CanPrev Indole-3-Carbinol 200mg - I3C for Women | 90 Caps
Visit the CanPrev Store| Brand | CanPrev |
| Serving | 200-400 mg (1-2 capsules) |
| Licensed Natural Health Product | NPN 80033685 |
| Quality Standards | Made in Canada |
| Country | Made in Canada  |
About this item
- SUPPORTS HEALTHY ESTROGEN METABOLISM: CanPrev Indole-3-Carbinol 200mg delivers a pure, single-ingredient dose of I3C, derived from cruciferous vegetables, to help support healthy estrogen metabolism - the Health Canada-authorized use on this product's NPN license.
- SOURCE OF ANTIOXIDANT: Indole-3-carbinol is also licensed as a source of antioxidant for the maintenance of good health.
- SKIN & CELLULAR WELLNESS SUPPORT: Part of a daily routine aimed at supporting skin clarity and overall cellular wellness, alongside a balanced diet.
- FLEXIBLE, LABEL-GUIDED DOSING: Adults (19 years and older) take 1 capsule, 1 to 2 times per day (200-400mg I3C daily), or as directed by a healthcare practitioner.
- SIMPLE FORMULA, NO FILLERS: 200mg of pure indole-3-carbinol per vegetable capsule, with only hypromellose and magnesium carbonate besides the medicinal ingredient - no artificial colours, flavours or preservatives.
- VEGAN & ALLERGEN-CONSCIOUS: Vegan, non-GMO, gluten-free, dairy-free and soy-free formula in a vegetable capsule.
- MADE IN CANADA, LICENSED: Formulated and made in Canada by CanPrev, licensed by Health Canada as a Natural Health Product, NPN 80033685.
Product Description
I-3-C 200 - Pure Indole-3-Carbinol for Estrogen Metabolism Support
CanPrev Indole-3-Carbinol 200mg delivers a pure, single-ingredient 200mg dose of I3C per vegetable capsule - a compound derived from cruciferous vegetables - to help support healthy estrogen metabolism. Also a source of antioxidant for the maintenance of good health. A simple, vegan, non-GMO, gluten-free formula made in Canada. Licensed Natural Health Product NPN 80033685.
CanPrev Indole-3-Carbinol 200mg offre une dose pure et unique de 200 mg d'I3C par capsule vegetale - un compose derive de legumes crucifers - pour aider a soutenir un metabolisme sain de l'oestrogene. Egalement une source d'antioxydants pour le maintien d'une bonne sante. Une formule simple, vegane, sans OGM et sans gluten, fabriquee au Canada. Produit de sante naturel homologue. NPN 80033685.
Take 1 Capsule, 1 to 2 Times Daily
90 vegetable capsules - a 45 to 90-day supply, depending on dose
200mg Pure Indole-3-Carbinol Per Capsule
A focused, single-ingredient dose of I3C, derived from cruciferous vegetables, with only two non-medicinal ingredients besides the medicinal ingredient itself - no unnecessary fillers or binders.
Flexible Dosing, 1 to 2 Capsules Daily
Take 1 capsule, 1 to 2 times per day (200-400mg I3C daily), or as directed by a healthcare practitioner - a 90-capsule bottle lasts 45 to 90 days depending on your dose.
What CanPrev I-3-C 200 Supports
Indole-3-carbinol (I3C) is a phytonutrient found in cruciferous vegetables like broccoli, kale and brussels sprouts. Here's what the label and the research summarize about its role.
Estrogen Metabolism
Helps to support healthy estrogen metabolism - the Health Canada-authorized use on this product's NPN license.
Antioxidant Support
A source of antioxidant for the maintenance of good health, from a compound found naturally in cruciferous vegetables.
Skin & Cellular Wellness
Part of a daily routine aimed at supporting skin clarity and overall cellular wellness, alongside a balanced diet.
Everyday Hormonal Balance
A single-ingredient way to support the body's natural hormone-metabolism processes as part of a broader wellness routine.
CanPrev Indole-3-Carbinol: Supplement Facts
Each Vegetable Capsule contains:
- Indole-3-Carbinol200 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Hypromellose, magnesium carbonate.
Recommended Use or Purpose: Indole-3-carbinol 200mg helps to support healthy estrogen metabolism. It is a source of antioxidant for the maintenance of good health.
Recommended Dose (Adults 19 years and older): Take 1 capsule, 1 to 2 times per day, or as directed by a healthcare practitioner.
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Ask a healthcare practitioner prior to use if you are attempting to conceive, have symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness, or irregular menstruation), if you are taking medications or natural health products, or if you have a liver disorder. Stop use and ask a healthcare practitioner if you develop liver-related symptoms (such as yellowing of the eyes or skin, dark urine, or abdominal pain). Keep out of reach of children. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule végétale contient :
- Indole-3-carbinol200 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Carbonate de magnésium, hypromellose.
Usage ou fins recommandés : Indole-3-carbinol 200 mg aide à soutenir un métabolisme sain d'oestrogènes. C'est une source d'antioxydants pour le maintien d'une bonne santé.
Dose recommandée (adultes de 19 ans et plus) : Prendre 1 capsule, 1 à 2 fois par jour, ou selon les directives d'un praticien de la santé.
Mises en garde et précautions : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Consulter un praticien de soins de santé avant l'usage si vous tentez de concevoir, si vous présentez des symptômes d'un faible taux d'oestrogène (tels que douleurs articulaires, changements d'humeur, changements de la libido, bouffées de chaleur, sueurs nocturnes, sécheresse vaginale ou menstruations irrégulières), si vous prenez des médicaments ou des produits de santé naturels, ou si vous souffrez d'un trouble du foie. Cesser l'usage et consulter un praticien de soins de santé si vous développez des symptômes reliés au foie (tels que jaunissement des yeux ou de la peau, urine foncée, ou douleurs abdominales). Garder hors de la portée des enfants. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80033685
Support healthy estrogen metabolism, one capsule at a time
Get CanPrev I-3-C 200 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy CanPrev I-3-C 200
A pure, single-ingredient 200mg dose of Indole-3-Carbinol per capsule - simple, focused estrogen-metabolism support, premium CanPrev quality.
200mg pure Indole-3-Carbinol
A focused single-ingredient dose of I3C, the formula's only medicinal ingredient, for supporting healthy estrogen metabolism.
The authorized estrogen-metabolism claim
Health Canada licenses this product to help support healthy estrogen metabolism and as a source of antioxidant - clear, verified uses, not vague wellness claims.
Simple, two-ingredient formula
Only hypromellose and magnesium carbonate join indole-3-carbinol in this vegetable capsule - no unnecessary fillers or binders.
Trusted Canadian brand
CanPrev - formulated and made in Canada, licensed under Health Canada NPN 80033685.
How to use it
Take 1 capsule, 1 to 2 times per day
Adults (19 years and older): take 1 capsule, 1 to 2 times per day (200-400mg I3C daily), or as directed by a healthcare practitioner.
Swallow with water
Take the vegetable capsule whole with water.
Watch for signs of low estrogen or liver symptoms
Ask a healthcare practitioner if you develop symptoms of low estrogen, or liver-related symptoms such as abdominal pain, jaundice or dark urine.
What the research says about Indole-3-Carbinol
Educational summaries of published research on the ingredient indole-3-carbinol generally - not claims about this finished product. CanPrev I-3-C 200's own claim is the authorized use under NPN 80033685: helps to support healthy estrogen metabolism, and is a source of antioxidant for the maintenance of good health.
Oral I3C raised the protective estrogen ratio in overweight women
In a small clinical intervention study, five overweight premenopausal women who took 400mg of indole-3-carbinol daily for two months showed a significantly increased ratio of 2-hydroxyestrone to estriol in their urine, indicating induced estrogen 2-hydroxylation similar to that seen in non-obese women.
Human studyA 3-month randomized trial found indole-3-carbinol's effect on estrogen metabolism was sustained
In a three-arm randomized trial, women given 400mg/day of indole-3-carbinol for three months showed a substantial, sustained increase in the urinary 2-hydroxyestrone-to-estriol ratio starting at month one and maintained through month three, while a fiber-only arm and placebo arm showed no change.
Human RCTPhase I trial found the estrogen-metabolite shift peaked at 400mg/day, with no benefit from doubling the dose
In a phase I trial in 17 women, chronic dosing of 400mg and then 800mg of indole-3-carbinol daily was well tolerated; the urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio rose by 66% at the 800mg dose, but the maximal increase was already observed at the 400mg/day dose, with no further increase at the higher amount.
Human study (Phase I)A dose-ranging trial identified 300mg/day as a minimum effective dose
In a placebo-controlled, double-blind dose-ranging study of 57 women at increased breast cancer risk, only the 300-400mg/day dose group showed a significantly greater shift in the urinary estrogen-metabolite ratio than placebo, identifying 300mg/day as a minimum effective dose in this trial.
Human RCT400mg/day increased the protective estrogen ratio, but the effect depended on genotype
African-American women with the common CYP1A1 gene variant showed a significant rise in their 2-hydroxyestrone/16-hydroxyestrone ratio after 5 days of 400mg/day indole-3-carbinol, while women carrying a specific CYP1A1 polymorphism (Msp1) showed no significant increase - illustrating that individual genetics can affect the size of the response.
Human clinical trialAnimal study: indole-3-carbinol shifted estrogen metabolism through a different pathway than soy isoflavones
In mice, dietary indole-3-carbinol reduced the 16alpha-hydroxyestrone-to-2-hydroxyestrone ratio by increasing liver cytochrome P-450 content, while soy isoflavones (genistein, daidzein) achieved a similar metabolite shift without that enzyme induction - suggesting the two work through distinct mechanisms toward a similar outcome.
Preclinical studyReview: indole-3-carbinol shifts estrogen metabolism by inducing one enzyme and suppressing another
This review describes how indole-3-carbinol induces CYP1A1, increasing 2-hydroxylation of estrogens toward the protective 2-hydroxyestrone metabolite, while separately decreasing CYP1B1, reducing formation of a different, less favourable metabolite.
ReviewCell-culture study: indole-3-carbinol competed with estradiol for estrogen-receptor binding
In cervical cell cultures, indole-3-carbinol bound to the estrogen receptor in competition with estradiol and induced the same enzymes responsible for 2-hydroxylation of estrogen, generating more of the metabolite 2-hydroxyestrone.
Preclinical studyReview: cruciferous-vegetable compounds alter estrogen metabolite profiles in women
This review of cruciferous vegetables and cancer risk notes that supplementation with indole-3-carbinol or its metabolite DIM reliably alters urinary estrogen-metabolite profiles in women, while cautioning that individual genetic variation in metabolism can influence the size of the protective effect.
ReviewIndole-3-carbinol reversed an unfavourable estrogen-metabolite shift caused by pesticide exposure in breast cells
In estrogen-receptor-negative human breast cancer cell lines, certain organochlorine pesticides increased production of the less-favourable 16alpha-hydroxyestrone relative to 2-hydroxyestrone; indole-3-carbinol was shown to help reverse this shift back toward the more favourable metabolite ratio.
Preclinical studyReview: estrogen-metabolism modulators like indole-3-carbinol require menopausal-status-specific study design
This review of estrogen modulators for breast cancer chemoprevention discusses how a compound's hormonal effects - and the biomarkers used to study them - differ between premenopausal and postmenopausal women, framing how agents like indole-3-carbinol should be evaluated in clinical trials.
ReviewIndole-3-carbinol modulated inflammatory signaling through the aryl hydrocarbon receptor
In human monocyte and macrophage cell cultures, indole-3-carbinol (alongside its metabolite DIM) suppressed a specific inflammatory cytokine response in an aryl-hydrocarbon-receptor-dependent manner, illustrating one of the cellular pathways through which this cruciferous-vegetable compound is thought to act.
Preclinical studyRandomized trial: oral indole-3-carbinol was linked to regression of cervical cell changes
In a placebo-controlled trial of 30 women with biopsy-proven cervical intraepithelial neoplasia (CIN), 4 of 8 women taking 200mg/day and 4 of 9 taking 400mg/day of indole-3-carbinol for 12 weeks had complete regression on repeat biopsy, versus none of the 10 women on placebo; the estrogen-metabolite ratio changed in a dose-dependent fashion.
Human RCTCommentary: cervical-tissue findings raise the question of whether indole-3-carbinol's effects extend to other tissue types
This commentary on indole-3-carbinol research in cervical intraepithelial neoplasia discusses whether the same estrogen-metabolism-based mechanism might extend to other food components and other estrogen-sensitive tissues, an open question for future research.
ReviewCochrane review: one trial compared low- versus high-dose indole-3-carbinol for vulval tissue changes
This Cochrane systematic review of treatments for high-grade vulval intraepithelial neoplasia (VIN) identified one randomized trial comparing low-dose versus high-dose indole-3-carbinol, alongside other studied approaches, concluding that more data on medical (non-surgical) options for VIN, including indole-3-carbinol, are still needed.
Systematic reviewHonest finding: larger placebo-controlled cervical chemoprevention trials have often been disappointing
This review of cervical chemoprevention research (including indole-3-carbinol) found that while small phase I/IIa trials showed promising response rates, larger placebo-controlled phase IIb trials were often disappointing - confounded by surprisingly high spontaneous regression rates in placebo-treated patients.
ReviewReview: indole-3-carbinol showed efficacy in small trials, but needs larger confirmation
This review of therapies for HPV-related genital disease notes that agents such as indole-3-carbinol have shown efficacy in small clinical trials, but states plainly that these effects need to be confirmed in larger, randomized, placebo-controlled trials before being considered clinically established.
ReviewCell-line study only: indole-3-carbinol triggered cancer-cell death via the AhR pathway in the lab, not in patients
In multiple human colorectal cancer cell lines, indole-3-carbinol reduced cell viability and induced apoptosis in a dose-dependent, aryl-hydrocarbon-receptor-dependent manner - a laboratory finding about a cellular pathway, not a clinical trial result in patients.
Preclinical studyReview: indole-3-carbinol is grouped among established dietary antioxidant compounds
This pharmaceutical review of antioxidants as prophylactic and therapeutic agents lists indole-3-carbinol alongside compounds like vitamin C, vitamin E, coenzyme Q10 and quercetin as a dietary antioxidant studied for its free-radical-scavenging role, while noting that bioavailability varies by delivery method.
ReviewLow concentrations of I3C's metabolite protected cells against oxidative stress
In cultured human and mouse cells, low, physiologically relevant concentrations of 3,3'-diindolylmethane (DIM, indole-3-carbinol's main metabolite) protected cells from oxidative damage caused by hydrogen peroxide, acting through the tumor-suppressor protein BRCA1 and the antioxidant transcription factor NRF2.
Preclinical studyIndole-3-carbinol blocked oxidative-stress-driven cell death in bone-forming cells
In cultured osteoblast (bone-forming) cells, indole-3-carbinol suppressed excess reactive-oxygen-species production and blocked the resulting apoptosis triggered by a glucocorticoid drug, acting through the antioxidant Nrf2 pathway - a laboratory finding illustrating a broader cellular-protection role beyond estrogen metabolism.
Preclinical studyAnimal study: an antioxidant counteracted indole-3-carbinol's high-dose liver effects in rats
In rats fed a high-dose indole-3-carbinol diet (0.5% of total diet) after a liver-cancer-initiating chemical, co-administering the antioxidant N-acetyl-cysteine suppressed the reactive-oxygen-species-mediated liver changes that high-dose indole-3-carbinol otherwise promoted - implicating oxidative stress in the effect and showing it could be blunted.
Animal studyAnimal study: high dietary doses of indole-3-carbinol increased oxidative stress markers in rat liver
In rats pre-treated with a liver-cancer-initiating chemical, high dietary doses of indole-3-carbinol (0.25% to 1.0% of total diet, well above typical human supplemental intake) increased microsomal reactive oxygen species and oxidative DNA damage markers alongside liver cell changes - a high-dose animal finding, not a result at typical human supplemental doses, consistent with why product labels caution people with liver disorders to consult a healthcare practitioner.
Animal studyEx vivo study: indole-3-carbinol shifted immune-cell activity in lupus patients' cells toward an anti-inflammatory profile
In cell samples taken from people with systemic lupus erythematosus (an autoimmune condition), indole-3-carbinol activated the aryl hydrocarbon receptor in immune cells (monocyte-derived macrophages) and shifted their cytokine output toward a less inflammatory profile - a specific ex vivo finding in this patient population's cells, not a claim that this product treats lupus or any autoimmune disease.
Ex vivo human studyFrequently asked questions
What is CanPrev I-3-C 200 and what does it do?
It's a single-ingredient formula providing 200mg of pure indole-3-carbinol (I3C) per vegetable capsule. Its Health Canada-authorized uses are to help support healthy estrogen metabolism and as a source of antioxidant for the maintenance of good health.
How do I take it?
Adults (19 years and older) take 1 capsule, 1 to 2 times per day (200-400mg daily), or as directed by a healthcare practitioner.
How long does one bottle last?
Each bottle contains 90 vegetable capsules - a 45 to 90-day supply depending on whether you take 1 or 2 capsules per day.
What is indole-3-carbinol?
Indole-3-carbinol (I3C) is a phytonutrient found in cruciferous vegetables such as broccoli, kale, brussels sprouts, bok choy and cauliflower.
Is this the same as CanPrev Healthy Hormones?
No. Healthy Hormones is a 6-ingredient combination formula (chasteberry, indole-3-carbinol, black cohosh, magnesium, B6 and D3) under its own NPN 80123756. This product is a standalone, single-ingredient 200mg indole-3-carbinol capsule, licensed under its own distinct NPN 80033685.
Who should use caution, or not use it?
Do not use if you are pregnant or breastfeeding. Ask a healthcare practitioner before use if you are attempting to conceive, have symptoms of low estrogen, are taking medications or natural health products, have a liver disorder, or if you develop liver-related symptoms such as abdominal pain, jaundice or dark urine.
Is it vegan and allergen-friendly?
Yes - vegan, non-GMO, gluten-free, dairy-free and soy-free, with no binders, fillers or artificial colours, flavours or preservatives.
Where do I buy it?
Use the orange button on this page - it takes you to the CanPrev listing on Amazon.ca for secure checkout and fast delivery.
Support healthy estrogen metabolism, one capsule at a time
Get CanPrev I-3-C 200 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80033685. Indole-3-carbinol 200mg helps to support healthy estrogen metabolism. It is a source of antioxidant for the maintenance of good health. The research summaries below concern the ingredient indole-3-carbinol generally and are educational - they are not claims about this finished product. Read and follow the label. Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if you are attempting to conceive, have symptoms of low estrogen, are taking medications or natural health products, have a liver disorder, or develop liver-related symptoms. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Ask a healthcare practitioner prior to use if you are attempting to conceive, have symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness, or irregular menstruation), if you are taking medications or natural health products, or if you have a liver disorder. Stop use and ask a healthcare practitioner if you develop liver-related symptoms (such as yellowing of the eyes or skin, dark urine, or abdominal pain). Keep out of reach of children. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: Indole-3-carbinol 200mg helps to support healthy estrogen metabolism. It is a source of antioxidant for the maintenance of good health.
Ingredients
Medicinal Ingredients (per capsule): Indole-3-carbinol 200 mg. Non-medicinal ingredients: Hypromellose, magnesium carbonate. NMIs are subject to change - always read and follow the label for accurate ingredients, cautions and allergen information.
Directions
Recommended Dose (Adults 19 years and older): Take 1 capsule, 1 to 2 times per day, or as directed by a healthcare practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.