CanPrev B12 Methyl 500mcg - Methylcobalamin Liquid Drops | 15mL
Visit the CanPrev Store| Brand | CanPrev |
| Serving | 1 to 2 drops daily (ages 1+) |
| Licensed Natural Health Product | NPN 80113357 |
| Quality Standards | Made in Canada |
| Country | Made in Canada  |
About this item
- HIGH POTENCY, ACTIVE FORM: Each drop delivers a concentrated 500mcg dose of vitamin B12 as methylcobalamin - the active, already-methylated form known for high bioavailability and efficient absorption.
- SUPPORTS VITALITY & METABOLISM: Helps to maintain a healthy metabolism and supports overall well-being as part of a daily routine, alongside its role in red blood cell formation and immune function.
- CONVENIENT LIQUID FORM: An easy-to-administer liquid drop format offers a simple, precise way to take vitamin B12 - no capsules or tablets to swallow.
- VEGAN-FRIENDLY: Sourced from non-animal origins, suitable for those following vegan and vegetarian diets who are at higher risk of low B12 intake.
- PURE AND SIMPLE INGREDIENTS: No artificial colours, flavours or preservatives - dairy-free, gluten-free, GMO-free, soy-free and sugar-free, with a natural blueberry flavour.
Product Description
B12 Methyl 500mcg Liquid Drops - Methylcobalamin for Energy, Red Blood Cells & Immune Support
500mcg of methylcobalamin - the active, body-ready form of vitamin B12 - in every natural blueberry-flavoured drop. Helps to prevent vitamin B12 deficiency, helps to form red blood cells, helps to maintain a healthy metabolism, and helps to maintain normal function of the immune system. Licensed Natural Health Product. NPN 80113357. Licensed Natural Health Product NPN 80113357.
500 mcg de methylcobalamine - la forme active et prête à l'emploi de la vitamine B12 - dans chaque goutte à saveur naturelle de bleuet. Aide à prévenir une carence en vitamine B12, aide à la formation des globules rouges, aide à maintenir un métabolisme en santé, et aide au fonctionnement normal du système immunitaire. Produit de santé naturel homologué. NPN 80113357.
One Drop, Active B12
500mcg Methylcobalamin per Drop - Vegan, Non-GMO, Gluten-Free
Active Methylcobalamin, Not Cyanocobalamin
Methylcobalamin is the already-active, methylated form of vitamin B12 - the body can use it directly, without the extra conversion step that cyanocobalamin requires.
Liquid Drops for Simple, Flexible Dosing
A flat 1 to 2 drop daily dose for ages 1 and up makes it easy to take an accurate dose straight from the dropper, from a single 15ml bottle providing up to 450 drops.
Advanced Ingredients, Superior Results
One active B vitamin, doing an outsized job - here is what's inside every drop of CanPrev B12 Methyl.
Vitamin B12 (methylcobalamin)
The active, coenzyme form of vitamin B12 that the body can use directly, supporting red blood cell formation, energy metabolism and immune function.
500 mcg per drop
CanPrev B12 Methyl 500mcg: Supplement Facts
Supplement Facts
- Vitamin B12 (methylcobalamin) per drop500 mcg
Non-Medicinal Ingredients: Non-medicinal ingredients: Blueberry flavour, disodium EDTA, flavour, glycerin, potassium phosphate (monobasic), potassium sorbate, purified water, stevia leaf.
Recommended Use or Purpose: Helps to prevent vitamin B12 deficiency. Helps to form red blood cells. Helps to maintain a healthy metabolism. Helps to maintain normal function of the immune system.
Recommended Dose: Children, adolescents and adults 1 year and older - take 1 to 2 drops per day, or as directed by a qualified health care practitioner.
Cautions and Warnings: Keep out of reach of children. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Fiche produit
- Vitamine B12 (méthylcobalamine) par goutte500 mcg
Ingrédients non médicinaux : Ingrédients non médicinaux : Arôme, arôme de bleuet, eau purifiée, EDTA de sodium, glycérine, phosphate de potassium, sorbate de potassium, sucres (stévia).
Usage ou fins recommandés : Aide à prévenir une carence en vitamine B12. Aide à la formation des globules rouges. Aide à maintenir un métabolisme en santé. Aide à maintenir le fonctionnement normal du système immunitaire.
Posologie recommandée : Enfants, adolescents et adultes de 1 an et plus - prendre 1 à 2 gouttes par jour, ou selon les directives d'un professionnel de la santé qualifié.
Mises en garde : Garder hors de la portée des enfants. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80113357
Support red blood cell formation, energy metabolism & immune function
Get CanPrev B12 Methyl drops on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy CanPrev B12 Methyl
500mcg of methylcobalamin - the active form of B12 - in easy liquid drops - premium CanPrev quality.
Active methylcobalamin form
500mcg of vitamin B12 as methylcobalamin per drop - the already-active form the body can use directly, unlike cyanocobalamin.
Supports red blood cells & metabolism
Helps to prevent vitamin B12 deficiency, helps to form red blood cells, and helps to maintain a healthy metabolism and immune function.
Liquid drops, not capsules
Blueberry-flavoured liquid drops with a simple 1 to 2 drop daily dose from a single 15ml bottle - no capsules to swallow.
Vegan, made in Canada
Vegan, non-GMO, gluten-free formula - a licensed Natural Health Product made in Canada. NPN 80113357.
Inside every drop
500mcg of vitamin B12 as methylcobalamin - the active, body-ready form - in a natural blueberry-flavoured liquid drop.
How to use it
Dispense with the dropper
Fill the dropper and dispense drops directly into the mouth, or add to food or a beverage.
Take 1 to 2 drops daily
Children, adolescents and adults 1 year and older: take 1 to 2 drops per day, or as directed by a health care practitioner.
Take it at a consistent time
For steady daily B12 intake, take your dose at a consistent time each day, directly under the tongue or mixed into food or a drink.
Consult a health care practitioner before use
Talk to a health care practitioner before use if you have questions about the right daily B12 intake for your needs.
What the research says about vitamin B12
Educational summaries of published research on vitamin B12 (cobalamin/methylcobalamin); not product-specific claims. CanPrev B12 Methyl's claim is the authorized use under NPN 80113357.
Oral B12 bioavailability is dose-dependent, reaching 46% at a low, requirement-matching dose
A stable-isotope study using [13C]-cyanocobalamin found oral vitamin B12 bioavailability averaged 46% at a low 2.3mcg dose approximating the normal daily requirement, dropping to 8% at a much higher 18mcg dose; parenteral B12 repletion in deficient individuals nearly doubled subsequent bioavailability.
Human clinical trialOral B12 bioavailability measured at 63%, with a delayed second absorption peak and a colonic contribution
Using a [13C]-cyanocobalamin tracer, researchers measured oral B12 bioavailability at 63% over 12 hours, including a late absorption peak roughly 9 hours after dosing, and found the colon itself absorbs a measurable share of vitamin B12.
Observational studyA low sublingual B12 dose matched a much higher dose at restoring status in a 12-week RCT
A randomized, double-blind trial in vegans and vegetarians with marginal B12 deficiency found a low sublingual dose (50mcg/day) was just as effective as a 2,000mcg/week dose at restoring serum B12 and improving related metabolic markers over 90 days.
Human RCTMetabolic B12 deficiency is highly prevalent among vegans without fortified foods or supplements
A review found metabolic vitamin B12 deficiency is highly prevalent in vegetarians across several countries and reaches as high as 80% among vegans in some regions where B12-fortified foods or supplements are rarely used, with vascular studies showing impaired arterial function in deficient individuals.
ReviewA 12-week RCT found B12 supplementation corrected deficiency markers in vegans, most in those not already supplementing
A double-blind, placebo-controlled trial in 76 vegans found B12 supplementation significantly raised serum B12 and holotranscobalamin and lowered methylmalonic acid compared to placebo, with the largest improvements seen in vegans who had not previously been taking a B12 supplement.
Human RCTA multinutrient supplement with B12 significantly improved B12 status markers in healthy vegans
The MultiVeg randomized, double-blind, placebo-controlled trial found that 4 months of a multinutrient supplement containing about 82mcg/day of vitamin B12 significantly improved B12 blood biomarkers, including holotranscobalamin and a combined B12 status indicator, in healthy vegan adults.
Human RCTCochrane review: B12 supplementation reduces B12 deficiency, a driver of impaired red blood cell formation
A Cochrane review of 16 randomized trials in over 4,000 children found vitamin B12 supplementation reduces vitamin B12 deficiency with high-certainty evidence and probably increases total B12 concentrations compared to placebo - B12 is required for red blood cell formation and DNA synthesis.
Cochrane systematic review80% of megaloblastic anemia patients in a case-control study had low B12, linked to elevated homocysteine
A case-control study comparing 50 megaloblastic anemia patients to 50 controls found 80% of anemia patients had low vitamin B12 and 88% had low folate, with correspondingly elevated homocysteine and abnormal p53 expression in bone marrow linked to the deficiency-driven anemia.
Case-control studyA pernicious anemia case shows the classic red-blood-cell signs of B12 deficiency
A case report describes a patient with pernicious anemia (an autoimmune cause of vitamin B12 deficiency) presenting with macrocytosis and hypersegmented neutrophils - the hallmark signs of the ineffective red blood cell formation that characterizes B12 deficiency.
Case reportLow B12 intake showed a stronger link to elevated homocysteine than low folate intake
A cross-sectional study of over 62,000 Korean adults found low vitamin B12 intake (under 5.4mcg/day) was more strongly associated with hyperhomocysteinemia than low folate intake, with combined deficiencies of both nutrients worsening the effect.
Cross-sectional studyA case series links B12-deficiency-driven hyperhomocysteinemia to venous thrombosis
A case series of 4 patients found pernicious anemia (autoimmune vitamin B12 deficiency) caused hyperhomocysteinemia severe enough to trigger venous vein thrombosis in each case, with favorable outcomes after cobalamin supplementation alongside anticoagulation.
Case seriesB12/methionine synthase status affected mitochondrial energy metabolism capacity in a mouse study
In a mouse model, impaired B12-dependent methionine synthase activity lowered skeletal muscle's maximal mitochondrial respiratory capacity by 50%, while intramuscular B12 supplementation improved mitochondrial complex IV activity in aged mice, a model of age-related muscle decline.
Animal study16-week RCT: oral methylcobalamin improved neuropathy symptoms in diabetic patients with low B12
A randomized trial in adults with diabetic peripheral neuropathy and low serum B12 found 16 weeks of daily oral methylcobalamin (at either 1,000mcg or 2,000mcg) significantly improved neuropathy pain and exam scores, with the higher dose offering no additional symptom benefit beyond a bigger rise in blood B12.
Human RCTSystematic review finds evidence supporting B12 for peripheral neuropathic pain
A systematic review of 24 studies found evidence supporting vitamin B12 as a treatment for neuropathic pain, including post-herpetic neuralgia and painful peripheral neuropathy, through proposed mechanisms of promoting nerve myelination and regeneration and decreasing abnormal nerve firing.
Systematic reviewPhase III RCT: methylcobalamin injection reduced herpetic nerve pain more than other delivery routes
A randomized Phase III trial in 105 patients with subacute ophthalmic post-herpetic neuralgia found local methylcobalamin injection produced significantly greater pain reduction (91% of patients with a clinically relevant improvement) than intramuscular or oral methylcobalamin administration.
Human RCT (Phase III)B12 depletion traps folate in the nucleus, impairing DNA synthesis and damaging the genome
Laboratory studies in human cell models found vitamin B12 depletion traps folate as 5-methylTHF specifically in the cell nucleus, reducing de novo DNA (thymidylate) synthesis capacity by up to 35% and increasing markers of DNA double-strand breaks - explaining the cellular mechanism behind B12-deficiency megaloblastic anemia.
Laboratory studyLow B12 combined with low methionine significantly increased genome damage in human cells
Using the cytokinesis-block micronucleus assay in human lymphoblastoid cell lines, researchers found low vitamin B12 combined with low methionine significantly increased markers of genotoxicity, while an optimal combination of both nutrients stabilized the genome.
In vitro studyB12 is the required cofactor that regenerates the body's usable folate for the methylation cycle
A laboratory-medicine review explains that vitamin B12 is required for the enzyme methionine synthase to convert homocysteine back to methionine while regenerating tetrahydrofolate from its 5-methyl form - directly linking B12 and folate status to homocysteine levels and one-carbon metabolism.
ReviewReview: insufficient B12 is linked to immune decline and inflammation in aging
A review of water-soluble vitamins in older adults found aging combined with insufficient B12 (among other B vitamins) is associated with immune decline and chronic low-grade inflammation, and that adequate B12 intake may help support immune cell metabolism and reduce infection susceptibility.
ReviewReview: B12 deficiency is common in autoimmune disease and supports immune-relevant methylation processes
A review of micronutrients in autoimmune diseases found vitamin B12 deficiency is commonly observed in conditions like rheumatoid arthritis and autoimmune thyroid disorders, and that B12 supports methylation processes and genomic stability relevant to normal immune cell function.
ReviewReview: cobalamin's roles extend to one-carbon metabolism and microbiome-linked immune regulation
A 2020-2025 review of cobalamin biology describes vitamin B12's roles beyond its classic haematinic function, including one-carbon and mitochondrial metabolism, and summarizes emerging evidence connecting cobalamin-family (corrinoid) metabolism to host-microbe interactions relevant to immune and metabolic regulation.
ReviewA decade-long Framingham study links higher B12 status to slower cognitive decline
A Framingham Heart Study analysis of nearly 2,000 dementia-free adults found those in the highest vitamin B12 status quartile had significantly slower annual declines in memory, executive function, and language over roughly a decade than those in the lowest quartile.
Longitudinal cohort studyHigher homocysteine (linked to lower B12) tracked with faster cognitive decline in Alzheimer's patients
A study of Alzheimer's disease patients found higher homocysteine levels (correlated with lower vitamin B12) and lower methionine/methylation levels were significantly associated with lower cognitive scores and a greater rate of cognitive decline over one year of follow-up.
Longitudinal studyLower B12 and folate related to cognitive impairment risk via a homocysteine-linked pathway
A cohort study of 1,614 older adults found lower vitamin B12 and folate concentrations were associated with greater cognitive impairment risk, acting in part through a sequential pathway of elevated homocysteine and a nerve-injury biomarker (neurofilament light chain).
Cohort studyFrequently asked questions
What is CanPrev B12 Methyl drops and what does it do?
It's a liquid supplement providing 500mcg of vitamin B12 (as methylcobalamin) per drop. It helps to prevent vitamin B12 deficiency, helps to form red blood cells, helps to maintain a healthy metabolism, and helps to maintain normal function of the immune system.
How many drops do I take?
Children, adolescents and adults 1 year and older take 1 to 2 drops per day, or as directed by a health care practitioner.
Why methylcobalamin instead of cyanocobalamin?
Methylcobalamin is the active, already-methylated form of vitamin B12 that the body can use directly, without the extra conversion step that cyanocobalamin requires - a common reason it's chosen for faster-acting B12 support.
Is it suitable for children?
Yes - the label's dose covers children, adolescents and adults from age 1 upward; consult a health care practitioner to confirm the right dose for your child.
Is it vegan and allergen-friendly?
Yes - the formula is vegan and free from gluten, dairy, soy, wheat, yeast, sugar, artificial colours, flavours, preservatives and animal products.
How long does one bottle last?
Each 15ml bottle provides up to 450 drops - up to a 450-day supply at the 1-drop dose, or 225 days at the 2-drop dose.
Is this product still sold on Amazon.ca?
This particular Amazon.ca listing is currently inactive. CanPrev B12 Methyl 500mcg drops remain a real, current CanPrev product available through canprev.ca and Canadian retailers under the same NPN 80113357.
Where do I buy it?
Use the orange button on this page - it takes you to the CanPrev listing on Amazon.ca for secure checkout.
Support red blood cell formation, energy metabolism & immune function
Get CanPrev B12 Methyl drops on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80113357. B12 Methyl drops help to prevent vitamin B12 deficiency, help to form red blood cells, help to maintain a healthy metabolism, and help to maintain normal function of the immune system. The research summaries below concern vitamin B12 generally and are educational - they are not claims about this finished product. Consult a health care practitioner prior to use. Read and follow the label. Results may vary.
Important information
Safety Information
Cautions and Warnings: Keep out of reach of children. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: Helps to prevent vitamin B12 deficiency. Helps to form red blood cells. Helps to maintain a healthy metabolism. Helps to maintain normal function of the immune system.
Ingredients
Medicinal Ingredients (per drop): Vitamin B12 (methylcobalamin) 500 mcg. Non-medicinal ingredients: Blueberry flavour, disodium EDTA, flavour, glycerin, potassium phosphate (monobasic), potassium sorbate, purified water, stevia leaf. Vegan. GMO-free. No gluten, dairy, soy, wheat, yeast, sugar, artificial colours, flavours, preservatives or animal products. NMIs are subject to change - always read and follow the label for accurate ingredients, cautions and allergen information.
Directions
Recommended Dose: Children, adolescents and adults 1 year and older - take 1 to 2 drops per day, or as directed by a qualified health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.