AOR Cogni-Q Coenzyme Q10 300mg with PQQ 20mg - Cognitive & Cellular Support | 30-60 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 vegan capsule / day |
| Licensed Natural Health Product | NPN 80030871 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- TWO REAL ACTIVE INGREDIENTS: 300 mg of Coenzyme Q10 and 20 mg of Pyrroloquinoline Quinone (PQQ, as disodium salt) per vegan capsule - both amounts printed plainly on the label, no proprietary blend.
- ANTIOXIDANT FOR THE MAINTENANCE OF GOOD HEALTH: Coenzyme Q10 is a source of antioxidant activity, helping protect cells against the effects of free radicals as part of the body's natural defenses.
- SUPPORTS MITOCHONDRIAL ENERGY PRODUCTION: Coenzyme Q10 is a central component of the mitochondrial electron transport chain - the pathway every cell uses to convert nutrients into usable energy.
- PQQ - A DIFFERENT, COMPLEMENTARY MECHANISM: Unlike CoQ10, PQQ is studied for its role in stimulating mitochondrial biogenesis - the growth of new mitochondria - and has been studied in human trials for memory, attention and cognitive measures.
- HIGH-POTENCY, TRANSPARENT LABEL: 300 mg CoQ10 and 20 mg PQQ per capsule - the full amounts are printed on the label so you know exactly what you are taking.
- SIMPLE ONE-CAPSULE DAILY DOSE: Take 1 capsule per day with food - available in a 30-capsule (1-month) or 60-capsule (2-month) bottle.
- VEGAN, NON-GMO, GLUTEN-FREE: A vegan hypromellose capsule, formulated without gluten or GMO ingredients.
- MADE IN CANADA, NPN LICENSED: Manufactured to AOR's quality standards in a GMP-compliant Canadian facility. Licensed Natural Health Product, NPN 80030871.
Product description
AOR Cogni-Q - Coenzyme Q10 300 mg with PQQ 20 mg
A closer look at AOR Cogni-Q - 300 mg of Coenzyme Q10 and 20 mg of Pyrroloquinoline Quinone (PQQ) per vegan capsule, an antioxidant formula supporting mitochondrial and cellular health. Made in Canada. Licensed Natural Health Product NPN 80030871.
CoQ10 + PQQ Antioxidant Complex
300 mg Coenzyme Q10 and 20 mg PQQ per capsule - vegan, non-GMO, gluten-free
Two Complementary Mitochondrial Nutrients
Coenzyme Q10 is a core electron-transport-chain component that helps produce cellular energy, while PQQ is studied for stimulating the growth of new mitochondria - two different mechanisms in one capsule.
High-Potency, Transparent Label
300 mg of Coenzyme Q10 and 20 mg of PQQ per vegan capsule, made in Canada in a GMP-compliant facility and licensed by Health Canada, NPN 80030871.
Advanced Ingredients, Superior Results
Two real active ingredients - here is what each one contributes.
Pyrroloquinoline Quinone (PQQ)
A redox cofactor studied for its role in stimulating mitochondrial biogenesis - the growth of new mitochondria - and for effects on memory, attention and cognitive measures in human trials.
20 mg (disodium salt) per capsule
Coenzyme Q10
A vitamin-like compound naturally present in every cell, central to the mitochondrial electron transport chain that produces cellular energy, and a source of antioxidant that helps protect cells against free radicals.
300 mg per capsuleAOR Cogni-Q: Supplement Facts
Medicinal Ingredients (per capsule)
- Pyrroloquinoline Quinone (disodium salt)20 mg
- Coenzyme Q10300 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: dibasic calcium phosphate, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.
Recommended Use or Purpose: Antioxidant for the maintenance of good health. Contains Coenzyme Q10 and Pyrroloquinoline Quinone (PQQ). Licensed Natural Health Product, NPN 80030871.
Recommended Dose (Adults 18 years and older): Take 1 capsule per day with food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules. Swallow capsules whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Cautions and Warnings: Do not use if pregnant or breastfeeding. Consult a health care practitioner before use if you are taking blood thinners or blood pressure medication, or for use beyond 12 weeks. May cause cold, abdominal symptoms, headache, fatigue (fatigability) and diarrhea. Other Information: GMP manufacturing, independent laboratory testing, quality assured. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Ingrédients médicinaux (par capsule)
- Pyrroloquinoline quinone (sel disodique)20 mg
- Coenzyme Q10300 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : phosphate dicalcique, dioxyde de silicium, stéarylfumarate de sodium. Capsule : hypromellose.
Usage ou fins recommandés : Antioxydant pour le maintien d'une bonne santé. Contient de la Coenzyme Q10 et de la Pyrroloquinoline Quinone (PQQ). Produit de santé naturel homologué, NPN 80030871.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule par jour avec de la nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas écraser, mélanger ou mixer les capsules. Avalez les capsules entières. Ne pas dépasser la dose quotidienne sauf indication contraire d'un professionnel de la santé.
Mises en garde et précautions : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Consultez un professionnel de la santé avant l'utilisation si vous prenez des anticoagulants ou des médicaments contre l'hypertension, ou pour une utilisation au-delà de 12 semaines. Peut provoquer un rhume, des symptômes abdominaux, des maux de tête, de la fatigue (fatigabilité) et de la diarrhée. Autres renseignements : Fabriqué selon les bonnes pratiques de fabrication (BPF), testé en laboratoire indépendant, qualité garantie. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec.
NPN 80030871
Support your cells with two real antioxidant ingredients
Get AOR Cogni-Q on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Cogni-Q
Two real antioxidant ingredients, working through different, complementary mechanisms.
Antioxidant Support
Antioxidant for the maintenance of good health - Coenzyme Q10 is a source of antioxidant activity, helping protect cells against the effects of free radicals.
Mitochondrial Energy Production
Coenzyme Q10 is a core component of the mitochondrial electron transport chain, the pathway every cell uses to produce usable energy.
PQQ's Distinct Mechanism
Unlike CoQ10, PQQ is studied for stimulating mitochondrial biogenesis - helping cells generate new mitochondria - a separate, complementary avenue of research.
Transparent, High-Potency Formula
300 mg Coenzyme Q10 and 20 mg PQQ per vegan capsule, the full amounts printed on the label. Made in Canada, GMP-compliant, licensed NPN 80030871.
Inside every capsule
300 mg of Coenzyme Q10 and 20 mg of Pyrroloquinoline Quinone (PQQ) - two antioxidant, mitochondria-supporting nutrients in one vegan capsule.
How to use
Take 1 capsule
Adults take 1 capsule per day with food, or as directed by a qualified health care practitioner.
With food
Take with a meal as part of a consistent daily routine.
Swallow whole
Do not crush, mix or blend the capsule - swallow it whole with water.
Stay consistent
Use daily; one bottle provides up to a 1-month supply (30 capsules) or 2-month supply (60 capsules) at 1 capsule per day.
What the research says about Coenzyme Q10 and PQQ
Peer-reviewed studies and reviews on Coenzyme Q10 and Pyrroloquinoline Quinone (PQQ) at the ingredient level - shared for education, not as claims about this finished product. AOR Cogni-Q's claims are the statements authorized under its Natural Health Product licence, NPN 80030871. PQQ has no independent Health Canada monograph entry, so the PQQ-specific research below is educational context on the ingredient, not an authorized health claim. The CoQ10+PQQ combination research reflects preclinical (animal) evidence of complementary mechanisms, not a human clinical trial of the two ingredients combined.
Mixed but promising evidence for CoQ10 and cognitive function
A review of animal and human research found that in eight human clinical trials testing CoQ10 supplementation and cognition, four showed a beneficial effect on cognitive performance and two showed increases in cerebral blood flow, while other trials reported no benefit. The authors note that CoQ10's roles in ATP production and reducing oxidative stress are plausible mechanisms, but call for more consistent testing methods across future studies.
ReviewCoQ10 linked to improved cognitive and fatigue symptoms across neurological conditions
A literature review of randomized controlled trials and open-label studies found that CoQ10 supplementation had positive effects on fatigue, cognitive impairment and affective symptoms across several neurological and neuropsychiatric conditions associated with mitochondrial dysfunction, supporting further study of CoQ10 in conditions involving impaired brain energy metabolism.
ReviewCoQ10 preserved mitochondrial biogenesis in neurons under excitotoxic stress
In a study using mouse hippocampal neuronal cells, glutamate-induced excitotoxicity reduced markers of mitochondrial biogenesis, including PGC-1alpha and NRF2. Pretreatment with a water-soluble CoQ10 formulation prevented this decline, preserving the cells' mitochondrial biogenesis pathways.
Mechanistic studyCoQ10 gained orphan drug status for Parkinson's disease and related conditions
A clinical review described CoQ10 as a compound involved in cellular energy metabolism and oxidative protection. Its most consistent supporting evidence at the time was in neurodegenerative conditions such as Parkinson's disease and certain encephalomyopathies, for which it had gained orphan drug status, while findings in areas like heart failure and diabetes were described as less consistent.
ReviewCoQ10's reduced form directly neutralizes lipid-damaging radicals
A mechanistic study identified an enzyme, FSP1, that regenerates the reduced, antioxidant form of coenzyme Q10 (ubiquinol) using NAD(P)H. This reduced CoQ10 then traps lipid peroxyl radicals that would otherwise damage cell membranes through lipid peroxidation, revealing an antioxidant pathway that works independently of glutathione.
Mechanistic studyUbiquinone acts as both a cellular pro-oxidant and a membrane antioxidant depending on context
A scientific review examined how ubiquinone (coenzyme Q), as a mobile component of the mitochondrial electron transport chain, can act as a pro-oxidant in one intermediate redox state while also functioning as a membrane antioxidant, with transgenic mouse studies helping clarify exactly where and how ubiquinone performs each role in different parts of the cell.
ReviewCoQ10 activated the body's own antioxidant defense pathway under hyperglycemic stress
In diabetic rats, high blood sugar suppressed the Nrf2 antioxidant signaling pathway and reduced liver antioxidant enzyme activity, alongside increased markers of oxidative damage. CoQ10 supplementation reversed these changes, upregulating Nrf2 and its downstream antioxidant genes while lowering oxidative damage markers in liver tissue.
Mechanistic studyCoQ10 recycling protects fat-storing organelles from oxidative damage
A study found that the enzyme FSP1 localizes to lipid droplets, the cell's fat-storage organelles, where it recycles coenzyme Q10 to its active antioxidant form to protect stored fats from oxidation; when this CoQ10-recycling system was impaired, oxidized lipids accumulated and triggered ferroptosis, a form of cell death driven by lipid oxidation.
Mechanistic studyCoenzyme Q functions as a central hub of the cell's overall redox balance
A comprehensive 2024 review described coenzyme Q as central to the entire redox balance of the cell, detailing its role as an electron transporter in the mitochondrial electron transport chain and its involvement in several other cellular enzymatic processes, alongside the biological consequences of CoQ deficiency from rare genetic mutations or age- and disease-related decline.
ReviewComplex I oxidizes fuel and reduces ubiquinone to help power the mitochondrial proton gradient
A foundational biochemistry review described how mitochondrial Complex I oxidizes NADH generated from fuel metabolism, reduces ubiquinone (coenzyme Q) and pumps protons across the inner mitochondrial membrane, a process central to generating the proton-motive force mitochondria use to produce cellular energy.
ReviewCoQ10 cycles through non-mitochondrial membranes as an antioxidant, not just an ATP-synthesis cofactor
A foundational biochemistry review described coenzyme Q10's established role in mitochondrial oxidative phosphorylation, where it helps convert energy from carbohydrates and fats into ATP, as well as evidence for CoQ10's redox cycling in other cell membranes, including lysosomes, Golgi and the plasma membrane, where its reduced form provides antioxidant activity and supports regeneration of vitamin E and vitamin C.
ReviewDisrupting one enzyme in the CoQ biosynthesis pathway halted mitochondrial energy production
A mechanistic study found that excess cellular manganese selectively disrupts coenzyme Q biosynthesis by degrading Coq7, an enzyme that catalyzes a key step in building the CoQ molecule; without CoQ available to carry electrons, oxidative phosphorylation failed even though the rest of the respiratory chain machinery remained intact, and restoring the CoQ pathway fully corrected electron transport and cell viability.
Mechanistic studyCrystal dispersion in formulation is critical to how well CoQ10 is absorbed
A review of CoQ10 absorption and metabolism traced how the compound passes from the stomach through the small intestine into the lymphatic system and blood. The authors emphasized that the degree of crystal dispersion in a CoQ10 formulation is critical to absorption, noting that formulations lacking proper crystal dispersion can have bioavailability reduced by as much as 75 percent.
ReviewWater-soluble CoQ10 formulation outperformed standard capsules in older adults
A randomized crossover trial in adults aged 65 to 74 compared three CoQ10 formulations - a water-soluble syrup, ubiquinol capsules and standard ubiquinone capsules - and found the water-soluble formulation produced 2.4-fold higher blood levels of CoQ10 than the standard ubiquinone capsule. Regardless of which form was ingested, CoQ10 appeared in the blood mostly in its reduced (ubiquinol) form.
Human RCTUbiquinol produced higher blood CoQ10 levels than ubiquinone in healthy adults
In a study of 12 healthy volunteers given 200 mg per day of each form for 4 weeks, separated by a washout period, plasma total CoQ10 rose from a baseline of 0.9 to 2.5 micrograms/mL after ubiquinone. After ubiquinol, plasma CoQ10 rose from 0.9 to 4.3 micrograms/mL, indicating better absorption for the reduced form in this comparison.
Human studyCarrier lipids and solubilization method significantly affect CoQ10 absorption
A crossover study testing seven different CoQ10 supplement formulations in 14 healthy young adults found large, statistically significant differences in bioavailability between formulations. Soft-gel capsules containing either ubiquinone or ubiquinol were the best absorbed, and the carrier matrix used to dissolve CoQ10, along with additives like vitamin C, meaningfully affected how much reached the bloodstream.
Human studyPQQ acts as a mitochondrial and redox regulator via AMPK and SIRT1/PGC-1alpha pathways
A 2026 review describes PQQ as functioning primarily as a mitochondrial and redox regulator that enhances mitochondrial biogenesis and bioenergetic capacity through activation of the AMPK and SIRT1/PGC-1alpha signaling pathways, positioning this as PQQ's core mechanism distinct from simple antioxidant activity.
ReviewPQQ deficiency reduces mitochondrial content; repletion restores mitochondrial gene expression
A review of PQQ's biological roles found that in animal models, perinatal PQQ deficiency reduces mitochondrial content and mitochondria-related gene expression, and that PQQ appears to enhance NAD+-dependent sirtuin activity acting on PGC-1alpha, NRF-1, NRF-2 and TFAM, the core regulators of new mitochondria formation.
ReviewPQQ restored mitochondrial biogenesis signaling (PGC-1alpha/NRF-1) in a folate-deficiency model
In a laboratory model of folate-deficiency-induced blood-brain-barrier dysfunction, PQQ treatment upregulated PGC-1alpha/NRF-1 signaling and improved mitochondrial biogenesis, alongside reduced oxidative stress and inflammation markers.
Mechanistic studyAMPK/PGC-1alpha activation proposed as a key mechanism in PQQ's neuroprotective effects
A 2025 review of PQQ's therapeutic potential in neurodegenerative disease identified enhancement of mitochondrial biogenesis and function through the AMPK/PGC-1alpha pathway as one of PQQ's key proposed molecular mechanisms, alongside Nrf2/ARE antioxidant activation and NF-kB inhibition.
ReviewImproved memory, attention, judgment and cognitive flexibility after 12 weeks
A randomized, double-blind, placebo-controlled trial of PQQ disodium salt (about 21.5 mg/day for 12 weeks) in healthy adults aged 40 to under 80 found significant improvements versus placebo in composite memory, verbal memory, reaction time, complex attention, cognitive flexibility, executive function and motor speed, along with improved forgetfulness and MMSE-J scores.
Human RCTAge-dependent pattern: faster processing-speed gains in younger adults, memory gains in older adults
A 12-week randomized, placebo-controlled trial of PQQ disodium salt (20 mg/day) found overall improvements in composite and verbal memory; an age-stratified analysis showed younger adults (20-40 years) improved in cognitive flexibility and processing/execution speed as early as 8 weeks, while older adults (41-65 years) showed improvements in complex and verbal memory at 12 weeks.
Human RCTIncreased BDNF, cerebral oxygenation and orientation scores in adults with mild cognitive impairment
A 6-week randomized trial of dihydrogen-PQQ in older adults with mild cognitive impairment found serum BDNF rose significantly within the treatment group, cerebral oxygenation increased significantly after treatment, and the treatment group showed significantly better orientation scores on a standard cognitive scale (ADAS-Cog) than placebo.
Human RCTImproved selective attention and increased prefrontal blood flow after 12 weeks
A randomized, placebo-controlled trial of PQQ disodium salt (20 mg/day for 12 weeks) in 41 elderly adults found significantly smaller Stroop interference (better selective attention) than placebo, along with preliminary near-infrared spectroscopy data suggesting increased cerebral blood flow in the prefrontal cortex.
Human RCTCoQ10 functions as an electron-transport-chain cofactor for cellular ATP production
A review of CoQ10's biology describes its main biochemical action as a cofactor in the mitochondrial electron transport chain, where it is essential for synthesizing ATP - a mechanism distinct from PQQ's role in stimulating formation of new mitochondria.
ReviewPQQ's role in cell-signaling pathways linked to new mitochondria formation
An early review of PQQ's physiological importance highlighted its involvement in cell-signaling pathways relevant to mitochondriogenesis (formation of new mitochondria) in animal models, proposing this as a mechanism distinct from conventional electron-transport-chain cofactors like CoQ10.
ReviewCombined PQQ and CoQ10 markedly preserved memory under oxidative stress in an animal model
In a rat study, dietary PQQ and coenzyme Q10 each supported learning and memory when given alone; combining them did not further improve baseline learning versus PQQ alone, but when rats were subjected to induced oxidative stress, the combined PQQ+CoQ10 diet markedly improved the resulting memory deficit compared to controls. This is preclinical (rodent) evidence consistent with the two nutrients acting through different, complementary mechanisms - no human trial testing the combination for cognitive outcomes has been identified.
Mechanistic studyNo reported toxicity or genotoxicity across PQQ safety studies reviewed
A 2024 review of PQQ's health impacts concluded that PQQ's safety has been established, with no reported toxicity or genotoxicity across the studies reviewed, supporting its use as a safe nutritional supplement ingredient.
ReviewNo abnormal blood, urinary or clinical exam findings in a 12-week RCT at the same 20 mg/day PQQ dose
A randomized, placebo-controlled trial of PQQ disodium salt (20 mg/day for 12 weeks) in elderly adults found no abnormal blood or urinary adverse events, and no adverse findings on internal or physical examination, at any point during the study.
Human RCTCoQ10 doses up to 1,800 mg/day were safe and well tolerated in a dose-escalation study
A dose-escalation study in hemodialysis patients found CoQ10 supplementation at doses as high as 1,800 mg per day was safe in all subjects and well tolerated in most, while also reducing a marker of oxidative stress in a dose-dependent manner.
Human studyAdverse event rates for high-dose ubiquinol were comparable to placebo in a randomized trial
A multicentre, randomized, double-blind, placebo-controlled phase 2 trial of high-dose ubiquinol (1,500 mg/day for 48 weeks) found rates of treatment-related adverse events were comparable between the ubiquinol group (23.8%) and placebo group (30.9%), supporting good tolerability at this high dose.
Human RCTFrequently asked questions
What is AOR Cogni-Q?
It is a licensed Natural Health Product that combines 300 mg of Coenzyme Q10 and 20 mg of Pyrroloquinoline Quinone (PQQ, as disodium salt) in one vegan capsule - an antioxidant formula for the maintenance of good health. NPN 80030871.
How do I take it?
Adults take 1 capsule per day with food, or as directed by a qualified health care practitioner. Do not crush, mix or blend the capsule - swallow it whole.
What is the difference between the 30-capsule and 60-capsule bottles?
Both are the exact same formula and dose - 300 mg Coenzyme Q10 and 20 mg PQQ per capsule, NPN 80030871. The 30-capsule bottle is a 1-month supply and the 60-capsule bottle is a 2-month supply at 1 capsule per day.
What are the non-medicinal ingredients?
Dibasic calcium phosphate, silicon dioxide and sodium stearyl fumarate, in a hypromellose (vegan) capsule.
Why does Cogni-Q combine CoQ10 and PQQ?
The two ingredients work through different, complementary mechanisms: Coenzyme Q10 is a core part of the mitochondrial electron transport chain that produces cellular energy, while PQQ is studied separately for stimulating the growth of new mitochondria. Both are included as real, disclosed amounts per capsule - not a proprietary blend.
Is it vegan?
Yes. The capsule shell is hypromellose (vegan), and the formula is non-GMO and gluten-free.
Who should consult a health care practitioner before use?
Do not use if pregnant or breastfeeding. Consult a health care practitioner before use if you are taking blood thinners or blood pressure medication, or before using this product for more than 12 weeks. May cause cold, abdominal symptoms, headache, fatigue and diarrhea.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support your cells with two real antioxidant ingredients
Get AOR Cogni-Q on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80030871. Antioxidant for the maintenance of good health. The research summaries below concern Coenzyme Q10 and Pyrroloquinoline Quinone at the ingredient level and are educational - they are not claims about this finished product. Read and follow the label. Do not use if pregnant or breastfeeding. Consult a health care practitioner before use if you are taking blood thinners or blood pressure medication, or before using this product for more than 12 weeks. May cause cold, abdominal symptoms, headache, fatigue and diarrhea. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if pregnant or breastfeeding. Consult a health care practitioner before use if you are taking blood thinners or blood pressure medication, or for use beyond 12 weeks. May cause cold, abdominal symptoms, headache, fatigue (fatigability) and diarrhea. Other Information: GMP manufacturing, independent laboratory testing, quality assured. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Indications
Recommended Use or Purpose: Antioxidant for the maintenance of good health. Contains Coenzyme Q10 and Pyrroloquinoline Quinone (PQQ). Licensed Natural Health Product, NPN 80030871.
Ingredients
Medicinal Ingredients (per capsule): Pyrroloquinoline Quinone (disodium salt) 20 mg, Coenzyme Q10 300 mg. Non-medicinal ingredients: dibasic calcium phosphate, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule per day with food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules. Swallow capsules whole. Do not exceed the daily dose unless instructed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.