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Health Canada NPN 80037247 100 mg 5-HTP + Magnesium 60 mg + B6 33.3 mg per capsule Vegan · Non-GMO · Gluten-free Made in Canada · GMP facility
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CanPrev 5-HTP 100mg - Sleep & Relaxation Support | 60 Veg Capsules

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$26.99 CAD ($0.45 / capsule)
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BrandCanPrev
Serving1 capsule (3 times daily with food)
Licensed Natural Health ProductNPN 80037247
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • SEROTONIN SUPPORT FROM GRIFFONIA SEED: Each vegetarian capsule delivers 100 mg of 5-HTP (5-Hydroxy-L-Tryptophan) sourced from Griffonia simplicifolia seed, the direct precursor the body converts into serotonin.
  • TWO CO-FACTORS FOR UTILIZATION: Magnesium (as magnesium bisglycinate) 60 mg and Vitamin B6 33.3 mg are included alongside the 5-HTP as co-factors involved in the body's conversion and use of the ingredient.
  • MOOD BALANCE AND RESTFUL SLEEP: Licensed by Health Canada to help promote healthy mood balance and help support restful sleep, alongside relief of fibromyalgia symptoms and reduced severity/duration of migraine and tension headache when used preventatively.
  • SIMPLE, CONSISTENT DOSING: Adults take 1 capsule 3 times daily with food. One 60-capsule bottle is a 20-day supply at the labelled dose.
  • VEGAN, GLUTEN-FREE FORMULA: Vegetarian capsules free from gluten, dairy and soy, with no artificial colours or flavours - formulated for a clean daily routine.
  • MADE IN CANADA, LICENSED: Manufactured in Canada in a GMP-compliant facility and licensed by Health Canada as a Natural Health Product, NPN 80037247.

Product description

Mood balance, restful sleep and inner calm - with two co-factors built in

CanPrev 5-HTP

A closer look at CanPrev 5-HTP 100 - 100 mg of 5-HTP from Griffonia seed, paired with Magnesium and Vitamin B6 co-factors, made in Canada. Licensed Natural Health Product NPN 80037247.

5-HTP lifestyle
CanPrev 5-HTP
100mg 5-HTP + Magnesium & B6 Co-Factors

Why CanPrev 5-HTP 100

One serotonin precursor, two co-factors, one simple daily dose.

Griffonia seed-derived 5-HTP

Each capsule delivers 100 mg of 5-HTP (5-Hydroxy-L-Tryptophan) from Griffonia simplicifolia seed, the direct precursor the body converts into serotonin.

Built-in co-factors

Magnesium (as magnesium bisglycinate) 60 mg and Vitamin B6 33.3 mg are formulated alongside the 5-HTP as co-factors, rather than requiring separate supplements.

Simple, consistent dosing

Take 1 vegetarian capsule 3 times daily with food. One 60-capsule bottle covers a 20-day supply at the labelled dose.

Clean, licensed formula

Vegan, gluten-free vegetarian capsules, made in Canada in a GMP-compliant facility and licensed by Health Canada, NPN 80037247.

Advanced Ingredients, Superior Results

A closer look at CanPrev 5-HTP 100 - 100 mg of 5-HTP from Griffonia seed, paired with Magnesium and Vitamin B6 co-factors, made in Canada.

5-HTP (5-Hydroxy-L-Tryptophan)

Sourced from Griffonia simplicifolia seed, 5-HTP is the direct precursor the body converts into serotonin, the mechanism behind this product's mood-balance and sleep-support claims.

100 mg per capsule

Magnesium (magnesium bisglycinate)

A chelated, well-tolerated form of magnesium included as a co-factor alongside 5-HTP, supporting relaxation as part of this combination formula.

60 mg per capsule

Vitamin B6 (pyridoxine HCl)

Vitamin B6 is a required cofactor in the enzymatic pathway that converts 5-HTP into serotonin, included here to support the body's use of the formula's primary ingredient.

33.3 mg per capsule

CanPrev 5-HTP: Supplement Facts

CanPrev™5-HTP
English

Each capsule contains:

  • 5-HTP (5-Hydroxy-L-Tryptophan, from Griffonia simplicifolia seed)100 mg
  • Magnesium (magnesium bisglycinate)60 mg
  • Vitamin B6 (pyridoxine HCl)33.3 mg

Non-Medicinal Ingredients: Hypromellose (capsule), magnesium stearate, microcrystalline cellulose.

Recommended Use or Purpose: Helps promote healthy mood balance. Helps relieve the symptoms of fibromyalgia. Helps reduce the severity and duration of migraine and tension headache when taken as a preventative. Helps support restful sleep.

Recommended Dose (Adults): Take 1 capsule 3 times daily with food, or as directed by a health care practitioner. Do not exceed the recommended dose. Introduce gradually and use consistently for 2-3 weeks before assessing effects.

Cautions and Warnings: Do not use if you have scleroderma. Ask a health care practitioner before use if you are taking carbidopa or any other health product with serotonergic activity, or if you are pregnant, breastfeeding or trying to conceive. Consult a health care practitioner for use beyond 1 year. Discontinue use and consult a health care practitioner if you experience signs of muscle weakness, oral ulcers, skin hardening or changes, or abdominal pain with severe muscle pain. Gastrointestinal discomfort may occur. Keep out of reach of children. Store in a cool, dry place. Sealed for your protection - do not use if the seal is broken.

Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.

Français

Chaque capsule contient :

  • 5-HTP (5-Hydroxy-L-Tryptophane, extrait de graine de Griffonia simplicifolia)100 mg
  • Magnésium (bisglycinate de magnésium)60 mg
  • Vitamine B6 (chlorhydrate de pyridoxine)33.3 mg

Ingrédients non médicinaux : Hypromellose (capsule), stéarate de magnésium, cellulose microcristalline.

Usage ou fins recommandés : Aide à promouvoir un bon équilibre de l'humeur. Aide à soulager les symptômes de la fibromyalgie. Aide à réduire la sévérité et la durée des migraines et des céphalées de tension lorsqu'utilisé à titre préventif. Aide à soutenir un sommeil réparateur.

Dose recommandée (adultes) : Prendre 1 capsule 3 fois par jour avec de la nourriture, ou selon les indications d'un praticien de soins de santé. Ne pas dépasser la dose recommandée. Introduire progressivement et utiliser de manière constante pendant 2 à 3 semaines avant d'évaluer les effets.

Mises en garde et précautions : Ne pas utiliser si vous avez la sclérodermie. Consultez un praticien de soins de santé avant l'utilisation si vous prenez du carbidopa ou tout autre produit de santé à activité sérotoninergique, ou si vous êtes enceinte, si vous allaitez ou prévoyez le devenir. Consultez un praticien de soins de santé pour une utilisation de plus d'un an. Cessez l'utilisation et consultez un praticien de soins de santé si vous ressentez des signes de faiblesse musculaire, des ulcères buccaux, un durcissement ou des changements de la peau, ou des douleurs abdominales accompagnées de douleurs musculaires sévères. Un inconfort gastro-intestinal peut survenir. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec. Scellé pour votre protection - ne pas utiliser si le sceau est brisé.

NPN 80037247

100 mg 5-HTP + Magnesium & B6 co-factors60 capsules · 20-day supplyVegan · Non-GMO · Gluten-freeMade in Canada

Support mood balance, restful sleep and inner calm the easy way

Get CanPrev 5-HTP 100 on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Why people choose CanPrev 5-HTP 100

One serotonin precursor plus two built-in co-factors - four ways it supports daily and nightly balance.

Mood & Emotional Balance

5-HTP is a direct precursor to serotonin; this product is licensed to help promote healthy mood balance in adults.

Restful Sleep Support

Licensed to help support restful sleep, as part of the same serotonin pathway involved in regulating the sleep-wake cycle.

Migraine & Tension Headache Comfort

Licensed to help reduce the severity and duration of migraine and tension headache when taken as a preventative.

Fibromyalgia Symptom Relief

Licensed to help relieve the symptoms of fibromyalgia, alongside co-factors Magnesium and Vitamin B6 formulated to support the body's use of 5-HTP.

Inside every capsule

100 mg of 5-HTP from Griffonia simplicifolia seed, paired with Magnesium (as magnesium bisglycinate) 60 mg and Vitamin B6 33.3 mg as co-factors, in one vegetarian capsule.

5-HTP (5-Hydroxy-L-Tryptophan) 100 mg per capsuleMagnesium (magnesium bisglycinate) 60 mg per capsuleVitamin B6 (pyridoxine HCl) 33.3 mg per capsule

How to use

Take with food

Adults: take 1 capsule 3 times per day with food, or as directed by a health care practitioner.

Introduce gradually

As with any new 5-HTP supplement, allow your body to adjust; consistent daily use over 2-3 weeks is typical before assessing effects.

Stay consistent

One 60-capsule bottle provides a 20-day supply at the labelled dose of 3 capsules per day. Swallow capsules whole with water.

Check in on longer use

Consult a health care practitioner before using for longer than 1 year, or if you are pregnant, breastfeeding, or taking any serotonergic medication.

What the research says about the ingredients in CanPrev 5-HTP 100

Peer-reviewed studies and reviews on the individual ingredients in this formula - 5-HTP, magnesium and vitamin B6 - shared for education, not as claims about this finished product. CanPrev 5-HTP 100's claims are the statements authorized under its Natural Health Product licence, NPN 80037247.

5-HTP & Mood Balance

A precursor with real antidepressant signal

An early review of 5-HTP trials concluded the compound shows antidepressant properties in depressed patients, with relatively few adverse effects reported at the doses studied.

Review
Byerley et al., Journal of Clinical Psychopharmacology (1987)
5-HTP & Mood Balance

How a precursor raises brain serotonin

A pharmacology review traced how orally taken 5-HTP is converted to serotonin and summarized double-blind, placebo-controlled trial evidence supporting its use for mood.

Review
Turner et al., Pharmacology & Therapeutics (2005)
5-HTP & Mood Balance

Mood and cognitive scores improved over 12 weeks

In a randomized controlled trial, older adults taking 100 mg of 5-HTP daily for 12 weeks showed improved depression-scale scores and cognitive assessment scores alongside a rise in serum serotonin.

Human RCT
Li et al., Nutrients (2025)
5-HTP & Restful Sleep

An early EEG look at 5-HTP and sleep

A classic sleep-laboratory study used EEG, EMG and EOG recordings to characterize how oral 5-hydroxytryptophan altered the sleep of normal human volunteers.

Human study
Wyatt et al., Electroencephalography and Clinical Neurophysiology (1971)
5-HTP & Restful Sleep

Combined with GABA to reverse sleeplessness

In caffeine-induced sleepless animal models, combined GABA and 5-HTP significantly increased total sleep time and improved sleep quality measures compared to either ingredient alone.

Preclinical study
Hong et al., Nutrition Research and Practice (2018)
5-HTP & Restful Sleep

A serotonergic route to deeper sleep

An animal study found 5-HTP augmented a sedative's effect on slow-wave sleep architecture through the brain's serotonergic sleep-regulating circuitry.

Preclinical study
Zhao et al., Neuropharmacology (2009)
5-HTP & Migraine and Headache Comfort

A serotonin-hormone link to migraine aura

An animal-model study found 5-HTP reduced the cortical spreading depression associated with migraine aura in the presence of ovarian hormones, pointing to a serotonin-estrogen interaction.

Preclinical study
Chauvel et al., Cephalalgia (2017)
5-HTP & Migraine and Headache Comfort

A possible pain-modulation mechanism

L-5-HTP, with or without carbidopa, significantly raised plasma beta-endorphin levels in healthy volunteers, a finding the authors linked to possible implications for migraine prophylaxis.

Human study
Genazzani et al., Cephalalgia (1986)
5-HTP & Migraine and Headache Comfort

A childhood migraine crossover trial

In a double-blind crossover study of children with migraine, both L-5-HTP and placebo reduced migraine frequency during later treatment periods, with a period effect complicating interpretation of a specific 5-HTP benefit.

Human RCT
Santucci et al., Cephalalgia (1986)
5-HTP & Fibromyalgia Symptom Relief

Improvement across fibromyalgia symptoms

A double-blind, placebo-controlled trial in 50 patients with primary fibromyalgia syndrome found that 5-HTP significantly improved the clinical measures studied, with only mild, transient side effects.

Human RCT
Caruso et al., Journal of International Medical Research (1990)
5-HTP & Fibromyalgia Symptom Relief

Pairing 5-HTP for pain relief

A clinical study in fibromyalgia patients found that combining 5-HTP with a monoamine-oxidase inhibitor improved pain scores more than either serotonergic approach alone.

Human study
Nicolodi & Sicuteri, Advances in Experimental Medicine and Biology (1996)
5-HTP & Fibromyalgia Symptom Relief

A dietary strategy case report

A case report described remission of fibromyalgia symptoms, including chronic pain, morning stiffness and non-restorative sleep, following a dietary approach designed to support serotonin synthesis.

Case report
Lattanzio & Imbesi, Frontiers in Medicine (2018)
Magnesium Bisglycinate & Sleep Quality

A placebo-controlled trial in poor sleepers

In a randomized, placebo-controlled trial, magnesium bisglycinate supplementation (250 mg elemental magnesium daily) produced a modestly greater reduction in Insomnia Severity Index scores than placebo over 4 weeks.

Human RCT
Schuster et al., Nature and Science of Sleep (2025)
Magnesium Bisglycinate & Sleep Quality

Lower magnesium linked to worse sleep

A study measuring hair magnesium concentration found significantly lower levels in patients reporting increased sleep latency or decreased sleep duration.

Human study
Gilca-Blanariu et al., Nutrients (2022)
Magnesium Bisglycinate & Sleep Quality

Magnesium among nutrients supporting sleep in aging

A review of nutritional supplements for healthy aging identified magnesium, alongside tart cherry and kiwifruit, as showing promising though still limited evidence for improving sleep.

Review
Kaufman et al., American Journal of Lifestyle Medicine (2024)
Magnesium & Vitamin B6 - Calm and Emotional Balance

A magnesium-B6 synergy for anxiety-related symptoms

A randomized, double-blind, crossover study found that combined magnesium (200 mg) and vitamin B6 (50 mg) daily significantly reduced anxiety-related premenstrual symptoms, an effect neither nutrient produced alone at these doses.

Human RCT
De Souza et al., Journal of Women's Health & Gender-Based Medicine (2000)
Magnesium & Vitamin B6 - Calm and Emotional Balance

A review of magnesium for subjective anxiety

A review of the evidence for magnesium supplementation found it suggestive of a beneficial effect on mild-to-moderate subjective anxiety, while calling for further randomized trials.

Review
Boyle et al., Magnesium Research (2016)
Magnesium & Vitamin B6 - Calm and Emotional Balance

Vitamin B6 alone reduced PMS symptoms

A randomized, double-blind, treatment-controlled trial found daily vitamin B6 (80 mg) produced comparable symptom reduction to a broader micronutrient formula, with 60% of the B6 group in full symptom remission after three cycles.

Human RCT
Retallick-Brown et al., Journal of Alternative and Complementary Medicine (2020)
Vitamin B6 & Serotonin Synthesis

The enzyme B6 activates

A structural biology study describes how active vitamin B6 (pyridoxal-5'-phosphate) is transferred to and activates DOPA decarboxylase, the same B6-dependent enzyme required for serotonin biosynthesis.

Mechanistic study
Al Mughram et al., International Journal of Molecular Sciences (2023)
Vitamin B6 & Serotonin Synthesis

B6 supplementation and depression symptoms

A randomized, double-blind crossover trial found that 100 mg of vitamin B6 daily reduced depression inventory scores by 20% over 4 weeks in young women, versus an 11% rise with placebo.

Human RCT
Curtin & Johnston, Journal of Dietary Supplements (2022)
Vitamin B6 & Serotonin Synthesis

A systematic review of B6 for psychological symptoms

A systematic review of 31 randomized controlled trials found that vitamin B6, alongside calcium and zinc, consistently produced significant positive effects on the psychological symptoms of premenstrual syndrome.

Systematic review
Robinson et al., Nutrition Reviews (2025)
Safety & Serotonin Awareness

Two decades of safety monitoring

A review of 5-HTP safety over roughly 20 years of consumer use found no definitive cases of toxicity or contamination comparable to the L-tryptophan issue that preceded it, while noting continued vigilance is warranted.

Review
Das et al., Toxicology Letters (2004)
Safety & Serotonin Awareness

What happens well beyond the labelled dose

A case report described serotonin syndrome following a large accidental 5-HTP overdose, successfully treated with haemodialysis, illustrating why the recommended label dose should never be exceeded.

Case report
Arbona et al., Veterinary Medicine and Science (2023)
Safety & Serotonin Awareness

Recognizing serotonin syndrome early

A case report of serotonin syndrome following 5-HTP supplement ingestion described agitation, elevated heart rate and temperature, and hypertension, underscoring why the label's dose and drug-interaction cautions exist.

Case report
Hopkins et al., Journal of Medical Toxicology (2017)

Frequently asked questions

What is CanPrev 5-HTP 100?

It is a Health Canada licensed Natural Health Product (NPN 80037247) that combines 100 mg of 5-HTP from Griffonia simplicifolia seed with Magnesium (as magnesium bisglycinate) 60 mg and Vitamin B6 33.3 mg as co-factors, in a vegetarian capsule.

How do I take it?

Adults take 1 capsule 3 times per day with food, or as directed by a health care practitioner. One 60-capsule bottle is a 20-day supply at that dose.

What is 5-HTP is used for on this product's label?

This product is licensed to help promote healthy mood balance, help relieve the symptoms of fibromyalgia, help reduce the severity and duration of migraine and tension headache when taken as a preventative, and help support restful sleep.

Why does it include Magnesium and Vitamin B6?

Magnesium (as magnesium bisglycinate) and Vitamin B6 are formulated alongside the 5-HTP as co-factors, so you do not need to take separate supplements to support the body's use of the primary ingredient.

How long until I notice an effect?

Effects from 5-HTP supplementation are typically assessed after 2-3 weeks of consistent daily use. Consult a health care practitioner for use beyond 1 year.

Can I take it with my antidepressant or other medication?

Consult a health care practitioner before use if you are taking carbidopa or any other health product with serotonergic activity, or if you are pregnant, breastfeeding, or under the care of a physician for a medical condition.

Who should not use it?

Do not use if you have scleroderma. Consult a health care practitioner before use if you are pregnant, breastfeeding, or taking any serotonergic medication.

Where do I buy it?

Use the orange button on this page - it takes you to the CanPrev listing on Amazon.ca for secure checkout and fast delivery.

100 mg 5-HTP + Magnesium & B6 co-factors60 capsules · 20-day supplyVegan · Non-GMO · Gluten-freeMade in Canada

Support mood balance, restful sleep and inner calm the easy way

Get CanPrev 5-HTP 100 on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Natural Health Product NPN 80037247. Helps promote healthy mood balance. Helps relieve the symptoms of fibromyalgia. Helps reduce the severity and duration of migraine and tension headache when taken as a preventative. Helps support restful sleep. The research summaries below concern the individual ingredients in this formula - 5-HTP, magnesium and vitamin B6 - and are educational; they are not claims about this finished product. Read and follow the label. Do not use if you have scleroderma. Consult a health care practitioner before use if you are pregnant, breastfeeding, or taking carbidopa or any other health product with serotonergic activity. Results may vary.

Important information

Safety Information

Cautions and Warnings: Do not use if you have scleroderma. Ask a health care practitioner before use if you are taking carbidopa or any other health product with serotonergic activity, or if you are pregnant, breastfeeding or trying to conceive. Consult a health care practitioner for use beyond 1 year. Discontinue use and consult a health care practitioner if you experience signs of muscle weakness, oral ulcers, skin hardening or changes, or abdominal pain with severe muscle pain. Gastrointestinal discomfort may occur. Keep out of reach of children. Store in a cool, dry place. Sealed for your protection - do not use if the seal is broken.

Indications

Recommended Use or Purpose: Helps promote healthy mood balance. Helps relieve the symptoms of fibromyalgia. Helps reduce the severity and duration of migraine and tension headache when taken as a preventative. Helps support restful sleep.

Ingredients

Medicinal Ingredients (per 1 capsule): 5-HTP (5-Hydroxy-L-Tryptophan, from Griffonia simplicifolia seed) 100 mg, Magnesium (magnesium bisglycinate) 60 mg, Vitamin B6 (pyridoxine HCl) 33.3 mg. Non-medicinal Ingredients: Hypromellose (capsule), magnesium stearate, microcrystalline cellulose. Vegan, non-GMO and gluten-free. NMIs are subject to change - always read and follow the label.

Directions

Recommended Dose (Adults): Take 1 capsule 3 times daily with food, or as directed by a health care practitioner. Do not exceed the recommended dose. Introduce gradually and use consistently for 2-3 weeks before assessing effects.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.