CanPrev Berberine 500mg - Cholesterol & Glucose Support | 60 Caps
Visit the CanPrev Store Read all reviews on Amazon →| Brand | CanPrev |
| Serving | 500 mg (1 capsule) |
| Licensed Natural Health Product | NPN 80128242 |
| Quality Standards | Made in Canada |
| Country | Made in Canada  |
About this item
- 500MG BERBERINE PER CAPSULE: A full 500 mg dose of berberine from Berberis aquifolium (Oregon grape root) in every vegan capsule - a clean, single-ingredient formula.
- SUPPORTS HEALTHY GLUCOSE METABOLISM: Provides support for healthy glucose metabolism and helps support healthy glucose levels as part of a daily wellness routine.
- HELPS SUPPORT HEALTHY CHOLESTEROL & LIPID LEVELS: Helps support healthy cholesterol levels (serum triglyceride, total and LDL) and healthy blood lipid levels.
- SOURCE OF ANTIOXIDANTS: Provides support for healthy lipid metabolism and is a source of antioxidants for the maintenance of good health.
- SIMPLE TWICE-DAILY CAPSULE: One vegan capsule, twice a day at the beginning of each meal - a 60-capsule bottle provides a full 30-day supply.
- CLEAN VEGAN FORMULA: Vegan, non-GMO capsules free from gluten, dairy, soy, wheat, yeast, sugar and animal products, with no artificial colours or flavours.
- PREMIUM CANADIAN QUALITY: Formulated and made in Canada by CanPrev, licensed under Health Canada NPN 80128242.
Product Description
Berberine 500 - Glucose Metabolism & Cholesterol Support
A full 500 mg dose of berberine from Berberis aquifolium (Oregon grape root) in every vegan capsule. Provides support for healthy glucose metabolism, helps support healthy cholesterol and blood lipid levels, and is a source of antioxidants - a clean, single-ingredient formula with no gelatin. Licensed Natural Health Product NPN 80128242.
Une dose complète de 500 mg de berbérine provenant du Berberis aquifolium (racine de raisin d'Oregon) dans chaque capsule végétale. Fournit un soutien pour le métabolisme sain du glucose, aide à soutenir des taux sains de cholestérol et de lipides sanguins, et constitue une source d'antioxydants. Produit de santé naturel homologué. NPN 80128242.
One Capsule, Full-Dose Berberine
500mg Berberine (Berberis aquifolium) - Vegan, Non-GMO, Gluten-Free
Full 500mg Dose, Single Ingredient
No fillers or blends - just a therapeutic 500 mg dose of berberine from Berberis aquifolium in every vegan capsule.
Glucose & Cholesterol Support
Provides support for healthy glucose metabolism and helps support healthy cholesterol and blood lipid levels.
What Berberine 500 Supports
Berberine is one of the most widely studied plant compounds in metabolic health research - here is what CanPrev Berberine 500 is formulated to support.
Healthy Glucose Metabolism
Provides support for healthy glucose metabolism and helps support healthy glucose levels.
Healthy Cholesterol & Lipid Levels
Helps support healthy cholesterol levels (serum triglyceride, total and LDL) and healthy blood lipid levels.
Antioxidant Support
A source of antioxidants for the maintenance of good health.
Simple Daily Routine
One easy-to-swallow vegan capsule, twice a day with food - a full 30-day supply per bottle.
CanPrev Berberine: Supplement Facts
Product Facts
- Berberine root, Berberis aquifolium500 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Vegetable-grade magnesium stearate, silicon dioxide, microcrystalline cellulose, vegetable capsule.
Recommended Use or Purpose: Provides support for healthy glucose metabolism. Provides support for healthy lipid metabolism. Helps support healthy cholesterol levels (serum triglyceride, total, and LDL). Helps support healthy glucose levels. Helps support healthy blood lipid levels. Source of antioxidants.
Recommended Dose (Adults 18 years and older): Take 1 capsule, 2 times per day at the beginning of each meal, or as directed by a qualified health care practitioner. For use beyond 3 months, consult a health care practitioner.
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you have diabetes, gallstones, hypoglycemia, hypotension, a liver disorder, or cardiovascular disease, or if you are taking other medications, as berberine may affect the metabolism of other drugs. May cause gastrointestinal irritation such as constipation, vomiting, abdominal pain or diarrhea, in which case discontinue use and consult a health care practitioner. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Info-produit
- Berbérine racine, Berberis aquifolium500 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : Stéarate de magnésium de qualité végétale, dioxyde de silicium, cellulose microcristalline, capsule végétale.
Usage ou fins recommandés : Fournit un soutien pour le métabolisme sain du glucose. Fournit un soutien pour le métabolisme sain des lipides. Aide à soutenir des taux sains de cholestérol (triglycérides sériques, total et LDL). Aide à maintenir des taux sains de glucose. Aide à maintenir des taux sains de lipides sanguins. Source d'antioxydants.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule, 2 fois par jour, au début de chaque repas, ou selon les directives d'un praticien de la santé qualifié. Consultez un praticien de la santé pour un usage de plus de 3 mois.
Mises en garde et précautions : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Consulter un praticien de la santé avant l'usage si vous avez le diabète, des calculs biliaires, de l'hypoglycémie, de l'hypotension, un trouble du foie ou une maladie cardiovasculaire, ou si vous prenez d'autres médicaments, car la berbérine peut modifier le métabolisme de ces médicaments. Peut causer une irritation gastro-intestinale telle que constipation, vomissements, douleurs abdominales ou diarrhée; le cas échéant, cessez l'utilisation et consultez un praticien de la santé. Garder hors de la portée des enfants.
NPN 80128242
Support healthy glucose metabolism & cholesterol levels
Get CanPrev Berberine 500 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy CanPrev Berberine 500
A full 500mg dose of single-ingredient berberine, formulated for glucose and cholesterol support - premium CanPrev quality.
Full 500mg therapeutic dose
A complete 500 mg dose of berberine from Berberis aquifolium in every vegan capsule - no blends, no fillers.
Glucose metabolism & cholesterol support
Provides support for healthy glucose metabolism and helps support healthy cholesterol and blood lipid levels.
Antioxidant support
A source of antioxidants for the maintenance of good health.
Premium Canadian brand
CanPrev - Pro Essentials line, formulated and made in Canada. NPN 80128242.
How to use it
Take 1 capsule, twice daily
Adults (18 years and older) take 1 capsule, 2 times per day at the beginning of each meal.
With food
Take each capsule at the start of a meal, or as directed by a qualified health care practitioner.
Ask a professional beyond 3 months
For use beyond 3 months, consult a health care practitioner.
Watch for GI symptoms
Discontinue use and consult a health care practitioner if you experience gastrointestinal irritation such as constipation, vomiting, abdominal pain or diarrhea.
What the research says about berberine
Educational summaries of published research on the compound berberine - not claims about this finished product. CanPrev Berberine 500's claim is the authorized use under NPN 80128242.
Recognized among evidence-based cholesterol nutraceuticals
A 2025 commentary on the ESC/EAS dyslipidemia guidelines notes that several nutraceuticals - including berberine, along with plant sterols, soluble fibers and bergamot - are supported by meta-analyses documenting real LDL-cholesterol-lowering efficacy and safety.
Expert commentaryA reviewed mechanism among cholesterol-lowering foods
A 2025 review of functional foods and nutraceutical ingredients for cholesterol management summarizes berberine's mechanisms of action and the typical LDL-cholesterol reductions reported in clinical studies.
ReviewNetwork meta-analysis across four herbal phytochemicals
A Bayesian network meta-analysis of 17 studies in adults with type 2 diabetes found that berberine could lower blood glucose and help regulate blood lipids, among several herbal phytochemicals compared for cardio-metabolic risk factors.
Network meta-analysisImproved lipid and glycemic markers over 60 days
In a randomized, double-blind, placebo-controlled trial in overweight adults with impaired fasting glucose, 60 days of oral berberine phytosome supplementation significantly reduced glycemia, total cholesterol, triglycerides and insulin versus placebo, with no adverse events reported.
Human RCTConsistent lipid improvements across pooled reviews
An overview of systematic reviews and meta-analyses on a traditional formula and its main constituents found that berberine intervention could effectively reduce total cholesterol, triglycerides and LDL cholesterol while increasing HDL cholesterol.
Overview of systematic reviewsA berberine-containing combination lowered LDL-C
In a clinical trial of patients with moderate hypercholesterolemia and cardiovascular risk, a nutraceutical tablet combining monacolin K, berberine and coenzyme Q10 lowered LDL cholesterol and total cholesterol versus placebo over three and six months, with good tolerance and safety.
Human RCTLower fasting glucose, HbA1c and LDL-C in type 2 diabetes
A 12-week randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes found that daily berberine combined with cinnamon significantly lowered fasting blood sugar, HbA1c and LDL cholesterol compared with placebo.
Human RCTA well-characterized multi-pathway mechanism
A 2026 review of traditional-medicine-derived compounds for type 2 diabetes describes berberine's effects as mainly linked to activating AMP-activated protein kinase, promoting glucose transport, reducing liver glucose production, and changing gut bacteria composition.
ReviewModulating insulin-signalling pathways
A 2026 review of phytochemicals for type 2 diabetes describes berberine, alongside curcumin and resveratrol, as modulating AMPK, PI3K/AKT and related pathways to help enhance insulin sensitivity, glucose regulation and beta-cell protection.
ReviewReduced postoperative heart-rhythm complications after surgery
In a randomized, double-blind, placebo-controlled trial of 200 patients undergoing coronary artery bypass surgery, oral berberine reduced the incidence of postoperative atrial fibrillation from 35% to 20% and lowered inflammatory markers, with no difference in perioperative mortality.
Human RCTA mechanistic trial in men with hyperlipidemia
In a randomized, double-blind, placebo-controlled trial of 84 men with hyperlipidemia, berberine 500 mg twice daily for 12 weeks produced larger reductions in total cholesterol than placebo, with no serious adverse events reported.
Human RCTImproved the most atherogenic LDL particles
In a multicenter, double-blind, placebo-controlled trial of 158 patients with metabolic syndrome and left ventricular hypertrophy, a nutraceutical combination containing 500 mg of berberine significantly improved total cholesterol, LDL cholesterol and small dense LDL particles - considered especially atherogenic - versus placebo.
Human RCTA systematic review of human microbiome trials
A 2026 systematic review of seven randomized controlled trials found that berberine supplementation consistently altered gut microbial composition across diverse patient groups, with these shifts co-occurring with improvements in fasting glucose, lipid profiles and inflammatory markers.
Systematic reviewAntimicrobial action that reshapes gut bacteria
A 2026 review describes berberine's antimicrobial properties against gut pathogens and its ability to promote intestinal short-chain fatty acid production, helping enrich beneficial microbial populations while inhibiting some pathogenic bacteria.
ReviewGut microbiota as a key mechanistic link
A 2026 review of traditional-medicine-derived compounds for type 2 diabetes management identifies gut microbiota modulation as one of the key mechanisms through which berberine and related natural compounds are studied to influence disease progression.
ReviewActivating a key cellular energy-sensing pathway
In mouse and cell models, berberine activated the AMPK/SIRT1/PGC-1-alpha signaling pathway, improving fatty-acid metabolism in the liver and reducing triglycerides, cholesterol, LDL cholesterol and fasting glucose alongside improved insulin sensitivity.
Preclinical studyA berberine-derived compound with the same key target
A 2026 review of dihydroberberine - a naturally occurring, more bioavailable derivative of berberine - describes its activation of AMP-activated protein kinase and glucokinase as central to its studied effects on lipid metabolism and metabolic health.
ReviewSignalling pathways studied in diabetic heart research
In a diabetic cardiomyopathy animal model, berberine - particularly alongside insulin - reduced markers of dyslipidemia, oxidative stress and inflammation and improved cardiac structure and function, effects linked to modulation of the PI3K/Akt/mTOR and Nrf2 signaling pathways.
Preclinical studyAn 18-week, nearly 300-person safety and efficacy trial
In an 18-week, multi-center, double-blind, placebo-controlled trial of 297 adults with hyperglycemia, berberine significantly reduced fasting plasma glucose compared with placebo and altered the composition of the gut microbiota.
Human RCTA dedicated Phase I safety trial
A Phase I randomized trial in patients with ulcerative colitis found that berberine 900 mg per day for three months, combined with mesalamine, was well tolerated - only one case of mild nausea and one transient liver-enzyme elevation were observed among those on berberine.
Phase I clinical trialNo added gastrointestinal risk across pooled trials
A systematic review and meta-analysis of randomized trials found that berberine did not increase the incidence of gastrointestinal adverse events, or of serious events during pregnancy, compared with placebo.
Meta-analysisImprovements across multiple metabolic-syndrome markers
A systematic review and meta-analysis of placebo-controlled randomized trials found that berberine significantly reduced triglycerides, fasting plasma glucose and waist circumference, along with LDL cholesterol, total cholesterol and body mass index, with a favorable safety profile.
Systematic review & meta-analysisLower inflammatory markers in metabolic syndrome
A meta-analysis of 52 randomized controlled trials in patients with metabolic syndrome and related disorders found that berberine significantly reduced inflammatory markers including C-reactive protein, TNF-alpha and IL-6.
Meta-analysisA pooled analysis of nearly 4,000 patients
A meta-analysis of 11 randomized controlled trials totaling 3,924 patients found that a nutraceutical combination containing berberine, policosanol and red yeast rice produced significant improvements in total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides versus control.
Meta-analysisFrequently asked questions
What is CanPrev Berberine 500 and what does it do?
It's a full 500 mg dose of berberine (from Berberis aquifolium, Oregon grape root) per vegan capsule. Berberine provides support for healthy glucose metabolism, helps support healthy cholesterol and blood lipid levels, and is a source of antioxidants.
How do I take it?
Adults 18 years and older take 1 capsule, 2 times per day at the beginning of each meal, or as directed by a qualified health care practitioner. For use beyond 3 months, consult a health care practitioner.
How long does one bottle last?
Each bottle contains 60 vegan capsules - at the recommended dose of 1 capsule twice daily, that's a full 30-day supply.
Is it vegan?
Yes - the berberine and the vegetable capsule are both vegan, with a clean formula free of GMOs, gluten, dairy, soy, wheat, yeast, sugar and animal products.
What else is in the capsule besides berberine?
Non-medicinal ingredients are vegetable-grade magnesium stearate, silicon dioxide, microcrystalline cellulose and the vegetable capsule itself - no other medicinal ingredients.
Who should use caution, or not use it?
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner before use if you have diabetes, gallstones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease, or if you are taking other medications, as berberine may affect how they are metabolized. May cause gastrointestinal irritation such as constipation, vomiting, abdominal pain or diarrhea - discontinue use and consult a practitioner if this occurs.
Where do I buy it?
Use the orange button on this page - it takes you to the CanPrev listing on Amazon.ca for secure checkout and fast delivery.
Support healthy glucose metabolism & cholesterol levels
Get CanPrev Berberine 500 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80128242. Berberine provides support for healthy glucose metabolism and helps support healthy cholesterol and blood lipid levels, and is a source of antioxidants. The research summaries below concern the compound berberine generally and are educational - they are not claims about this finished product. Read and follow the label. Do not use if you are pregnant or breastfeeding. Consult a health care practitioner before use if you have diabetes, gallstones, hypoglycemia, hypotension, a liver disorder or cardiovascular disease, or are taking other medications. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you have diabetes, gallstones, hypoglycemia, hypotension, a liver disorder, or cardiovascular disease, or if you are taking other medications, as berberine may affect the metabolism of other drugs. May cause gastrointestinal irritation such as constipation, vomiting, abdominal pain or diarrhea, in which case discontinue use and consult a health care practitioner. Keep out of reach of children.
Indications
Recommended Use or Purpose: Provides support for healthy glucose metabolism. Provides support for healthy lipid metabolism. Helps support healthy cholesterol levels (serum triglyceride, total, and LDL). Helps support healthy glucose levels. Helps support healthy blood lipid levels. Source of antioxidants.
Ingredients
Medicinal Ingredient (per capsule): Berberine (root, Berberis aquifolium) 500 mg. Non-medicinal ingredients: Vegetable-grade magnesium stearate, silicon dioxide, microcrystalline cellulose, vegetable capsule. NMIs are subject to change - always read and follow the label for accurate ingredients, cautions and allergen information.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule, 2 times per day at the beginning of each meal, or as directed by a qualified health care practitioner. For use beyond 3 months, consult a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.