AOR MSM 1000mg - Methylsulfonylmethane for Joint Comfort | 100-200 Caps
Visit the AOR Store| Brand | AOR |
| Dose | 1 capsule, 3 times daily, with food |
| Licensed Natural Health Product | NPN 80004411 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- PURE 1000 MG MSM PER CAPSULE: Each vegan capsule delivers 1000 mg of methylsulfonylmethane (MSM), a naturally occurring organosulfur compound, with no unnecessary fillers.
- LICENSED JOINT-COMFORT CLAIM: A Health Canada licensed Natural Health Product (NPN 80004411) - evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis.
- A NATURAL SOURCE OF DIETARY SULFUR: MSM supplies sulfur, an element involved in the body's production of collagen - promoting healthy skin alongside its joint-comfort role.
- SUPPORTS OVERALL JOINT MOBILITY: Formulated to help support joint comfort and everyday mobility and flexibility as part of a daily routine.
- SIMPLE DAILY DOSE: Take 1 capsule 3 times daily with food. Avoid taking at bedtime. Use for a minimum of 4 weeks to see beneficial effects.
- VEGAN, NON-GMO AND GLUTEN-FREE: A vegan hypromellose capsule with no animal-derived ingredients, formulated to be non-GMO and gluten-free.
- TWO CONVENIENT SIZES: Available in a 100-capsule (33-day supply) or 200-capsule (66-day supply) bottle - both the same NPN 80004411 formula, at 1000 mg of MSM per capsule.
- MADE IN CANADA, LICENSED QUALITY: Manufactured for AOR - Advanced Orthomolecular Research, Calgary, Alberta - in a GMP-compliant facility and licensed by Health Canada under NPN 80004411.
Product description
AOR MSM - pure methylsulfonylmethane for joint comfort
A closer look at AOR MSM - 1000 mg of pure methylsulfonylmethane (MSM) per vegan capsule. Licensed Natural Health Product, NPN 80004411. Evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis. Licensed Natural Health Product NPN 80004411.
Un regard plus approfondi sur AOR MSM - 1000 mg de méthylsulfonylméthane (MSM) pur par capsule végétalienne. Produit de santé naturel homologué, NPN 80004411. Des preuves démontrent que le MSM peut jouer un rôle dans le soulagement de la douleur articulaire associée à l'arthrose.
One Pure Sulfur Compound, Studied for Joint Comfort
1000 mg of methylsulfonylmethane (MSM) in a single vegan capsule - no other medicinal ingredients.
Methylsulfonylmethane (MSM)
1000 mg of pure MSM per capsule - an organosulfur compound naturally present in small amounts in fruits, vegetables and grains, and formed naturally in the body.
The AOR difference
A single-ingredient, vegan capsule with no unnecessary fillers, made in Canada to GMP standards and licensed by Health Canada.
What AOR MSM Supports
MSM is a naturally occurring source of dietary sulfur - here is what AOR MSM is formulated to support.
Joint Comfort
Evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis.
Healthy Skin
MSM supplies sulfur, involved in the body's production of collagen - promoting healthy skin.
Connective Tissue Function
Provides sulfur to support the connective tissue that cushions and supports the joints.
Overall Mobility
Formulated to support overall joint health and everyday mobility and flexibility.
AOR MSM: Supplement Facts
Medicinal Ingredient (per capsule)
- Methylsulfonylmethane (MSM) vegan, synthetic1000 mg
Non-Medicinal Ingredients: Non-medicinal Ingredients: Sodium stearyl fumarate, silica. Capsule: hypromellose.
Recommended Use or Purpose (NPN 80004411): Evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis.
Recommended Dose (Adults 18 years and older): Take 1 capsule 3 times daily with food, or as directed by a qualified health care practitioner. Avoid taking at bedtime. Use for a minimum of 4 weeks to see beneficial effects. Do not crush, mix or blend capsules; swallow whole.
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms worsen. You may experience mild gastrointestinal discomfort, such as bloating, constipation or indigestion. Avoid taking at bedtime. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Ingrédient médicinal (par capsule)
- Méthylsulfonylméthane (MSM) végétalien, synthétique1000 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Stéarylfumarate de sodium, silice. Capsule : hypromellose.
Usage ou fins recommandés (NPN 80004411) : Des preuves démontrent que le MSM peut jouer un rôle dans le soulagement de la douleur articulaire associée à l'arthrose.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule 3 fois par jour avec de la nourriture, ou selon les directives d'un professionnel de la santé qualifié. Éviter de prendre au coucher. Utiliser pendant au moins 4 semaines pour constater les effets bénéfiques. Ne pas écraser, mélanger ou broyer les capsules; avaler entières.
Mises en garde et précautions : Consultez un praticien de soins de santé avant l'utilisation si vous êtes enceinte ou si vous allaitez. Consultez un praticien de soins de santé si les symptômes s'aggravent. Vous pourriez souffrir d'un léger inconfort gastro-intestinal, comme des ballonnements, de la constipation ou de l'indigestion. Éviter de prendre au coucher. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec.
NPN 80004411
Ease into joint comfort, the simple way
Get AOR MSM on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR MSM
One pure, well-studied sulfur compound - here is what it is formulated to support.
Joint Comfort
Evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis.
Healthy Skin
MSM's sulfur content is involved in the body's production of collagen, promoting healthy skin.
Single-Ingredient Purity
1000 mg of MSM per capsule, with no other medicinal ingredients - simple to understand, simple to take.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, Calgary, Alberta, since 1991. Vegan, non-GMO, gluten-free, GMP-manufactured.
How to use
Take with food
Adults 18 years and older: take 1 capsule 3 times daily with food, or as directed by a qualified health care practitioner.
Avoid at bedtime
Avoid taking MSM at bedtime.
Swallow whole
Do not crush, mix or blend capsules - swallow them whole with water.
Give it time
Use for a minimum of 4 weeks of consistent use to see beneficial effects.
What the research says about MSM
Peer-reviewed studies and reviews on the ingredient MSM (methylsulfonylmethane) - shared for education, not as claims about this finished product. AOR MSM's claims are the statements authorized under its Natural Health Product licence, NPN 80004411.
The foundational MSM osteoarthritis trial
In a 12-week pilot trial, 50 adults with knee osteoarthritis took 3 g of MSM twice daily (6 g/day) or placebo. MSM produced significant decreases in WOMAC pain and physical-function impairment, and improved daily-activity scores, versus placebo.
Human RCTImproved knee-related quality of life over 12 weeks
In an 88-person randomized, double-blind, placebo-controlled trial, healthy adults with mild knee pain who took 2,000 mg of MSM daily for 12 weeks showed a significantly better total score on the Japanese Knee Osteoarthritis Measure (JKOM) than the placebo group.
Human RCTA null result when used preventively in young trainees
In 180 military initial-entry trainees aged 18-40, 3 g of MSM daily for 8 weeks did not significantly improve knee-outcome or mood-state scores versus placebo - though the dose was reported as safe. A reminder that MSM's studied benefit is for existing osteoarthritis pain, not injury prevention in young, healthy joints.
Human RCTDampens a key inflammatory signaling pathway
In human monocytes exposed to a bacterial inflammatory trigger (LPS), natural sulfur compounds including MSM suppressed activation of the TLR4/NF-kB signaling pathway and reduced reactive-oxygen-species generation and DNA damage.
Lab studyReduces inflammatory cytokines in skin cells
In cultured human skin fibroblasts, MSM and a related natural sulfur compound inhibited LPS-triggered NF-kB signaling and reduced the inflammatory cytokines COX-2, IL-1beta and IL-6, alongside lower oxidative DNA damage.
Lab studyReduced oxidative-stress effects in an animal model
In mice exposed to alcohol and circadian disruption, MSM administration reduced anxiety-like behavior and was associated with improved markers of oxidative stress and inflammation, illustrating its antioxidant activity outside the joint.
Animal studyA trend toward less soreness, a rise in antioxidant capacity
In a pilot study, 8 moderately trained men took 1.5 g or 3 g of MSM daily for 30 days around muscle-damaging knee-extension exercise. The 3 g dose showed a trend toward less muscle soreness and a significant rise in blood antioxidant capacity (TEAC) after exercise.
Human RCTClinically meaningful pain reduction after a half-marathon
In a placebo-controlled trial around a half-marathon, 3 g/day of MSM did not significantly change lab markers of oxidative stress or muscle damage, but the MSM group saw a clinically meaningful (though not statistically significant) reduction in post-race muscle and joint pain.
Human RCTLower muscle-damage markers after a 14 km run
Healthy young men who took MSM for 10 days before a 14 km run showed significantly lower post-exercise creatine kinase and bilirubin (markers of muscle damage) and significantly higher total antioxidant capacity than the placebo group.
Human RCTReduced visible signs of skin aging over 16 weeks
Across two human studies (a 20-person pilot and a 63-person dose-response study), oral MSM at 1 g or 3 g per day for 16 weeks significantly reduced facial wrinkles and skin roughness and improved skin firmness, elasticity and hydration versus placebo - even at the lower 1 g/day dose.
Human studyProtected skin structure against UV damage in mice
In hairless mice exposed to 6 weeks of UVB irradiation, MSM reduced the wrinkle score and epidermal thickening, and preserved more collagen and elastic-fiber structure than the UV-damaged control group.
Animal studyA cell-level look at sulfur's role in skin biology
In cultured melanocytes, MSM activated the JNK signaling pathway and increased melanin production - a mechanism the researchers suggest could be explored for pigment-related skin conditions, illustrating sulfur's broader role in skin cell biology.
Lab studyA well-tolerated, GRAS-recognized supplement
A review of MSM research across animal models and human trials describes it as a Generally Recognized As Safe (GRAS) substance that is well tolerated by most people at daily doses of up to 4 g, with few and typically mild side effects.
ReviewNo evidence of liver toxicity in an animal safety study
Mice given MSM-containing water for 17 days showed no evidence of liver toxicity and no induction of liver-metabolizing (cytochrome P450) enzymes, including when combined with a cannabidiol-rich cannabis extract in the same study.
Animal studyLow potential for interactions with other medications
Testing MSM alongside glucosamine and chondroitin sulfate in human liver microsomes found no significant inhibition of seven major drug-metabolizing (cytochrome P450) enzymes, suggesting a low potential for interactions with commonly co-administered osteoarthritis medications.
Lab studyOne of 20 supplements assessed for osteoarthritis
A systematic review and meta-analysis of 69 trials covering 20 dietary supplements for hand, hip or knee osteoarthritis found MSM among six supplements (alongside undenatured type II collagen, glucosamine and chondroitin) with a statistically significant, if not always clinically large, short-term pain benefit versus placebo.
Systematic reviewAdding MSM to a joint-support combination sped up relief
In a 100-patient randomized comparative study of knee osteoarthritis, a chondroitin-glucosamine-hyaluronate combination with added MSM produced faster patient- and physician-reported improvement than the same type of combination without MSM, though both formulas significantly reduced pain over 4 months.
Human RCTAn MSM-containing combination matched a standard regimen
A 70-patient randomized study compared a combination of undenatured type II collagen, Boswellia serrata, MSM and vitamins C/D against standard glucosamine hydrochloride plus chondroitin sulfate for knee osteoarthritis; the MSM-containing combination was not inferior in efficacy over 6 months, with a greater reduction in morning stiffness.
Human RCTMSM is a natural product of the body's own sulfur metabolism
A review of microbial-mammalian co-metabolism traces how gut microbiota help convert dietary sulfur compounds into dimethyl sulfone (MSM) - showing MSM is a naturally occurring part of the human metabolome, not solely a manufactured additive.
ReviewHow the body forms MSM from a related sulfur compound
A classic primate study found that an orally dosed, related sulfur compound (dimethyl sulfoxide) is converted in the body to dimethyl sulfone (MSM), which then circulates with a blood half-life of about 38 hours before being cleared - part of the metabolic pathway that produces MSM in vivo.
Animal studyThe molecular structure behind sulfur's natural cycle
Structural biology research solved the crystal structure of a bacterial enzyme that breaks down dimethyl sulfone as part of environmental sulfur cycling, giving scientists a detailed molecular picture of how this simple organosulfur compound is processed in nature.
Lab studyHow quickly MSM is absorbed and cleared
A radiolabeled pharmacokinetic study in rats found orally dosed MSM was rapidly absorbed (peak blood levels at about 2.1 hours), distributed fairly evenly through soft tissues, and almost entirely eliminated in urine within 120 hours - supporting a rationale for regular daily dosing.
Animal studyWell tolerated across a range of doses
A dose-ranging animal study found typical dietary-supplement-range doses of MSM caused no meaningful changes in blood chemistry, with only the highest tested doses (well above typical human supplemental intake) producing minor, transient blood-count shifts; daily dosing for 21 days caused no adverse effects on growth, and MSM was detected even in untreated control animals, confirming the body makes some MSM on its own.
Animal studyNo interaction when combined with other joint-support ingredients
A human crossover study found that when MSM was taken together with Boswellia serrata, curcumin and pine bark extract - other ingredients commonly found in joint-support supplements - there were no significant changes in the pharmacokinetics of any ingredient compared with taking them alone.
Human PK studyFrequently asked questions
What is AOR MSM for?
It is a Health Canada licensed Natural Health Product (NPN 80004411). Evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis.
What is in each capsule?
Each vegan capsule provides 1000 mg of Methylsulfonylmethane (MSM), plus sodium stearyl fumarate and silica as non-medicinal ingredients. The capsule shell is hypromellose.
How do I take it?
Adults 18 years and older: take 1 capsule 3 times daily with food, or as directed by a qualified health care practitioner. Avoid taking at bedtime. Use for a minimum of 4 weeks to see beneficial effects.
Who should check with a health care practitioner before use?
Consult a health care practitioner before use if you are pregnant or breastfeeding, or if symptoms worsen while using this product. Mild gastrointestinal discomfort, such as bloating, constipation or indigestion, may occur.
What size options are available?
AOR MSM comes in a 100-capsule (33-day supply) and a 200-capsule (66-day supply) bottle - both the same NPN 80004411 formula, at 1000 mg of MSM per capsule and the same recommended dose.
Is it vegan?
Yes. Both the MSM and the hypromellose capsule shell are vegan - the formula is also non-GMO and gluten-free, with no animal-derived ingredients.
Is it made in Canada?
Yes. It is manufactured for Advanced Orthomolecular Research (AOR), Calgary, Alberta, and licensed by Health Canada under NPN 80004411.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Ease into joint comfort, the simple way
Get AOR MSM on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80004411. Evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis. The research summaries below concern the ingredient MSM (methylsulfonylmethane) and are educational - they are not claims about this finished product. Read and follow the label. Consult a health care practitioner before use if you are pregnant or breastfeeding, or if symptoms worsen. Mild gastrointestinal discomfort may occur. Avoid taking at bedtime. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms worsen. You may experience mild gastrointestinal discomfort, such as bloating, constipation or indigestion. Avoid taking at bedtime. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Indications
Recommended Use or Purpose (NPN 80004411): Evidence supports a role for MSM in helping to relieve joint pain associated with osteoarthritis.
Ingredients
Medicinal Ingredient (per capsule): Methylsulfonylmethane (MSM) 1000 mg. Non-medicinal Ingredients: Sodium stearyl fumarate, silica. Capsule: hypromellose. Non-medicinal ingredients are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule 3 times daily with food, or as directed by a qualified health care practitioner. Avoid taking at bedtime. Use for a minimum of 4 weeks to see beneficial effects. Do not crush, mix or blend capsules; swallow whole.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.