AOR Max Methyl 517mg - TMG Active Folate B12 & B6 for Methylation | 90 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 capsule (517 mg), 3 times daily |
| Licensed Natural Health Product | NPN 80026949 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- FOUR REAL METHYL DONORS IN ONE CAPSULE: 500 mg trimethylglycine (TMG/betaine), 267 mcg active folate (calcium L-5-MTHF), 216 mcg active B12 (methylcobalamin) and 17 mg active B6 (P5P) - combined for comprehensive methylation support.
- SUPPORTS HEALTHY HOMOCYSTEINE METABOLISM: Trimethylglycine (TMG/betaine) is a methyl donor studied for its role in the remethylation of homocysteine to methionine, a process linked to cardiovascular wellness.
- HELPS FORM RED BLOOD CELLS: Folate, vitamin B6 and vitamin B12 each help in the formation of red blood cells, factors in the maintenance of good health.
- ACTIVE, BIOAVAILABLE FORMS: Folate as calcium L-5-MTHF, vitamin B12 as methylcobalamin and vitamin B6 as pyridoxal-5-phosphate (P5P) - forms the body can use directly, without needing further conversion.
- THREE-TIMES-DAILY DOSING FOR STEADY SUPPORT: 1 capsule 3 times daily with or without food - 90 vegan capsules provide up to a 30-day supply at the standard dose.
- NERVOUS SYSTEM SUPPORT: Vitamin B6 and vitamin B12 each help maintain normal function of the nervous system.
- CLEAN VEGAN FORMULA: Vegan, non-GMO and gluten-free with no other non-medicinal ingredients, in a vegetarian hypromellose capsule.
- PREMIUM CANADIAN QUALITY: Made in Canada in a GMP-compliant facility by Advanced Orthomolecular Research (AOR), licensed under Health Canada NPN 80026949.
Product description
AOR Max Methyl - TMG, Active Folate, B12 & B6 for Methylation Support
A closer look at Max Methyl - trimethylglycine (TMG/betaine), bioactive folate (calcium L-5-MTHF), active B12 (methylcobalamin) and active B6 (P5P) combined in one vegan capsule, taken three times daily, made in Canada. Licensed Natural Health Product NPN 80026949.
Advanced Methylation Support
Four real methyl donors and cofactors - TMG, active folate, active B12 and active B6 - in one 517 mg vegan capsule.
Active, Ready-to-Use Forms
Folate as calcium L-5-MTHF, vitamin B12 as methylcobalamin and vitamin B6 as pyridoxal-5-phosphate (P5P) are already in the form the body uses, alongside trimethylglycine (TMG), a direct methyl donor.
Red Blood Cells & Nervous System Support
Folate, vitamin B6 and vitamin B12 each help form red blood cells, and vitamin B6 and B12 help maintain normal function of the nervous system.
Advanced Ingredients, Superior Results
Four real, active-form methyl donors and cofactors - here is what TMG, folate, B12 and B6 each contribute.
Trimethylglycine (TMG, Betaine)
A naturally occurring methyl donor that supplies a methyl group for the remethylation of homocysteine to methionine - an alternate pathway to the folate/B12 route, studied for supporting healthy homocysteine metabolism.
500 mg (as betaine anhydrous) per capsuleFolic Acid (Calcium L-5-MTHF)
A bioactive, ready-to-use form of folate that helps in the formation of red blood cells, helps prevent a folate deficiency, and helps reduce the risk of neural tube defects when taken daily before and during early pregnancy.
267 mcg per capsule
Vitamin B6 (Pyridoxal-5-Phosphate, P5P)
The active, coenzyme form of vitamin B6 that helps in energy metabolism and tissue formation, helps form red blood cells, and helps maintain normal function of the nervous system.
17 mg per capsuleVitamin B12 (Methylcobalamin)
The methylated, bioactive form of vitamin B12 that helps in energy metabolism, helps form red blood cells, and helps maintain normal function of the nervous system and immune function.
216 mcg per capsuleAOR Max Methyl: Supplement Facts
Each capsule contains:
- Trimethylglycine (betaine anhydrous)500 mg
- Folic acid (calcium L-5-MTHF)267 mcg
- Vitamin B6 (pyridoxal-5-phosphate)17 mg
- Vitamin B12 (methylcobalamin)216 mcg
Non-Medicinal Ingredients: None. Capsule: hypromellose.
Recommended Use or Purpose: Provides nutrients that help in tissue formation and the formation of red blood cells, which are factors in the maintenance of good health. Helps in the formation of red blood cells (folate, vitamin B6, vitamin B12). Helps in energy metabolism and tissue formation (vitamin B6, vitamin B12). Helps to maintain/support normal function of the nervous system (vitamin B6, vitamin B12). Helps to maintain/support immune function (vitamin B12). Helps to prevent a folate deficiency in individuals with a low intake. Helps to reduce the risk of neural tube defects and supports the normal development of the fetus (brain and spinal cord) when taken daily at least three months before becoming pregnant and during early pregnancy (folate). Licensed Natural Health Product, NPN 80026949.
Recommended Dose (Adults 18 years and older): Take 1 capsule three times daily with or without food, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules. Swallow the capsule whole. Do not exceed the recommended dose unless instructed by a health care practitioner.
Cautions and Warnings: Consult a health care practitioner before use if you have liver disease, if you are pregnant or breastfeeding, or if you have cardiovascular disease. Stop use and consult a health care practitioner if you develop symptoms of sensory nerve problems, such as numbness, tingling or pain in the extremities. Do not crush, blend or mix the capsules; swallow the capsule whole. Do not exceed the recommended dose unless instructed by a health care practitioner. Keep out of reach of children. Store tightly sealed in a cool, dry place, protected from sunlight. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- Triméthylglycine (bétaine anhydre)500 mg
- Acide folique (L-5-MTHF de calcium)267 mcg
- Vitamine B6 (pyridoxal-5-phosphate)17 mg
- Vitamine B12 (méthylcobalamine)216 mcg
Ingrédients non médicinaux : Aucun. Capsule : hypromellose.
Usage ou fins recommandés : Fournit des nutriments qui aident à la formation des tissus et à la formation des globules rouges, des facteurs dans le maintien d'une bonne santé. Aide à la formation des globules rouges (folate, vitamine B6, vitamine B12). Aide au métabolisme énergétique et à la formation des tissus (vitamine B6, vitamine B12). Aide à maintenir/soutenir les fonctions normales du système nerveux (vitamine B6, vitamine B12). Aide à maintenir/soutenir les fonctions immunitaires (vitamine B12). Aide à prévenir une carence en folate chez les personnes ayant un faible apport. Aide à réduire le risque d'anomalies du tube neural et soutient le développement précoce normal du fœtus (cerveau et moelle épinière) lorsqu'il est pris quotidiennement au moins trois mois avant de devenir enceinte et en début de grossesse (folate). Produit de santé naturel homologué, NPN 80026949.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule trois fois par jour, avec ou sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas écraser, mélanger ou broyer les capsules. Avaler la capsule entière. Ne dépassez pas la dose recommandée sauf indication contraire d'un professionnel de la santé.
Mises en garde et précautions : Consultez un professionnel de la santé avant l'utilisation si vous avez une maladie du foie, si vous êtes enceinte ou allaitez, ou si vous avez une maladie cardiovasculaire. Cessez d'utiliser le produit et consultez un professionnel de la santé si vous développez des symptômes de troubles nerveux sensoriels, tels qu'un engourdissement, des picotements ou des douleurs dans les extrémités. Ne pas écraser, mélanger ou broyer les capsules; avaler la capsule entière. Ne dépassez pas la dose recommandée sauf indication contraire d'un professionnel de la santé. Garder hors de la portée des enfants. Conserver bien scellé dans un endroit frais et sec, à l'abri de la lumière du soleil. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80026949
Support methylation, homocysteine balance and red blood cell formation the easy way
Get AOR Max Methyl on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Max Methyl
Four real methyl donors and cofactors, in active/bioactive forms - four ways it supports everyday methylation health.
Homocysteine & Cardiovascular Wellness
Trimethylglycine (TMG/betaine) is a methyl donor studied for its role in supporting healthy homocysteine metabolism, a process linked to cardiovascular wellness.
Red Blood Cell Formation
Folate, vitamin B6 and vitamin B12 each help the body form red blood cells, supporting healthy blood and everyday nutritional wellness.
Nervous System Support
Vitamin B6 and vitamin B12 help maintain normal function of the nervous system.
Active, Bioactive Forms
Folate as calcium L-5-MTHF, vitamin B12 as methylcobalamin and vitamin B6 as pyridoxal-5-phosphate (P5P) - active forms designed for better bioavailability than standard forms.
Inside every capsule
500 mg of trimethylglycine (TMG/betaine), 267 mcg of active folate (calcium L-5-MTHF), 216 mcg of active B12 (methylcobalamin) and 17 mg of active B6 (P5P) - four real methyl donors and cofactors in one vegan capsule.
How to use
Take 1 capsule
Adults (18 years and older) take 1 capsule with or without food, or as directed by a qualified health care practitioner.
Three times daily
Take 1 capsule three times daily - for example, morning, midday and evening.
Swallow whole
Do not crush, blend or mix the capsules. Swallow the capsule whole.
Stay within the dose
Do not exceed the recommended dose unless instructed by a health care practitioner; 90 capsules provide up to a 30-day supply at 3 capsules per day.
What the research says about TMG (betaine), folate, B12 and B6 in methylation support
Peer-reviewed studies and reviews on trimethylglycine (TMG/betaine), folate, vitamin B12 and vitamin B6 - shared for education, not as claims about this finished product. AOR Max Methyl's claims are the statements authorized under its Natural Health Product licence, NPN 80026949.
Betaine as a homocysteine-lowering methyl donor
A review describes betaine as a methyl-donor agent that lowers homocysteine through the remethylation of methionine, noting its established use (alone or as adjunctive therapy) in classical homocystinuria and other hyperhomocysteinemic conditions.
ReviewDose-dependent homocysteine lowering from betaine
A review found betaine supplementation lowers fasting plasma homocysteine dose-dependently by up to 20% at 6 g/day in healthy volunteers, and acutely blunts the homocysteine rise after a methionine load by up to 50% - an effect not seen with folic acid.
ReviewLow-dose B vitamins plus betaine lowered homocysteine in a trial
A randomized, double-blind, controlled trial in Chinese adults with hyperhomocysteinemia found 12 weeks of daily low-dose B-vitamin plus betaine supplementation significantly reduced plasma homocysteine by about 10% versus placebo, with the decrease linked to rises in both blood folate and betaine.
Human RCTFolate and B12 as linked cofactors in one-carbon metabolism
A 2025 review explains that folate and vitamin B12 are essential cofactors in folate-mediated one-carbon metabolism, supporting methionine regeneration and nucleotide synthesis, and describes how the two nutrients' metabolism is closely interconnected.
ReviewHow B12 and folate intersect at the methionine cycle
A review of cobalamin (B12) metabolism describes how methionine synthase uses vitamin B12 to remethylate homocysteine to methionine, drawing on 5-methyltetrahydrofolate as the one-carbon donor - the biochemical junction where the folate and methionine cycles meet.
ReviewFolate and B12's shared role in nervous-system function
A review in The Lancet Neurology describes the methionine-synthase-mediated conversion of homocysteine to methionine - dependent on both folate and vitamin B12 - as essential for nucleotide synthesis and genomic methylation throughout the nervous system.
ReviewB6, alongside folate and B12, governs homocysteine breakdown
A review explains that homocysteine is degraded through metabolic pathways that require folic acid, vitamin B6 and vitamin B12, and that a deficiency in any of these vitamins - B6 included - can raise homocysteine levels.
ReviewB6 deficiency raises homocysteine and disrupts liver mitochondria
A study in newborn rats found vitamin B6 deficiency during pregnancy increased homocysteine concentrations by 89% alongside gene-methylation changes, and separately altered hepatic mitochondrial cardiolipin composition and reduced oxidative phosphorylation capacity.
Animal studyB-vitamin doses for brain function often exceed standard intakes
A review of B-vitamins and brain function notes that most human research on B6, B9 (folate) and B12 has focused on their shared role in homocysteine metabolism, and argues that doses above current governmental recommendations may be warranted for optimal neurological function when diet alone falls short.
ReviewActive-form folate, B6 and B12 combined cut homocysteine 30% in a trial
A randomized, double-blind, placebo-controlled trial gave adults with elevated homocysteine a combination of methylfolate, pyridoxal-5-phosphate (active B6) and methylcobalamin (active B12) for 6 months, finding a 30% reduction in homocysteine and a 7.5% reduction in LDL cholesterol versus placebo, with larger effects in those homozygous for relevant gene variants.
Human RCTFolate, B6 and B12 together lowered homocysteine in patients with MTHFR mutations
A study of patients with recurrent pregnancy loss and MTHFR mutations found combined supplementation with methylfolate, vitamin B6 and vitamin B12 reduced mean homocysteine from 19.4 to 6.9 micromol/L, with most participants going on to a successful pregnancy.
Human studyMeta-analysis: combined B-vitamins reliably lower homocysteine
A meta-analysis of 12 randomized trials in over 34,000 patients found combined folic acid, vitamin B6 and vitamin B12 supplementation significantly lowered plasma homocysteine compared with placebo, though this specific pooled analysis found no significant reduction in cardiovascular event rates.
Meta-analysisHigh-dose betaine was well tolerated over 3 months
A prospective trial giving patients 10 g/day of betaine anhydrous for three months found the most common side effects were transient diarrhea and nausea, reported by 62% of participants, but these were not severe enough to require stopping treatment.
Human studyNo link found between dietary betaine/choline intake and diabetes risk
A 2026 systematic review and meta-analysis of observational studies found dietary choline and betaine intake were not associated with the risk of developing type 2 diabetes.
Meta-analysisAn attractive safety profile across B6, folate and B12 trials
A systematic review of vitamin B6, folate and B12 supplementation trials (mostly for migraine prophylaxis) reported an overall attractive safety profile across the studies, with mild gastrointestinal events the most commonly reported side effect.
Systematic reviewComparing folic acid with the active 5-MTHF folate form
A review comparing folic acid with 5-methyltetrahydrofolate (5-MTHF) supplementation notes that folic acid must first be converted by the liver into the active 5-MTHF molecule, whereas 5-MTHF is immediately available to the body without requiring this conversion step.
ReviewGenotype shapes the methylation response to micronutrient support
A study found that changes in genome-wide DNA methylation patterns following micronutrient supplementation differed depending on a person's MTHFR genotype, suggesting individual genetic variation influences how methylation-support nutrients act.
Human studyGenotype-stratified methylation response to a B-vitamin
A study of adults stratified by MTHFR C677T genotype found riboflavin supplementation altered DNA methylation of hypertension-related genes differently according to genotype, illustrating how genetic variation can shape the response to methylation-support nutrients.
Human RCTTwo pathways clear homocysteine - and TMG/B6 both matter
A foundational review describes homocysteine metabolism as standing at the intersection of two pathways: remethylation to methionine (requiring folate and vitamin B12, or betaine as an alternative route) and transsulfuration to cystathionine (requiring pyridoxal-5-phosphate, active vitamin B6).
ReviewFolate, B12, B6, betaine and choline all feed one methylation network
A review of one-carbon metabolism and epigenetics identifies folate, vitamin B12, vitamin B6, betaine and choline as nutrients with major roles as cofactors, methyl donors or methyl acceptors supplying the methyl groups used in DNA and histone methylation.
ReviewMethyl-donor micronutrients shape gene function via DNA methylation
A review of nutritional epigenetics identifies choline, betaine, methionine, folic acid, vitamin B6 and vitamin B12 as the methyl-donor micronutrients of one-carbon metabolism, describing their critical roles in DNA and histone methylation.
ReviewEven near-dietary betaine doses lower homocysteine
A randomized trial found 6 weeks of betaine supplementation at 1.5, 3 or 6 g/day lowered fasting plasma homocysteine by 12%, 15% and 20% respectively versus placebo - an effect seen even at doses within the normal range of dietary betaine intake.
Human RCTA single betaine dose acts on homocysteine within hours
A randomized crossover trial found single oral doses of 3 and 6 g of betaine measurably lowered plasma homocysteine within 2 hours, with the effect size linearly related to the dose given.
Human RCTA ~500 mg betaine dose measurably raised plasma betaine
A randomized crossover study using a betaine supplement dose of about 500 mg - comparable to a single capsule of this product - found it significantly raised plasma betaine and attenuated the rise in homocysteine after a methionine load, compared with a low-betaine control.
Human RCTFrequently asked questions
What is AOR Max Methyl?
AOR Max Methyl is a 4-ingredient methylation-support formula providing 500 mg trimethylglycine (TMG/betaine), 267 mcg active folate (calcium L-5-MTHF), 17 mg active vitamin B6 (P5P) and 216 mcg active vitamin B12 (methylcobalamin) per capsule, in 90 vegan capsules. It is a licensed Natural Health Product, NPN 80026949.
How do I take it?
Adults (18 years and older) take 1 capsule three times daily with or without food, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules; swallow the capsule whole.
What forms of folate, B12 and B6 does it use?
Folate is provided as calcium L-5-MTHF (the bioactive, ready-to-use form), vitamin B12 as methylcobalamin, and vitamin B6 as pyridoxal-5-phosphate (P5P) - the active coenzyme form of B6.
Why does it include TMG (betaine)?
Trimethylglycine (TMG), also called betaine, is a methyl donor studied for its role in the remethylation of homocysteine to methionine, an alternate route to the folate/B12-dependent pathway.
How many capsules are in a bottle, and how long does it last?
Each bottle has 90 vegan capsules - up to a 30-day supply at the standard dose of 1 capsule three times daily.
Is it vegan and allergen-friendly?
Yes. The capsules are vegan, non-GMO and gluten-free, with no non-medicinal ingredients other than the vegetarian hypromellose capsule shell.
Who should consult a health care practitioner before use?
Consult a health care practitioner before use if you have liver disease, are pregnant or breastfeeding, or have cardiovascular disease. Stop use and consult a health care practitioner if you develop symptoms of sensory nerve problems, such as numbness, tingling or pain in the extremities.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support methylation, homocysteine balance and red blood cell formation the easy way
Get AOR Max Methyl on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80026949. Max Methyl provides nutrients that help in tissue formation and the formation of red blood cells, factors in the maintenance of good health, and helps reduce the risk of neural tube defects when folate is taken daily at least three months before becoming pregnant and during early pregnancy. The research summaries below concern the individual nutrients TMG (betaine), folate, vitamin B12 and vitamin B6 and are educational - they are not claims about this finished product. Read and follow the label. Consult a health care practitioner before use if you have liver disease, are pregnant or breastfeeding, or have cardiovascular disease. Stop use and consult a health care practitioner if you develop symptoms of sensory nerve problems. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner before use if you have liver disease, if you are pregnant or breastfeeding, or if you have cardiovascular disease. Stop use and consult a health care practitioner if you develop symptoms of sensory nerve problems, such as numbness, tingling or pain in the extremities. Do not crush, blend or mix the capsules; swallow the capsule whole. Do not exceed the recommended dose unless instructed by a health care practitioner. Keep out of reach of children. Store tightly sealed in a cool, dry place, protected from sunlight. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: Provides nutrients that help in tissue formation and the formation of red blood cells, which are factors in the maintenance of good health. Helps in the formation of red blood cells (folate, vitamin B6, vitamin B12). Helps in energy metabolism and tissue formation (vitamin B6, vitamin B12). Helps to maintain/support normal function of the nervous system (vitamin B6, vitamin B12). Helps to maintain/support immune function (vitamin B12). Helps to prevent a folate deficiency in individuals with a low intake. Helps to reduce the risk of neural tube defects and supports the normal development of the fetus (brain and spinal cord) when taken daily at least three months before becoming pregnant and during early pregnancy (folate). Licensed Natural Health Product, NPN 80026949.
Ingredients
Medicinal Ingredients (per capsule): Trimethylglycine (betaine anhydrous) 500 mg, Folic acid (calcium L-5-MTHF) 267 mcg, Vitamin B6 (pyridoxal-5-phosphate) 17 mg, Vitamin B12 (methylcobalamin) 216 mcg. Non-medicinal ingredients: None. Capsule: hypromellose. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule three times daily with or without food, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules. Swallow the capsule whole. Do not exceed the recommended dose unless instructed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.