AOR Methyl B12 Lozenge 15mg - Sublingual Vitamin B12 Supplement | 60 Count
Visit the AOR Store| Brand | AOR |
| Serving | 15 mg (1 lozenge) |
| Licensed Natural Health Product | NPN 80025586 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- ULTRA-HIGH-DOSE SUBLINGUAL B12: 15 mg (15,000 mcg) of vitamin B12 as methylcobalamin in one easy-to-use lozenge that dissolves under the tongue - no capsule to swallow.
- HELPS PREVENT VITAMIN B12 DEFICIENCY: A source of vitamin B12 that helps prevent vitamin B12 deficiency - the licensed use of this Natural Health Product.
- SUPPORTS NERVE FUNCTION & ENERGY METABOLISM: Vitamin B12 plays a well-established role in healthy nerve function and in the body's energy metabolism.
- AIDS RED BLOOD CELL PRODUCTION: Vitamin B12 is essential for the normal formation of red blood cells.
- SUBLINGUAL, NOT SWALLOWED: Dissolve 1 to 3 unflavoured lozenges under the tongue first thing in the morning, with or without food.
- VEGAN, CLEAN FORMULA: Vegan, non-GMO and gluten-free, in a small unflavoured lozenge with a short non-medicinal ingredient list.
- UP TO A 2-MONTH SUPPLY: 60 lozenges per bottle - a 60-day supply at the standard 1-lozenge daily dose.
- PREMIUM CANADIAN QUALITY: Made in Canada in a GMP-compliant facility by Advanced Orthomolecular Research (AOR), licensed under Health Canada NPN 80025586.
Product Description
AOR Methyl B12 - Ultra-High-Dose Sublingual Vitamin B12
15 mg of vitamin B12 (as methylcobalamin) in a single sublingual lozenge that dissolves under the tongue - an ultra-high-dose, ready-to-use form of B12 formulated to be a source of vitamin B12 and help prevent vitamin B12 deficiency, while supporting healthy nerve function and the body's energy metabolism. Licensed Natural Health Product NPN 80025586.
15 mg de vitamine B12 (sous forme de méthylcobalamine) dans une seule pastille sublinguale qui se dissout sous la langue - une forme de B12 à dose ultra-élevée, prête à l'emploi, formulée pour être une source de vitamine B12 et aider à prévenir la carence en vitamine B12, tout en soutenant le fonctionnement normal du système nerveux et le métabolisme énergétique de l'organisme. Produit de santé naturel homologué. NPN 80025586.
AOR Methyl B12 - 15 mg Sublingual Lozenge
An ultra-high-dose, ready-to-use form of vitamin B12 - dissolves under the tongue, not swallowed.
Ultra-High-Dose Sublingual Lozenge
15 mg of methylcobalamin per lozenge, dissolved under the tongue rather than swallowed like a capsule.
Nerve Function & Energy Metabolism
Vitamin B12 supports healthy nerve function and plays a key role in the body's energy metabolism, alongside red blood cell formation.
Why Vitamin B12 Matters
Research supports vitamin B12's role across nerve health, energy metabolism, cognitive function and red blood cell production - here is what each benefit means.
Nerve Function Support
Vitamin B12 supports the healthy function of the nervous system.
Red Blood Cell Production
Vitamin B12 is essential for the normal formation of red blood cells.
Cognitive Health
Vitamin B12 supports normal cognitive function as part of a healthy nervous system.
Energy Metabolism
Vitamin B12 plays a key coenzyme role in the body's energy metabolism.
AOR Methyl B12 Lozenge: Supplement Facts
Each lozenge contains:
- Vitamin B12 (as Methylcobalamin)15 mg
Non-Medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate, xylitol, tapioca syrup, distilled water and hydroxypropylcellulose (hyprolose).
Recommended Use or Purpose: Methyl B12 - 15 mg is an ultra-high-dose formulation of methylcobalamin, which is a source of vitamin B12 and helps prevent vitamin B12 deficiency. Licensed Natural Health Product, NPN 80025586.
Recommended Dose (Adults 18 years and older): Dissolve 1 to 3 lozenges under the tongue first thing in the morning, with or without food, or as directed by a qualified health care practitioner. Do not exceed the recommended daily dose unless instructed by a health care practitioner.
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant or breastfeeding. Allergen: this product contains corn. Do not exceed the recommended dose unless instructed by a qualified health care practitioner. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque pastille contient :
- Vitamine B12 (sous forme de méthylcobalamine)15 mg
Ingrédients non médicinaux : Cellulose microcristalline, stéarylfumarate de sodium, xylitol, sirop de tapioca, eau distillée et hyprolose (hydroxypropylcellulose).
Usage ou fins recommandés : Méthyl B12 - 15 mg est une formulation à dose ultra-élevée de méthylcobalamine, qui est une source de vitamine B12 et aide à prévenir la carence en vitamine B12. Produit de santé naturel homologué, NPN 80025586.
Dose recommandée (adultes de 18 ans et plus) : Dissoudre 1 à 3 pastilles sous la langue dès le matin, avec ou sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Ne dépassez pas la dose quotidienne recommandée sauf indication contraire d'un professionnel de la santé.
Mises en garde et précautions : Consultez un professionnel de la santé avant l'utilisation si vous êtes enceinte ou si vous allaitez. Allergène : ce produit contient du maïs. Ne dépassez pas la dose recommandée sauf indication contraire d'un professionnel de la santé qualifié. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec. Garder hors de la portée des enfants.
NPN 80025586
Support nerve health & energy the easy way
Get AOR Methyl B12 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Methyl B12
An ultra-high-dose, sublingual form of vitamin B12 - premium AOR quality.
Ultra-High-Dose Methylcobalamin
15 mg of methylcobalamin per lozenge - the active, coenzyme form of vitamin B12.
Sublingual, Not Swallowed
Dissolves under the tongue rather than being swallowed whole like a capsule.
Nerve Function & Energy Metabolism
Vitamin B12 supports healthy nerve function and plays a key role in the body's energy metabolism.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, since 1991. NPN 80025586.
How to use
Let it dissolve under the tongue
Place 1 lozenge under the tongue first thing in the morning and let it dissolve completely - do not chew or swallow it whole.
With or without food
Take with or without food, whichever fits your morning routine.
Follow the recommended dose
Adults (18 years and older): dissolve 1 to 3 lozenges daily. Do not exceed the recommended dose unless directed by a qualified health-care practitioner.
Store it properly
Store tightly sealed in a cool, dry place, and do not use if the safety seal is broken.
What the research says about vitamin B12 (methylcobalamin)
Peer-reviewed studies and reviews on vitamin B12 and methylcobalamin - shared for education, not as claims about this finished product. AOR Methyl B12's claim is the statement authorized under its Natural Health Product licence, NPN 80025586.
Comparing B12 doses for diabetic nerve symptoms
A 16-week randomized trial in adults with diabetic peripheral neuropathy and low vitamin B12 found that both 1000 mcg and 2000 mcg daily oral methylcobalamin significantly improved neuropathy symptom scores, with the higher dose producing a greater rise in serum B12.
Human RCTMethylcobalamin supports nerve regeneration in injury models
In a rat brachial plexus injury model, early methylcobalamin treatment - alone or combined with low-intensity pulsed ultrasound - improved sensory and motor recovery and favourably modulated nerve-repair markers.
Animal studyPerineural B12 injection aids recovery after nerve injury
A preliminary clinical report described ultrasound-guided perineural vitamin B12 injection around an injured brachial plexus nerve root, with motor and sensory function in the arm improving over the following six months.
Case studySublingual B12 matches injections in a large meta-analysis
Pooling 16 studies and over 6,000 participants, a systematic review found sublingual and oral vitamin B12 raised serum cobalamin and lowered homocysteine to a similar degree as intramuscular injections, with no significant difference between routes.
Meta-analysisEngineering a longer-acting sublingual B12 tablet
Pharmaceutical researchers developed a mucoadhesive sublingual cyanocobalamin tablet designed to stay in place under the tongue for close to two hours, aiming to give the vitamin more time to cross the sublingual membrane.
Formulation studySublingual B12 corrected a deficiency without injections
A child with short-bowel syndrome and vitamin B12 malabsorption normalized low serum cobalamin after one month of daily sublingual B12, avoiding the monthly injections typically needed when the gut cannot absorb the vitamin normally.
Case reportB-vitamin supplementation improved exercise endurance
In a randomized, double-blind trial, 28 days of a vitamin B1/B2/B6/B12 complex improved running time to exhaustion and reduced blood lactate and ammonia during exercise compared with placebo, without adverse effects.
Human RCTPatients report more energy with high-dose B12
In interviews about their experience with high-dose methylcobalamin, patients consistently described increased energy, reduced fatigue and improved balance as the benefits they noticed most.
Qualitative studyB12 is a key cofactor in energy metabolism
A review of vitamins in inflammatory disease notes that vitamin B12 is vital for energy metabolism and neurological function, and that a B12 deficiency can worsen the fatigue patients already experience.
ReviewOral B12 lowers deficiency rates in a Cochrane review
A Cochrane review of 16 randomized trials in over 4,000 children found oral vitamin B12 supplementation - which supports DNA synthesis and red blood cell formation - reduced the rate of B12 deficiency and raised total B12 concentrations compared with placebo.
Meta-analysisWhy B12 shortfalls disrupt normal red cell production
An animal study showed that a functional cobalamin deficiency produces the hallmark features of megaloblastic anemia - abnormally large red blood cells, Howell-Jolly bodies and elevated homocysteine - illustrating B12's role in effective red blood cell production.
Animal studyReversing megaloblastic anemia with B12
A case report described an older adult with megaloblastic anemia and undetectable vitamin B12; blood counts and related iron markers returned to normal within three months of vitamin B12 supplementation.
Case reportDaily oral B12 was well tolerated over three months
A randomized trial comparing daily oral vitamin B12 with intermittent intramuscular injections over 90 days found both formulations were well tolerated, with only mild-to-moderate adverse effects reported.
Human RCTA rare reaction reported with intravenous B12
A published case report described anaphylactic shock following an intravenous methylcobalamin injection in a hospitalized patient, who recovered fully after emergency treatment - a reminder that even well-tolerated nutrients can rarely cause serious reactions by some routes.
Case reportWhy B12 fortification limits are set by cost, not toxicity
An analysis of vitamin fortification standards noted that, unlike folic acid, the ceiling on how much vitamin B12 can be added to foods is set mainly by cost rather than by safety concerns - reflecting the vitamin's wide margin of safety.
AnalysisOral methylcobalamin matched injections after gastrectomy
In gastric cancer patients with vitamin B12 deficiency after total gastrectomy, daily oral methylcobalamin normalized serum B12 and relieved neurologic symptoms as effectively as the standard intramuscular cyanocobalamin injection schedule.
Human studyHow the body processes different B12 forms
A review of cobalamin coenzyme forms found that methylcobalamin and adenosylcobalamin are processed through the same cellular pathway as cyanocobalamin before the body can use them, concluding neither coenzyme form has an inherent efficacy advantage for everyday deficiency prevention.
ReviewConverting cyanocobalamin into its active coenzyme forms
Laboratory research in human cells showed that cyanocobalamin must first be converted into methylcobalamin and adenosylcobalamin before the body's cobalamin-dependent enzymes can use it, and that this conversion step can itself be impaired during a deficiency.
Lab studyThe molecular machinery behind vitamin B12
A structural biology review mapped the transport proteins and enzymes - including intrinsic factor, transcobalamin, and the methionine synthase and methylmalonyl-CoA mutase enzymes - that capture, carry and activate vitamin B12 inside the body.
ReviewHow the body absorbs vitamin B12
A physiology review traces B12's journey from food: released in the stomach and bound to haptocorrin, handed off to intrinsic factor in the duodenum, then taken up by a dedicated receptor in the distal small intestine.
ReviewB vitamins and the biology of ageing
A review of the B-vitamin complex describes vitamin B12's role, alongside its sister B vitamins, in energy metabolism, DNA maintenance and immune function - and why adequate B12 status becomes more important with age.
ReviewA common diabetes medication raises B12 deficiency risk
Among more than 7,000 hospitalized older adults, metformin use was independently associated with a significantly higher, dose-dependent risk of vitamin B12 deficiency.
Cross-sectional studyWho is most likely to need extra B12
A clinical review notes that an increasing number of adults are at risk of vitamin B12 deficiency from reduced dietary intake or impaired gut absorption, and that the two causes call for different management approaches.
ReviewPernicious anemia often goes undiagnosed for years
A patient survey of nearly 1,200 people with pernicious anemia - an autoimmune cause of vitamin B12 deficiency - found more than a third waited three years or longer for a diagnosis, and nearly half also had another autoimmune condition.
Patient surveyFrequently asked questions
What is AOR Methyl B12 and what does it do?
AOR Methyl B12 provides 15 mg of vitamin B12 (as methylcobalamin) per lozenge. It is a source of vitamin B12 and helps prevent vitamin B12 deficiency.
Why is the dose so much higher than other B12 products?
This is an ultra-high-dose sublingual formulation. Vitamin B12 taken this way is absorbed largely by passive diffusion, and only a small fraction of a given dose is typically absorbed, which is why a 15 mg lozenge is formulated rather than a microgram-level dose.
How do I take it - do I swallow the lozenge?
No - this is a sublingual lozenge, not a capsule. Adults (18 years and older) dissolve 1 to 3 lozenges under the tongue first thing in the morning, with or without food, or as directed by a qualified health-care practitioner. Do not exceed the recommended dose unless instructed.
Is this the same as AOR BioFolate or other AOR B-vitamin products?
No. AOR Methyl B12 is a standalone, single-ingredient, high-dose methylcobalamin lozenge (NPN 80025586). It contains no folate/5-MTHF and is a different product, form and dose than AOR's folate-containing B-vitamin combination products.
Is it vegan and allergen-friendly?
The lozenge itself is vegan, non-GMO and gluten-free. Please note the label discloses that this product contains corn.
Who should check with a health-care practitioner before using it?
Consult a health-care practitioner before use if you are pregnant or breastfeeding.
Is it made in Canada?
Yes. It is manufactured in Canada by Advanced Orthomolecular Research (AOR) and licensed by Health Canada under NPN 80025586.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support nerve health & energy the easy way
Get AOR Methyl B12 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80025586. Methyl B12 is a source of vitamin B12 and helps prevent vitamin B12 deficiency. The research summaries below concern vitamin B12 (methylcobalamin) generally and are educational - they are not claims about this finished product. Read and follow the label. Consult a health-care practitioner before use if you are pregnant or breastfeeding. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant or breastfeeding. Allergen: this product contains corn. Do not exceed the recommended dose unless instructed by a qualified health care practitioner. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place. Keep out of reach of children.
Indications
Recommended Use or Purpose: Methyl B12 - 15 mg is an ultra-high-dose formulation of methylcobalamin, which is a source of vitamin B12 and helps prevent vitamin B12 deficiency. Licensed Natural Health Product, NPN 80025586.
Ingredients
Medicinal Ingredients (per lozenge): Vitamin B12 (as Methylcobalamin) 15 mg. Non-medicinal ingredients: Microcrystalline cellulose, sodium stearyl fumarate, xylitol, tapioca syrup, distilled water and hydroxypropylcellulose (hyprolose). Contains corn. Non-medicinal ingredients are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Dissolve 1 to 3 lozenges under the tongue first thing in the morning, with or without food, or as directed by a qualified health care practitioner. Do not exceed the recommended daily dose unless instructed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.