AOR Ortho Glucose II 285mg - 5-Ingredient Blood Sugar Support | 90 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 285 mg (1 capsule) |
| Licensed Natural Health Product | NPN 80027523 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- FIVE REAL GLUCOSE-SUPPORT ACTIVES: Combines chromium (as chromium picolinate), cinnamon cassia extract, gymnema sylvestre extract, bitter melon extract and R(+) alpha-lipoic acid in one capsule - no need for five separate pills.
- SUPPORTS HEALTHY GLUCOSE METABOLISM: Chromium helps to maintain the body's ability to metabolize nutrients, the licensed claim behind this formula under NPN 80027523.
- TAKE HALF AN HOUR BEFORE A MEAL: 1 capsule daily, 30 minutes before a meal - timed to when these ingredients are studied to act.
- STANDARDIZED BOTANICAL EXTRACTS: Cinnamon cassia (10:1), gymnema sylvestre (20:1) and bitter melon (10:1) extracts, each providing a defined dried-herb equivalent (DHE).
- INCLUDES R(+) ALPHA-LIPOIC ACID: 100 mg of the sodium-salt form of R-alpha-lipoic acid per capsule, a source of an antioxidant that also helps promote healthy glucose metabolism.
- SIMPLE, ONCE-DAILY DOSE: Take 1 capsule daily - 90 capsules provide up to a 90-day (3-month) supply.
- VEGAN, NON-GMO & GLUTEN-FREE: A clean, vegan formula in a hypromellose (vegetable) capsule - non-GMO and gluten-free.
- PREMIUM CANADIAN QUALITY: Made in Canada by Advanced Orthomolecular Research (AOR), GMP-compliant and licensed under Health Canada NPN 80027523.
Product Description
Ortho Glucose II - Five Real Actives for Glucose Metabolism Support
AOR Ortho Glucose II combines chromium (167 mcg, as chromium picolinate), cinnamon cassia extract, gymnema sylvestre extract, bitter melon extract and R(+) alpha-lipoic acid (100 mg) in one 285 mg capsule. Supports healthy glucose metabolism; chromium helps maintain the body's ability to metabolize nutrients. Take 1 capsule daily, half an hour before a meal. Licensed Natural Health Product NPN 80027523.
AOR Ortho Glucose II combine le chrome (167 mcg, sous forme de picolinate de chrome), l'extrait de cannelle cassia, l'extrait de Gymnema sylvestre, l'extrait de margose et l'acide R(+) alpha-lipoïque (100 mg) en une seule capsule de 285 mg. Favorise un métabolisme sain du glucose; le chrome aide à maintenir la capacité de l'organisme à métaboliser les nutriments. Prendre 1 capsule par jour, une demi-heure avant un repas. Produit de santé naturel homologué. NPN 80027523.
Five Real, Dosed Glucose-Support Actives
Chromium, Cinnamon Cassia, Gymnema Sylvestre, Bitter Melon & R-Alpha-Lipoic Acid - Vegan, Non-GMO, Gluten-Free
Five Real Ingredients, One Capsule
Chromium, cinnamon cassia extract, gymnema sylvestre extract, bitter melon extract and R(+) alpha-lipoic acid combined in a single 285 mg daily capsule - no need for separate single-ingredient pills.
Timed to When It Matters
Take 1 capsule half an hour before a meal, timing supplementation to when these ingredients are studied to act on glucose metabolism.
Advanced Ingredients, Superior Results
A closer look at the five real, dosed ingredients inside every capsule.
Chromium
An essential trace mineral that helps maintain the body's ability to metabolize nutrients - the ingredient behind this formula's licensed glucose-metabolism claim.
as chromium picolinate, 167 mcg per capsuleCinnamon Cassia Extract
A concentrated cassia-cinnamon extract, traditionally used in Herbal Medicine and studied for its role in supporting healthy blood glucose levels.
Cinnamomum cassia extract (10:1, DHE 330 mg), 33 mg per capsuleGymnema Sylvestre Extract
A traditional Ayurvedic herb known as gurmar ("sugar destroyer"), studied for its effect on sweet-taste perception and glucose metabolism.
Gymnema sylvestre (Gurmar) extract (20:1, DHE 1.33 g), 66.5 mg per capsule
Bitter Melon Extract
A traditional botanical widely studied for its glucose-lowering properties, included here at a dedicated, dosed amount.
Momordica charantia extract (10:1, DHE 850 mg), 85 mg per capsuleR(+) Alpha-Lipoic Acid
A source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals, and helps promote healthy glucose metabolism.
sodium salt, 100 mg per capsule (contains 10 mg sodium)AOR Ortho Glucose II: Supplement Facts
Medicinal Ingredients (per capsule):
- Chromium as chromium picolinate167 mcg
- Cinnamomum cassia (Cinnamon) extract 10:1, DHE 330 mg33 mg
- Gymnema sylvestre (Gurmar) extract 20:1, DHE 1.33 g66.5 mg
- Momordica charantia (Bitter Melon) extract 10:1, DHE 850 mg85 mg
- R(+) alpha-Lipoic Acid sodium salt, contains 10 mg sodium100 mg
Non-Medicinal Ingredients: Microcrystalline cellulose, maltodextrin (corn), sodium stearyl fumarate. Capsule: hypromellose. NMIs are subject to change - always read and follow the label.
Recommended Use or Purpose: Supports healthy glucose metabolism. Chromium helps to maintain the body's ability to metabolize nutrients.
Recommended Dose (Adults 18 years and older): Take 1 capsule daily, half an hour before a meal, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules; swallow the capsule whole. Do not exceed the daily dose unless instructed by a health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 6 months.
Cautions and Warnings: Do not use if you are pregnant or breastfeeding, taking acetaminophen, or hypersensitive or allergic to cinnamon or Peruvian balsam, or if you suffer from acid reflux, stomach or intestinal ulcers, liver disease or alcoholism. Discontinue use and consult a health care practitioner if you experience symptoms of hypoglycemia, including feelings of anxiety, dizziness or confusion, tremor, sweating, paleness, chills, nausea or headache (as these may be symptoms of low blood sugar), or in the case of an allergic reaction. Known Adverse Reactions: May cause irritation of the gastric mucous membranes and reflux. Consult a health care practitioner prior to use if you have a kidney disorder, if you have diabetes, or for use beyond 6 months. This product is not suitable for children. Keep out of reach of children. Store in a cool, dry place.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings and directions before using or consuming a product. Manufactured by Advanced Orthomolecular Research (AOR), Calgary, Alberta. This item is sold and shipped by Amazon.ca.
Ingrédients médicinaux (par capsule) :
- Chrome sous forme de picolinate de chrome167 mcg
- Extrait de Cinnamomum cassia (cannelle) 10:1, équivalent en plante séchée 330 mg33 mg
- Extrait de Gymnema sylvestre (Gurmar) 20:1, équivalent en plante séchée 1,33 g66.5 mg
- Extrait de Momordica charantia (margose) 10:1, équivalent en plante séchée 850 mg85 mg
- Acide R(+) alpha-lipoïque sel de sodium, contient 10 mg de sodium100 mg
Ingrédients non médicinaux : Cellulose microcristalline, maltodextrine (maïs), stéaryl fumarate de sodium. Capsule : hypromellose. Les ingrédients non médicinaux peuvent changer - toujours lire et suivre l'étiquette.
Usage ou fins recommandés : Favorise un métabolisme sain du glucose. Le chrome aide à maintenir la capacité de l'organisme à métaboliser les nutriments.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule par jour, une demi-heure avant un repas, ou selon les directives d'un praticien de soins de santé qualifié. Ne pas écraser, broyer ou mélanger les capsules; avaler la capsule entière. Ne pas dépasser la dose quotidienne sauf indication contraire d'un praticien de soins de santé. Durée d'utilisation recommandée : Consulter un praticien de soins de santé pour un usage au-delà de 6 mois.
Mises en garde et précautions : Ne pas utiliser si vous êtes enceinte ou si vous allaitez, si vous prenez de l'acétaminophène, ou si vous êtes hypersensible ou allergique à la cannelle ou au baume du Pérou, ou si vous souffrez de reflux gastrique, d'ulcères gastriques ou intestinaux, d'une maladie du foie ou d'alcoolisme. Cessez l'utilisation et consultez un professionnel de la santé si vous ressentez des symptômes d'hypoglycémie, y compris de l'anxiété, des étourdissements ou de la confusion, des tremblements, des sueurs, de la pâleur, des frissons, des nausées ou des maux de tête (car ceux-ci peuvent être des symptômes d'une faible glycémie), ou en cas de réaction allergique. Réactions indésirables connues : Peut causer une irritation des muqueuses gastriques et des reflux. Consultez un professionnel de la santé avant l'utilisation si vous avez un trouble rénal, si vous êtes diabétique, ou pour un usage au-delà de 6 mois. Ce produit ne convient pas aux enfants. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec.
NPN 80027523
Support healthy glucose metabolism every day
Get AOR Ortho Glucose II on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Ortho Glucose II
Five real, dosed glucose-support ingredients in one capsule - premium AOR quality.
Five real, dosed ingredients
Chromium, cinnamon cassia, gymnema sylvestre, bitter melon and R(+) alpha-lipoic acid, each at a defined dose - no proprietary blend.
Glucose metabolism support
Supports healthy glucose metabolism; chromium helps maintain the body's ability to metabolize nutrients.
Timed for how you eat
Take 1 capsule half an hour before a meal, matching how these ingredients are studied to work.
Premium Canadian brand
AOR - Advanced Orthomolecular Research, since 1991. Licensed Natural Health Product, NPN 80027523.
Inside every capsule
Five real, dosed glucose-support actives - chromium, cinnamon cassia extract, gymnema sylvestre extract, bitter melon extract and R(+) alpha-lipoic acid - in one 285 mg capsule, taken half an hour before a meal.
How to use it
Take 1 capsule daily
Adults 18 years and older: take 1 capsule daily, half an hour before a meal, or as directed by a qualified health care practitioner.
Swallow whole
Do not crush, mix or blend the capsules - swallow the capsule whole.
Guided long-term use
Consult a health care practitioner if you have a kidney disorder or diabetes, or for use beyond 6 months.
What the research says about this 5-ingredient blend
Educational summaries of published research on chromium, cinnamon, gymnema sylvestre, bitter melon and R-alpha-lipoic acid - the medicinal ingredients in this formula; not product-specific claims. AOR Ortho Glucose II's own claim is the statement authorized under its Natural Health Product licence, NPN 80027523: supports healthy glucose metabolism; chromium helps to maintain the body's ability to metabolize nutrients.
Chromium improved insulin markers in a meta-analysis of PCOS trials
A meta-analysis of 10 randomized trials (683 women) found chromium supplementation - including chromium picolinate at 200 mcg - significantly reduced fasting insulin and improved insulin-sensitivity markers, performing comparably to metformin on several measures.
Meta-analysisChromium picolinate lowered insulin-resistance markers in a placebo-controlled trial
In a double-blind, placebo-controlled trial in patients with non-alcoholic fatty liver disease, 400 mcg per day of chromium picolinate for 3 months significantly reduced insulin, HOMA-IR and several inflammatory markers versus placebo.
Human RCTA chromium-containing combination improved glycemic status in dysglycemia
In a randomized trial, a nutraceutical combining chromium picolinate with Ilex paraguariensis and white mulberry reduced fasting and postprandial glucose and glycated hemoglobin versus placebo in adults with dysglycemia, alongside improved insulin sensitivity.
Human RCTA 28-trial meta-analysis found cinnamon improved glycemic markers
A systematic review and meta-analysis of 28 randomized trials (3,054 patients with type 2 diabetes) found cinnamon supplementation significantly reduced fasting blood glucose, postprandial glucose, HbA1c and HOMA-IR versus control, with the largest effects seen in capsule form.
Meta-analysisA dose-response meta-analysis confirmed glycemic benefits across 24 trials
An updated dose-response meta-analysis of 24 randomized trials found cinnamon supplementation produced a statistically significant reduction in fasting blood sugar, HOMA-IR and HbA1c in people with type 2 diabetes.
Meta-analysisAn honest null result for cassia bark powder
An updated systematic review and meta-analysis of cassia ground bark powder (1-2 g per day for 90 days) in type 2 diabetes found only an insignificant reduction in glucose and lipid measures - a reminder that not every cinnamon form or dose shows a significant effect.
Meta-analysisA 14-day gymnema regimen reduced sugar cravings and sweetened-beverage intake
In a randomized crossover trial, adults identifying as having a 'sweet tooth' who used Gymnema sylvestre mints ad libitum for 14 days reduced their daily sugar-sweetened beverage intake by 42% and overall sugar cravings by 28% versus placebo.
Human RCTA 14-day intervention lowered chocolate consumption in a laboratory setting
Healthy adults given a 14-day Gymnema sylvestre (gymnemic acid) intervention ate significantly fewer chocolate bars than a control group by the end of the study, with reduced pleasantness ratings for sweet food.
Human RCTGymnema tea blunted sweet-taste perception and shifted food preference
A randomized study found tea containing Gymnema sylvestre diminished perceived sweetness intensity, reduced liking for sweet foods, and increased the sucrose concentration participants desired in a mixing task - direct evidence of its taste-modulating mechanism.
Human RCT12 weeks of bitter gourd improved glucose markers in prediabetes
A 12-week randomized controlled trial in a prediabetic population found bitter gourd (Momordica charantia) supplementation significantly reduced fasting plasma glucose, fasting insulin and HOMA-IR compared with a matched placebo.
Human RCTA meta-analysis found bitter melon improved glycemic control in type 2 diabetes
A meta-analysis of 10 studies (1,045 patients) found Momordica charantia preparations significantly reduced fasting glucose, postprandial glucose and HbA1c compared with placebo, though evidence quality was rated low to moderate.
Meta-analysisAn underpowered but honest trial found only a small HbA1c change
A randomized, placebo-controlled trial added Momordica charantia capsules to standard diabetes therapy and found only a small, non-significant 0.22% difference in HbA1c versus placebo - the trial was underpowered, illustrating why larger studies are needed.
Human RCTA foundational review of thioctic acid's role in insulin sensitivity
A review of thioctic acid (alpha-lipoic acid) describes its effects on insulin sensitivity and glucose metabolism, summarizing the biochemical basis for its use as a glucose-metabolism-support ingredient.
ReviewALA is an established adjunct for neuropathy symptoms - with an honest caveat
A critical review of alpha-lipoic acid for diabetic peripheral neuropathy found it consistently improves short-term symptoms across multiple randomized trials, while noting the long-term NATHAN 1 trial showed only a marginal, borderline-significant effect on its primary endpoint with no significant nerve-conduction improvement.
Critical reviewOxidative stress as the mechanistic hub linking ALA to nerve protection
A review of oxidative stress in diabetic neuropathy names alpha-lipoic acid among the classical antioxidant strategies showing reproducible benefits on neuropathic symptoms and oxidative stress markers, while noting evidence for sustained structural nerve repair remains limited.
ReviewA network meta-analysis ranked six herbs for glycemic control
A systematic review and network meta-analysis of 44 trials (3,130 participants) compared six herbal formulations, finding apple cider vinegar, cinnamon, curcumin and fenugreek each significantly reduced fasting blood glucose versus placebo.
Network meta-analysisA multi-herb supplement significantly lowered HbA1c in one month
A randomized trial of a multi-herb supplement (Curalin) in people with type 2 diabetes found HbA1c fell by 0.94% versus 0.4% with placebo after one month, with higher patient-reported satisfaction in the active group.
Human RCTAn honest mixed result for a different combined-ingredient approach
A meta-analysis of curcumin combined with piperine in prediabetes and type 2 diabetes found only a numerical, non-statistically-significant improvement in fasting glucose and insulin resistance - a reminder that combining ingredients does not automatically guarantee a significant result.
Meta-analysisAn umbrella review flags monitoring needs when herbs meet antidiabetic drugs
An umbrella review of herbal medicines for type 2 diabetes concluded that careful monitoring for hypoglycemia is essential when herbal medicines are used concurrently with antidiabetic drugs, citing a current lack of data on herb-drug interactions.
Umbrella reviewA modeling study flags a possible bitter-melon/antidiabetic-drug interaction
A molecular docking study modeling bitter melon's phytoconstituents against the antidiabetic drug miglitol's target enzymes found charantin may enhance miglitol's glucose-lowering effect, raising a theoretical additive-hypoglycemia concern the authors say warrants careful patient monitoring.
In silico modeling studyReal hospital cases show herb-plus-antidiabetic-drug hypoglycemia is not just theoretical
A hospital reminder-system study of drug-herb interactions found that among patients concurrently using an herbal product (ginseng) and antidiabetic drugs, several developed real, measured hypoglycemia - concrete evidence behind label cautions to consult a health care practitioner when combining glucose-lowering herbs with diabetes medication.
Clinical safety studyMapping the body's own glucose-lowering pathways
A comprehensive pharmacology review lays out the physiological levers that regulate blood glucose - hepatic glucose production, muscle glucose uptake and intestinal glucose absorption - the same fundamental pathways that glucose-metabolism-supporting nutrients are studied to influence.
ReviewHow plant compounds slow the glucose rise after a meal
A review of dietary polyphenols describes how these plant compounds can blunt the after-meal blood-sugar rise by inhibiting carbohydrate-digesting enzymes and modulating the GLUT2/GLUT4/SGLT1 transporters that move glucose into cells - core biochemistry shared by several botanical glucose-support ingredients.
ReviewA multi-target mechanistic map of a 'sugar destroyer' herb
A comprehensive review of Gymnema sylvestre maps its bioactive compounds to multiple points in glucose regulation - inhibiting intestinal glucose absorption, preserving pancreatic beta-cell function and stimulating insulin secretion - illustrating how a single botanical can act on glucose metabolism through several mechanisms at once.
ReviewFrequently asked questions
What is AOR Ortho Glucose II?
A 5-ingredient formula combining chromium (167 mcg, as chromium picolinate), cinnamon cassia extract, gymnema sylvestre extract, bitter melon extract and R(+) alpha-lipoic acid (100 mg) in one 285 mg capsule. It is a licensed Natural Health Product, NPN 80027523, that supports healthy glucose metabolism.
How do I take it?
Adults 18 years and older take 1 capsule daily, half an hour before a meal, or as directed by a qualified health care practitioner. Do not crush, mix or blend the capsules - swallow whole.
How is this different from AOR's single-ingredient Chromium Picolinate or High Dose R-Lipoic Acid products?
AOR's single-ingredient Chromium Picolinate and High Dose R-Lipoic Acid products are separate products, each with its own Health Canada licence and its own, different dose (600 mcg chromium and 300 mg R-lipoic acid respectively). Ortho Glucose II (NPN 80027523) is a different, 5-ingredient combination product with its own doses (167 mcg chromium, 100 mg R-alpha-lipoic acid) - each product's dose, directions and claims are governed by its own separate licence, so always follow the label of the specific product you are using.
What does each ingredient contribute?
Chromium helps maintain the body's ability to metabolize nutrients; cinnamon cassia, gymnema sylvestre and bitter melon are traditional botanicals studied for their role in glucose metabolism; R(+) alpha-lipoic acid is a source of an antioxidant that also helps promote healthy glucose metabolism.
Why take it half an hour before a meal?
The label directs taking Ortho Glucose II 30 minutes before a meal, timing the ingredients to when dietary carbohydrates are digested and blood glucose rises.
Is it vegan and allergen-friendly?
Yes - vegan, non-GMO and gluten-free, in a hypromellose (vegetable) capsule.
Who should not use it?
Do not use if you are pregnant or breastfeeding, taking acetaminophen, or hypersensitive or allergic to cinnamon or Peruvian balsam, or if you suffer from acid reflux, stomach or intestinal ulcers, liver disease or alcoholism. Consult a health care practitioner prior to use if you have a kidney disorder or diabetes, or for use beyond 6 months. Stop use and consult a health care practitioner if you experience symptoms of low blood sugar (anxiety, dizziness, confusion, tremor, sweating, paleness, chills, nausea or headache). Not suitable for children.
How long does one bottle last?
90 capsules provide up to a 90-day (3-month) supply at 1 capsule per day.
Support healthy glucose metabolism every day
Get AOR Ortho Glucose II on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80027523. Supports healthy glucose metabolism; chromium helps to maintain the body's ability to metabolize nutrients. The research summaries below concern the ingredients generally and are educational - they are not product-specific claims. Read and follow the label. Do not use if you are pregnant or breastfeeding, taking acetaminophen, or hypersensitive or allergic to cinnamon or Peruvian balsam, or if you suffer from acid reflux, stomach or intestinal ulcers, liver disease or alcoholism. Consult a health care practitioner prior to use if you have a kidney disorder or diabetes, or for use beyond 6 months. Results may vary.
Important information
Safety Information
Cautions and Warnings: Do not use if you are pregnant or breastfeeding, taking acetaminophen, or hypersensitive or allergic to cinnamon or Peruvian balsam, or if you suffer from acid reflux, stomach or intestinal ulcers, liver disease or alcoholism. Discontinue use and consult a health care practitioner if you experience symptoms of hypoglycemia, including feelings of anxiety, dizziness or confusion, tremor, sweating, paleness, chills, nausea or headache (as these may be symptoms of low blood sugar), or in the case of an allergic reaction. Known Adverse Reactions: May cause irritation of the gastric mucous membranes and reflux. Consult a health care practitioner prior to use if you have a kidney disorder, if you have diabetes, or for use beyond 6 months. This product is not suitable for children. Keep out of reach of children. Store in a cool, dry place.
Indications
Recommended Use or Purpose: Supports healthy glucose metabolism. Chromium helps to maintain the body's ability to metabolize nutrients.
Ingredients
Medicinal Ingredients (per capsule): Chromium (as chromium picolinate) 167 mcg, Cinnamomum cassia (Cinnamon) extract (10:1, DHE 330 mg) 33 mg, Gymnema sylvestre (Gurmar) extract (20:1, DHE 1.33 g) 66.5 mg, Momordica charantia (Bitter Melon) extract (10:1, DHE 850 mg) 85 mg, R(+) alpha-Lipoic Acid (sodium salt) 100 mg (contains 10 mg sodium per capsule). Non-medicinal Ingredients: Microcrystalline cellulose, maltodextrin (corn), sodium stearyl fumarate. Capsule: hypromellose. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule daily, half an hour before a meal, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules; swallow the capsule whole. Do not exceed the daily dose unless instructed by a health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 6 months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings and directions before using or consuming a product. Manufactured by Advanced Orthomolecular Research (AOR), Calgary, Alberta. This item is sold and shipped by Amazon.ca.