AOR 5-HTP 50mg - Serotonin, Mood & Sleep Support | 90 Capsules
Visit the AOR Store| Brand | AOR |
| Serving | 1 capsule (see dose for daily use) |
| Licensed Natural Health Product | NPN 80010414 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- SUPPORTS EMOTIONAL BALANCE: AOR 5-HTP provides 50 mg of L-5-Hydroxytryptophan (griffonia seed extract) per capsule, a direct precursor the body converts into serotonin to help support emotional and mood balance.
- MAY EASE HEADACHE FREQUENCY AND INTENSITY: 5-HTP has been associated with more comfortable headache frequency and intensity, an area where serotonin pathways are believed to play a role.
- RESTFUL SLEEP WITHOUT MORNING GROGGINESS: As a precursor further upstream in the serotonin pathway, 5-HTP is associated with supporting restful sleep without the next-day grogginess some sleep aids can bring.
- PHYSICAL COMFORT AND RELAXATION: Beyond mood, 5-HTP is associated with supporting physical comfort and a relaxed, calm feeling throughout the day.
- VEGAN, NON-GMO, GLUTEN-FREE FORMULA: A clean, single-ingredient capsule - vegan, non-GMO and gluten-free, with no unnecessary fillers beyond the minimal capsule and flow-agent ingredients on the label.
- TASTELESS, EASY-TO-SWALLOW CAPSULES: Each capsule is tasteless and easy to swallow, simple to fit into a daily morning or evening routine.
- PLANT-DERIVED FROM GRIFFONIA SEED: Sourced from Griffonia simplicifolia seed extract rather than synthesized tryptophan, for a plant-based route to supporting serotonin production.
- TRUSTED CANADIAN MANUFACTURING: Made in Canada in a GMP-compliant facility by Advanced Orthomolecular Research (AOR), licensed under Health Canada NPN 80010414.
Product description
Plant-based support for serotonin, mood balance and restful sleep
A closer look at AOR 5-HTP - a single-ingredient, plant-derived amino acid supplement made in Canada. Licensed Natural Health Product NPN 80010414.
Why AOR 5-HTP
One clean ingredient, sourced from griffonia seed - nothing else needed.
Griffonia seed-derived
Each capsule delivers 50 mg of L-5-Hydroxytryptophan from griffonia seed extract, a direct precursor to serotonin - not a synthetic additive.
Vegan, easy-to-swallow capsules
Tasteless, vegan, non-GMO and gluten-free capsules made to fit easily into a daily routine, with no unnecessary fillers.
What AOR 5-HTP supports
Four ways AOR 5-HTP supports your day and night.
Serotonin Production
5-HTP is the direct precursor the body converts into serotonin, supporting healthy mood balance.
Restful Sleep
Supports healthy sleep patterns as part of the same serotonin pathway that helps regulate the sleep-wake cycle.
Relaxation & Calm
Associated with supporting physical comfort and a relaxed, calm feeling throughout the day.
Clean, Licensed Formula
Vegan, non-GMO, gluten-free and made in Canada in a GMP-compliant facility under Health Canada NPN 80010414.
AOR 5-HTP: Supplement Facts
Each capsule contains:
- L-5-Hydroxytryptophan (griffonia seed extract)50 mg
Non-Medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate.
Recommended Use or Purpose: Helps promote healthy mood balance. Helps relieve symptoms of fibromyalgia, in adults 18 years of age and older.
Recommended Dose (Adults 18 years and older): For healthy mood balance: take 1 to 2 capsules three times daily with food (150-300 mg per day). For relief of fibromyalgia symptoms: take 2 capsules 3 to 4 times daily with food (300-400 mg per day); do not exceed 6 capsules (300 mg) per single dose. To minimize the risk of gastrointestinal side effects, start at 1-2 capsules 2 to 3 times daily and slowly increase to an effective dose over 2 weeks. Use for at least 2 weeks to see beneficial effects. Do not crush, mix or blend capsules; swallow capsules whole. Do not exceed the recommended dose unless directed by a health care practitioner.
Cautions and Warnings: Do not use if you have scleroderma. Do not use if you are taking antidepressants. Ask a health care practitioner before use if you are taking carbidopa or any other health product with serotonergic activity. Exercise caution while driving a motor vehicle or operating machinery, as you may experience drowsiness. Discontinue use and consult a health care practitioner if you experience skin hardening, pain or stiffness of muscles or joints, tremors, agitation, confusion, or an increased heart rate. Gastrointestinal discomfort or disturbances may occur. Do not use if you are pregnant, breastfeeding or trying to conceive, or if you are under 18, without consulting a health care practitioner. Keep out of reach of children. Store in a cool, dry place. Sealed for your protection - do not use if the seal is broken.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- L-5-Hydroxytryptophane (extrait de graine de griffonia)50 mg
Ingrédients non médicinaux : Cellulose microcristalline, stéarylfumarate de sodium.
Usage ou fins recommandés : Aide à promouvoir un bon équilibre de l'humeur. Aide à soulager les symptômes de la fibromyalgie, chez les adultes de 18 ans et plus.
Dose recommandée (adultes de 18 ans et plus) : Pour un bon équilibre de l'humeur : prendre 1 à 2 capsules trois fois par jour avec de la nourriture (150 à 300 mg par jour). Pour soulager les symptômes de la fibromyalgie : prendre 2 capsules 3 à 4 fois par jour avec de la nourriture (300 à 400 mg par jour); ne pas dépasser 6 capsules (300 mg) par dose unique. Pour minimiser le risque d'effets gastro-intestinaux, commencer par 1 à 2 capsules 2 à 3 fois par jour et augmenter progressivement jusqu'à une dose efficace sur 2 semaines. Utiliser pendant au moins 2 semaines afin de constater les effets bénéfiques. Ne pas écraser, mélanger ou broyer les capsules; avaler les capsules entières. Ne pas dépasser la dose recommandée sauf sur indication d'un praticien de soins de santé.
Mises en garde et précautions : Ne pas utiliser si vous avez la sclérodermie. Ne pas utiliser si vous prenez des antidépresseurs. Consultez un praticien de soins de santé avant l'utilisation si vous prenez du carbidopa ou tout autre produit de santé à activité sérotoninergique. Soyez prudent si vous conduisez un véhicule ou utilisez de la machinerie, car vous pourriez ressentir de la somnolence. Cessez l'utilisation et consultez un praticien de soins de santé si vous ressentez un durcissement de la peau, une douleur ou une raideur des muscles ou des articulations, des tremblements, de l'agitation, de la confusion, ou une augmentation du rythme cardiaque. Un inconfort gastro-intestinal peut survenir. Ne pas utiliser si vous êtes enceinte, si vous allaitez ou prévoyez le devenir, ou si vous avez moins de 18 ans, sans consulter un praticien de soins de santé. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec. Scellé pour votre protection - ne pas utiliser si le sceau est brisé.
NPN 80010414
Support mood balance, serotonin and restful sleep the easy way
Get AOR 5-HTP on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy people choose AOR 5-HTP
One plant-derived amino acid - four ways it supports mood, sleep and daily comfort.
Mood & Emotional Balance
5-HTP is a direct precursor to serotonin, supporting emotional and mood balance for adults 18 and older.
Restful, Natural Sleep
Supports healthy sleep patterns without the grogginess some sleep aids can bring the next morning.
Headache Comfort
Associated with more comfortable headache frequency and intensity through its role in the serotonin pathway.
Physical Comfort & Relaxation
Supports physical comfort and a relaxed, calm feeling as part of a daily wellness routine.
How to use
Start low
Adults 18+: to minimize gastrointestinal effects, start at 50-100 mg (1-2 capsules) 2 to 3 times daily with food.
Take with food
For healthy mood balance, take 1 to 2 capsules three times daily with food, or as directed by a health care practitioner.
Increase gradually
Slowly increase to an effective dose over 2 weeks; swallow capsules whole - do not crush, mix or blend them.
Give it time
Use for a minimum of 1 week to notice effects for mood balance; do not exceed the recommended dose unless directed by a health care practitioner.
What the research says about 5-HTP
Peer-reviewed studies and reviews on the ingredient L-5-Hydroxytryptophan (5-HTP) - shared for education, not as claims about this finished product. AOR 5-HTP's claims are the statements authorized under its Natural Health Product licence, NPN 80010414.
A precursor with real antidepressant signal
An early review of 5-HTP trials concluded the compound shows antidepressant properties in depressed patients, with relatively few adverse effects reported at the doses studied.
ReviewHow a precursor raises brain serotonin
A pharmacology review traced how orally taken 5-HTP crosses into the brain and is converted to serotonin, summarizing double-blind, placebo-controlled trial evidence for its use in depression.
ReviewMood scores improved over 12 weeks
In a randomized controlled trial, older adults taking 100 mg of 5-HTP daily for 12 weeks showed a significant improvement in depression-scale scores alongside a rise in serum serotonin.
Human RCTAn early EEG look at 5-HTP and sleep
A classic sleep-laboratory study used EEG, EMG and EOG recordings to characterize how oral 5-hydroxytryptophan altered the sleep of normal human volunteers.
Human studyLess nighttime movement with a 5-HTP pairing
A pilot trial combining melatonin with 5-HTP reported a significant within-group reduction in nighttime motor activity (Sleep Movement Index) after four weeks, though the sample was small.
Pilot RCTListed among traditional sleep-support uses
A clinical monograph on 5-hydroxytryptophan summarizes reported uses spanning sleep-initiation difficulty alongside mood, headache and appetite, and outlines its contraindications.
Monograph reviewHead-to-head with a migraine-prevention drug
In a randomized trial of 124 migraine sufferers, 5-HTP improved symptoms in 71% of patients versus 75% on methysergide, with fewer side effects, and the biggest benefit was on attack intensity and duration.
Human RCTMeasuring pain sensitivity directly
A randomized, double-blind, placebo-controlled crossover trial in healthy volunteers used quantitative sensory testing to examine how 28 days of griffonia-derived 5-HTP affected pain sensitization and modulation.
Human RCTA serotonin link to migraine aura
An animal-model study found 5-HTP reduced the cortical spreading depression associated with migraine aura in the presence of ovarian hormones, pointing to a serotonin-estrogen interaction.
Preclinical studyWeight loss without a prescribed diet
In a double-blind trial, obese adults taking 900 mg of 5-HTP daily lost significant weight and reported early satiety and reduced carbohydrate intake, even before any diet was prescribed.
Human RCTCurbing carbohydrate intake
A placebo-controlled trial in overweight patients found that 750 mg of 5-HTP daily significantly reduced daily energy intake, largely by lowering carbohydrate and fat consumption.
Human RCTA boost in the feeling of fullness
Over eight weeks, overweight women taking a 5-HTP-containing plant-extract spray reported a significantly greater increase in satiety than the placebo group, alongside favorable body-composition changes.
Human RCTImprovement across fibromyalgia symptoms
A double-blind, placebo-controlled trial in 50 patients with primary fibromyalgia syndrome found that 5-HTP significantly improved the clinical measures studied, with only mild, transient side effects.
Human RCTA serotonin-pathway explanation
A review of fibromyalgia and the serotonin pathway describes how supplementing serotonin's building blocks, including 5-HTP, has been linked to improvement in the pain, sleep and mood complaints common in fibromyalgia.
ReviewPairing 5-HTP for pain relief
A clinical study in fibromyalgia patients found that combining 5-HTP with a monoamine-oxidase inhibitor improved pain scores more than either serotonergic approach alone, consistent with a shared serotonin mechanism proposed for fibromyalgia and migraine.
Human studyWhy combining serotonergic products needs care
A study of patients hospitalized after overdosing on serotonergic medications identified combining multiple serotonin-boosting agents as a key predictor of serotonin syndrome, reinforcing why label cautions about drug combinations exist.
Human studyWhat happens well beyond the labeled dose
A case report described a large accidental overdose of 5-HTP producing serotonin syndrome that required intensive supportive care, illustrating why the recommended dose on the label should not be exceeded.
Case reportA monograph's contraindication summary
A clinical monograph on 5-hydroxytryptophan outlines its studied uses alongside its contraindications and cautions, the same category of information summarized on this product's label.
Monograph reviewThe direct precursor to serotonin
A review of 5-HTP biology describes it as the immediate precursor the body converts into serotonin, with roles that touch mood, sleep, pain perception and body-temperature regulation.
ReviewAmplifying serotonin synthesis
A five-decade review of clinical evidence describes how boosting serotonin synthesis with precursors like 5-HTP raises extracellular brain serotonin through a different mechanism than reuptake-blocking drugs.
ReviewFrom capsule to the brain
A pharmacology review explains how, unlike serotonin itself, 5-HTP crosses the blood-brain barrier, and how a peripheral decarboxylase inhibitor such as carbidopa can be used to direct more of an oral dose toward the central nervous system.
ReviewTested head-to-head against a standard anxiolytic
A double-blind, placebo-controlled trial in 45 patients with anxiety disorders found that 5-HTP produced a moderate reduction in anxiety symptom scores, supporting a role for serotonin pathways in anxiety.
Human RCTA serotonin challenge in panic disorder
A randomized, double-blind study gave escalating doses of 5-HTP to people with panic disorder and to healthy volunteers, finding it did not trigger panic or anxiety at any of the doses tested.
Human RCTA gentler biological marker of serotonin activity
A study measuring saliva instead of blood found that a single oral dose of 5-HTP produced a measurable cortisol response in both panic disorder patients and healthy volunteers, a non-invasive way to probe serotonin function.
Human RCTFrequently asked questions
What is 5-HTP and what does it do?
5-HTP (5-Hydroxytryptophan) is a plant-derived amino acid, sourced here from griffonia seed extract, that the body converts directly into serotonin. Research supports a role for 5-HTP in supporting mood balance and relieving the symptoms of fibromyalgia.
How do I take it?
Adults 18 years and older: for healthy mood balance, take 1 to 2 capsules three times daily with food. To minimize gastrointestinal effects, start at 50-100 mg 2 to 3 times daily and increase gradually over 2 weeks, or as directed by a health care practitioner.
How long until I notice an effect?
The label suggests using AOR 5-HTP for a minimum of 1 week to see beneficial effects for mood balance, and 2 weeks for the alleviation of fibromyalgia symptoms.
Can I take it with my antidepressant or other medication?
Consult a health care practitioner before use if you are taking carbidopa or any drug or supplement with serotonergic activity, including L-tryptophan, SAMe, St. John's Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, or anti-nausea or anti-migraine medication.
Who should not use it?
Do not use if you are pregnant, breastfeeding or trying to conceive, if you are under 18, or if you have a medical condition, without first consulting a health care practitioner.
What's in each capsule besides 5-HTP?
Each capsule contains 50 mg of L-5-Hydroxytryptophan (griffonia seed extract) as the only medicinal ingredient, plus microcrystalline cellulose and sodium stearyl fumarate as non-medicinal ingredients, in a hypromellose capsule. It is vegan, non-GMO and gluten-free.
Is it made in Canada?
Yes. AOR 5-HTP is manufactured in Canada and licensed by Health Canada as a Natural Health Product under NPN 80010414.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support mood balance, serotonin and restful sleep the easy way
Get AOR 5-HTP on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80010414. Helps promote healthy mood balance and relieve symptoms of fibromyalgia. The research summaries below concern the ingredient L-5-Hydroxytryptophan (5-HTP) and are educational - they are not claims about this finished product. Read and follow the label. Do not use if you have scleroderma or are taking antidepressants. Ask a health care practitioner before use if taking carbidopa or any other health product with serotonergic activity, or if pregnant, breastfeeding or under 18. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if you have scleroderma. Do not use if you are taking antidepressants. Ask a health care practitioner before use if you are taking carbidopa or any other health product with serotonergic activity. Exercise caution while driving a motor vehicle or operating machinery, as you may experience drowsiness. Discontinue use and consult a health care practitioner if you experience skin hardening, pain or stiffness of muscles or joints, tremors, agitation, confusion, or an increased heart rate. Gastrointestinal discomfort or disturbances may occur. Do not use if you are pregnant, breastfeeding or trying to conceive, or if you are under 18, without consulting a health care practitioner. Keep out of reach of children. Store in a cool, dry place. Sealed for your protection - do not use if the seal is broken.
Indications
Recommended Use or Purpose: Helps promote healthy mood balance. Helps relieve symptoms of fibromyalgia, in adults 18 years of age and older.
Ingredients
Medicinal Ingredients (per 1 capsule): L-5-Hydroxytryptophan (griffonia seed extract, Griffonia simplicifolia) 50 mg. Non-medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: Hypromellose. Vegan, non-GMO and gluten-free. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): For healthy mood balance: take 1 to 2 capsules three times daily with food (150-300 mg per day). For relief of fibromyalgia symptoms: take 2 capsules 3 to 4 times daily with food (300-400 mg per day); do not exceed 6 capsules (300 mg) per single dose. To minimize the risk of gastrointestinal side effects, start at 1-2 capsules 2 to 3 times daily and slowly increase to an effective dose over 2 weeks. Use for at least 2 weeks to see beneficial effects. Do not crush, mix or blend capsules; swallow capsules whole. Do not exceed the recommended dose unless directed by a health care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.