AOR Estro Adapt - 5-Ingredient Estrogen Metabolism & Liver Support | 60 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 2 Capsules (60 per bottle) |
| Licensed Natural Health Product | NPN 80115719 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- SUPPORTS HEALTHY ESTROGEN METABOLISM: Formulated with LIFENOL hops extract, calcium D-glucarate, DIM and broccoli extract to help support the body's natural estrogen metabolism and hormonal balance.
- HELPS REDUCE CYCLICAL BREAST PAIN: Licensed to help reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia).
- FIVE REAL, DOSED ACTIVES: Each 2-capsule serving delivers LIFENOL Hops extract 120 mg, Calcium D-Glucarate 150 mg, DIM 108 mg, Choline (bitartrate) 27.6 mg and Broccoli extract 300 mg - a transparent formula, not a proprietary blend.
- SUPPORTS LIVER FUNCTION: Choline is included as a nutrient that helps support liver function - optimal liver function is essential to hormonal health.
- TRADITIONAL CALMATIVE SUPPORT: Hops are traditionally used in Herbal Medicine to help relieve restlessness and/or nervousness.
- ANTIOXIDANT SUPPORT: Provides antioxidants that help protect cells against the oxidative damage caused by free radicals.
- VEGAN, NON-GMO, GLUTEN-FREE: 60 vegan (hypromellose) capsules - a 30-day supply at 2 capsules daily - non-GMO and gluten-free.
- TRUSTED CANADIAN MANUFACTURING: Made in Canada by Advanced Orthomolecular Research (AOR), a science-based supplement brand since 1991, licensed under Health Canada NPN 80115719.
Product Description
Estro Adapt - Five-Ingredient Support for Estrogen Metabolism & Liver Function
A closer look at AOR Estro Adapt - a five-ingredient formula combining LIFENOL hops extract, calcium D-glucarate, DIM, choline and broccoli extract to help support healthy estrogen metabolism and liver function. Licensed Natural Health Product NPN 80115719.
Five Real Ingredients, One Estrogen-Metabolism Focus
LIFENOL Hops extract, Calcium D-Glucarate, DIM, Choline and Broccoli extract - vegan, non-GMO and gluten-free capsules
Licensed to Help Reduce Cyclical Breast Pain
Estro Adapt is licensed by Health Canada to help reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia), alongside its estrogen-metabolism and liver-function support.
A Transparent, Five-Ingredient Formula
No proprietary blend - each 2-capsule serving lists the exact dose of all five actives, so you know precisely what you are taking and why.
Advanced Ingredients, Superior Results
Five real, dosed ingredients - not a proprietary blend. Here is what each one is and why it is included.
LIFENOL Hops Extract
A standardized hops extract; hops are traditionally used in Herbal Medicine to help relieve restlessness and/or nervousness (calmative), and hop compounds have been studied for their interaction with estrogen receptors.
120 mg per 2-capsule serving (Humulus lupulus, 22.5:1 extract)Calcium D-Glucarate
The calcium salt of D-glucaric acid, a compound the body also produces naturally; studied for inhibiting beta-glucuronidase, an enzyme involved in Phase II liver detoxification and estrogen metabolism.
150 mg per 2-capsule serving (D-glucaric acid calcium salt)DIM (3,3'-Diindolylmethane)
A compound formed from indole-3-carbinol in cruciferous vegetables; studied for its influence on cytochrome P450-dependent estrogen metabolism, including the ratio of 2-hydroxyestrone to 16-hydroxyestrone.
108 mg per 2-capsule serving
Choline (bitartrate)
An essential nutrient included to help support liver function; optimal liver function is considered essential to hormonal health.
27.6 mg per 2-capsule servingBroccoli Extract
A concentrated extract of broccoli (Brassica oleracea), a cruciferous vegetable source of indole compounds studied for their role in supporting healthy estrogen metabolism.
300 mg per 2-capsule serving (Brassica oleracea)AOR Estro Adapt: Supplement Facts
Each 2-capsule serving contains:
- LIFENOL Hops extract Humulus lupulus, 22.5:1 extract120 mg
- Calcium D-Glucarate D-glucaric acid calcium salt150 mg
- DIM 3,3'-diindolylmethane108 mg
- Choline as bitartrate27.6 mg
- Broccoli extract Brassica oleracea300 mg
Non-Medicinal Ingredients: Carrot root powder, hypromellose, microcrystalline cellulose, silicon dioxide, sodium stearyl fumarate, stearic acid, xylitol.
Recommended Use or Purpose: Helps reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia). Helps to support/promote healthy estrogen metabolism and balance. Provides antioxidants that help protect cells against the oxidative damage caused by free radicals. Traditionally used in Herbal Medicine to help relieve restlessness and/or nervousness (calmative). A factor in the maintenance of good health. Helps to support liver function; optimal liver function is essential to hormonal health. Licensed Natural Health Product, NPN 80115719.
Recommended Dose (Adults 18 years and older): Take 2 capsules daily with breakfast, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules; swallow the capsule whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Cautions and Warnings: Ask a health care practitioner before use if you are attempting to conceive, are taking hormone replacement therapy, birth control pills, other medications or natural health products, if you have a liver disorder, are predisposed to cancer, or have symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruation) - consult a health care practitioner to exclude a serious cause of hormonal imbalance. Consult a health care practitioner prior to use if you are taking blood thinners, or if you have depression and/or related diseases. Consult a health care practitioner if symptoms persist or worsen, or if sleeplessness persists continuously for more than 4 weeks (chronic insomnia). Stop use and consult a health care practitioner if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. Avoid taking with alcohol or other products that cause drowsiness. Contraindications: Do not use this product if you are pregnant or breastfeeding. Known Adverse Reactions: Some people may experience drowsiness; exercise caution if operating heavy machinery, driving a motor vehicle or engaging in activities requiring mental alertness. Keep out of reach of children. Store in a cool, dry place protected from sunlight. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque portion de 2 capsules contient :
- Extrait de houblon LIFENOL Humulus lupulus, extrait 22,5:1120 mg
- D-Glucarate de calcium sel de calcium de l'acide D-glucarique150 mg
- DIM 3,3'-diindolylméthane108 mg
- Choline sous forme de bitartrate27.6 mg
- Extrait de brocoli Brassica oleracea300 mg
Ingrédients non médicinaux : Poudre de racine de carotte, hypromellose, cellulose microcristalline, dioxyde de silicium, stéaryl fumarate de sodium, acide stéarique, xylitol.
Usage ou fins recommandés : Aide à réduire la gravité et la durée des symptômes associés à la douleur mammaire cyclique récurrente (mastalgie cyclique). Aide à soutenir/favoriser un métabolisme et un équilibre sains des oestrogènes. Fournit des antioxydants qui aident à protéger les cellules contre les dommages oxydatifs causés par les radicaux libres. Traditionnellement utilisé en phytothérapie pour aider à soulager l'agitation et/ou la nervosité (calmant). Un facteur du maintien d'une bonne santé. Aide à soutenir la fonction hépatique; une fonction hépatique optimale est essentielle à une bonne santé hormonale. Produit de santé naturel homologué, NPN 80115719.
Dose recommandée (adultes de 18 ans ou plus) : Prendre 2 capsules par jour au déjeuner, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas écraser, mélanger ou broyer les capsules; avaler la capsule entière. Ne pas dépasser la dose quotidienne recommandée à moins d'avis contraire d'un professionnel de la santé.
Mises en garde et précautions : Consulter un professionnel de la santé avant l'utilisation si vous planifiez une grossesse, si vous suivez une hormonothérapie substitutive, si vous prenez des contraceptifs oraux, d'autres médicaments ou produits de santé naturels, si vous avez une maladie du foie, si vous êtes prédisposée au cancer, ou si vous avez des symptômes associés à un faible taux d'oestrogène (tels que des douleurs articulaires, des changements d'humeur, des changements de libido, des bouffées de chaleur, des sueurs nocturnes, une sécheresse vaginale ou des menstruations irrégulières) - consulter un professionnel de la santé afin d'exclure une cause grave de déséquilibre hormonal. Consulter un professionnel de la santé avant l'utilisation si vous prenez des anticoagulants, ou si vous souffrez de dépression et/ou de troubles connexes. Consulter un professionnel de la santé si les symptômes persistent ou s'aggravent, ou si l'insomnie persiste au-delà de 4 semaines (insomnie chronique). Cessez l'utilisation et consultez un professionnel de la santé si vous développez des symptômes de troubles hépatiques (par ex. jaunissement des yeux et/ou de la peau, urine foncée, douleurs abdominales, ictère/jaunisse) ou des symptômes de faible taux d'oestrogène. Évitez de consommer de l'alcool ou d'autres produits pouvant causer de la somnolence. Contre-indications : Ne pas utiliser ce produit si vous êtes enceinte ou si vous allaitez. Réactions indésirables connues : Certaines personnes peuvent ressentir de la somnolence; soyez prudent si vous conduisez un véhicule, utilisez de la machinerie lourde ou effectuez des activités nécessitant de la vigilance. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec, à l'abri du soleil. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80115719
Support estrogen balance and liver function the easy way
Get AOR Estro Adapt on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Estro Adapt
A five-ingredient formula for estrogen metabolism and liver function support - premium AOR quality.
Five real, dosed ingredients
LIFENOL Hops extract, Calcium D-Glucarate, DIM, Choline and Broccoli extract, each at a declared dose - no proprietary blend.
Licensed for cyclical breast pain relief
Health Canada licensed to help reduce the severity and duration of symptoms associated with recurrent (cyclical) breast pain.
Estrogen metabolism & liver support
Formulated to help support healthy estrogen metabolism and liver function, with choline included specifically for liver health.
Premium Canadian brand
AOR - Advanced Orthomolecular Research, since 1991. Licensed Natural Health Product, NPN 80115719.
Inside every serving
Five real, dosed ingredients - LIFENOL Hops extract, Calcium D-Glucarate, DIM, Choline and Broccoli extract in 2 vegan capsules.
How to use it
2 capsules daily
Adults take 2 capsules daily with breakfast, or as directed by a qualified health care practitioner.
Swallow capsules whole
Do not crush, blend or mix the capsules.
Stay consistent
Do not exceed the daily dose unless instructed by a health care practitioner; one 60-capsule bottle is a 30-day supply.
What the research says about estrogen metabolism support
Peer-reviewed studies on DIM, calcium D-glucarate, hops and broccoli-derived compounds, the active ingredients in this formula, verified via PubMed. These summaries are educational and concern the ingredients generally - they are not claims about this finished product. This product's own claims are the statements authorized under its Natural Health Product licence, NPN 80115719.
DIM shifted estrogen metabolites in postmenopausal women
A study of 1,458 postmenopausal women using a transdermal estradiol patch found that the 108 women concurrently taking a DIM supplement had significantly altered urinary estrogen profiles, including changes in estrone, estriol, 2-OHE1, 2-OHE2, 4-OHE2, 16-OHE1 and the 2-OHE1/16-OHE1 ratio.
Observational studyLarge cohort study of DIM and the urinary estrogen profile
Comparing 909 women reporting DIM use with 18,385 who did not, researchers found significant differences in nearly every urinary estrogen and estrogen metabolite, with the 2-hydroxyestrone:16-hydroxyestrone ratio increasing significantly with DIM use.
Retrospective cohortDIM increased the 2/16alpha-OHE1 ratio in a placebo-controlled trial
In a randomized, double-blind trial, daily BR-DIM (150 mg twice daily) significantly increased the urinary 2/16alpha-hydroxyestrone ratio compared with placebo over 12 months, with minimal adverse events reported.
Human RCTA natural beta-glucuronidase inhibitor
A clinical review describes calcium-D-glucarate as inhibiting beta-glucuronidase, an enzyme involved in Phase II liver detoxification; elevated beta-glucuronidase activity has been associated with increased risk of hormone-dependent cancers, and oral calcium-D-glucarate has been studied for regulating estrogen metabolism.
ReviewFour pathways behind D-glucaric acid's liver-detox role
A computational systems-biology analysis modeled how D-glucaric acid, the metabolite of calcium D-glucarate, supports liver detoxification through four molecular pathways: reduced reactive-oxygen production, reduced glucuronide deconjugation, lower hepatocyte apoptosis, and inhibition of beta-glucuronidase.
Computational modelClassic research on glucarate and mammary tumor growth
In rat models, dietary glucarate inhibited the growth of mammary tumors, acting directly on tumor cells rather than as an adjuvant, and was shown to suppress protein kinase C activity while inducing transforming growth factor-beta.
Animal modelHow hop compounds interact with estrogen receptors
A review of hops (Humulus lupulus) mechanisms describes its constituents, including 8-prenylnaringenin and xanthohumol, as capable of binding estrogen receptors, and notes that clinical trials have documented significant reductions in hot-flush frequency with hop-containing preparations.
ReviewA standardized soy-and-hop extract eased menopausal symptoms in a 12-week trial
In a randomized, double-blind, placebo-controlled trial of 78 women with moderate-to-severe menopausal symptoms, a combined soy and hop extract significantly reduced Kupperman Menopausal Index scores versus placebo after 12 weeks, with no serious adverse events.
Human RCTStandardizing a hop extract for estrogenic activity
Researchers developed and chemically/biologically standardized a hop dietary-supplement extract, measuring the estrogenic constituents 8-prenylnaringenin, isoxanthohumol and xanthohumol using an Ishikawa cell bioassay and LC-MS/MS to ensure a reproducible, traceable botanical extract.
Laboratory standardizationReviewing cruciferous compounds and breast cancer risk
An Annual Review of Nutrition analysis examined the evidence through 2024 for sulforaphane and indole-3-carbinol/DIM on breast cancer risk and outcomes, and discussed how individual variation in gut microbiome and glucosinolate metabolism may modify the benefits of cruciferous vegetable intake.
ReviewHow broccoli-derived indoles are hypothesized to shift estrogen metabolism
A review of indoles derived from glucobrassicin, found in broccoli and other crucifers, describes DIM's most well-characterized mechanism, modulation of aryl hydrocarbon receptor signaling, and notes that altered cytochrome P450-dependent estrogen metabolism is hypothesized to be an important driver of its studied breast-health effects.
ReviewSulforaphane reduced mammary tumor formation in an estrogen-exposed animal model
In rats co-exposed to 17beta-estradiol over 56 weeks, sulforaphane, a broccoli-derived compound, significantly protected against mammary tumor formation, reduced DNA damage, and lowered circulating free fatty acids and triglycerides.
Animal modelPlasma choline tracks dietary intake and liver-fat response
In a controlled crossover feeding study, plasma choline and betaine concentrations reliably discriminated adequate from low dietary choline intake, and liver ultrasound elastography detected increased liver fat in a subset of participants on the lowest-choline diet arm.
Human RCTCholine bitartrate supplementation improved liver fat in a clinical study
In patients with elevated homocysteine on standard therapy, 8 weeks of choline bitartrate supplementation (1000 mg/day) significantly raised plasma choline, lowered homocysteine, and was associated with regression of hepatic steatosis (fatty liver) in three of four affected patients.
Clinical studyCholine status is linked to fatty-liver outcomes
Research on dietary choline deficiency during pregnancy and lactation found inadequate choline intake was associated with fatty liver and downstream metabolic changes in offspring, reinforcing choline's recognized role as a nutrient the liver needs for normal fat processing.
Animal modelDIM is well tolerated across a range of oral doses
A single-ascending-dose pharmacokinetic study in healthy adults found absorption-enhanced DIM was well tolerated at doses up to 200 mg, with only mild, infrequent effects (nausea, headache) reported at a 300 mg dose.
Human studyA formal safety trial for a hops-derived compound
Xanthohumol, a flavonoid from hops, underwent a phase I, triple-masked, placebo-controlled clinical trial under a US FDA Investigational New Drug application specifically to establish its clinical safety and tolerability in healthy adults.
Clinical trial protocolA placebo-controlled human trial reported DIM's side-effect profile
A double-blind, placebo-controlled trial of diindolylmethane reported the specific rate of adverse events by dose group; no serious adverse events occurred in any group, and reported side effects were mild.
Human RCTA multi-ingredient breast-health formula raised the 2:16alpha-OHE ratio
A randomized controlled trial of a combination supplement containing indole-3-carbinol, HMR lignan, calcium glucarate, milk thistle, Schisandra and nettle found a significant increase in urinary 2-hydroxyestrone and the 2:16alpha-hydroxyestrone ratio versus placebo in both pre- and post-menopausal women.
Human RCTComparing DIM with its precursor indole-3-carbinol
A head-to-head laboratory comparison of DIM and its precursor indole-3-carbinol found both compounds inhibited androgen- and estrogen-mediated pathways at low concentrations, while identifying real differences in their effective concentrations and mechanisms.
Laboratory comparisonComparing whole cabbage juice with purified indoles
A study comparing cabbage and sauerkraut juices with purified indole-3-carbinol and DIM found that both approaches induced the estrogen-metabolizing CYP1 enzyme family in breast cell lines, though the induction pattern varied by cell type.
Laboratory studyWhy the 2-hydroxylation pathway is considered the favorable one
Research on cytochrome P450 enzymes (CYP1A1, CYP1A2, CYP1B1) shows they convert estradiol into either 2-hydroxyestradiol, not associated with increased breast cancer risk, or 4-hydroxyestradiol, a pathway with genotoxic potential - the biochemical basis for why supporting the 2-hydroxylation route is a studied area of interest.
MechanismMapping the metabolites of estrogen metabolism
Analytical chemistry research characterized the parent estrogens and 13 distinct urinary estrogen metabolites formed via hydroxylation at the C-2, C-4 or C-16 positions of the steroid ring, the same metabolic map used to study how supplements shift estrogen metabolism.
Analytical methodPopulation data linking estrogen metabolism patterns to breast cancer risk
Comparing premenopausal women across three countries, researchers found the ratio of non-parent (metabolized) to parent estrogens was highest in the population with the lowest breast cancer rate, consistent with estrogen metabolism pattern, not just estrogen level, as a factor in relative risk.
Population studyFrequently asked questions
What is AOR Estro Adapt?
It is a five-ingredient formula combining LIFENOL Hops extract, Calcium D-Glucarate, DIM, Choline and Broccoli extract, formulated to help support healthy estrogen metabolism and liver function. It is a licensed Natural Health Product, NPN 80115719.
How do I take it?
Adults take 2 capsules daily with breakfast, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules - swallow them whole.
What does this product help with?
It helps reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia), helps support/promote healthy estrogen metabolism and balance, provides antioxidants, and helps support liver function.
What is DIM and why is it included?
DIM (3,3'-diindolylmethane) is a compound derived from cruciferous vegetables, including the broccoli extract also in this formula, that has been studied for its influence on estrogen metabolism.
What does calcium D-glucarate do?
Calcium D-glucarate is the calcium salt of D-glucaric acid, a compound the body also produces naturally, studied for supporting the liver's natural detoxification pathways.
Is it vegan and allergen-friendly?
Yes - the capsules are vegan (hypromellose), non-GMO and gluten-free.
Who should not use it?
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner before use if you are attempting to conceive, taking hormone replacement therapy, birth control pills, other medications or natural health products, or if you have a liver disorder or are predisposed to cancer.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support estrogen balance and liver function the easy way
Get AOR Estro Adapt on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80115719. AOR Estro Adapt helps to support healthy estrogen metabolism and liver function, and helps reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia). Read and follow the label. Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you are attempting to conceive, taking hormone replacement therapy, birth control pills, other medications or natural health products, or if you have a liver disorder, are predisposed to cancer, or have symptoms of low estrogen. Results may vary.
Important information
Safety Information
Cautions and Warnings: Ask a health care practitioner before use if you are attempting to conceive, are taking hormone replacement therapy, birth control pills, other medications or natural health products, if you have a liver disorder, are predisposed to cancer, or have symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruation) - consult a health care practitioner to exclude a serious cause of hormonal imbalance. Consult a health care practitioner prior to use if you are taking blood thinners, or if you have depression and/or related diseases. Consult a health care practitioner if symptoms persist or worsen, or if sleeplessness persists continuously for more than 4 weeks (chronic insomnia). Stop use and consult a health care practitioner if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. Avoid taking with alcohol or other products that cause drowsiness. Contraindications: Do not use this product if you are pregnant or breastfeeding. Known Adverse Reactions: Some people may experience drowsiness; exercise caution if operating heavy machinery, driving a motor vehicle or engaging in activities requiring mental alertness. Keep out of reach of children. Store in a cool, dry place protected from sunlight. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: Helps reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia). Helps to support/promote healthy estrogen metabolism and balance. Provides antioxidants that help protect cells against the oxidative damage caused by free radicals. Traditionally used in Herbal Medicine to help relieve restlessness and/or nervousness (calmative). A factor in the maintenance of good health. Helps to support liver function; optimal liver function is essential to hormonal health. Licensed Natural Health Product, NPN 80115719.
Ingredients
Medicinal Ingredients (per 2-capsule serving): LIFENOL Hops (Humulus lupulus) extract 120 mg (22.5:1 extract; each capsule's 60 mg extract is equivalent to 1350 mg dried strobile), Calcium D-Glucarate (D-glucaric acid calcium salt) 150 mg, DIM (3,3'-diindolylmethane) 108 mg, Choline (bitartrate) 27.6 mg, Broccoli extract (Brassica oleracea) 300 mg. Non-medicinal ingredients: carrot root powder, hypromellose, microcrystalline cellulose, silicon dioxide, sodium stearyl fumarate, stearic acid, xylitol. Capsule: hypromellose (vegan). Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 2 capsules daily with breakfast, or as directed by a qualified health care practitioner. Do not crush, blend or mix the capsules; swallow the capsule whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.