AOR Calcium D-Glucarate + Milk Thistle - Liver Support Formula | 60 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 2 Capsules (60 per bottle) |
| Licensed Natural Health Product | NPN 80028143 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- PROMOTES LIVER FUNCTION AND CLEANSE SUPPORT: Combines the traditional liver-protectant benefits of milk thistle with calcium D-glucarate, supporting the body's natural cleanse pathways for a balanced, energized daily routine.
- SUPPORTS HEALTHY CELLULAR FUNCTION: D-glucarate, found naturally in certain vegetables, plays a role in the body's natural processes that help maintain healthy cells, supporting long-term cellular vitality.
- COMPREHENSIVE LIVER SUPPORT FORMULA: A thoughtfully dosed blend of calcium D-glucarate (150 mg) and standardized milk thistle extract (175 mg, 80% silymarin) per serving, formulated to help the liver perform at its best.
- SUPPORTS THE BODY'S NATURAL DEFENSES: Calcium D-glucarate is included to help support the body's defenses against everyday environmental toxin exposure, paired with milk thistle for added protective support.
- GENTLE, DAILY WELLNESS SUPPORT: A consistent, gentle daily formula that supports the body's cleanse processes and helps balance internal systems as part of a long-term wellness routine.
- TRANSPARENT, TWO-INGREDIENT LABEL: Just two medicinal ingredients per capsule - Calcium D-Glucarate 75 mg and standardized Milk Thistle extract 87.5 mg (150 mg / 175 mg per 2-capsule serving) - no proprietary blend.
- VEGAN, NON-GMO, GLUTEN-FREE: 60 vegan capsules (a 30-day supply at 2 capsules daily), non-GMO and gluten-free, manufactured by AOR in Calgary, Canada.
Product Description
Calcium D-Glucarate + Milk Thistle - Liver Health Formula
A closer look at AOR Calcium D-Glucarate + Milk Thistle - a two-ingredient formula pairing calcium D-glucarate with standardized milk thistle extract to help support liver function and the body's natural detoxification pathways. Licensed Natural Health Product NPN 80028143.
Two Ingredients, One Liver-Health Focus
Calcium D-glucarate and standardized milk thistle extract (80% silymarin) - vegan, non-GMO and gluten-free capsules
Standardized 80% Silymarin Extract
Milk thistle is standardized to its active silymarin content (40:1 extract, 80% silymarin) so every capsule delivers a consistent, traceable dose - not a generic raw-herb powder.
Vegan Capsules, No Animal By-Products
Each hypromellose (vegan) capsule is gluten-free and non-GMO, for a 30-day supply of daily liver support without animal-derived ingredients.
Advanced Ingredients, Superior Results
Two real, dosed ingredients - not a proprietary blend. Here is what each one is and why it is included.
Calcium D-Glucarate
The calcium salt of D-glucaric acid, a compound the body also produces naturally; included to help support the liver's natural detoxification pathways.
150 mg per 2-capsule serving (75 mg/capsule)
Milk Thistle Extract
A concentrated, standardized extract of Silybum marianum, traditionally used in Herbal Medicine as a hepatoprotectant to help support liver function.
175 mg per 2-capsule serving, 40:1 extract (80% silymarin)AOR Calcium D-Glucarate + Milk Thistle: Supplement Facts
Each 2-capsule serving contains:
- Calcium D-Glucarate D-glucaric acid calcium salt150 mg
- Milk Thistle dry extract 40:1, 80% silymarin175 mg
Non-Medicinal Ingredients: Carrot root powder, hypromellose, microcrystalline cellulose, purified water, silicon dioxide.
Recommended Use or Purpose: Helps to support liver function and used as a hepatoprotectant/liver protectant. Milk Thistle (Silybum marianum) is traditionally used in Herbal Medicine as a hepatoprotectant/liver protectant to help support liver function. Licensed Natural Health Product, NPN 80028143.
Recommended Dose (Adults 18 years and older): Take 1 capsule 2 times per day with food, or as directed by a qualified health care practitioner. Do not crush, mix, or blend capsules; swallow whole. Do not exceed the recommended dose. Recommended Duration of Use: Use for a minimum of 3 weeks to see beneficial effects.
Cautions and Warnings: Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you are taking other medications or antibiotics. Contraindications: Do not use if you are pregnant or breastfeeding. Do not use if you have Sly syndrome or a liver or eye condition. Known Adverse Reactions: Hypersensitivity (an allergy) has been known to occur; if so, discontinue use. Keep out of reach of children. Store in a cool, dry place.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque portion de 2 capsules contient :
- D-Glucarate de calcium sel de calcium de l'acide D-glucarique150 mg
- Extrait sec de chardon-Marie 40:1, 80 % silymarine175 mg
Ingrédients non médicinaux : Poudre de racine de carotte, hypromellose, cellulose microcristalline, eau purifiée, dioxyde de silicium.
Usage ou fins recommandés : Aide à soutenir la fonction hépatique et utilisé comme agent hépatoprotecteur/protecteur du foie. Le chardon-Marie (Silybum marianum) est traditionnellement utilisé en phytothérapie comme agent hépatoprotecteur/protecteur du foie pour aider à soutenir les fonctions hépatiques. Produit de santé naturel homologué, NPN 80028143.
Dose recommandée (adultes de 18 ans ou plus) : Prendre 1 capsule 2 fois par jour avec de la nourriture, ou selon les directives d'un praticien de soins de santé qualifié. Ne pas écraser, mélanger ou broyer les capsules; avaler entières. Ne pas dépasser la dose recommandée. Durée d'utilisation recommandée : Utiliser pendant un minimum de 3 semaines pour observer les effets bénéfiques.
Mises en garde et précautions : Consulter un praticien de soins de santé si les symptômes persistent ou s'aggravent. Consulter un praticien de soins de santé avant l'utilisation si vous prenez d'autres médicaments ou des antibiotiques. Contre-indications : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Ne pas utiliser si vous êtes atteint du syndrome de Sly ou d'une condition hépatique ou oculaire. Réactions indésirables connues : Une hypersensibilité (allergie) a été rapportée; le cas échéant, cesser l'utilisation. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec.
NPN 80028143
Support liver function the easy way
Get AOR Calcium D-Glucarate + Milk Thistle on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Calcium D-Glucarate + Milk Thistle
A focused two-ingredient formula for liver function support - premium AOR quality.
Two real, dosed ingredients
Calcium D-glucarate 150 mg and standardized milk thistle extract 175 mg per serving - no proprietary blend, no filler herbs.
Standardized silymarin extract
Milk thistle is a 40:1 extract standardized to 80% silymarin, for consistent potency capsule to capsule.
Liver function support
Formulated to help support liver function and the body's natural detoxification pathways.
Premium Canadian brand
AOR - Advanced Orthomolecular Research, since 1991. Licensed Natural Health Product, NPN 80028143.
Inside every serving
Two real, dosed ingredients - Calcium D-Glucarate 150 mg and Milk Thistle extract 175 mg (80% silymarin) in 2 vegan capsules.
How to use it
1 capsule, twice daily
Adults take 1 capsule 2 times per day with food, or as directed by a qualified health care practitioner.
Swallow capsules whole
Do not crush, mix or blend capsules. Do not exceed the recommended dose.
Give it at least 3 weeks
Use for a minimum of 3 weeks to see beneficial effects, then continue as part of your daily routine.
What the research says about D-glucarate and milk thistle
Peer-reviewed studies on calcium D-glucarate and milk thistle/silymarin, the two active ingredients in this formula, verified via PubMed. These summaries are educational and concern the ingredients generally - they are not claims about this finished product. This product's own claims are the statements authorized under its Natural Health Product licence, NPN 80028143.
Reduced liver-related deaths in cirrhosis patients
A narrative review of silymarin's clinical research found that in a pooled analysis of trials in cirrhosis patients, silymarin treatment was associated with a significant reduction in liver-related deaths, and it also improved glycemic control in patients with diabetes and alcoholic cirrhosis.
ReviewMeta-analysis: lower ALT/AST and improved liver histology
A meta-analysis of 26 randomized trials (2,375 NAFLD patients) found silymarin significantly reduced ALT, AST, and cholesterol/triglyceride levels, and improved hepatic steatosis on liver histology.
Meta-analysisCochrane review: modest ALT benefit, low-certainty evidence
A Cochrane systematic review of 17 randomized trials (2,069 MASLD/NAFLD patients) found silymarin monotherapy may modestly lower ALT versus placebo, but rated the overall certainty of evidence as low to very low - an honest picture of where the research still stands.
Cochrane reviewFour pathways behind D-glucaric acid's liver-detox role
A computational systems-biology analysis modeled how D-glucaric acid (the metabolite of calcium D-glucarate) supports liver detoxification through four molecular pathways: reduced reactive-oxygen production, reduced glucuronide deconjugation, lower hepatocyte apoptosis, and inhibition of beta-glucuronidase.
Computational modelD-glucaric acid as a natural beta-glucuronidase inhibitor
A review of D-glucaric acid's biological role describes it and its lactone form as natural, non-toxic inhibitors of beta-glucuronidase, an enzyme that otherwise reverses Phase II liver detoxification by uncoupling conjugated compounds marked for excretion.
ReviewMapping the enzyme D-glucarate is built to inhibit
Structural biology research resolved three distinct beta-glucuronidase enzymes produced by gut bacteria, detailing how these enzymes hydrolyze glucuronide conjugates - the same enzyme class that D-glucarate's own metabolite is known to inhibit.
MechanismA reviewed role in estrogen metabolism regulation
A clinical review of calcium D-glucarate describes oral supplementation as inhibiting beta-glucuronidase, a Phase II liver-detoxification enzyme, and notes regulation of estrogen metabolism among its studied clinical applications.
ReviewUsed clinically alongside hormone-metabolite testing
An integrative-medicine case report describes calcium D-glucarate (paired with DIM) being added to a patient's regimen and monitored with before-and-after urinary hormone-metabolite testing to help manage estrogen metabolite balance.
Case reportClassic research on the glucarate/hormone-metabolite link
In foundational rat research, dietary calcium D-glucarate inhibited serum beta-glucuronidase activity and was linked to lower endogenous estradiol and steroid-hormone precursor levels, illustrating the biochemical basis for its traditional use as a hormone-metabolism support ingredient.
Animal modelFree-radical scavenging protects stressed tissue
A mechanistic review of ischemia-reperfusion injury (a model of oxidative tissue stress) found silymarin and its component silibinin help protect tissue by scavenging free radicals, lowering inflammatory cytokines, and increasing the body's own antioxidant enzyme activity.
ReviewRaised the body's own antioxidant enzyme activity
In a 6-month double-blind clinical trial of patients with alcoholic liver disease, silymarin corrected the reduced superoxide-dismutase activity of red and white blood cells alongside improvements in liver function markers.
Human RCTLowered inflammatory markers in a diet-induced model
In rats fed a high-fat diet, silymarin treatment reduced oxidative stress and downregulated inflammatory markers (IL-1beta, IL-6, TNF-alpha, CRP) and improved measures of liver fat and fibrosis; a nanoparticle-enhanced formulation showed an even stronger effect than the standard extract.
Animal modelWell tolerated even at high doses in clinical trials
An updated safety review found silymarin is generally safe and well tolerated in humans, even at doses of 700 mg three times daily for 24 weeks, with occasional mild gastrointestinal effects like nausea or diarrhea.
ReviewA real reason silymarin carries a medication-interaction caution
Laboratory research found that several silymarin components and their metabolites can inhibit certain cytochrome P450 drug-metabolizing enzymes, supporting the standard caution to use care when combining high-dose silymarin with other medications.
MechanismQuality varies - why a standardized extract matters
A safety-oriented review of milk thistle supplements found silymarin itself is considered safe and well tolerated at appropriate doses, but flagged that some commercial preparations do not contain their labeled silymarin concentration, underscoring the importance of a standardized extract.
ReviewHow silymarin stacks up against other liver-support botanicals
A network meta-analysis of 37 randomized trials (2,509 NAFLD patients) compared seven natural products; artichoke leaf extract and naringenin ranked ahead of silymarin on some lipid and enzyme measures - an honest reminder that no single botanical wins on every marker.
Network meta-analysisAmong the most-studied natural options for fatty liver
A scoping review of 131 primary studies and 49 systematic reviews on bioactive substances for fatty liver disease identified curcumin and silymarin as the two most heavily studied options, ahead of resveratrol, coffee, green tea and berberine.
Scoping reviewCombining silymarin with curcumin in a small clinical trial
In a small 4-week clinical trial of adults with NAFLD (15 participants), curcuminoids and silymarin - individually and combined - were associated with improved liver-enzyme and lipid measures.
Human trialWhy urinary D-glucaric acid matters
A review of urinary detoxification markers explains that general hepatic Phase II detoxification, whether stimulated by natural compounds, drugs, or everyday xenobiotic exposure, is reflected in elevated levels of urinary D-glucaric acid.
ReviewA liver-support regimen raised this same detox marker
In an 8-week pilot study of 30 adults following a multi-ingredient liver-support supplement regimen, urinary D-glucaric acid and mercapturic acid levels rose significantly, consistent with increased Phase II detoxification activity, regardless of participants' detox-gene variants.
Human pilot studyHow blocking beta-glucuronidase changes detox chemistry
Laboratory research on saccharolactone (D-glucaro-1,4-lactone), the active lactone form of D-glucarate and a beta-glucuronidase inhibitor, showed that blocking this enzyme measurably shifts glucuronide-pathway drug metabolism in human liver tissue.
MechanismA 55-study meta-analysis on liver enzymes
A meta-analysis of 55 randomized trials (3,545 patients) found silymarin significantly reduced AST and ALT overall, with the largest effects in NAFLD and viral hepatitis, and better results at lower doses (under 400 mg) and shorter courses (2 months or less).
Meta-analysisMixed results on insulin resistance, stated honestly
A meta-analysis of 6 randomized trials (673 participants) found silymarin improved HOMA-IR, a marker of insulin resistance, in people with type 2 diabetes or alcohol-related cirrhosis, but found no significant change in NAFLD patients specifically or in fasting insulin overall.
Meta-analysisA phase II trial's nuanced, honestly reported result
A phase II randomized trial of 146 patients testing a Phyllanthus niruri plus milk thistle combination found ALT and AST both fell significantly from baseline at the higher dose, though the reduction was not statistically greater than placebo - a real result reported without overstatement.
Human RCT (Phase II)Frequently asked questions
What is AOR Calcium D-Glucarate + Milk Thistle?
It is a two-ingredient liver-health formula combining calcium D-glucarate (150 mg per serving) with a standardized milk thistle extract (175 mg per serving, 80% silymarin), in vegan capsules. It is a licensed Natural Health Product, NPN 80028143.
How do I take it?
Adults take 1 capsule 2 times per day with food, or as directed by a qualified health care practitioner. Swallow capsules whole - do not crush, mix or blend them. Use for a minimum of 3 weeks to see beneficial effects.
What does milk thistle do in this formula?
Milk Thistle (Silybum marianum) is traditionally used in Herbal Medicine as a hepatoprotectant/liver protectant to help support liver function. This formula uses a standardized 40:1 extract at 80% silymarin.
What does calcium D-glucarate do?
Calcium D-glucarate is the calcium salt of D-glucaric acid, a compound the body also produces naturally in small amounts. It is included to help support the liver's natural detoxification pathways and the body's defenses against everyday environmental toxin exposure.
Is it vegan and allergen-friendly?
Yes - the capsules are vegan (hypromellose), non-GMO and gluten-free.
Who should not use it?
Do not use if you are pregnant or breastfeeding, or if you have Sly syndrome or a liver or eye condition. Consult a health care practitioner before use if you are taking other medications or antibiotics, or if symptoms persist or worsen.
How long does one bottle last?
Each bottle has 60 capsules - a 30-day supply at the recommended dose of 1 capsule twice daily.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support liver function the easy way
Get AOR Calcium D-Glucarate + Milk Thistle on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80028143. AOR Calcium D-Glucarate + Milk Thistle helps to support liver function and is used as a hepatoprotectant/liver protectant. Read and follow the label. Do not use if you are pregnant or breastfeeding, or if you have Sly syndrome or a liver or eye condition. Consult a health care practitioner prior to use if you are taking other medications or antibiotics, or if symptoms persist or worsen. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you are taking other medications or antibiotics. Contraindications: Do not use if you are pregnant or breastfeeding. Do not use if you have Sly syndrome or a liver or eye condition. Known Adverse Reactions: Hypersensitivity (an allergy) has been known to occur; if so, discontinue use. Keep out of reach of children. Store in a cool, dry place.
Indications
Recommended Use or Purpose: Helps to support liver function and used as a hepatoprotectant/liver protectant. Milk Thistle (Silybum marianum) is traditionally used in Herbal Medicine as a hepatoprotectant/liver protectant to help support liver function. Licensed Natural Health Product, NPN 80028143.
Ingredients
Medicinal Ingredients (per 2-capsule serving): Calcium D-Glucarate (D-glucaric acid calcium salt) 150 mg (75 mg per capsule), Milk Thistle (Silybum marianum) dry extract (40:1, DHE 3.5 g, standardized to 80% silymarin) 175 mg (87.5 mg per capsule). Non-medicinal ingredients: carrot root powder, hypromellose, microcrystalline cellulose, purified water, silicon dioxide.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule 2 times per day with food, or as directed by a qualified health care practitioner. Do not crush, mix, or blend capsules; swallow whole. Do not exceed the recommended dose. Recommended Duration of Use: Use for a minimum of 3 weeks to see beneficial effects.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.