CanPrev EliteNeuro Zembrin Sceletium 25mg | 45 Vegetable Capsules
Visit the CanPrev Store Read all reviews on Amazon →| Brand | CanPrev |
| Serving | 1 capsule daily |
| Licensed Natural Health Product | NPN 80091056 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 25 MG ZEMBRIN SCELETIUM EXTRACT PER CAPSULE: Each vegetable capsule provides 25 mg of Zembrin (Sceletium tortuosum, herb top) 2:1 extract equivalent to 50 mg of dried herb, standardized to 0.4% alkaloids - take 1 capsule per day, or as directed by a healthcare practitioner.
- DAILY FOCUS AND CLARITY FORMULA: Featuring Zembrin, a clinically studied botanical extract, this supplement helps support focus, clarity, and a sense of calm as part of your daily wellness routine.
- HELPS SUPPORT COGNITIVE FUNCTION IN ADULTS: The recommended use authorized on this product's Health Canada licence (NPN 80091056): helps support cognitive function in adults and helps support cognitive performance in a healthy aging population.
- ONE CAPSULE A DAY: Adults (19 years and older) take 1 capsule per day - consult a healthcare practitioner for use beyond 3 months.
- VEGAN, GMO-FREE FORMULA: No gluten, dairy, wheat, soy, yeast, sugar, artificial colours, flavours, preservatives or animal products.
- MADE IN CANADA, LICENSED BY HEALTH CANADA: Formulated and made in Canada by CanPrev Natural Health Products Ltd. and licensed under NPN 80091056.
Product Description
EliteNeuro - Zembrin Sceletium, 25 mg Clinically Studied Kanna Extract
EliteNeuro features Zembrin, the world's most researched Sceletium tortuosum (kanna) extract, delivering a standardized 25 mg dose in every vegetable capsule. Traditionally used by the indigenous peoples of South Africa for centuries, Zembrin's dual mechanism of action is associated with serotonin reuptake and phosphodiesterase-4 (PDE4) activity. Helps support cognitive function in adults and helps support cognitive performance in a healthy aging population. Vegan and licensed as a Natural Health Product. Licensed Natural Health Product NPN 80091056.
EliteNeuro contient du Zembrin, l'extrait de Sceletium tortuosum (kanna) le plus étudié au monde, offrant une dose normalisée de 25 mg dans chaque capsule végétale. Traditionnellement utilisé depuis des siècles par les peuples autochtones d'Afrique du Sud, le mécanisme d'action double de Zembrin est associé à l'activité de recaptage de la sérotonine et de la phosphodiestérase de type 4 (PDE4). Aide à soutenir les fonctions cognitives chez les adultes et aide à soutenir le rendement cognitif chez une population vieillissante en santé. Végétalien et homologué comme produit de santé naturel.
Built for Mental Clarity
25 mg Zembrin (Sceletium tortuosum) 2:1 extract, standardized to 0.4% alkaloids - one vegetable capsule daily
25 mg of Clinically Studied Zembrin Sceletium Extract
Each vegetable capsule delivers a standardized 25 mg dose of Zembrin (Sceletium tortuosum, herb top) 2:1 extract, equivalent to 50 mg of dried herb and standardized to 0.4% alkaloids.
A Traditional South African Botanical, Modernized
Sceletium tortuosum (kanna) has been used traditionally by the San and Khoikhoi peoples of South Africa; Zembrin is the only kanna extract to carry the logo of its indigenous beneficiaries, the South African San Council.
Why This Formula
EliteNeuro is built around one clinically studied active - Zembrin Sceletium extract - delivered at its standardized research dose in an easy-to-swallow vegetable capsule.
Cognitive Function Support
Helps support cognitive function in adults and helps support cognitive performance in a healthy aging population - this product's Health Canada-authorized use.
25 mg Zembrin Sceletium Extract
Each capsule delivers a standardized 25 mg dose of Zembrin (Sceletium tortuosum) 2:1 extract, standardized to 0.4% alkaloids.
Dual-Mechanism Botanical
Zembrin's mesembrine alkaloids are associated with serotonin reuptake and PDE4 activity, mechanisms studied in relation to mood and cognitive function.
Simple, Once-Daily Vegetable Capsule
Take 1 capsule per day - easy to fit into your daily routine, in a vegan capsule with no animal gelatin.
CanPrev EliteNeuro Zembrin Sceletium: Supplement Facts
Each vegetable capsule contains:
- Zembrin Sceletium (herb top, Sceletium tortuosum) 2:1 extract, standardized to 0.4% alkaloids25 mg
Non-Medicinal Ingredients: Hypromellose, magnesium stearate, microcrystalline cellulose, silicon dioxide.
Recommended Use or Purpose: Helps support cognitive function in adults. Helps support cognitive performance in a healthy aging population.
Recommended Dose (Adults 19 years and older): Take 1 capsule per day. Consult a healthcare practitioner for use beyond 3 months.
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if you are taking anxiolytics, MAO inhibitors, antidepressant medications (e.g. selective serotonin reuptake inhibitors (SSRI)), or phosphodiesterase type 4 (PDE4) inhibitors. Consult a healthcare practitioner if symptoms persist or worsen. Do not use if the safety seal is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.
Chaque capsule végétale contient :
- Zembrin Sceletium (sommité (herbe), Sceletium tortuosum) extrait 2:1, normalisé à 0,4% d'alcaloïdes25 mg
Ingrédients non médicinaux : Cellulose microcristalline, dioxyde de silicium, hypromellose, stéarate de magnésium.
Usage ou fins recommandés : Aide à soutenir les fonctions cognitives chez les adultes. Aide à soutenir le rendement cognitif chez une population vieillissante en santé.
Dose recommandée (adultes de 19 ans et plus) : Prendre 1 capsule par jour. Consulter un praticien de soins de santé pour un usage de plus de 3 mois.
Mises en garde et avertissements : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Consulter un praticien de soins de santé avant d'en faire l'usage si vous prenez des anxiolytiques, des inhibiteurs de la MAO, des antidépresseurs (par exemple des inhibiteurs sélectifs du recaptage de la sérotonine (ISRS)), ou des inhibiteurs de la phosphodiestérase de type 4 (PDE4). Consulter un praticien de soins de santé si les symptômes persistent ou s'aggravent. Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.
NPN 80091056
Add CanPrev EliteNeuro to your daily routine
Get CanPrev EliteNeuro Zembrin Sceletium on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy CanPrev EliteNeuro
25 mg of clinically studied Zembrin Sceletium extract in an easy, once-daily vegetable capsule.
25 mg of clinically studied Zembrin extract
Each capsule delivers a standardized 25 mg dose of Zembrin (Sceletium tortuosum), the world's most researched kanna extract.
A traditional botanical with a modern dual mechanism
Zembrin's mesembrine alkaloids are studied for serotonin-reuptake and PDE4-inhibiting activity, mechanisms linked to mood and cognitive function.
Simple once-daily dosing
Take 1 vegetable capsule per day - no need to track multiple doses through the day.
Trusted Canadian brand
CanPrev - formulated and made in Canada, licensed under NPN 80091056.
Inside every capsule
25 mg Zembrin Sceletium (Sceletium tortuosum) extract, standardized to 0.4% alkaloids - take 1 capsule daily, or as directed by a healthcare practitioner.
How to use it
Take 1 capsule daily
Adults (19 years and older): take 1 capsule per day, or as directed by a healthcare practitioner.
Consult a practitioner beyond 3 months
This product is intended for use up to 3 months; consult a healthcare practitioner before continuing use beyond that.
Give it time
Take consistently, once daily, as part of your ongoing wellness routine.
What the research says about Zembrin Sceletium tortuosum extract
Educational summaries of published research on Zembrin (Sceletium tortuosum extract), its mesembrine alkaloids, and related PDE4-inhibition/serotonin-reuptake mechanisms generally - not additional product-specific claims. CanPrev EliteNeuro's own label claim is the use authorized under NPN 80091056: helps support cognitive function in adults and helps support cognitive performance in a healthy aging population.
A 21-person RCT found 25 mg Zembrin improved cognitive flexibility and executive function over 3 weeks
In this randomized, double-blind, placebo-controlled crossover trial, healthy adults (mean age 54.6) took 25 mg Zembrin or placebo daily for 3 weeks; Zembrin significantly improved cognitive set flexibility and executive function on the CNS Vital Signs test battery versus placebo, with positive changes in mood and sleep also reported.
Human RCTA placebo-controlled trial found a single 25 mg Zembrin dose eased subjective anxiety before a public-speaking stress task
Across two studies in 20 healthy young volunteers, a single 25 mg dose of Zembrin showed no effect on mood during a multitasking challenge, but before a simulated public-speaking task subjective anxiety was significantly lower in the Zembrin group than placebo, with a significant treatment-by-time interaction on heart rate.
Human RCTAn fMRI study found a single 25 mg Zembrin dose calmed the brain's fear-response circuitry
In a double-blind, placebo-controlled crossover fMRI study of 16 healthy adults, a single 25 mg dose of Zembrin reduced amygdala reactivity to fearful faces and reduced amygdala-hypothalamus connectivity, consistent with Zembrin's reported dual serotonin-reuptake-inhibition and PDE4-inhibition mechanism attenuating the brain's threat circuitry.
Human RCT (fMRI)A 3-month RCT found both an 8 mg and 25 mg daily dose of Zembrin were well tolerated in 37 healthy adults
In this randomized, double-blind, placebo-controlled trial, neither dose of Zembrin produced meaningful changes in vital signs, ECG, body weight, or blood work versus placebo over 3 months; headache was the most common side effect, reported more often in the placebo group, and some participants' diaries noted improved coping with stress and sleep.
Human RCT14-day and 90-day rat toxicology studies found no adverse effects even at high Zembrin doses
Repeated-dose oral toxicity studies in Wistar rats found no mortality or treatment-related adverse effects at doses up to 5,000 mg/kg/day (14 days) or 600 mg/kg/day (90 days) - the highest doses tested in each study - supporting Zembrin's safety margin at the much lower doses used in supplements.
Animal studyA 2026 systematic review found a favorable safety profile for Zembrin but called for larger, more relevant clinical trials
Reviewing published animal and clinical studies on Sceletium tortuosum, Zembrin, and mesembrine alkaloids, this review found a generally favorable safety profile and some positive findings on anxiety, cognitive function, stress resilience and mood - but flagged small sample sizes and inconsistent outcomes across studies, concluding that large-scale trials in clinically relevant populations are still needed.
Systematic reviewA rat EEG study found Zembrin's brain-wave signature resembled both cognitive-enhancing and antidepressant reference compounds
Recording brain electrical activity in rats given Zembrin at 3 doses, researchers found a dose-dependent EEG signature most similar to citicoline (a cognitive-enhancing compound) and to the PDE4 inhibitor drug rolipram, suggesting Zembrin may share cognitive-enhancing and antidepressant-like electrophysiological features with these reference compounds.
Animal studyA hippocampus slice study found Zembrin and its alkaloids dampened neural over-excitability
Testing Zembrin and four of its isolated alkaloids on rat hippocampal brain slices, researchers found all attenuated electrically-evoked neural signaling, with two alkaloids (mesembranol and mesembrenol) acting on AMPA-receptor-mediated transmission, a pathway linked to successful adjunctive epilepsy treatment.
Ex vivo / in vitro studyA chronic-stress rat study found low-dose Zembrin reduced stress-induced anhedonia and anxiety-like behavior
In male rats subjected to 8 weeks of unpredictable chronic mild stress, a lower dose of Zembrin (12.5 mg/kg) reduced anhedonia- and anxiety-like behavior, lowered stress-elevated PDE4B expression in the brain, and increased an anti-inflammatory marker (interleukin-10) - while its main alkaloid mesembrine separately increased hippocampal serotonergic and cortical dopaminergic activity.
Animal studyIn a genetic rat model of depression, Zembrin performed comparably to a standard antidepressant
In Flinders Sensitive Line rats (a genetic model of depression), Zembrin at 25 and 50 mg/kg significantly reversed depression-like immobility in the forced swim test, with the 50 mg/kg dose showing effects equivalent to a 5 mg/kg dose of the antidepressant escitalopram.
Animal studyA zebrafish study traced Zembrin's anxiolytic effect mainly to its mesembrine alkaloid
Using a light-dark locomotor test in zebrafish larvae, researchers found an optimal Zembrin concentration reduced anxiety-like hyperactivity, and of the four major alkaloids tested individually only mesembrine reproduced this anxiolytic-like effect at a matching dose - while the full extract's antidepressant-like effect at higher concentrations could not be pinned to any single alkaloid, suggesting synergy among constituents.
Animal studyReceptor-binding assays confirmed Zembrin's dual serotonin-transporter and PDE4-inhibiting mechanism
Testing Zembrin and its purified alkaloids against a panel of receptors and enzymes, researchers found the whole extract potently blocked the serotonin (5-HT) transporter and inhibited phosphodiesterase 4 (PDE4), with mesembrine the most active alkaloid at the serotonin transporter and mesembrenone active at both targets - a mechanistic basis for the plant's traditional mood-related use.
In vitro studyA review of mesembrine alkaloids confirmed their serotonin-reuptake-inhibiting and PDE4-inhibiting activity
Summarizing the chemistry and pharmacology of Sceletium tortuosum's mesembrine-type alkaloids, this review concluded that mesembrine and mesembrenone are serotonin reuptake inhibitors - providing a rationale for the plant's traditional antidepressant-like use - with mesembrenone additionally showing meaningful PDE4-inhibitory activity.
ReviewA comprehensive review found Sceletium tortuosum shows potential for cognition, anxiety and depression, but lacked trials in clinical populations
Reviewing a decade of phytochemistry and pharmacology research, this review catalogued 25 alkaloids across 4 structural classes in S. tortuosum (mesembrine-type predominant) and a wide spectrum of biological activities in lab and animal studies - noting the plant had, at the time, only been studied in healthy volunteers, not in clinical populations with anxiety or depression.
ReviewA broad review identified PDE4 inhibitors, Zembrin's mechanism class, among the most promising emerging targets for depression and anxiety
Reviewing phosphodiesterase inhibitors across psychiatric conditions, this review found PDE2 and PDE4 inhibitors among the most promising preclinical candidates for depression and anxiety, acting via the cAMP-PKA-CREB signaling pathway, reducing neuroinflammation, and supporting neural plasticity - though it called for larger, better-designed clinical trials before conclusions can be drawn for humans.
ReviewRestoring the CREB memory pathway, the same pathway PDE4 inhibition targets, protected neurons in an Alzheimer's model
Using human stem-cell-derived neurons and a mouse Alzheimer's model, researchers found that dual inhibition of PDE4 (and a related enzyme, PDE10) restored activity of CREB1, a transcription factor central to memory, reducing hallmark Alzheimer's proteins and improving synaptic plasticity and cognitive performance - illustrating the mechanistic pathway Zembrin's PDE4-inhibiting activity is thought to engage.
Animal/cell studyA 2024 review catalogued how PDE4 inhibition supports memory and mood across multiple brain conditions
This review of PDE4 inhibitors in central nervous system disease found they enhance CREB phosphorylation and memory-related gene expression in the hippocampus, improving cognitive impairment in Alzheimer's models, and separately reduce neuroinflammatory signaling implicated in depression - the general enzyme-inhibition mechanism attributed to Zembrin's mesembrine alkaloids.
ReviewA review identified PDE4 inhibitors as among the first compounds shown to restore memory in Alzheimer's animal models
This review found that rolipram, a selective PDE4 inhibitor, was the first compound shown to effectively restore cognitive deficits in animal models of Alzheimer's disease by increasing cAMP signaling to the CREB memory pathway, establishing PDE4 inhibition as a mechanistic strategy for memory support later applied to natural PDE4-inhibiting extracts like Zembrin.
ReviewThe PDE4 inhibitor rolipram reduced anxiety and improved memory in mice after a brain-blood-flow injury
In mice subjected to transient global cerebral ischemia, chronic treatment with the PDE4 inhibitor rolipram reduced anxiety-like and depression-like behavior, improved spatial memory performance, and supported hippocampal neuron survival and plasticity markers - illustrating PDE4 inhibition's mood and memory benefits in an animal brain-injury model.
Animal studyPDE4 inhibitor drugs reversed memory deficits caused by high blood pressure in rats
In hypertensive rats with impaired learning and memory, the PDE4 inhibitors rolipram and roflumilast significantly reversed memory deficits on object-recognition and maze tasks, correlating with reduced PDE4B/PDE4D gene expression in the hippocampus, independent of any blood-pressure-lowering effect.
Animal studyA mechanistic review explains why PDE4 inhibition, Zembrin's mechanism class, is being explored for antidepressant and memory-enhancing drugs
This review explains how PDE4 enzymes regulate cAMP and CREB signaling in the brain, and how PDE4 inhibitors have shown antidepressant and memory-enhancing activity in preclinical models and early clinical trials - while noting that side effects have limited some synthetic PDE4 drugs, motivating interest in gentler, plant-derived PDE4-modulating compounds.
ReviewRats with reduced serotonin-transporter function showed heightened fear learning and slower fear extinction
Studying rats genetically engineered with reduced serotonin transporter (SERT) expression, researchers found these animals acquired fear responses more readily and were slower to extinguish them, linked to changes in serotonin-related genes and disrupted inhibitory signaling in the amygdala - underscoring the amygdala's central role in the serotonin-anxiety relationship that Zembrin's serotonin-reuptake-inhibiting mechanism is thought to engage.
Animal studyIncreasing serotonin transporter activity in mice's amygdala blunted their fear response
Mice engineered to overexpress the serotonin transporter showed impaired fear responses linked to reduced activity of specific inhibitory neurons in the amygdala's fear circuitry, revealing a cellular mechanism connecting serotonin signaling to fear regulation in this brain region.
Animal studyPET neuroimaging found SSRI treatment for social anxiety reduces amygdala activity, the same region where Zembrin's own imaging effect was found
In a series of neuroimaging studies of social anxiety disorder patients, SSRI treatment reduced activity in the amygdala (the brain's fear-processing hub) alongside symptom improvement - the same brain region where a single dose of Zembrin has separately been shown to reduce fear-related activity, situating Zembrin's proposed mechanism within a broader body of amygdala-focused anxiety research.
Human neuroimaging reviewFrequently asked questions
How do I take CanPrev EliteNeuro?
Adults (19 years and older) take 1 capsule per day, or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 3 months.
What's in each capsule?
Each vegetable capsule contains 25 mg of Zembrin (Sceletium tortuosum, herb top) 2:1 extract, equivalent to 50 mg of dried herb, standardized to 0.4% alkaloids. Non-medicinal ingredients are hypromellose, magnesium stearate, microcrystalline cellulose and silicon dioxide.
What is Zembrin?
Zembrin is a patented, standardized extract of Sceletium tortuosum (kanna), a succulent plant traditionally used by the San and Khoikhoi peoples of South Africa. It is the only kanna extract to carry the logo of its indigenous beneficiaries, the South African San Council.
What is the licensed use of this product?
This product's Health Canada licence (NPN 80091056) authorizes it to help support cognitive function in adults and help support cognitive performance in a healthy aging population.
Can I take this if I'm pregnant or breastfeeding?
No - do not use if you are pregnant or breastfeeding.
Does this interact with any medications?
Consult a healthcare practitioner before use if you are taking anxiolytics, MAO inhibitors, antidepressant medications (including SSRIs), or phosphodiesterase type 4 (PDE4) inhibitors. Consult a healthcare practitioner if symptoms persist or worsen.
Is it vegan and allergen-friendly?
Yes - it is vegan, GMO-free, and free of gluten, dairy, wheat, soy, yeast, sugar, and artificial colours, flavours or preservatives.
Is CanPrev EliteNeuro made in Canada?
Yes. It is formulated and made in Canada by CanPrev Natural Health Products Ltd. (Toronto, ON) and licensed by Health Canada under NPN 80091056.
Is EliteNeuro a stimulant?
No. EliteNeuro is formulated to support mental clarity and focus without the jittery, stimulant-like side effects associated with caffeine-based products.
Add CanPrev EliteNeuro to your daily routine
Get CanPrev EliteNeuro Zembrin Sceletium on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80091056. Helps support cognitive function in adults. Helps support cognitive performance in a healthy aging population. Research summaries on this page concern Zembrin (Sceletium tortuosum extract) and related mechanisms generally and are educational - they are not additional product-specific claims beyond this product's Health Canada-authorized use. Read and follow the label. Consult a health care practitioner before use, especially if pregnant or breastfeeding, or if taking anxiolytics, MAO inhibitors, antidepressant medications (including SSRIs), or phosphodiesterase type 4 (PDE4) inhibitors. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if you are taking anxiolytics, MAO inhibitors, antidepressant medications (e.g. selective serotonin reuptake inhibitors (SSRI)), or phosphodiesterase type 4 (PDE4) inhibitors. Consult a healthcare practitioner if symptoms persist or worsen. Do not use if the safety seal is broken. Keep out of reach of children.
Indications
Recommended Use or Purpose: Helps support cognitive function in adults. Helps support cognitive performance in a healthy aging population.
Ingredients
Medicinal Ingredients (per capsule): Zembrin Sceletium (herb top, Sceletium tortuosum) 2:1 extract equivalent to 50 mg of dried herb, standardized to 0.4% alkaloids, 25 mg. Non-medicinal Ingredients: Hypromellose, magnesium stearate, microcrystalline cellulose, silicon dioxide.
Directions
Recommended Dose (Adults 19 years and older): Take 1 capsule per day. Consult a healthcare practitioner for use beyond 3 months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca.