AOR Glucosamine & Chondroitin - Joint Support Formula | 120-240 Caps
Visit the AOR Store| Brand | AOR |
| Dose | 3-4 capsules daily, with food |
| Licensed Natural Health Product | NPN 80042966 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- TWO JOINT-HEALTH NUTRIENTS IN ONE CAPSULE: Each vegetarian capsule provides 375 mg of Glucosamine Sulfate 2KCl and 300 mg of Chondroitin Sulfate (bovine cartilage) - two of the most widely studied nutrients for joint health, combined so there is no need to take separate pills.
- SHELLFISH-FREE FORMULA: Formulated without shellfish - the glucosamine is a vegetarian-sourced sulfate salt, an option for people who avoid shellfish-derived ingredients or have shellfish sensitivities.
- LICENSED JOINT-PAIN RELIEF CLAIM: A Health Canada licensed Natural Health Product (NPN 80042966) that helps relieve joint pain associated with osteoarthritis of the knee.
- SUPPORTS CARTILAGE: Glucosamine and chondroitin are natural building blocks of cartilage, the connective tissue that cushions and supports the joints.
- FOR ACTIVE LIFESTYLES: A daily formula for people who want to stay active - through sports, exercise or everyday movement - while supporting their joints along the way.
- SIMPLE DAILY DOSE: Take 3-4 capsules daily with food. Allow a minimum of 1 month of consistent use to see beneficial effects.
- NON-GMO AND GLUTEN-FREE: Non-GMO and gluten-free capsules, manufactured in a GMP-compliant facility.
- MADE IN CANADA, LICENSED QUALITY: Manufactured for AOR - Advanced Orthomolecular Research, Calgary, Alberta - and licensed by Health Canada under NPN 80042966.
Product description
AOR Glucosamine & Chondroitin - shellfish-free joint support
A closer look at AOR Glucosamine & Chondroitin - glucosamine sulfate and chondroitin sulfate together in one shellfish-free, vegetarian-sourced capsule. Licensed Natural Health Product, NPN 80042966. Licensed Natural Health Product NPN 80042966.
Un regard plus approfondi sur AOR Glucosamine & Chondroïtine - sulfate de glucosamine et sulfate de chondroïtine dans une capsule sans mollusque, d'origine végétarienne. Produit de santé naturel homologué, NPN 80042966.
Two Joint-Health Nutrients, One Capsule
Glucosamine sulfate and chondroitin sulfate together in a single vegetarian-sourced, shellfish-free capsule.
Glucosamine Sulfate 2KCl
375 mg of vegetarian-sourced glucosamine sulfate per capsule - made without shellfish, a common source for other glucosamine products.
Chondroitin Sulfate
300 mg of chondroitin sulfate (from bovine cartilage) per capsule - a structural component of cartilage.
Advanced Ingredients, Superior Results
Each vegetarian capsule combines two of the most widely studied joint-health nutrients.
Glucosamine Sulfate 2KCl
A natural building block of cartilage and joint fluid; this vegetarian sulfate salt form avoids the shellfish sourcing used in some glucosamine products.
375 mg - vegetarian, shellfish-free
Chondroitin Sulfate
A structural component of cartilage that helps it resist compression and retain water, supporting joint cushioning.
300 mg - bovine cartilageAOR Glucosamine & Chondroitin: Supplement Facts
Medicinal Ingredients (per capsule)
- Glucosamine Sulfate 2KCl vegetarian375 mg
- Chondroitin Sulfate bovine cartilage300 mg
Non-Medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose.
Recommended Use or Purpose (NPN 80042966): Helps to relieve joint pain associated with osteoarthritis of the knee.
Recommended Dose (Adults 19 years and older): Take 3-4 capsules daily with food, or as directed by a qualified health care practitioner. Allow a minimum of 1 month to see beneficial effects. Do not crush, blend or mix the capsules; swallow whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Cautions and Warnings: Allergens: contains corn and an animal by-product. Consult a health care practitioner before use if you are pregnant or breastfeeding. When using this product, consult a health care practitioner if symptoms worsen. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Ingrédients médicinaux (par capsule)
- Sulfate de glucosamine 2KCl végétarien375 mg
- Sulfate de chondroïtine cartilage bovin300 mg
Ingrédients non médicinaux : Cellulose microcristalline, stéarylfumarate de sodium. Capsule : hypromellose.
Usage ou fins recommandés (NPN 80042966) : Aide à soulager la douleur associée à l'arthrose du genou.
Dose recommandée (adultes de 19 ans et plus) : Prendre 3 à 4 capsules par jour avec de la nourriture, ou selon les directives d'un professionnel de la santé qualifié. Comptez au moins 1 mois pour constater les effets bénéfiques. Ne pas écraser, broyer ni mélanger les capsules; avaler les capsules entières. Ne pas dépasser la dose quotidienne recommandée sauf indication contraire d'un professionnel de la santé.
Mises en garde et précautions : Allergènes : contient du maïs et un sous-produit animal. Consultez un professionnel de la santé avant l'utilisation si vous êtes enceinte ou si vous allaitez. Lors de l'utilisation de ce produit, consultez un professionnel de la santé si les symptômes s'aggravent. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec.
NPN 80042966
Support your joints the simple way
Get AOR Glucosamine & Chondroitin on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Glucosamine & Chondroitin
Two joint-health nutrients, sourced without shellfish, in one capsule.
Two Nutrients, One Capsule
375 mg glucosamine sulfate 2KCl plus 300 mg chondroitin sulfate per capsule - no separate pills to track.
Shellfish-Free Sourcing
Formulated without shellfish, using a vegetarian glucosamine sulfate source - an option for those avoiding shellfish-derived ingredients.
Licensed Joint-Health Claim
Helps relieve joint pain associated with osteoarthritis of the knee - the use authorized under NPN 80042966.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, Calgary, Alberta, since 1991. Non-GMO, gluten-free, GMP-manufactured.
Inside every capsule
Two widely studied joint-health nutrients - glucosamine sulfate and chondroitin sulfate - in one shellfish-free, vegetarian-sourced capsule.
How to use
Take with food
Adults 19 years or older: take 3-4 capsules daily with food, or as directed by a qualified health care practitioner.
Swallow whole
Do not crush, blend or mix the capsules - swallow them whole with water.
Give it time
Allow a minimum of 1 month of consistent use to see beneficial effects.
Check before use
Consult a health care practitioner before use if you are pregnant or breastfeeding, or if symptoms worsen.
What the research says about the ingredients
Peer-reviewed studies and reviews on the individual ingredients in this formula - glucosamine sulfate and chondroitin sulfate. Shared for education, not as claims about this finished product. AOR Glucosamine & Chondroitin's claims are the statements authorized under its Natural Health Product licence, NPN 80042966.
Mixed results in the largest US trial
In the 1,583-patient GAIT trial, glucosamine and chondroitin sulfate - alone or combined - did not significantly reduce knee pain overall versus placebo, but the combination showed a significantly higher response rate in the subgroup with moderate-to-severe pain (79.2% vs 54.3%, p=0.002).
Human RCTA large meta-analysis found no clinically relevant effect
A network meta-analysis pooling 10 trials (3,803 patients) found glucosamine, chondroitin and their combination did not meaningfully reduce pain or slow joint-space narrowing versus placebo, with industry-independent trials showing smaller effects than commercially funded ones.
Meta-analysisComparable to a standard prescription pain reliever
In the 606-patient MOVES trial, a chondroitin sulfate plus glucosamine hydrochloride combination reduced WOMAC pain by about 50% over 6 months in knee osteoarthritis, matching the reduction seen with the prescription NSAID celecoxib.
Human RCTNo significant slowing of joint space loss in GAIT
In the GAIT structural sub-study (357 patients over 2 years), no treatment group - including combined glucosamine and chondroitin sulfate - showed a statistically significant difference in loss of knee joint space width compared with placebo.
Human RCTPooled analysis suggests a modest structural benefit
A meta-analysis of osteoarthritis progression trials found glucosamine or chondroitin sulfate use was associated with a modest reduction in radiographic joint-space narrowing compared with placebo.
Meta-analysisSulfate forms improved pain and function over 6 months
A network meta-analysis of 80 randomized trials found prescription-grade crystalline glucosamine sulfate and prescription-grade chondroitin sulfate each significantly improved pain, and glucosamine sulfate significantly improved physical function, over a 6-month treatment period.
Meta-analysisChondroitin's effect on joint swelling in GAIT
An ancillary GAIT report examined chondroitin sulfate's effect on knee swelling and effusion, part of the trial's broader look at glucosamine and chondroitin's impact on osteoarthritis symptoms beyond pain scores alone.
Human RCTRanked second only to a prescription NSAID for pain
A network meta-analysis of 61 trials found that, among oral options studied for knee or hip osteoarthritis, the combination of glucosamine and chondroitin ranked just behind celecoxib for pain relief, and glucosamine alone significantly reduced stiffness versus placebo.
Meta-analysisCombination therapies still debated, but some show benefit
A 2024 systematic review of 30 trials (5,265 patients) noted ongoing debate over glucosamine's efficacy for knee osteoarthritis pain, while finding that a glucosamine, chondroitin sulfate and methylsulfonylmethane combination met the threshold for a clinically important pain reduction (rated low-quality evidence).
Meta-analysisA documented interaction with blood thinners
A published case report described a patient on long-term warfarin whose INR (a measure of blood-clotting time) rose after starting combined glucosamine-chondroitin, prompting a warfarin dose reduction - a reminder to tell your doctor about supplement use if you take blood thinners.
Case reportA second case report and literature review
A separate case report and literature review described a patient with an elevated INR after adding glucosamine to a stable warfarin regimen, reinforcing the recommendation to monitor patients on anticoagulants who start glucosamine-containing supplements.
Case reportA broad look at glucosamine sulfate's safety profile
An umbrella review of glucosamine sulfate research across multiple health outcomes described it as generally well tolerated in clinical trials, with adverse events similar in frequency to placebo.
ReviewSulfate reached higher joint-fluid levels than hydrochloride
A head-to-head pharmacokinetic study found an oral dose of glucosamine sulfate produced significantly higher glucosamine concentrations in synovial (joint) fluid than an equal dose of glucosamine hydrochloride, though whether this translates into a therapeutic difference was not established.
Animal studyA review argues the salt form matters
A review of the glucosamine literature contends that crystalline glucosamine sulfate reaches plasma levels needed to inhibit inflammation-related gene expression in laboratory models, while glucosamine hydrochloride preparations reached only sub-therapeutic levels in the trials reviewed - a position most associated with researchers who have specifically studied the patented sulfate form.
ReviewDifferentiating glucosamine preparations
A companion review argues that glucosamine sulfate, glucosamine hydrochloride and various generic and patented preparations differ substantially in molecular form, dosing and clinical evidence, and should not be treated as interchangeable when evaluating research results.
ReviewHow chondroitin sulfate may help protect cartilage
A review of chondroitin sulfate's molecular mechanisms describes its association with reduced activation of the inflammatory NF-kB and p38 MAPK pathways in cartilage, alongside increased activity of Nrf2, a pathway involved in cellular antioxidant defense.
ReviewGlucosamine sulfate reduced inflammatory signals in lab-grown joint cells
In human osteoarthritic chondrocytes grown in the lab, glucosamine sulfate reduced the release of inflammatory mediators (including COX-2, prostaglandin E2, IL-6 and TNF-alpha) and reduced markers of oxidative stress and cell death.
Lab studySupplement-form chondroitin tested directly on human joint cells
Chondroitin sulfate and glucosamine dietary supplements were tested on chondrocytes and synoviocytes taken from human osteoarthritic joints; the best-performing supplement reduced NF-kB activation and lowered the inflammatory cytokines IL-6 and IL-8, though less potently than pharmaceutical-grade material.
Lab studyEstablishing the dose-to-blood-level relationship
A dose-ranging study in healthy adults measured plasma glucosamine levels after increasing oral doses of crystalline glucosamine sulfate, helping establish the pharmacokinetic basis for once-daily dosing regimens.
Human studyCombining the two doesn't reduce absorption
A human pharmacokinetic study found that taking glucosamine and chondroitin sulfate together produced blood levels of each compound comparable to taking them separately, supporting the rationale for a combined capsule.
Human studyA dose-response relationship in an animal model
In a rat model of induced arthritis, increasing glucosamine doses produced a measurable dose-concentration-effect relationship, supporting the rationale that adequate daily intake matters for the compound's studied effects.
Animal studyTwo-year follow-up confirmed the earlier pattern
A 2-year continuation of the GAIT trial in 662 patients found the same overall pattern as the original 24-week results: no significant difference from placebo for the full group, with adverse events mild, infrequent and similarly distributed across all treatment arms.
Human RCTSix years of real-world data linked longer use to less cartilage loss
Using MRI data from the Osteoarthritis Initiative, people who used glucosamine and chondroitin sulfate for 2 years or more showed significantly less cartilage volume loss over 6 years than non-users, in this observational analysis of a large cohort.
Observational studyWhat years of follow-up trials have added since GAIT
A review of randomized trials published in the years following GAIT found genuinely mixed results, and suggested that a high placebo response rate and the use of rescue pain medication in trial protocols may obscure the slow-acting effects glucosamine and chondroitin sulfate are believed to have.
ReviewFrequently asked questions
What is AOR Glucosamine & Chondroitin for?
It is a Health Canada licensed Natural Health Product (NPN 80042966) that helps relieve joint pain associated with osteoarthritis of the knee.
What is in each capsule?
Each vegetarian capsule provides Glucosamine Sulfate 2KCl (375 mg) and Chondroitin Sulfate from bovine cartilage (300 mg), plus microcrystalline cellulose and sodium stearyl fumarate. The capsule shell is hypromellose.
Is the glucosamine shellfish-derived?
No. This is a shellfish-free formula - the glucosamine sulfate is a vegetarian-sourced 2KCl salt, not derived from shellfish, per the product label.
How do I take it?
Adults 19 years or older: take 3-4 capsules daily with food, or as directed by a qualified health care practitioner. Allow a minimum of 1 month to see beneficial effects.
Who should check with a health care practitioner before use?
Consult a health care practitioner before use if you are pregnant or breastfeeding, or if symptoms worsen while using this product. Allergen note: this product contains corn-derived ingredients and an animal by-product (bovine-sourced chondroitin).
What size options are available?
AOR Glucosamine & Chondroitin comes in a 120-capsule (40-day supply) and a 240-capsule (80-day supply) bottle - both are the same NPN 80042966 formula, at 375 mg glucosamine sulfate and 300 mg chondroitin sulfate per capsule.
Is it made in Canada?
Yes. It is manufactured for Advanced Orthomolecular Research (AOR), Calgary, Alberta, and licensed by Health Canada under NPN 80042966.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support your joints the simple way
Get AOR Glucosamine & Chondroitin on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80042966. Helps relieve joint pain associated with osteoarthritis of the knee. This shellfish-free, vegetarian-sourced formula combines glucosamine sulfate with chondroitin sulfate (sourced from bovine cartilage) in one capsule. The research summaries below concern the individual ingredients (glucosamine and chondroitin sulfate) and are educational - they are not claims about this finished product. Read and follow the label. Consult a health care practitioner before use if you are pregnant or breastfeeding, or if symptoms worsen with ongoing use. This product contains corn-derived ingredients and an animal by-product (bovine chondroitin) - do not use if you have a corn allergy. Allow a minimum of 1 month to see beneficial effects. Results may vary.
Important information
Safety Information
Cautions and Warnings: Allergens: contains corn and an animal by-product. Consult a health care practitioner before use if you are pregnant or breastfeeding. When using this product, consult a health care practitioner if symptoms worsen. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Indications
Recommended Use or Purpose (NPN 80042966): Helps to relieve joint pain associated with osteoarthritis of the knee.
Ingredients
Medicinal Ingredients (per capsule): Glucosamine Sulfate 2KCl (vegetarian) 375 mg; Chondroitin Sulfate (bovine cartilage) 300 mg. Non-medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose. Non-medicinal ingredients are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 19 years and older): Take 3-4 capsules daily with food, or as directed by a qualified health care practitioner. Allow a minimum of 1 month to see beneficial effects. Do not crush, blend or mix the capsules; swallow whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.