicotinic acid.
500 mg per capsule, from inositol hexanicotinate
Inositol
A naturally occurring carbocyclic sugar alcohol released alongside niacin from the inositol hexanicotinate ester, and independently studied in its own right as myo-inositol.
121 mg per capsuleAOR Niacin No-Flush: Supplement Facts
Medicinal Ingredient (per 1 capsule)
- Inositol Hexanicotinate providing:550 mg
- Niacin (vitamin B3)500 mg
- Inositol121 mg
Non-Medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: Hypromellose.
Recommended Use or Purpose: Niacin No-Flush is inositol hexanicotinate, an ester of the B vitamin niacin. Regular niacin can cause unpleasant side effects such as itchy, burning skin - the niacin "flush". Inositol hexanicotinate has not been associated with the niacin "flush". Niacin is a factor in the maintenance of good health, normal growth and development. Licensed Natural Health Product, NPN 80015111.
Recommended Dose (Adults 18 years and over): Take 1 capsule daily, with or without food, or as directed by a qualified health care practitioner. Do not exceed the recommended dose except on the advice of a physician. Do not crush, mix or blend capsules; swallow capsules whole.
Cautions and Warnings: Do not exceed the recommended dose except on the advice of a physician or qualified health care practitioner. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Ingrédient médicinal (par 1 capsule)
- Hexanicotinate d'inositol fournissant :550 mg
- Niacine (vitamine B3)500 mg
- Inositol121 mg
Ingrédients non médicinaux : Cellulose microcristalline, stéarylfumarate de sodium. Capsule : Hypromellose.
Usage ou fins recommandés : Niacine Sans Rougeur est de l'hexanicotinate d'inositol, un ester de la vitamine B, la niacine. La niacine ordinaire peut provoquer des effets secondaires désagréables tels que des démangeaisons et des brûlures cutanées - la « rougeur » de la niacine. L'hexanicotinate d'inositol n'a pas été associé au « flush » de la niacine. La niacine est un facteur de maintien d'une bonne santé, d'une croissance et d'un développement normaux. Produit de santé naturel homologué, NPN 80015111.
Dose recommandée (Adultes de 18 ans et plus) : Prendre 1 capsule par jour, avec ou sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas dépasser la dose recommandée sauf sur avis d'un médecin. Ne pas écraser, mélanger ou mixer les capsules; avaler les capsules entières.
Mises en garde et précautions : Ne pas dépasser la dose recommandée sauf sur avis d'un médecin ou d'un professionnel de la santé qualifié. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec.
NPN 80015111
Get niacin's benefits without the flush
Get AOR Niacin No-Flush on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Niacin No-Flush
One ester compound, formulated for comfort, providing two real, distinct nutrients.
No-Flush Comfort
Inositol hexanicotinate has not been associated with the flushing reaction that regular (nicotinic acid) niacin can cause.
Niacin (Vitamin B3)
500 mg of niacin per capsule - a factor in the maintenance of good health, normal growth and development.
Plus Inositol
121 mg of inositol per capsule, independently studied in its own right alongside niacin.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, since 1991. Vegan, non-GMO, gluten-free. NPN 80015111.
Inside every capsule
550 mg of inositol hexanicotinate - a no-flush niacin ester providing 500 mg of niacin (vitamin B3) and 121 mg of inositol - in every vegan capsule.
How to use
Take 1 capsule daily
Adults (18 years and over): take 1 capsule daily, with or without food, or as directed by a qualified health care practitioner.
Swallow whole
Do not crush, mix or blend capsules - swallow whole.
Stay consistent
Use daily as part of your routine; do not exceed the recommended dose except on the advice of a physician.
Choose your supply
Pick the 90-capsule (90-day) or 180-capsule (6-month) bottle to match how long you'd like your supply to last.
What the research says about Niacin No-Flush
Peer-reviewed studies on niacin, inositol hexanicotinate and inositol - shared for education, not as claims about this finished product. AOR Niacin No-Flush's own claims are the statements authorized under its Natural Health Product licence, NPN 80015111.
Meta-analysis: niacin improved the full lipid panel in type 2 diabetes
Pooling randomized controlled trials in adults with type 2 diabetes, niacin significantly raised HDL cholesterol (+0.27 mmol/L) and lowered LDL cholesterol (-0.25 mmol/L) and triglycerides (-0.39 mmol/L) versus control, though longer-term use modestly raised fasting glucose.
Meta-analysisNiacin's classic lipid effects confirmed, alongside a newer nuance in HDL protein composition
A 20-week study of extended-release niacin monotherapy reproduced niacin's typical lipid effects (HDL-C +16%, LDL-C -20%, triglycerides -15%) while also finding that niacin raised the HDL-associated inflammatory marker serum amyloid A - a reminder that modern research keeps refining, not abandoning, the classic niacin-lipid story.
Human studyFour decades of niacin as a lipid-lowering therapy, in perspective
A review tracing over 40 years of niacin research for cholesterol and cardiovascular risk argues that niacin's real lipid benefits (raising HDL, lowering LDL and triglycerides) are well established, and that differences in formulation, dose and dosing time - not the nutrient itself - explain why some later trials failed to show added cardiovascular benefit on top of statins.
ReviewHead-to-head trial: inositol hexanicotinate showed no measurable bioavailability
A blinded, placebo-controlled trial comparing wax-matrix extended-release niacin with inositol hexanicotinate ("no-flush" niacin), both at 1,500 mg/day, found extended-release niacin significantly improved cholesterol and triglycerides while inositol hexanicotinate performed no differently from placebo on lipids, with pharmacokinetic testing showing no evidence of niacin bioavailability from the inositol ester at that dose.
Human RCTA literature review of every commercial niacin form, including the inositol ester
A review for healthcare professionals compared free nicotinic acid, extended-release nicotinic acid, inositol hexanicotinate and nicotinamide, describing inositol hexanicotinate's chemistry (six niacin molecules bound to one inositol molecule) and summarizing the published risk and efficacy literature for each form.
ReviewThe biology behind why regular niacin causes flushing
A review of niacin-induced flushing describes how free nicotinic acid activates the receptor GPR109A, triggering a prostaglandin (PGD2) signaling cascade that dilates skin blood vessels and produces the classic warmth and redness - the specific reaction that slow-releasing niacin esters like inositol hexanicotinate are formulated to avoid triggering as abruptly.
ReviewRaising HDL cholesterol, including with niacin, has not clearly reduced cardiovascular risk
A 2026 review of HDL cholesterol's role in cardiovascular disease notes that pharmacologic strategies aimed at raising HDL-C, including niacin, have not demonstrated clear cardiovascular benefit in large trials, reframing HDL-C as a heterogeneous biomarker rather than a treatment target in its own right.
ReviewExtended-release niacin lowered lipoprotein(a) by reducing its production
In a crossover study using tracer kinetics, extended-release niacin lowered triglycerides, raised HDL cholesterol and reduced circulating lipoprotein(a) by 20%, because the rate the body produced new lipoprotein(a) particles fell further (50%) than the rate it cleared them slowed (37%).
Human studyIn a real-world statin-treated cohort, niacin use did not predict residual heart-disease risk
Building a 5-year cardiovascular risk model from the AIM-HIGH trial cohort of statin-treated adults with existing cardiovascular disease, researchers found factors like lipoprotein(a), sex and family history predicted residual risk, while niacin treatment status did not enter the final model.
Cohort studyInositol reduced obsessive-compulsive symptoms in a controlled crossover trial
Thirteen patients with obsessive-compulsive disorder completed a double-blind, placebo-controlled crossover trial of 18 g/day of inositol; scores on the Yale-Brown Obsessive Compulsive Scale were significantly lower while taking inositol than while taking placebo.
Human RCTA research group's own series of controlled inositol trials, across seven conditions
Summarizing a series of double-blind, placebo-controlled trials from one research group, inositol (12-18 g/day) showed significant benefit versus placebo for depression, panic disorder and obsessive-compulsive disorder, with minimal side effects, but no benefit for schizophrenia, Alzheimer's disease, ADHD, autism or ECT-related memory loss.
ReviewMeta-analysis found no overall significant effect of inositol on mood, with a signal in PMDD
Pooling 7 randomized trials in depression and 4 in anxiety disorders, a meta-analysis found no statistically significant overall effect of inositol on depressive, anxiety or obsessive-compulsive symptoms, though inositol showed a trend toward more treatment responders in depression and toward superior benefit specifically in premenstrual dysphoric disorder.
Meta-analysisA fatal case of liver injury tied to high-dose, self-initiated extended-release niacin
A case report describes a patient hospitalized with acute decompensated cirrhosis after self-initiating large quantities of extended-release niacin without medical supervision - a reminder that over-the-counter niacin's easy availability can mask its potential for serious liver injury at high, unsupervised doses.
Case reportAcute liver failure after switching a patient from immediate- to extended-release niacin
A 74-year-old woman developed acute liver failure with a distinctive pattern of fatty liver injury after her home dose of immediate-release niacin was replaced with an extended-release formulation during a hospital stay - a case the authors say points to mitochondrial impairment as the likely mechanism of niacin-related liver toxicity.
Case reportLiver enzyme elevations after niacin misuse at high, non-medical doses
A case report describes marked liver enzyme elevations in a patient who took over-the-counter sustained-release niacin at high doses in an attempt to alter a urine drug test result; enzymes returned to normal after stopping the niacin.
Case reportWhy "no-flush" niacin supplements may not deliver niacin's studied lipid effects
A review contrasting prescription niacin products with over-the-counter dietary-supplement forms notes that immediate-release and extended-release supplement niacin can show a real lipid response in trials, but products marketed as "no-flush" or "flush-free" generally contain minimal or no free, pharmacologically active niacin and therefore lack the lipid-modifying effects seen with other niacin forms.
ReviewImmediate-release and extended-release niacin affect LDL particle size differently
In a randomized trial of 180 people with high cholesterol, both high-dose immediate-release niacin (3,000 mg/day) and extended-release niacin (1,500 mg/day) shifted small, dense LDL particles toward larger, less atherogenic sizes, with the two forms and doses showing differing magnitudes of effect depending on a person's starting LDL particle pattern.
Human RCTSwitching brands of extended-release niacin left lipids and liver enzymes essentially unchanged
A retrospective review of 142 patients switched from branded to generic extended-release niacin (Niaspan to Slo-Niacin) found no significant change in liver transaminase levels, LDL or triglycerides, with only a small, statistically significant rise in HDL cholesterol on the generic formulation.
Retrospective studyHow niacin's discovery solved the mystery of pellagra
A historical review traces how early-20th-century epidemiologist Joseph Goldberger's studies of pellagra, a once-widespread deficiency disease, led to the recognition of niacin as an essential vitamin - foundational work behind why niacin is classified as a vitamin today.
Historical reviewVitamin B3's role as the backbone of NAD, a cell's central energy coenzyme
A foundational review describes how niacin (vitamin B3) is converted in the body into nicotinamide adenine dinucleotide (NAD), the coenzyme that shuttles electrons in hundreds of energy-metabolism reactions, tracing over a century of research into this core biochemical role.
ReviewA modern case of pellagra shows why niacin remains an essential nutrient
A recent case report describes an adult who developed a full pellagra syndrome - rash, digestive symptoms and neuropsychiatric decline - after years on a restrictive diet low in niacin, with rapid, complete recovery once niacin and B-vitamin supplementation began.
Case reportHDL response to niacin varies by person, even at the same 500 mg dose
Studying niacin extended-release specifically at the 500 mg dose in 834 adults, researchers found baseline HDL cholesterol level was the strongest predictor of response, with both men and women who started with low HDL cholesterol far more likely to be high responders to treatment.
Human studyDose-titrated extended-release niacin, up to 1,500 mg/day, tested in a controlled trial
A placebo-controlled trial titrated extended-release niacin upward in 500 mg increments to a maximum of 1,500 mg/day - the same titration structure commonly used in niacin dosing research - to study its effects on HDL cholesterol and vascular function in adults with low HDL levels.
Human RCTVery low daily doses of niacin were titrated upward in a dialysis study
A randomized trial in patients on dialysis titrated nicotinic acid from 25 mg/day up to 100 mg/day over 8 weeks based on response, showing niacin dosing research spans a wide range - from these low doses studied for phosphorus control up to the much higher gram-level doses studied for cholesterol.
Human RCTFrequently asked questions
What is AOR Niacin No-Flush?
A Natural Health Product providing 550 mg of inositol hexanicotinate per capsule - an ester form of niacin (vitamin B3) bound to inositol - supplying 500 mg of niacin and 121 mg of inositol per capsule. Licensed NPN 80015111.
What does "no-flush" mean?
Regular niacin (nicotinic acid) can cause a temporary flushing reaction - itchy, burning, warm or red skin. Inositol hexanicotinate is a different, ester form of niacin that has not been associated with this flush.
How do I take it?
Adults (18 years and over): take 1 capsule daily, with or without food, or as directed by a qualified health care practitioner. Do not exceed the recommended dose except on the advice of a physician. Do not crush, mix or blend capsules - swallow whole.
What's the difference between the 90-capsule and 180-capsule bottles?
Both are the same 550 mg inositol hexanicotinate formula at the labelled 1-capsule-daily dose. The 90-capsule bottle is a 90-day supply and the 180-capsule bottle is a 6-month supply, so you can choose based on how long you'd like your supply to last.
Does it also provide inositol?
Yes - each capsule's 550 mg of inositol hexanicotinate provides 121 mg of inositol alongside the 500 mg of niacin, since the compound is niacin chemically bound to inositol.
Is it vegan and allergen-friendly?
Yes - vegan hypromellose capsules, non-GMO and gluten-free, with only two non-medicinal ingredients (microcrystalline cellulose, sodium stearyl fumarate).
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Get niacin's benefits without the flush
Get AOR Niacin No-Flush on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80015111. Niacin No-Flush provides 550 mg of inositol hexanicotinate per capsule (500 mg niacin + 121 mg inositol). The research summaries below concern niacin, inositol hexanicotinate and inositol generally and are educational - they are not claims about this finished product. Read and follow the label. Do not exceed the recommended dose except on the advice of a physician. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not exceed the recommended dose except on the advice of a physician or qualified health care practitioner. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Indications
Recommended Use or Purpose: Niacin No-Flush is inositol hexanicotinate, an ester of the B vitamin niacin. Regular niacin can cause unpleasant side effects such as itchy, burning skin - the niacin "flush". Inositol hexanicotinate has not been associated with the niacin "flush". Niacin is a factor in the maintenance of good health, normal growth and development. Licensed Natural Health Product, NPN 80015111.
Ingredients
Medicinal Ingredient (per 1 capsule): Inositol Hexanicotinate 550 mg [providing Niacin (vitamin B3) 500 mg, Inositol 121 mg]. Non-medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: Hypromellose. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and over): Take 1 capsule daily, with or without food, or as directed by a qualified health care practitioner. Do not exceed the recommended dose except on the advice of a physician. Do not crush, mix or blend capsules; swallow capsules whole.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.