CanPrev Lion's Mane Full Spectrum Mushroom - Brain & Nerve | 60 Caps
Visit the CanPrev Store| Brand | CanPrev |
| Serving | 1 capsule, once daily (450 mg full-spectrum Lion's Mane per capsule) |
| Licensed Natural Health Product | NPN 80124703 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 450 MG FULL-SPECTRUM LION'S MANE, ONCE DAILY: One vegetable capsule combines 250 mg Lion's Mane (fruiting body) 8:1 extract (equivalent to 2000 mg dry fruiting body) with 200 mg cultured Lion's Mane mycelium (Hericium erinaceus) - the full spectrum of Lion's Mane compounds in a single daily dose.
- SOURCE OF FUNGAL POLYSACCHARIDES WITH IMMUNOMODULATING PROPERTIES: The recommended use authorized on this product's Health Canada licence (NPN 80124703).
- COGNITIVE FUNCTION, FOCUS & MEMORY: Lion's Mane is traditionally used, and widely researched, for supporting mental clarity, focus and healthy memory function.
- EMOTIONAL WELLBEING SUPPORT: Contains compounds studied for their support of a calm, balanced mood as part of everyday emotional wellbeing.
- ANTIOXIDANT SUPPORT: Contains fungal polysaccharides and compounds studied for antioxidant activity, helping support the body's response to everyday oxidative stress.
- NERVE HEALTH RESEARCH FOCUS: Lion's Mane is one of the most-studied traditional mushrooms for nerve-growth-factor and nervous-system research.
- ORGANICALLY SOURCED, VEGAN FORMULA: Organically grown Lion's Mane in a vegan vegetable capsule - non-GMO, gluten-free, dairy-free, soy-free, wheat-free, yeast-free and sugar-free, with no artificial colours, flavours or preservatives.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated and made in Canada by CanPrev Natural Health Products Ltd. and licensed under NPN 80124703.
Product Description
Lion's Mane Full Spectrum - Fruiting Body Extract + Cultured Mycelium
450 mg of full-spectrum Lion's Mane in every vegetable capsule: 250 mg of Lion's Mane (fruiting body, Hericium erinaceus) 8:1 extract (equivalent to 2000 mg dry fruiting body, a hot water and alcohol extract) plus 200 mg of cultured Lion's Mane mycelium (Hericium erinaceus) - the full spectrum of Lion's Mane compounds, taken once a day. A source of fungal polysaccharides with immunomodulating properties. Organically sourced, vegan, and licensed as a Natural Health Product. Licensed Natural Health Product NPN 80124703.
450 mg d'Hydne hérisson (Lion's Mane) à spectre complet dans chaque capsule végétale : 250 mg d'extrait 8:1 d'Hydne hérisson (corps fructifère, Hericium erinaceus) équivalent à 2000 mg de corps fructifère sec (extrait à l'alcool et à l'eau chaude), ainsi que 200 mg d'Hydne hérisson cultivé (mycélium, Hericium erinaceus) - le spectre complet des composés de l'Hydne hérisson, à prendre une fois par jour. Source de polysaccharides fongiques ayant des propriétés immunomodulatrices. Source biologique, végétalien, et homologué comme produit de santé naturel.
One Capsule, the Full Spectrum
250 mg Lion's Mane (fruiting body) 8:1 extract + 200 mg cultured Lion's Mane mycelium, once daily
450 mg of Full-Spectrum Lion's Mane, Once Daily
Each vegetable capsule delivers 250 mg of an 8:1 Lion's Mane fruiting body extract (equivalent to 2000 mg dry fruiting body) plus 200 mg of cultured Lion's Mane mycelium (Hericium erinaceus) - the full daily dose in a single capsule, once a day.
Fruiting Body + Cultured Mycelium - the Full Spectrum
Most Lion's Mane products use only one part of the mushroom. This formula pairs an organically sourced fruiting body extract with cultured Hericium erinaceus mycelium, for a broader compound profile than a single-source extract.
What the Research Explores About Lion's Mane
Educational summaries of published research on Hericium erinaceus (Lion's Mane) - CanPrev Lion's Mane Full Spectrum's own label claim is the use authorized under NPN 80124703: a source of fungal polysaccharides with immunomodulating properties.
Cognitive Function & Memory
Studied in human trials for supporting working memory, focus and reaction time.
Nerve Growth Factor Research
Lion's Mane compounds (hericenones, erinacines) are studied for stimulating nerve growth factor and neurotrophic signaling.
Immune Support
A source of fungal polysaccharides with immunomodulating properties - the authorized use on this product's Health Canada licence.
Mood & Emotional Wellbeing
Studied for supporting a calm, balanced mood as part of everyday emotional wellbeing.
Antioxidant Activity
Lion's Mane polysaccharides and compounds have been studied in laboratory and animal research for antioxidant activity.
Nerve Health & Regeneration
One of the most-studied traditional mushrooms for nervous-system and nerve-regeneration research.
CanPrev Lion's Mane Full Spectrum: Supplement Facts
Each capsule contains:
- Lion's Mane (fruiting body, Hericium erinaceus) 8:1 extract equivalent to 2000 mg dry fruiting body* *Hot water and alcohol extract250 mg
- Lion's Mane (cultured mycelia, Hericium erinaceus)200 mg
Non-Medicinal Ingredients: Acacia gum, hypromellose, magnesium stearate.
Recommended Use or Purpose: Source of fungal polysaccharides with immunomodulating properties.
Recommended Dose (Adults 18 years and older): Take 1 capsule per day. Recommended Duration of Use: No specific duration restriction is stated on this product's Health Canada licence; as with any natural health product, consult a health care practitioner about use beyond a few months.
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or you are breastfeeding. Keep out of reach of children. Do not use if the safety seal is broken. Store in a cool, dry place.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule contient :
- Hydne hérisson (corps fructifère, Hericium erinaceus) extrait 8:1 équivalent à 2000 mg de corps fructifère sec* *Extrait à l'alcool et à l'eau chaude250 mg
- Hydne hérisson (mycélium cultivé, Hericium erinaceus)200 mg
Ingrédients non médicinaux : Gomme d'acacia, hypromellose, stéarate de magnésium.
Usage ou fins recommandés : Source de polysaccharides fongiques ayant des propriétés immunomodulatrices.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule par jour. Durée d'utilisation recommandée : aucune restriction de durée particulière n'est indiquée pour ce produit en vertu de sa licence de Santé Canada; comme pour tout produit de santé naturel, consultez un praticien de soins de santé pour un usage prolongé au-delà de quelques mois.
Mises en garde : Consultez un praticien de soins de santé avant l'usage si vous êtes enceinte ou si vous allaitez. Garder hors de la portée des enfants. Ne pas utiliser si le sceau de sécurité est brisé. Conserver dans un endroit frais et sec.
NPN 80124703
Add CanPrev Lion's Mane Full Spectrum to your daily routine
Get CanPrev Lion's Mane Full Spectrum on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy CanPrev Lion's Mane Full Spectrum
A full-spectrum 450 mg Lion's Mane formula - organically sourced fruiting body extract plus cultured mycelium - in one vegan capsule, once daily.
450 mg Full-Spectrum Lion's Mane, once daily
Combines 250 mg Lion's Mane (fruiting body) 8:1 extract with 200 mg cultured Lion's Mane mycelium (Hericium erinaceus) - the full spectrum of Lion's Mane compounds in a single daily capsule.
Licensed source of immunomodulating polysaccharides
A Health Canada-licensed source of fungal polysaccharides with immunomodulating properties (NPN 80124703).
Organically sourced, vegan simplicity
Organically grown Lion's Mane in a vegan vegetable capsule - non-GMO, gluten-free, dairy-free, soy-free, wheat-free, yeast-free and sugar-free, with no artificial colours, flavours or preservatives.
Trusted Canadian brand
CanPrev - formulated and made in Canada, licensed under NPN 80124703.
Inside every capsule
450 mg of full-spectrum Lion's Mane - 250 mg Lion's Mane (fruiting body, Hericium erinaceus) 8:1 extract equivalent to 2000 mg dry fruiting body, plus 200 mg cultured Lion's Mane mycelium (Hericium erinaceus) - one capsule, once a day.
How to use it
Take 1 capsule, once per day
Adults 18 years and older: take one vegetable capsule daily, or as directed by a qualified health care practitioner.
One capsule delivers the full 450 mg dose
Each capsule provides 250 mg Lion's Mane (fruiting body) 8:1 extract plus 200 mg cultured Lion's Mane mycelium (Hericium erinaceus) - no need to split doses through the day.
A 2-month supply per bottle
60 capsules lasts 60 days at 1 capsule per day, so you can stay consistent without frequent reordering.
What the research says about Lion's Mane (Hericium erinaceus)
Educational summaries of published research on Hericium erinaceus (Lion's Mane) fruiting body and mycelium; not product-specific claims. CanPrev Lion's Mane Full Spectrum's own label claim is the use authorized under NPN 80124703: a source of fungal polysaccharides with immunomodulating properties.
A crossover trial found a single dose of Lion's Mane improved working memory and reaction time
In a randomized, double-blind, placebo-controlled crossover trial, a single 1 g dose of Nordic-grown Lion's Mane extract significantly improved the number of attempts on a Serial 7s task, reaction time on an N-Back working-memory task, and Go-stimulus reaction time on a Go/No-go task versus placebo, with benefits most evident 2 hours after intake.
Human RCTA 28-day pilot trial found Lion's Mane sped up Stroop-task performance
A double-blind, placebo-controlled, parallel-groups pilot study in 41 healthy young adults found a single 1.8 g dose of Lion's Mane significantly sped up performance on the Stroop task 60 minutes after intake, with a non-significant trend toward reduced subjective stress after 28 days of daily supplementation - the small sample size means the findings should be interpreted cautiously.
Human RCT (pilot)A 12-week trial found oral Lion's Mane improved cognitive test scores
A randomized, double-blind, placebo-controlled trial testing 12 weeks of oral Hericium erinaceus fruiting-body supplementation found the Mini-Mental State Examination (MMSE), one of three cognitive tests used, showed significantly improved cognitive function and prevented decline versus placebo.
Human RCTHericerin compounds activated a nerve-growth signaling pathway and boosted spatial memory in mice
Researchers isolated a hericerin derivative (hericene A) from Hericium erinaceus and found it strongly promoted axon outgrowth in cultured hippocampal neurons, activating ERK1/2 signaling through a pathway that works alongside the BDNF/TrkB receptor; mice fed the crude extract or hericene A showed increased neurotrophin signaling and significantly enhanced hippocampal spatial memory.
Animal / in vitro studyA 2023 review maps how Lion's Mane compounds support nerve growth factor release
A review of Hericium erinaceus's neurotrophic and neuroprotective effects concluded the mushroom's active compounds (erinacines, hericenones) stimulate nerve growth factor release, help regulate inflammatory processes, reduce oxidative stress, and protect nerve cells from apoptosis, while noting further standardization work is needed for dietary-supplement research.
ReviewA modified hericenone compound boosted BDNF expression more than its parent form in the lab
Researchers treated hericenone C (isolated from Lion's Mane fruiting bodies) with a lipase enzyme to remove its fatty-acid side chain, producing 'deacylhericenone' - this modified compound raised BDNF (brain-derived neurotrophic factor) mRNA expression in human astrocytoma cells, and protected the cells against oxidative stress, more strongly than the original hericenone C.
In vitro studyA 4-week trial found Lion's Mane cookies reduced depression and anxiety scores in women
In a randomized, double-blind, placebo-controlled trial, 30 women who ate cookies containing Hericium erinaceus for 4 weeks showed significantly lower depression scores (CES-D) and Indefinite Complaints Index scores than the placebo group, with 'concentration,' 'irritability' and 'anxiousness' also trending lower.
Human RCTA review names Lion's Mane among three herbs with favourable evidence for easing anxiety and depression
Reviewing three traditional herbs studied for mental-health support (Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea), researchers described Lion's Mane as counteracting oxidative stress, mitochondrial dysfunction and inflammation while stimulating neurogenesis and neurotrophic-factor synthesis, mechanisms that parallel, to some extent, how conventional antidepressants work.
ReviewA 2025 systematic review maps how medicinal mushrooms including Lion's Mane may ease depressive symptoms
A systematic review of edible medicinal fungi (including Hericium erinaceus) found their bioactive compounds showed antidepressant-like effects in preclinical studies by modulating serotonin and dopamine signaling, the stress-related HPA axis, and neuroinflammation, and by improving gut-microbiota health - though the authors noted clinical validation in humans remains limited.
Systematic reviewDaily Lion's Mane extract activated nerve-regeneration signaling after a crush injury in rats
In Sprague-Dawley rats with a peroneal nerve crush injury, daily oral Hericium erinaceus extract significantly raised markers of nerve-regeneration signaling (Akt, MAPK, c-Jun, c-Fos) and protein-synthesis activity in the injured nerve's sensory ganglia, compared to untreated controls.
Animal studyRats given oral Lion's Mane extract recovered hind-limb function faster after nerve-crush injury
Following a crush injury to the peroneal nerve, rats given daily oral aqueous Hericium erinaceus extract regained normal hind-limb walking function and showed better axon regeneration and neuromuscular reinnervation than an untreated control group, performing comparably to rats given mecobalamin (vitamin B12), a standard treatment for peripheral nerve disorders.
Animal studyA cell-culture study found Lion's Mane extract outperformed nerve growth factor alone at protecting injured neurons
Using a laser-microdissection technique to cut (axotomize) individual mouse sensory neurons in culture, researchers found Hericium erinaceus extract showed higher neuroprotective activity than nerve growth factor (NGF) alone at preventing neuron death, and combining the two maximized axon-regeneration ability.
In vitro studyErinacine A-enriched Lion's Mane mycelium improved learning and memory in aging mice
In senescence-accelerated (SAMP8) mice, 12 weeks of erinacine A-enriched Hericium erinaceus mycelium significantly improved learning and memory on passive- and active-avoidance tests even at the lowest dose tested, alongside dose-dependent reductions in oxidative-damage and inflammation markers linked to brain aging.
Animal studyA purified Lion's Mane polysaccharide eased Alzheimer's-like brain changes in transgenic mice
In APP/PS1 transgenic mice (a standard Alzheimer's disease model), six weeks of a purified Hericium erinaceus mycelium polysaccharide significantly improved cognitive behaviour and reduced amyloid-beta deposition and tau hyperphosphorylation, working partly by easing oxidative stress and restoring calcium balance in brain cells.
Animal studyErinacine compounds calmed harmful immune-cell activity in an Alzheimer's mouse model under metabolic stress
In APP/PS1 Alzheimer's-model mice placed under additional metabolic stress, erinacines from Hericium erinaceus mycelium promoted a more protective microglial (brain immune cell) profile, lowered blood glucose and insulin, reduced amyloid-beta plaque burden, and boosted neurogenesis, in a model designed to reflect the real-world overlap between Alzheimer's disease and metabolic syndrome.
Animal studyA 2025 review details Lion's Mane's antioxidant, anti-inflammatory and antimicrobial compounds
A narrative review of Hericium erinaceus found its polysaccharides, terpenoids (hericenones and erinacines) and phenolic compounds show potent antioxidant activity by scavenging reactive oxygen species and inducing the body's own antioxidant enzymes, alongside anti-inflammatory and antimicrobial effects, though the authors noted large-scale human clinical validation is still limited.
ReviewLion's Mane beta-glucan combined with a plant antioxidant accelerated wound healing in mice
Researchers formed a hydrogel from Hericium erinaceus beta-glucan and tannic acid (a plant antioxidant) and found it reduced inflammatory cytokines (TNF-alpha, IL-6) while boosting cell-proliferation and blood-vessel-growth markers, significantly accelerating tissue regeneration in mouse skin-wound and burn models.
Animal studyA 2025 review catalogues the antioxidant and anti-inflammatory activity of Lion's Mane polysaccharides
Reviewing the extraction, structure and bioactivity of Hericium erinaceus polysaccharides, researchers found this compound class shows a diverse range of biological activities, including immune enhancement, antioxidant capability, and anti-inflammatory properties, most commonly obtained via a water-extraction and alcohol-precipitation process.
ReviewLion's Mane polysaccharides favourably shifted gut bacteria linked to immune health in mice
Feeding Hericium erinaceus polysaccharides to adult and aged mice for 28 days significantly increased the relative abundance of beneficial gut bacteria (Lachnospiraceae, Akkermansiaceae), and in fermentation experiments the polysaccharides promoted immune-signaling molecule production (IL-6, IL-10, interferon-gamma, TNF-alpha) via recognized immune-signaling pathways (NF-kB, MAPK, PI3K/Akt).
Animal studyAn enzyme-modified Lion's Mane polysaccharide boosted immune-cell activation in mice
Researchers modified Hericium erinaceus polysaccharide with an enzyme treatment and found the modified version more strongly activated macrophages (immune cells), increasing phagocytosis and activation markers, and in mice with drug-suppressed immunity, better restored the normal structure of the spleen and immune-signaling activity than the unmodified polysaccharide.
Animal / in vitro studyLion's Mane polysaccharide protected immune function in mice given an immune-suppressing drug
In mice with cyclophosphamide-induced immunosuppression (a standard model for chemotherapy-related immune suppression), a Hericium erinaceus polysaccharide fraction significantly restored immune-organ size, immune-cell proliferation, natural-killer-cell activity, interleukin-2 production and macrophage phagocytosis versus untreated controls.
Animal studyA landmark review catalogues Lion's Mane's chemistry and full range of studied health properties
A comprehensive review of Hericium erinaceus chemistry surveyed its polysaccharides and secondary metabolites (erinacines, hericerins, hericenones, resorcinols, sterols, terpenes) and the broad range of properties reported across cell, animal and human studies, including anti-inflammatory, antioxidative, immunostimulating, and improvements in anxiety, cognitive function and depression.
ReviewThe scientist who first isolated Lion's Mane's signature compounds reviews decades of chemistry research
Reviewing his own research group's discovery of hericenones C-H (from the fruiting body) and erinacines A-I (from cultured mycelium), the compound families most closely tied to Hericium erinaceus's nerve-growth-factor-stimulating activity, the author describes the clinical studies these discoveries went on to inform.
ReviewA 2023 review takes stock of how far Lion's Mane research has come 'from bench to bedside'
Surveying the preclinical and clinical evidence for Hericium erinaceus in neurodegenerative and mood conditions (Alzheimer's disease, depression, Parkinson's disease, spinal cord injury), researchers found a large body of supportive in vitro and animal research tied to increased neurotrophic-factor production, but only a limited number of human clinical trials so far, concluding wider trials are needed to confirm safety and efficacy.
ReviewFrequently asked questions
How do I take CanPrev Lion's Mane Full Spectrum?
Adults 18 years and older take 1 capsule per day, or as directed by a qualified health care practitioner.
What's in each capsule?
Each capsule contains 250 mg of Lion's Mane (fruiting body, Hericium erinaceus) 8:1 extract (equivalent to 2000 mg dry fruiting body, a hot water and alcohol extract) plus 200 mg of cultured Lion's Mane mycelium (Hericium erinaceus) - 450 mg of full-spectrum Lion's Mane in total. Non-medicinal ingredients are acacia gum, hypromellose and magnesium stearate.
What does 'Full Spectrum' mean on this label?
It means the formula includes both the fruiting body (the above-ground part of the mushroom, here as a concentrated 8:1 extract) and the cultured mycelium of Hericium erinaceus - two Lion's Mane sources combined for a broader compound profile than a single-source extract.
What is the licensed use of this product?
This product's Health Canada licence (NPN 80124703) authorizes it as a source of fungal polysaccharides with immunomodulating properties. Broader research on Lion's Mane (cognitive function, mood, nerve health, and more) is educational and not an additional label claim for this specific product.
Can I take this if I'm pregnant or breastfeeding?
Consult a health care practitioner prior to use if you are pregnant or you are breastfeeding.
Is it vegan and allergen-friendly?
Yes - the capsules are vegan, organically sourced, non-GMO, gluten-free, dairy-free, soy-free, wheat-free, yeast-free and sugar-free, with no artificial colours, flavours or preservatives.
Is CanPrev Lion's Mane Full Spectrum made in Canada?
Yes. It is formulated and made in Canada by CanPrev Natural Health Products Ltd. (Scarborough, ON) and licensed by Health Canada under NPN 80124703.
Does this contain caffeine or stimulants?
No. Lion's Mane is not a stimulant. The only medicinal ingredients are Lion's Mane (fruiting body) extract and cultured Lion's Mane mycelium (Hericium erinaceus).
Add CanPrev Lion's Mane Full Spectrum to your daily routine
Get CanPrev Lion's Mane Full Spectrum on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80124703. Source of fungal polysaccharides with immunomodulating properties. Research summaries on this page concern Lion's Mane (Hericium erinaceus) generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Consult a health care practitioner before use if you are pregnant or breastfeeding. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or you are breastfeeding. Keep out of reach of children. Do not use if the safety seal is broken. Store in a cool, dry place.
Indications
Recommended Use or Purpose: Source of fungal polysaccharides with immunomodulating properties.
Ingredients
Medicinal Ingredients (each capsule contains): Lion's Mane (fruiting body, Hericium erinaceus) 8:1 extract equivalent to 2000 mg dry fruiting body (hot water and alcohol extract), 250 mg. Lion's Mane (cultured mycelia, Hericium erinaceus), 200 mg. Non-medicinal Ingredients: Acacia gum, hypromellose, magnesium stearate.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule per day. Recommended Duration of Use: No specific duration restriction is stated on this product's Health Canada licence; as with any natural health product, consult a health care practitioner about use beyond a few months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.