CanPrev BioPQQ Supplement - Pyrroloquinoline Quinone | 60 Caps
Visit the CanPrev Store| Brand | CanPrev |
| Serving | 2 capsules (20 mg BioPQQ) |
| Licensed Natural Health Product | NPN 80047056 |
| Quality Standards | Made in Canada |
| Country | Made in Canada  |
About this item
- 20MG BIOPQQ PER DAY: Two vegetable capsules deliver a full 20 mg of BioPQQ (pyrroloquinoline quinone disodium salt), 10 mg per capsule - a naturally fermented, highly bioavailable form of PQQ.
- SOURCE OF ANTIOXIDANTS: Pyrroloquinoline quinone is a source of antioxidants for the maintenance of good health, helping to neutralize free radicals and reduce oxidative stress at the cellular level.
- A REDOX COFACTOR STUDIED FOR MITOCHONDRIAL BIOGENESIS: PQQ is one of the most-studied compounds for its role in activating the cellular pathways (including PGC-1alpha) that govern the growth of new mitochondria - the energy-producing structures inside every cell.
- RESEARCHED FOR BRAIN, HEART & EYE HEALTH: A growing body of published research has examined PQQ's role in cognitive performance, cerebral blood flow, cholesterol markers and eye-cell mitochondrial health - see the Research section below for citations.
- CLINICALLY-STUDIED, PATENTED FORM: Formulated with BioPQQ, a proprietary, clinically-studied form of pyrroloquinoline quinone (a registered trademark of Mitsubishi Gas Chemical Company, Japan).
- CLEAN VEGAN FORMULA: Vegetable capsules free from gluten, dairy, soy and wheat, with no artificial colours, flavours or preservatives.
- PREMIUM CANADIAN QUALITY: Formulated and made in Canada by CanPrev, licensed under Health Canada NPN 80047056 - Pro Essentials line.
Product Description
BioPQQ - Clinically-Studied Pyrroloquinoline Quinone
20 mg daily of BioPQQ - a naturally fermented, highly bioavailable form of pyrroloquinoline quinone (PQQ), a redox cofactor studied for its role in mitochondrial biogenesis and antioxidant defense. A source of antioxidants for the maintenance of good health. Licensed Natural Health Product NPN 80047056.
20 mg par jour de BioPQQ - une forme de pyrroloquinoléine quinone (PQQ) naturellement fermentée et hautement biodisponible, un cofacteur redox étudié pour son rôle dans la biogenèse mitochondriale et la défense antioxydante. Source d'antioxydants pour le maintien d'une bonne santé. Produit de santé naturel homologué. NPN 80047056.
Two Capsules, One Clinically-Studied Antioxidant
10mg BioPQQ (Pyrroloquinoline Quinone) per capsule - Vegan, Non-GMO, Gluten-Free
Naturally Fermented, Highly Bioavailable
BioPQQ is produced by controlled bacterial fermentation and purified to a high standard, rather than being chemically synthesized.
A Redox Cofactor for Mitochondrial Health
PQQ is studied for its ability to activate the cellular signaling pathways (including PGC-1alpha) that drive the growth of new, healthy mitochondria.
What The Research On PQQ Has Examined
Pyrroloquinoline quinone is one of the most-studied compounds in mitochondrial and antioxidant research - here is what the published research on PQQ has examined.
Antioxidant Defense
A source of antioxidants for the maintenance of good health, helping to neutralize free radicals and reduce oxidative stress.
Mitochondrial Biogenesis
Widely studied for its role in activating the cellular pathways that support the growth of new mitochondria, the energy-producing structures inside cells.
Cognitive Research
Investigated in multiple human clinical trials for its effect on memory, attention and cognitive flexibility.
Cardiometabolic Research
Studied for its influence on cerebral blood flow, cholesterol markers and mitochondrial function in cardiovascular tissue.
CanPrev BioPQQ Supplement: Supplement Facts
Supplement Facts
- Pyrroloquinoline Quinone (disodium salt), as BioPQQ per capsule10 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Microcrystalline cellulose, hypromellose (capsule), magnesium stearate, silicon dioxide.
Recommended Use or Purpose: Source of antioxidants.
Recommended Dose (Adults 19 years and older): Take 2 capsules daily with food, or as directed by a qualified health care practitioner.
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. When taking this product, it may cause a cold, abdominal symptoms, headache, fatigue (fatigability) or diarrhea. Do not use if the safety seal is broken. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Fiche produit
- Pyrroloquinoléine quinone (sel disodique), sous forme de BioPQQ par capsule10 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Cellulose microcristalline, hypromellose (capsule), stéarate de magnésium, dioxyde de silicium.
Usage ou fins recommandés : Source d'antioxydants.
Posologie recommandée (adultes de 19 ans et plus) : Prendre 2 capsules par jour avec de la nourriture, ou selon les directives d'un professionnel de la santé qualifié.
Mises en garde : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Lorsque vous utilisez ce produit, il peut causer un rhume, des symptômes abdominaux, des maux de tête, de la fatigue (fatigabilité) ou de la diarrhée. Ne pas utiliser si le sceau de sécurité est brisé. Garder hors de la portée des enfants.
NPN 80047056
A clinically-studied source of antioxidants for cellular health
Get CanPrev BioPQQ on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy CanPrev BioPQQ
20mg of naturally fermented, clinically-studied BioPQQ per day - premium CanPrev quality.
20mg BioPQQ daily dose
Two vegetable capsules deliver a full 20mg of BioPQQ (pyrroloquinoline quinone), 10mg per capsule.
Source of antioxidants
Pyrroloquinoline quinone is a source of antioxidants for the maintenance of good health.
Naturally fermented, clinically-studied form
BioPQQ is produced by controlled bacterial fermentation, not chemical synthesis, and is the form used in the published human clinical research on PQQ.
Premium Canadian brand
CanPrev - Pro Essentials line, formulated and made in Canada. NPN 80047056.
How to use it
Take 2 capsules daily
Adults (19 years and older) take 2 capsules daily with food, or as directed by a qualified health care practitioner.
One 60-capsule bottle = 30 days
At 2 capsules per day, each bottle provides a full 30-day supply.
Watch for mild digestive effects
When taking this product, it may cause a cold, abdominal symptoms, headache, fatigue or diarrhea - discontinue and consult a health care practitioner if symptoms persist.
Not for use during pregnancy or breastfeeding
Do not use if you are pregnant or breastfeeding.
What the research says about pyrroloquinoline quinone (PQQ)
Educational summaries of published research on PQQ, BioPQQ's active ingredient; not product-specific claims. CanPrev BioPQQ's authorized claim is the one under NPN 80047056: a source of antioxidants for the maintenance of good health.
Activates the AMPK/SIRT1 pathway that builds new mitochondria
A 2026 review describes PQQ as a mitochondrial and redox regulator that enhances mitochondrial biogenesis and bioenergetic capacity through the AMPK and SIRT1/PGC-1alpha signaling pathways, among nutritional strategies reviewed for supporting cellular energy metabolism with aging.
ReviewIncreased ATP and mitochondrial membrane potential in a fertility model
In porcine oocytes matured in the lab, PQQ increased ATP levels and mitochondrial membrane potential, and upregulated the mitochondrial biogenesis genes PGC-1alpha, NRF2 and TFAM, alongside reduced oxidative stress markers.
Preclinical studyReversed folate-deficiency-linked mitochondrial DNA loss
In folate-deficient glial cells and mouse brain tissue, PQQ activated the PGC-1alpha/NRF-1 signaling pathway, increasing a key folate transporter and reversing the drop in mitochondrial DNA content caused by folate deficiency.
Preclinical studyBlocked a Parkinson's-linked protein aggregation pathway
In human neuronal cells, PQQ prevented reactive-oxygen-species formation triggered by copper and alpha-synuclein, and blocked the fibril formation of alpha-synuclein-119 associated with Parkinson's disease pathology.
Cell studyReduced oxidative stress markers in a bone-healing model
In estrogen-deficient (ovariectomized) mice with femur fractures, PQQ supplementation reduced oxidative stress, promoted osteoblastic bone formation and improved delayed fracture healing.
Animal studyProtected inner-ear cells from antibiotic-induced damage
In a cochlear cell model, PQQ reduced reactive oxygen species and recovered mitochondrial membrane potential, protecting the cells against gentamicin-induced ototoxic damage.
Cell studyImproved memory and attention scores over 12 weeks
In a randomized, placebo-controlled trial in adults aged 40 to under 80, 12 weeks of PQQ disodium salt (21.5 mg/day) significantly improved composite memory, verbal memory, reaction time, attention and cognitive flexibility scores versus placebo, with no adverse events reported.
Human RCTFaster gains in younger adults, later gains in older adults
A randomized trial giving 20 mg/day of PQQ for 12 weeks to adults aged 20-65 found improved composite and verbal memory overall; an age-stratified analysis showed younger adults (20-40) improved cognitive flexibility and processing speed by 8 weeks, while older adults (41-65) improved memory scores by 12 weeks.
Human RCTImproved selective attention in a Stroop-test trial
In healthy elderly subjects given 20 mg/day of BioPQQ for 12 weeks, Stroop and reverse-Stroop test performance improved significantly more than placebo, with no abnormal blood, urinary or physical-exam findings recorded.
Human RCTIncreased prefrontal cortex blood flow alongside cognitive gains
Using near-infrared spectroscopy in adults aged 50-70 given 20 mg/day of BioPQQ for 12 weeks, researchers measured significant increases in prefrontal cortex hemoglobin concentration and oxygen metabolism versus placebo, proposed as a physiological correlate of the cognitive changes seen with PQQ.
Human RCTPrevented drug-induced cognitive deficits in a mouse model
In mice given the NMDA-receptor blocker MK-801 to model cognitive impairment, daily PQQ significantly reduced the resulting stereotypical behavior and motor deficits, suggesting a protective effect against this type of neuronal dysfunction.
Animal studyPreserved memory in aged rats via nerve growth factor
In aged rats, PQQ - previously shown to increase nerve growth factor (NGF) production and protect neurons - preserved learning and memory performance in a water-maze test to an extent comparable with vitamin E supplementation.
Animal studyLowered LDL cholesterol in adults with elevated baseline levels
In a randomized, placebo-controlled trial, healthy Japanese adults with high baseline LDL cholesterol (>=140 mg/dL) who took 20 mg/day of BioPQQ for 12 weeks saw a significant decrease in LDL cholesterol compared to placebo; overall triglyceride levels did not change.
Human RCTShifted liver lipid and glucose metabolism genes without weight change
In mice fed normal or high-fat diets, three months of PQQ supplementation enhanced liver mitochondrial biogenesis and antioxidant capacity and altered expression of lipid- and glucose-metabolism genes (including CPT1a and HK2), without significantly changing body weight or energy metabolic rate.
Animal studyProtected blood vessel cells from chemotherapy-induced damage
In human vascular endothelial cells exposed to the chemotherapy drug doxorubicin, PQQ reduced autophagy-dependent cell death via the lysosomal-mitochondrial pathway, a mechanism relevant to doxorubicin's known cardiotoxic side effects.
Cell studyDelayed fatigue and reduced exercise-induced oxidative damage
In mice subjected to repeated exhaustive exercise, PQQ prolonged time-to-exhaustion, lowered markers of muscle damage and oxidative stress, and reduced inflammatory signaling (NF-kB), while preserving mitochondrial structure and function.
Animal studyImproved mitochondrial energy production in human eye cells
In human eye trabecular meshwork cells - tissue involved in regulating eye pressure - PQQ improved mitochondrial respiration and ATP production, and reduced hydrogen-peroxide-induced oxidative damage.
Cell studyProtected lung mitochondria and reduced pulmonary hypertension in rats
In rats exposed to ultrafine carbon particles (a model of air-pollution lung injury), daily PQQ improved mitochondrial structure and biogenesis in lung cells, reduced right-ventricular pressure and hypertrophy, and lessened associated pulmonary hypertension.
Animal studyA cofactor for the enzymes driving cellular ATP synthesis
A 2024 review describes PQQ as an essential cofactor for oxidative enzymes central to mitochondrial function and ATP synthesis, summarizing research across aging, cognitive, cardiovascular and metabolic contexts and noting no reported toxicity or genotoxicity across the studies reviewed.
ReviewCompared against NMN/NR as a healthy-aging nutrient
A review comparing PQQ with nicotinamide mononucleotide/riboside (NMN/NR) attributes PQQ's anti-aging effects primarily to enhanced mitochondrial biogenesis, antioxidant activity and modulation of inflammatory pathways, while noting that robust clinical evidence for combining the two remains limited.
ReviewPart of a proposed three-compound mitochondrial-aging framework
A 2026 review proposes PQQ, alongside NMN/NR and ergothioneine, as one axis of a three-compound framework targeting NAD+ homeostasis, mitochondrial quality control and redox stability in age-related mitochondrial decline.
ReviewEuropean food-safety opinion found no safety concerns at 20mg/day
Assessing BioPQQ as a novel food, the EFSA Panel on Dietetic Products, Nutrition and Allergies found the proposed intake of 20 mg/day (excluding pregnant and lactating women) provided a sufficient margin of exposure relative to the no-observed-adverse-effect level from 90-day toxicity studies, and raised no safety concerns.
Regulatory opinionNo mutagenic or irritant effects across a full GLP toxicity battery
A GLP-compliant toxicology program on PQQ disodium salt (mnemoPQQ) found it non-mutagenic, non-clastogenic, and non-irritant to skin and eyes, with no systemic toxicity observed in a 90-day study up to 600 mg/kg body weight per day.
Safety studyNo adverse findings in a 13-week rat feeding study
A subchronic oral toxicity study dosing rats with PQQ disodium salt for 13 weeks found no treatment-related mortality, clinical signs, or organ-weight changes at any dose tested, up to 400 mg/kg body weight per day - the highest dose used in the study.
Safety studyFrequently asked questions
What is CanPrev BioPQQ and what does it do?
It's a 20 mg daily dose (2 vegetable capsules, 10 mg each) of BioPQQ, a naturally fermented, highly bioavailable form of pyrroloquinoline quinone (PQQ). PQQ is a source of antioxidants for the maintenance of good health.
Does it contain CoQ10?
No - this product is a single-ingredient PQQ formula (BioPQQ only). CanPrev sells a separate Coenzyme Q10 Liposomal product that the manufacturer suggests pairing with BioPQQ, but they are two distinct products.
How do I take it?
Adults 19 years and older take 2 capsules daily with food, or as directed by a qualified health care practitioner.
How long does one bottle last?
Each bottle contains 60 vegetable capsules - at the recommended dose of 2 capsules daily, that's a full 30-day supply.
Is it vegan?
Yes - both the BioPQQ and the vegetable capsule are vegan, with a formula free of gluten, dairy, soy and wheat, and no artificial colours, flavours or preservatives.
Who should use caution, or not use it?
Do not use if you are pregnant or breastfeeding. When taking this product, it may cause a cold, abdominal symptoms, headache, fatigue or diarrhea.
Where do I buy it?
Use the orange button on this page - it takes you to the CanPrev listing on Amazon.ca for secure checkout and fast delivery.
A clinically-studied source of antioxidants for cellular health
Get CanPrev BioPQQ on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80047056. Pyrroloquinoline quinone (BioPQQ) is a source of antioxidants for the maintenance of good health. The research summaries below concern PQQ generally and are educational - they are not claims about this finished product. Read and follow the label. Do not use if you are pregnant or breastfeeding. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. When taking this product, it may cause a cold, abdominal symptoms, headache, fatigue (fatigability) or diarrhea. Do not use if the safety seal is broken. Keep out of reach of children.
Indications
Recommended Use or Purpose: Source of antioxidants.
Ingredients
Medicinal ingredient (per capsule): Pyrroloquinoline quinone (disodium salt), as BioPQQ, 10 mg. Non-medicinal ingredients: Microcrystalline cellulose, hypromellose (capsule), magnesium stearate, silicon dioxide. NMIs are subject to change - always read and follow the label for accurate ingredients, cautions and allergen information.
Directions
Recommended Dose (Adults 19 years and older): Take 2 capsules daily with food, or as directed by a qualified health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.