AOR MSM + Glucosamine - Vegan Joint Support Formula | 100-200 Caps
Visit the AOR Store| Brand | AOR |
| Dose | 1 capsule, 3 times daily with food |
| Licensed Natural Health Product | NPN 80009176 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- TWO JOINT-HEALTH NUTRIENTS IN ONE CAPSULE: Each vegan capsule provides 500 mg of Methylsulfonylmethane (MSM) and 500 mg of Glucosamine Sulfate KCl - two widely used joint-health nutrients combined so there's no need to take separate pills.
- VEGAN - NOT SHELLFISH-DERIVED: The glucosamine sulfate in this formula is a vegan-sourced KCl salt - not derived from shellfish - an option for people who prefer to avoid animal- or shellfish-derived ingredients.
- LICENSED CARTILAGE & JOINT-PAIN RELIEF CLAIMS: A Health Canada licensed Natural Health Product (NPN 80009176) that helps protect against the deterioration of cartilage, helps relieve joint pain associated with osteoarthritis, and is a factor in maintaining healthy cartilage and joint health.
- SIMPLE DAILY DOSE: Take 1 capsule 3 times daily with food. Avoid taking at bedtime. Allow a minimum of 1 month of consistent use to see beneficial effects.
- TWO SIZES TO MATCH YOUR SUPPLY: Available in a 100-capsule bottle (a 33-day supply) or a 200-capsule bottle (a 66-day supply) - same formula, same dose per capsule.
- NON-GMO AND GLUTEN-FREE: Non-GMO and gluten-free vegan capsules (hypromellose), manufactured in a GMP-compliant facility.
- FOR ACTIVE LIFESTYLES: A daily formula for people who want to stay active - through sports, exercise or everyday movement - while supporting their joints along the way.
- MADE IN CANADA, LICENSED QUALITY: Manufactured for AOR - Advanced Orthomolecular Research, Calgary, Alberta - and licensed by Health Canada under NPN 80009176.
Product description
AOR MSM + Glucosamine - vegan dual-action joint support
A closer look at AOR MSM + Glucosamine - Methylsulfonylmethane and Glucosamine Sulfate KCl together in one vegan capsule, not derived from shellfish. Licensed Natural Health Product, NPN 80009176. Licensed Natural Health Product NPN 80009176.
Un regard plus approfondi sur AOR MSM + Glucosamine - méthylsulfonylméthane et sulfate de glucosamine KCl (végétalien) réunis dans une seule capsule végétalienne. Produit de santé naturel homologué, NPN 80009176.
Two Joint-Health Nutrients, One Vegan Capsule
Methylsulfonylmethane (MSM) and Glucosamine Sulfate KCl together in a single vegan capsule - not derived from shellfish.
Methylsulfonylmethane (MSM)
500 mg of MSM per capsule - an organosulfur compound studied for helping relieve joint pain associated with osteoarthritis.
Glucosamine Sulfate KCl (vegan)
500 mg of vegan-sourced glucosamine sulfate per capsule - made without shellfish, a common source for other glucosamine products.
Advanced Ingredients, Superior Results
Each vegan capsule combines two widely used joint-health nutrients - MSM and glucosamine sulfate.
Methylsulfonylmethane (MSM)
An organosulfur compound and dietary source of sulfur, studied for helping to relieve joint pain associated with osteoarthritis.
500 mg per capsule
Glucosamine Sulfate KCl
A vegan-sourced (non-shellfish), potassium-chloride-stabilized form of glucosamine sulfate - a natural building block of cartilage and joint fluid.
500 mg per capsule - vegan, not shellfish-derivedAOR MSM + Glucosamine: Supplement Facts
Medicinal Ingredients (per capsule)
- Methylsulfonylmethane (MSM)500 mg
- Glucosamine Sulfate KCl vegan500 mg
Non-Medicinal Ingredients: Ascorbyl palmitate, sodium stearyl fumarate. Capsule: hypromellose.
Recommended Use or Purpose (NPN 80009176): Helps to protect against the deterioration of cartilage. Methylsulfonylmethane (MSM) helps to relieve joint pain associated with osteoarthritis. Glucosamine sulfate is a factor in maintaining healthy cartilage and joint health.
Recommended Dose (Adults 18 years and older): Take 1 capsule three times daily with food. Avoid taking at bedtime. Use for a minimum of 1 month (4 weeks) to see beneficial effects. Do not mix, crush or blend capsules; swallow whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Cautions and Warnings: Allergens: contains a corn-derived ingredient - do not use if you have a corn allergy. Do not use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms worsen or if an allergic reaction occurs. Some people may experience mild gastrointestinal bloating, constipation or indigestion. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Ingrédients médicinaux (par capsule)
- Méthylsulfonylméthane (MSM)500 mg
- Sulfate de glucosamine KCl végétalien500 mg
Ingrédients non médicinaux : Palmitate d'ascorbyle, stéarylfumarate de sodium. Capsule : hypromellose.
Usage ou fins recommandés (NPN 80009176) : Aide à protéger contre la détérioration du cartilage. Le méthylsulfonylméthane (MSM) aide à soulager les douleurs articulaires liées à l'arthrose. Le sulfate de glucosamine contribue au maintien d'un cartilage sain et à la santé des articulations.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule trois fois par jour avec de la nourriture. Éviter de prendre au coucher. Utiliser pendant au moins 1 mois (4 semaines) pour constater les effets bénéfiques. Ne pas écraser, broyer ni mélanger les capsules; avaler les capsules entières. Ne pas dépasser la dose quotidienne recommandée sauf indication contraire d'un professionnel de la santé.
Mises en garde : Allergènes : contient un ingrédient dérivé du maïs - ne pas utiliser si vous êtes allergique au maïs. Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Consultez un professionnel de la santé si les symptômes s'aggravent ou si une réaction allergique se produit. Certaines personnes peuvent ressentir de légers ballonnements gastro-intestinaux, de la constipation ou une indigestion. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec.
NPN 80009176
Support your joints the simple way
Get AOR MSM + Glucosamine on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR MSM + Glucosamine
Two joint-health nutrients, in a vegan capsule not derived from shellfish.
Two Nutrients, One Capsule
500 mg MSM plus 500 mg Glucosamine Sulfate KCl per capsule - no separate pills to track.
Vegan Sourcing
Formulated without shellfish - the glucosamine sulfate is a vegan-sourced KCl salt, an option for those avoiding shellfish-derived or animal ingredients.
Licensed Joint-Health Claims
Helps protect against the deterioration of cartilage, helps relieve joint pain associated with osteoarthritis, and is a factor in maintaining healthy cartilage and joint health - the uses authorized under NPN 80009176.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, Calgary, Alberta, since 1991. Vegan, non-GMO, gluten-free, GMP-manufactured.
Inside every capsule
Two widely used joint-health nutrients - Methylsulfonylmethane (MSM) and Glucosamine Sulfate KCl - combined in one vegan capsule, not derived from shellfish.
How to use
Take with food
Adults 18 years or older: take 1 capsule 3 times daily with food, or as directed by a qualified health care practitioner.
Avoid at bedtime
Avoid taking this product at bedtime.
Swallow whole
Do not crush, blend or mix the capsules - swallow them whole with water.
Give it time
Allow a minimum of 1 month (4 weeks) of consistent use to see beneficial effects.
What the research says about the ingredients
Peer-reviewed studies and reviews on the individual ingredients in this formula - Methylsulfonylmethane (MSM) and glucosamine sulfate. Shared for education, not as claims about this finished product. AOR MSM + Glucosamine's claims are the statements authorized under its Natural Health Product licence, NPN 80009176.
A head-to-head trial of glucosamine, MSM, and the combination
In a 12-week randomized, double-blind, placebo-controlled trial in 118 people with mild-to-moderate knee osteoarthritis, glucosamine (500 mg) and MSM (500 mg) each improved pain and swelling versus placebo when taken alone - and the combination, taken three times daily, produced a larger decrease in pain and swelling than either ingredient alone, with a faster onset of effect.
Human RCTAdding MSM to a glucosamine-chondroitin formula
In a double-blind trial of 147 people with knee osteoarthritis, a glucosamine-chondroitin sulfate formula alone did not significantly improve WOMAC or pain scores versus placebo over 12 weeks, but the same formula with MSM added showed a significant improvement on both measures.
Human RCTA commercial glucosamine-chondroitin-MSM-hyaluronate formula in a 100-patient trial
A randomized, open-label trial of 100 people with knee osteoarthritis compared a chondroitin/glucosamine-hydrochloride/MSM/hyaluronate combination against a similar formula without MSM; both reduced pain over 4 months, with the MSM-containing formula showing a faster onset of symptom relief reported by patients and physicians.
Human RCTGlucosamine sulfate linked to less joint-space narrowing over the long term
In a network meta-analysis of 47 trials and over 22,000 people with knee osteoarthritis followed for a year or more, glucosamine sulfate was one of the few interventions associated with reduced pain and with improvement in radiographic joint-space narrowing versus placebo - though the authors noted large uncertainty around the exact size of the effect for every treatment studied.
Meta-analysisA systematic review finds glucosamine reduces pain versus placebo
A systematic review of 15 randomized controlled trials found glucosamine significantly reduced global pain (visual analogue scale) compared with placebo in knee osteoarthritis, with improvements also seen in WOMAC stiffness and physical-function scores; long-term use of glucosamine sulfate 1,500 mg/day was reported as generally well tolerated.
Systematic review146 studies on glucosamine and chondroitin's real-world use
A systematic review of 146 studies (nearly 60% randomized controlled trials) on glucosamine and/or chondroitin found over 90% of efficacy studies reported positive outcomes for osteoarthritis and joint pain, most commonly at daily doses of 1,500 mg glucosamine and 1,200 mg chondroitin, with a favorable safety profile across the studies reviewed.
Systematic reviewThe first placebo-controlled pilot trial of MSM alone for knee pain
In a 12-week pilot trial, adults with knee osteoarthritis pain who took MSM (3 g twice daily) showed significantly greater improvement in WOMAC pain and physical-function scores than those on placebo, with no major adverse events reported - though the authors cautioned that long-term benefit and safety would need confirmation in larger trials.
Human RCTMSM and exercise-related muscle soreness
In a placebo-controlled trial, recreational runners who took MSM before and after a half-marathon reported less exercise-induced muscle pain and showed markers of reduced oxidative stress compared with the placebo group - evidence for MSM's pain- and inflammation-related effects outside a joint-disease setting.
Human RCTHow MSM may act on bone-resorbing cells
In laboratory experiments on bone marrow-derived cells, MSM suppressed the RANKL signal that drives osteoclast formation (the cells that break down bone), acting through the NF-kB and STAT3 pathways - a proposed mechanism for MSM's role in joint and bone tissue.
Lab studyA glucosamine-related sugar tag is elevated in osteoarthritic cartilage
Cartilage from people with knee osteoarthritis showed increased O-linked N-acetylglucosamine (O-GlcNAc), a glucosamine-derived protein modification involved in cell signaling, compared with healthy cartilage - and the inflammatory signal IL-1 could trigger the same change in lab-cultured cartilage cells, pointing to a mechanistic link between glucosamine metabolism and cartilage changes in osteoarthritis.
Lab studyGlucosamine's protective effect on cartilage tissue in the lab
In bovine cartilage explants exposed to the inflammatory trigger IL-1alpha, glucosamine hydrochloride reduced the release of cartilage breakdown products and inflammatory markers, an effect not matched by chondroitin sulfate alone under the same conditions in this model.
Lab studyA glucosamine-MSM combination limited joint damage in an animal model
In rats with formalin-induced knee-joint damage, an orally-dosed combination of glucosamine hydrochloride, chondroitin sulfate and MSM reduced markers of oxidative damage and improved biochemical and tissue measures of cartilage health compared with untreated controls.
Animal studyA review of real-world safety reports for joint supplements
A systematic review of post-marketing safety surveillance studies on osteoarthritis treatments found that non-pharmaceutical-grade glucosamine and chondroitin products were associated, in cohort studies, with allergic reactions and gastrointestinal complaints - a reminder that manufacturing quality and grade can affect a supplement's real-world tolerability.
Systematic reviewA 627-patient trial's adverse-event profile for glucosamine plus chondroitin
In a 627-patient, 24-week trial of a fixed-dose glucosamine sulfate (1,500 mg) and chondroitin sulfate (1,200 mg) combination, the therapy was non-inferior to a reference product for pain relief, and the most frequently reported treatment-related adverse events across both groups were headache and changes in glucose tolerance.
Human RCTExamining glucosamine's safety for people with a seafood allergy
A published clinical report examined whether glucosamine supplements, which are sometimes manufactured from shellfish shells, pose a cross-reactivity risk for patients with a confirmed seafood allergy, using skin testing - part of the broader safety literature behind why some glucosamine products (including this vegan, non-shellfish-derived formula) specify their sourcing.
Case reportMSM plus boswellic acids compared with glucosamine sulfate
In a 120-person randomized trial, a combination of MSM (5 g/day) and boswellic acids (7.2 mg/day) was compared against glucosamine sulfate (1,500 mg/day) alone for knee arthritis; both approaches improved pain and joint function over 6 months, with a trend toward better results in the MSM/boswellic-acid group at the later follow-up.
Human RCTTwo major guidelines, two different views on glucosamine
A comparison of the 2019 ESCEO and OARSI clinical guidelines for knee osteoarthritis found they agree on exercise, education and weight loss as core treatments, but diverge on glucosamine and chondroitin: ESCEO recommends pharmaceutical-grade glucosamine and chondroitin sulfate, while OARSI recommends against their use - a reflection of genuinely differing expert interpretations of the same evidence base.
Guideline comparisonA meta-analysis of glucosamine plus chondroitin versus other treatments
A meta-analysis of 8 randomized trials (3,793 patients) found the glucosamine-chondroitin combination showed a statistically significant advantage in total WOMAC score versus placebo, with safety comparable across groups, while noting the number of high-quality combination trials remains limited.
Meta-analysisSulfur's basic role in the body, and where MSM fits in
A foundational review of sulfur in human nutrition describes methylsulfonylmethane as a naturally occurring source of dietary sulfur, part of the same sulfur cycle as the sulfur-containing amino acids the body uses to build connective tissue and other proteins.
ReviewComparing two ways of manufacturing glucosamine sulfate
A crossover pharmacokinetic study comparing chitosan-derived glucosamine sulfate (a shellfish-shell-derived source) against biofermentation-derived glucosamine sulfate (a non-shellfish, fermentation-based source) found the two sources produced comparable blood levels of glucosamine after a single dose, supporting biofermentation as a viable non-shellfish raw-material source for glucosamine supplements.
Human studyDoes the salt form of glucosamine sulfate change how it's absorbed?
A crossover pharmacokinetic study comparing crystalline glucosamine sulfate to regular glucosamine sulfate stabilized with potassium or sodium chloride found no statistically significant difference in blood levels of glucosamine or its metabolite between the two salt forms, challenging marketing claims that one salt form absorbs meaningfully better than the other.
Human RCTWhy glucosamine's real-world results can vary from brand to brand
A crossover study in healthy volunteers found meaningful differences in the pharmacokinetics of glucosamine between two commercially available products taken at the same 1,500 mg/day dose, helping explain why clinical-trial results for glucosamine have not always been consistent.
Human studyBlood glucosamine levels vary widely with regular use
In people with osteoarthritis already taking glucosamine long-term, steady-state blood glucosamine concentrations varied considerably between individuals at the same reported dose, a finding the researchers suggested may help explain inconsistent clinical outcomes across glucosamine studies.
Human studyTesting MSM's effects at human-equivalent and higher doses in animal models
A study in growing rats and in an osteoarthritis mouse model tested MSM at a dose scaled to match typical human supplement intake, as well as at higher multiples of that dose, to assess dose-related effects on cartilage and bone - part of the safety and dose-finding work behind MSM's use as a joint-supplement ingredient.
Animal studyFrequently asked questions
What is AOR MSM + Glucosamine for?
It is a Health Canada licensed Natural Health Product (NPN 80009176) that helps protect against the deterioration of cartilage, helps relieve joint pain associated with osteoarthritis, and is a factor in maintaining healthy cartilage and joint health.
What is in each capsule?
Each vegan capsule provides Methylsulfonylmethane (MSM) 500 mg and Glucosamine Sulfate KCl 500 mg, plus ascorbyl palmitate and sodium stearyl fumarate. The capsule shell is hypromellose.
Is the glucosamine shellfish-derived?
No. This product's glucosamine sulfate is a vegan-sourced KCl salt, not derived from shellfish, per the product label.
How do I take it?
Adults 18 years and older: take 1 capsule 3 times daily with food. Avoid taking at bedtime. Allow a minimum of 1 month to see beneficial effects.
Who should not use this product, or should check with a health care practitioner first?
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms worsen or if an allergic reaction occurs. Allergen note: this product contains a corn-derived ingredient.
What size options are available?
AOR MSM + Glucosamine comes in a 100-capsule (33-day supply) and a 200-capsule (66-day supply) bottle - both are the same NPN 80009176 formula, at 500 mg MSM and 500 mg Glucosamine Sulfate KCl per capsule.
Is it made in Canada?
Yes. It is manufactured for Advanced Orthomolecular Research (AOR), Calgary, Alberta, and licensed by Health Canada under NPN 80009176.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support your joints the simple way
Get AOR MSM + Glucosamine on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80009176. Helps to protect against the deterioration of cartilage. MSM helps to relieve joint pain associated with osteoarthritis, and glucosamine sulfate is a factor in maintaining healthy cartilage and joint health. This formula's glucosamine sulfate is a vegan KCl salt, not derived from shellfish. The research summaries below concern the individual ingredients (MSM and glucosamine sulfate) and are educational - they are not claims about this finished product. Read and follow the label. Do not use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms worsen or if an allergic reaction occurs. Contains a corn-derived ingredient. Allow a minimum of 1 month to see beneficial effects. Results may vary.
Important information
Safety Information
Cautions and Warnings: Allergens: contains a corn-derived ingredient - do not use if you have a corn allergy. Do not use if you are pregnant or breastfeeding. Consult a health care practitioner if symptoms worsen or if an allergic reaction occurs. Some people may experience mild gastrointestinal bloating, constipation or indigestion. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Indications
Recommended Use or Purpose (NPN 80009176): Helps to protect against the deterioration of cartilage. Methylsulfonylmethane (MSM) helps to relieve joint pain associated with osteoarthritis. Glucosamine sulfate is a factor in maintaining healthy cartilage and joint health.
Ingredients
Medicinal Ingredients (per capsule): Methylsulfonylmethane 500 mg; Glucosamine Sulfate KCl (vegan) 500 mg. Non-medicinal Ingredients: Ascorbyl palmitate, sodium stearyl fumarate. Capsule: hypromellose. Non-medicinal ingredients are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule three times daily with food. Avoid taking at bedtime. Use for a minimum of 1 month (4 weeks) to see beneficial effects. Do not mix, crush or blend capsules; swallow whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.