CanPrev TUDCA Supplement 250mg + Choline - Liver Support | 60 Caps
Visit the CanPrev Store Read all reviews on Amazon →| Brand | CanPrev |
| Serving | 1 capsule, 2 times daily - 250mg TUDCA + 75mg Choline per capsule |
| Licensed Natural Health Product | NPN 80129648 |
| Quality Standards | GMP-compliant facility |
| Country | Formulated in Canada  |
About this item
- 250MG TUDCA + 75MG CHOLINE: Each vegetable capsule provides 250mg of TUDCA (tauroursodeoxycholic acid) together with 75mg of Choline (VitaCholine choline L(+) bitartrate).
- HELPS SUPPORT LIVER FUNCTION: Licensed by Health Canada to help support liver function - the core, authorized use of this formula.
- A NATURALLY OCCURRING BILE ACID: TUDCA is the taurine-conjugated form of ursodeoxycholic acid, a bile acid the body itself produces in small amounts as part of normal bile chemistry.
- SIMPLE TWICE-DAILY DOSE: Take 1 capsule, 2 times per day - a 30-day supply of 60 vegetable capsules in every bottle.
- CLEAN, VEGAN FORMULA: Vegan, non-GMO and gluten-free vegetable capsules with brown rice flour, dicalcium phosphate, hypromellose, magnesium stearate and microcrystalline cellulose as the only non-medicinal ingredients.
- TRUSTED CANADIAN BRAND: Formulated and made in Canada by CanPrev, a Health Canada-licensed natural health product company. NPN 80129648.
Product Description
TUDCA 250mg + Choline 75mg - Liver Function Support
250mg of TUDCA (tauroursodeoxycholic acid) together with 75mg of Choline (VitaCholine choline L(+) bitartrate) in a single vegetable capsule. Helps to support liver function. Licensed Natural Health Product, formulated and made in Canada. Licensed Natural Health Product NPN 80129648.
250 mg de TUDCA (acide tauroursodésoxycholique) avec 75 mg de choline (bitartrate de choline L(+) VitaCholine) dans une seule capsule végétale. Aide à maintenir la fonction hépatique. Produit de santé naturel homologué, formulé et fabriqué au Canada. NPN 80129648.
TUDCA + Choline, One Simple Capsule
250mg TUDCA + 75mg Choline per Capsule - No Artificial Colours - Vegan, Non-GMO, Gluten-Free
250mg TUDCA + 75mg Choline per Capsule
Each vegetable capsule delivers 250mg of TUDCA and 75mg of Choline (VitaCholine choline L(+) bitartrate) in one combined formula.
Helps to Support Liver Function
Licensed by Health Canada (NPN 80129648) to help support liver function - the authorized use of this formula.
Why TUDCA + Choline
TUDCA (tauroursodeoxycholic acid) and choline are both studied for their roles in liver biology - TUDCA as a naturally occurring bile acid and molecular chaperone, choline as an essential nutrient the liver needs for normal fat and methyl-group metabolism. Here is what the wider research on each ingredient explores.
Helps Support Liver Function
The core licensed use of this formula - TUDCA and choline together, at doses studied for liver-related biology.
A Naturally Occurring Bile Acid
TUDCA is the taurine-conjugated form of ursodeoxycholic acid, a bile acid that occurs naturally in the body's own bile chemistry.
Choline for Normal Liver Metabolism
Choline is an essential nutrient the liver uses in fat transport and methyl-group metabolism.
Vegan, Easy-to-Swallow Capsule
A vegetable capsule format that's vegan, non-GMO and gluten-free, with a simple twice-daily dose.
CanPrev TUDCA Supplement: Supplement Facts
Product Facts
- Tauroursodeoxycholic Acid (TUDCA) per capsule250 mg
- Choline (VitaCholine choline L(+) bitartrate) per capsule75 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Brown rice flour, dicalcium phosphate, hypromellose, magnesium stearate, microcrystalline cellulose.
Recommended Use or Purpose: Helps to support liver function.
Recommended Dose (Adults 19 years and older): Take 1 capsule, 2 times per day, or as directed by a health care practitioner.
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Stop use if gastrointestinal discomfort or disturbances occur. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Info-produit
- Acide tauroursodésoxycholique (TUDCA) par capsule250 mg
- Choline (bitartrate de choline L(+) VitaCholine) par capsule75 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Farine de riz brun, phosphate dicalcique, hypromellose, stéarate de magnésium, cellulose microcristalline.
Usage ou fins recommandés : Aide à maintenir la fonction hépatique.
Posologie recommandée (adultes de 19 ans et plus) : Prendre 1 capsule, 2 fois par jour, ou selon les directives d'un praticien de soins de santé.
Mises en garde : Consulter un praticien de soins de santé avant d'en faire l'usage si vous êtes enceinte ou vous allaitez. Cesser l'utilisation si d'inconfort gastro-intestinal ou de troubles gastro-intestinaux se manifeste. Garder hors de la portée des enfants.
NPN 80129648
Support your liver function with TUDCA and Choline
Get CanPrev TUDCA 250mg + Choline 75mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy CanPrev TUDCA
250mg TUDCA plus 75mg Choline per capsule, in a clean vegan formula - premium CanPrev quality.
250mg TUDCA + 75mg Choline
Each vegetable capsule combines tauroursodeoxycholic acid with Choline (VitaCholine choline L(+) bitartrate) in one formula.
Helps support liver function
Licensed under NPN 80129648 to help support liver function - the authorized use of this product.
Simple twice-daily dose
Take 1 capsule, 2 times per day - a 30-day supply of 60 vegetable capsules in every bottle.
Vegan, clean-label brand
CanPrev - vegan, non-GMO, gluten-free formula, formulated and made in Canada. NPN 80129648.
Inside every capsule
250mg of TUDCA (tauroursodeoxycholic acid) plus 75mg of Choline (VitaCholine choline L(+) bitartrate) in a single vegetable capsule - helps to support liver function.
How to use it
Take 1 capsule, 2 times daily
Adults (19 years and older): take one (1) capsule, two (2) times per day, or as directed by a health care practitioner.
A 30-day supply per bottle
Each bottle of 60 vegetable capsules provides a 30-day supply at the labelled twice-daily dose.
Consult a practitioner if pregnant or breastfeeding
Consult a health care practitioner prior to use if you are pregnant or breastfeeding.
Stop use if GI discomfort occurs
Stop use if gastrointestinal discomfort or disturbances occur. Keep out of reach of children.
What the research says about TUDCA and choline
Educational summaries of published research on TUDCA (tauroursodeoxycholic acid) and choline generally; not product-specific claims. CanPrev TUDCA's own authorized use under NPN 80129648 is that it helps to support liver function.
A landmark study showed TUDCA reduces cellular stress linked to insulin resistance
In obese, diabetic mice, orally active chemical chaperones - including taurine-conjugated ursodeoxycholic acid (TUDCA) - alleviated endoplasmic reticulum (ER) stress and led to normalized blood sugar, restored insulin sensitivity, and resolution of fatty liver disease.
Preclinical studyA review maps how TUDCA acts as a molecular chaperone across many disease models
A review describes TUDCA's cytoprotective mechanisms - easing ER stress, stabilizing the unfolded protein response, reducing oxidative stress and apoptosis - across preclinical models of diabetes, obesity, liver disease and neurodegeneration, while noting limitations that still restrain its wider clinical use.
ReviewA pharmacology review places TUDCA among leading ER-stress-targeted therapeutics
A 2025 review of the pharmacological landscape of ER stress discusses TUDCA alongside compounds like 4-phenylbutyric acid as small molecules being explored for metabolic and neurodegenerative diseases linked to unresolved ER stress, while flagging bioavailability and trial-scale gaps still facing this class of therapy.
ReviewTUDCA reduced liver fibrosis in a mouse model of bile duct obstruction
In mice with bile duct ligation-induced liver fibrosis, daily oral TUDCA significantly reduced fibrosis and lowered markers of the unfolded protein response and programmed cell death (CHOP, caspase 3/12), alongside a modest reduction in liver enzyme levels.
Preclinical studyTUDCA reduced fat buildup and reshaped gut bacteria in a fatty liver mouse model
In mice with diet-induced nonalcoholic fatty liver disease, TUDCA treatment reduced obesity and hepatic lipid accumulation, improved intestinal barrier function, and increased beneficial gut bacteria, while altering bile acid receptor signaling in the liver.
Preclinical studyTUDCA and its parent bile acid preserved mitochondrial function in liver cell models
In liver cell lines exposed to fructose overload, treatment with ursodeoxycholic acid or its taurine-conjugated form (TUDCA) strongly inhibited a marker of mitochondrial dysfunction, suggesting a protective, antioxidant-supporting effect relevant to early fatty liver changes.
Preclinical + cell studyA human trial found TUDCA improved liver and muscle insulin sensitivity in obese adults
In a randomized, placebo-controlled trial, 20 obese men and women given 1,750mg/day of TUDCA for 4 weeks showed roughly 30% improved hepatic and muscle insulin sensitivity versus placebo, along with increased muscle insulin-signaling activity, though adipose tissue sensitivity and ER stress markers were unchanged.
Human RCTA seaweed compound's anti-obesity effects were traced back to raising TUDCA levels
In obese mice, a fucoidan supplement raised serum TUDCA more than sixfold, and this TUDCA elevation was identified as the key driver of improved insulin resistance and reduced fat-tissue inflammation, acting through the bile acid receptor TGR5.
Preclinical studyTUDCA's role in liver cells was studied as a potential biomarker for type 2 diabetes
Using a validated laboratory method to measure TUDCA in cultured liver cells, researchers found TUDCA helps increase expression of the insulin-degrading enzyme, restoring insulin sensitivity - supporting further study of TUDCA as a biomarker and mechanism in type 2 diabetes.
In vitro studyA combination TUDCA therapy for ALS saw a promising Phase 2 result followed by a Phase 3 disappointment
A review traces how sodium phenylbutyrate-TUDCA (PB-TUDCA) gained FDA and Health Canada approval for ALS after the Phase 2 CENTAUR trial showed benefits on functional decline, survival and hospitalization risk - but the larger Phase 3 PHOENIX trial later found no significant change in functional score, leading the sponsor to voluntarily withdraw the drug's marketing authorization.
ReviewThe Phase 2 CENTAUR trial showed a slower rate of ALS functional decline with the combination therapy
A review of the Phase 2 CENTAUR trial (with open-label extension) found the sodium phenylbutyrate-taurursodiol combination slowed the rate of decline on the ALS Functional Rating Scale-Revised versus placebo, with a post hoc analysis suggesting a median 4.8-month survival benefit.
ReviewA review outlines the path from CENTAUR approval to a $158,000-a-year ALS therapy
A review of sodium phenylbutyrate-taurursodiol's pharmacology and trial history describes how CENTAUR led to conditional approval in Canada and full FDA approval in the US, while noting the therapy's steep annual cost as a potential access barrier for people living with ALS.
ReviewTUDCA reduced brain inflammation and improved outcomes after traumatic brain injury in mice
In a mouse model of traumatic brain injury, TUDCA improved behavioral deficits and reduced neuronal injury by inhibiting the STING and NF-kB/NLRP3 inflammatory pathways that drive persistent brain inflammation after injury.
Preclinical studyTUDCA preserved light-sensing cells in a mouse model of retinal degeneration
In mice with drug-induced photoreceptor degeneration, subcutaneous TUDCA reduced photoreceptor loss, preserved cone cells, and improved visual signal transmission measured by electroretinogram, by modulating apoptosis and oxidative stress in the retina.
Preclinical studyA review names TUDCA among the most promising neuroprotective candidates for retinal disease
A review of neuroprotective strategies for retinal disease highlights bile acids like UDCA and TUDCA as leading candidates for protecting photoreceptors, alongside progesterone and neurotrophic factors, while cautioning that translating any of these to human retinal disease remains an ongoing challenge.
ReviewA landmark human trial showed most adults develop liver problems on a choline-deficient diet
In a controlled feeding study, 77% of men and 80% of postmenopausal women developed fatty liver or muscle damage when fed a diet low in choline, versus only 44% of premenopausal women - and organ function was restored once choline was added back to the diet.
Human RCTMaternal choline supplementation favorably reshaped offspring liver lipid composition in mice
In a mouse model of maternal obesity, choline supplementation during pregnancy increased protective antioxidant phospholipids (plasmalogens) in offspring liver tissue, appearing to lower oxidative stress in the developing liver under a high-fat diet.
Preclinical studyA review finds most people fall well short of the recommended choline intake
A narrative review reports that roughly 90% of Americans, including most pregnant and lactating women, consume less than the recommended Adequate Intake for choline, an essential nutrient whose deficiency is linked to liver and muscle organ dysfunction.
ReviewA review describes choline's critical role in fetal brain development
A review explains that choline is critical during fetal development, where it influences DNA methylation and neural precursor cell proliferation, with long-term effects on brain structure and memory function - and that common genetic variants change how much dietary choline a person needs.
ReviewA review explains why some adults need more dietary choline than others
A review of choline's gene-nutrient interactions describes how estrogen allows premenopausal women to make more choline endogenously, while most men and postmenopausal women depend more heavily on dietary choline to avoid fatty liver, muscle damage and elevated homocysteine.
ReviewA review links dietary choline deficiency to DNA damage and altered gene-regulating marks
A review describes how choline deficiency increases mitochondrial reactive oxygen species, impairs folate metabolism, and alters DNA methylation patterns that regulate DNA repair genes - mechanisms proposed to explain why choline-deficient diets are linked to liver and other organ dysfunction.
ReviewA real-world ALS study found TUDCA was generally well tolerated at higher doses
In a retrospective population-based cohort of patients with ALS, TUDCA was generally well tolerated - 7 of 86 patients (8.1%) discontinued treatment due to side effects, primarily mild gastrointestinal symptoms, with only 2 adverse events requiring hospital access, both resolving without lasting effects.
Retrospective cohortA placebo-controlled trial found TUDCA safe and tolerable over 16 weeks in progressive MS
In a double-blind, placebo-controlled trial in people with progressive multiple sclerosis, 2g/day of TUDCA for 16 weeks showed no significant difference in adverse events versus placebo, supporting its safety and tolerability, though the trial's primary purpose was safety, not efficacy.
Human RCTA preclinical study flags a choline-related metabolite as a consideration in heart failure
In mice with induced heart failure, dietary choline raised levels of the gut-microbial metabolite TMAO, which worsened cardiac remodeling and function - withdrawing TMAO from the diet, or blocking its microbial production, improved heart structure and function, a preclinical finding relevant to how choline is metabolized by gut bacteria.
Preclinical studyFrequently asked questions
What is CanPrev TUDCA and what does it do?
It's a vegetable capsule combining 250mg of TUDCA (tauroursodeoxycholic acid) with 75mg of Choline (VitaCholine choline L(+) bitartrate). It is licensed by Health Canada to help support liver function.
How do I take it?
Adults (19 years and older) take 1 capsule, 2 times per day, or as directed by a qualified health care practitioner.
How long does one bottle last?
Each bottle contains 60 vegetable capsules - a 30-day supply at the labelled dose of 1 capsule twice daily.
Is it vegan, and what's in the capsule shell?
Yes - it's vegan, non-GMO and gluten-free. Non-medicinal ingredients are brown rice flour, dicalcium phosphate, hypromellose, magnesium stearate and microcrystalline cellulose.
Does this product help with digestion or fat-soluble vitamin absorption?
This product's Health Canada license covers only helping to support liver function. It does not carry a separate digestive-support or vitamin-absorption claim on its NPN.
Who should use caution, or not use it?
Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Stop use if gastrointestinal discomfort or disturbances occur. Keep out of reach of children.
Where do I buy it?
Use the orange button on this page - it takes you to the CanPrev listing on Amazon.ca for secure checkout and fast delivery.
Support your liver function with TUDCA and Choline
Get CanPrev TUDCA 250mg + Choline 75mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80129648. Helps to support liver function. The research summaries below concern TUDCA and choline generally and are educational - they are not claims about this finished product. Read and follow the label. Consult a health care practitioner if pregnant or breastfeeding. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Stop use if gastrointestinal discomfort or disturbances occur. Keep out of reach of children.
Indications
Recommended Use or Purpose: Helps to support liver function.
Ingredients
Medicinal ingredients (per capsule): Tauroursodeoxycholic Acid 250 mg, Choline (VitaCholine choline L(+) bitartrate) 75 mg. Non-medicinal ingredients: Brown rice flour, dicalcium phosphate, hypromellose, magnesium stearate, microcrystalline cellulose. NMIs are subject to change - always read and follow the label for accurate ingredients, cautions and allergen information.
Directions
Recommended Dose (Adults 19 years and older): Take 1 capsule, 2 times per day, or as directed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.