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Health Canada NPN 80039354 638 mg, 7-Ingredient Adaptogen Complex Non-GMO / Gluten-Free Made in Canada since 1991
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AOR Ortho Adapt 638mg - 7-Ingredient Adaptogen Complex | 120-240 Caps

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$41.90 CAD
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BrandAOR
Serving2-4 capsules (638 mg each)
Licensed Natural Health ProductNPN 80039354
Quality StandardsGMP-compliant facility
CountryMade in Canada Made in Canada

About this item

  • A 7-INGREDIENT ADAPTOGEN & NUTRIENT COMPLEX: Each capsule delivers 638 mg combining porcine adrenal gland cortex, Vitamin C, pantothenic acid (B5), licorice root, Siberian ginseng, rhodiola rosea and ashwagandha in one formula.
  • HELPS IMPROVE MENTAL & PHYSICAL PERFORMANCE: Used in Herbal Medicine to help improve mental and/or physical performance after periods of mental and/or physical exertion.
  • A TRADITIONAL TONIC FOR CONVALESCENCE: Also used as a tonic to help relieve general debility and/or to aid during convalescence.
  • SUPPORTS DIGESTIVE COMFORT: Licorice root is used in Herbal Medicine to help relieve inflammatory conditions of the gastrointestinal tract, such as gastritis, and Ortho Adapt also helps in wound healing and contains antioxidants for the maintenance of good health.
  • FLEXIBLE 2-4 CAPSULE DAILY DOSE: Take 2 to 4 capsules daily after a meal, or as directed by a qualified health care practitioner, so you can adjust within the recommended range to suit your routine.
  • TWO SIZES, ONE FORMULA: Choose 120 capsules for a 60-day supply or 240 capsules for a 120-day supply at the top 4-capsule dose - the same 638 mg formula and NPN in both bottles.
  • CONTAINS ANIMAL-DERIVED INGREDIENTS: Formulated with porcine adrenal gland cortex - not a vegan or vegetarian product. Also contains corn; do not use if you have an allergy to animal by-products or corn.
  • PREMIUM CANADIAN QUALITY SINCE 1991: Manufactured by Advanced Orthomolecular Research (AOR) in Calgary, Alberta, and licensed under Health Canada NPN 80039354.

Product Description

Ortho Adapt - Advanced Adaptogen & Nutrient Complex

AOR Ortho Adapt

638 mg of a multi-ingredient adaptogen and nutrient complex per capsule - porcine adrenal gland cortex, Vitamin C, pantothenic acid (B5), licorice root, Siberian ginseng, rhodiola rosea and ashwagandha. Used in Herbal Medicine to help improve mental and/or physical performance after periods of exertion, as a tonic to help relieve general debility and aid convalescence, and to help relieve inflammatory conditions of the gastrointestinal tract such as gastritis. Licensed Natural Health Product NPN 80039354.

638 mg d'un complexe adaptogène et nutritif multi-ingrédients par capsule - cortex surrénalien porcin, vitamine C, acide pantothénique (B5), racine de réglisse, ginseng sibérien, rhodiola rosea et ashwagandha. Utilisé en phytothérapie pour aider à améliorer les performances mentales et/ou physiques après des périodes d'effort, comme tonique pour aider à soulager la débilité générale et aider pendant la convalescence, et pour aider à soulager les conditions inflammatoires du tractus gastro-intestinal telles que la gastrite. Produit de santé naturel homologué. NPN 80039354.

Ortho Adapt lifestyle
AOR Ortho Adapt
Advanced - AOR

7 Real Ingredients, One Adaptogen Complex

638 mg per capsule - adrenal cortex, Vitamin C, B5, licorice, Siberian ginseng, rhodiola & ashwagandha

A Seven-Ingredient Adaptogen & Nutrient Complex

Each capsule delivers 638 mg combining a glandular-source ingredient (porcine adrenal gland cortex) with Vitamin C, pantothenic acid, licorice root, Siberian ginseng, rhodiola rosea and ashwagandha - formulated as a complete adaptogen system, not a single herb.

Flexible 2-4 Capsule Daily Dosing

Take 2 to 4 capsules daily after a meal, or as directed by a qualified health care practitioner, so you can adjust within the recommended range to suit your own routine.

Advanced Ingredients, Superior Results

Seven real ingredients working together - here is what each one contributes to this adaptogen complex.

Porcine Adrenal Gland Cortex

A glandular-source ingredient included at the highest dose in the formula, reflecting Ortho Adapt's traditional adrenal-support and tonic role; it is animal-derived (see allergen note - not vegan or vegetarian).

125 mg per capsule

Vitamin C (Ascorbic Acid)

An essential antioxidant vitamin and a required cofactor for collagen synthesis, contributing to wound healing and the maintenance of good health.

125 mg per capsule

Pantothenic Acid (Vitamin B5)

Vitamin B5 is a direct biochemical cofactor in the adrenal gland's own production of steroid hormones, supporting the body's response to everyday stress.

50 mg per capsule (as pantethine, calcium D-pantothenate)

Licorice Root Extract (Glycyrrhiza glabra)

Used in Herbal Medicine to help relieve inflammatory conditions of the gastrointestinal tract, such as gastritis. This is standard (whole) licorice root, not deglycyrrhizinated, so it carries real cautions around blood pressure and potassium - see Important Information.

200 mg per capsule (5:1 extract; dried herb equivalent 1000 mg)

Siberian Ginseng (Eleutherococcus senticosus)

A classic adaptogen, traditionally used in Herbal Medicine to help improve mental and physical performance after periods of exertion. This is Siberian ginseng, distinct from Panax ginseng.

50 mg per capsule (9-15:1 extract; dried herb equivalent 450-750 mg)

Rhodiola Rosea

An adaptogenic root standardized to its key marker compounds, researched for supporting the body's resistance to stress-related fatigue.

37.5 mg per capsule (1-6% rosavins, 0.8-3% salidroside)

Ashwagandha (Withania somnifera)

A traditional Ayurvedic adaptogen included at a supporting dose within this multi-ingredient blend, alongside rhodiola and Siberian ginseng.

50 mg per capsule (10:1 extract; dried herb equivalent 500 mg)

AOR Ortho Adapt: Supplement Facts

AOR™Ortho Adapt
English

Each capsule contains:

  • Porcine adrenal gland cortex125 mg
  • Vitamin C (ascorbic acid)125 mg
  • Pantothenic acid (B5) as pantethine, calcium D-pantothenate50 mg
  • Glycyrrhiza glabra (licorice extract 5:1; DHE 1000 mg)200 mg
  • Eleutherococcus senticosus (Siberian ginseng extract 9-15:1; DHE 450-750 mg)50 mg
  • Rhodiola rosea extract 1-6% rosavins, 0.8-3% salidroside37.5 mg
  • Withania somnifera (ashwagandha extract 10:1; DHE 500 mg)50 mg

Non-Medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate, silicon dioxide, dextrin (tapioca). Capsule: hypromellose.

Recommended Use or Purpose: Ortho Adapt helps in wound healing and contains antioxidants and factors for the maintenance of good health. Used in Herbal Medicine to help relieve inflammatory conditions of the gastrointestinal tract, such as gastritis, in adults. Also used in Herbal Medicine to help improve mental and/or physical performance after periods of mental and/or physical exertion, and as a tonic to help relieve general debility and/or to aid during convalescence.

Recommended Dose (Adults 18 years and older): Take 2 to 4 capsules daily after a meal, or as directed by a qualified health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 1 month. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Do not exceed the daily dose unless instructed by a health care practitioner.

Cautions and Warnings: This product contains animal by-product and corn - do not use if you have an allergy to these ingredients. Do not use if: you are taking thiazide diuretics, cardiac glycosides, corticosteroids, stimulant laxatives, or other medications which may aggravate electrolyte imbalance; you have hypokalemia, high blood pressure, or a kidney or cardiovascular disorder; or you have bipolar spectrum disorder. Consult a health care practitioner before use if: you are taking antidepressant medications, hormone replacement therapy (HRT), or birth control pills; you have any type of acute infection or a liver disorder; or you are pregnant or breastfeeding. When using this product, consult a health care practitioner if symptoms persist or worsen. Consumption with alcohol, other drugs, or natural health products with sedative properties is not recommended. Headaches, mild gastrointestinal disturbances (such as nausea), heart palpitations, or hyperactivity/insomnia may occur.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. Other Information: GMP Manufacturing, Independent Testing, Quality Assured. Do not use if safety seal is broken. Store tightly sealed in a cool, dry place. Manufactured by Advanced Orthomolecular Research (AOR), Calgary, Alberta. This item is sold and shipped by Amazon.ca.

Français

Chaque capsule contient :

  • Cortex surrénalien porcin125 mg
  • Vitamine C (acide ascorbique)125 mg
  • Acide pantothénique (B5) sous forme de pantéthine, D-pantothénate de calcium50 mg
  • Glycyrrhiza glabra (extrait de réglisse 5:1; DHE 1000 mg)200 mg
  • Eleutherococcus senticosus (extrait de ginseng sibérien 9-15:1; DHE 450-750 mg)50 mg
  • Extrait de Rhodiola rosea 1-6 % rosavine, 0,8-3 % salidroside37.5 mg
  • Withania somnifera (extrait d'ashwagandha 10:1; DHE 500 mg)50 mg

Ingrédients non médicinaux : Cellulose microcristalline, stéaryl fumarate de sodium, dioxyde de silicium, dextrine (tapioca). Capsule : hypromellose.

Usage ou fins recommandés : Ortho Adapt aide à la cicatrisation des plaies et contient des antioxydants et des facteurs pour le maintien d'une bonne santé. Utilisé en phytothérapie pour aider à soulager les conditions inflammatoires du tractus gastro-intestinal, telles que la gastrite, chez les adultes. Également utilisé en phytothérapie pour aider à améliorer les performances mentales et/ou physiques après des périodes d'effort mental et/ou physique, et comme tonique pour aider à soulager la débilité générale et/ou aider pendant la convalescence.

Dose recommandée (adultes de 18 ans et plus) : Prendre 2 à 4 capsules par jour après un repas, ou selon les recommandations d'un professionnel de la santé qualifié. Durée d'utilisation recommandée : Consulter un professionnel de la santé pour une utilisation au-delà d'un mois. Ne pas ouvrir les capsules, cela pourrait compromettre la stabilité des ingrédients médicinaux. Ne dépassez pas la dose quotidienne, sauf indication contraire d'un professionnel de la santé.

Mises en garde : Ce produit contient des sous-produits animaux et du maïs - ne l'utilisez pas si vous êtes allergique à ces ingrédients. Ne pas utiliser si : vous prenez des diurétiques thiazidiques, des glucosides cardiaques, des corticostéroïdes, des laxatifs stimulants, ou d'autres médicaments susceptibles d'aggraver le déséquilibre électrolytique; vous souffrez d'hypokaliémie, d'hypertension artérielle, ou de troubles rénaux ou cardiovasculaires; ou vous souffrez d'un trouble bipolaire ou d'un trouble du spectre bipolaire. Consultez un professionnel de la santé avant d'utiliser ce produit si : vous prenez des antidépresseurs, un traitement hormonal substitutif (THS), ou des contraceptifs oraux; vous souffrez d'une infection aiguë ou d'un trouble du foie; ou vous êtes enceinte ou vous allaitez. Lors de l'utilisation de ce produit, consultez un professionnel de la santé si les symptômes persistent ou s'aggravent. La consommation avec de l'alcool, d'autres drogues, ou des produits de santé naturels ayant des propriétés sédatives n'est pas recommandée. Des maux de tête, de légers troubles gastro-intestinaux (tels que des nausées), des palpitations cardiaques, ou une hyperactivité/insomnie peuvent survenir.

NPN 80039354

638 mg, 7-ingredient adaptogen complex120 or 240 capsules · 60- or 120-day supplyNon-GMO · Gluten-FreeMade in Canada

Add AOR Ortho Adapt to your daily routine

Get AOR Ortho Adapt on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Why AOR Ortho Adapt

A seven-ingredient adaptogen and nutrient complex - premium AOR quality since 1991.

638 mg, seven real ingredients

Adrenal gland cortex, Vitamin C, B5, licorice, Siberian ginseng, rhodiola and ashwagandha in one capsule - a complete adaptogen system.

Energy, performance & convalescence

Used in Herbal Medicine to help improve mental and physical performance after exertion, and as a tonic during convalescence or general debility.

Two sizes, same formula

120 or 240 capsules - the identical 638 mg formula and NPN, so you can choose the size that fits how often you want to reorder.

Premium Canadian brand

AOR - Advanced Orthomolecular Research, since 1991, manufactured in Canada. NPN 80039354.

Inside every capsule

638 mg combining porcine adrenal gland cortex, Vitamin C, pantothenic acid, licorice root, Siberian ginseng, rhodiola rosea and ashwagandha - 2 to 4 capsules daily.

Porcine Adrenal Gland Cortex 125 mg per capsuleVitamin C (Ascorbic Acid) 125 mg per capsulePantothenic Acid (Vitamin B5) 50 mg per capsule (as pantethine, calcium D-pantothenate)Licorice Root Extract (Glycyrrhiza glabra) 200 mg per capsule (5:1 extract; dried herb equivalent 1000 mg)Siberian Ginseng (Eleutherococcus senticosus) 50 mg per capsule (9-15:1 extract; dried herb equivalent 450-750 mg)Rhodiola Rosea 37.5 mg per capsule (1-6% rosavins, 0.8-3% salidroside)Ashwagandha (Withania somnifera) 50 mg per capsule (10:1 extract; dried herb equivalent 500 mg)

How to use it

Take 2 to 4 capsules daily

Adults 18 years and older: take 2 to 4 capsules daily, after a meal, or as directed by a qualified health care practitioner.

Keep capsules intact

Do not open the capsules - this may compromise the stability of the medicinal ingredients.

Check in for use beyond 1 month

Consult a health care practitioner before continuing use beyond one month, and do not exceed the daily dose unless a health care practitioner instructs otherwise.

What the research says about Ortho Adapt's ingredients

Educational summaries of published research on porcine adrenal gland cortex, Vitamin C, pantothenic acid, licorice root, Siberian ginseng, rhodiola rosea and ashwagandha generally; not product-specific claims. AOR Ortho Adapt's claims are the traditional and authorized uses under NPN 80039354.

Rhodiola & Stress/Fatigue

Health regulators recognize rhodiola as a stress adaptogen

A review of pharmacological approaches to stress and burnout found Rhodiola rosea extract is the main plant adaptogen approved by European health regulators (HMPC/EMA) for the indication of stress, working by influencing the release of stress hormones while supporting energy metabolism.

Review
Anghelescu, Edwards, Seifritz & Kasper, International Journal of Psychiatry in Clinical Practice (2018)
Rhodiola & Stress/Fatigue

Systematic review finds suggestive but mixed evidence for fatigue

A systematic review of 11 controlled trials found that about half of studies examining Rhodiola rosea for physical fatigue, and three of five examining mental fatigue, reported a benefit, while noting methodological limitations across the field that call for better-designed confirmatory trials.

Systematic review
Ishaque, Shamseer, Bukutu & Vohra, BMC Complementary and Alternative Medicine (2012)
Rhodiola & Stress/Fatigue

Rhodiola's key compound improved oxygen use and eased exercise fatigue

In a randomized, double-blind, placebo-controlled trial, 16 days of salidroside (one of rhodiola's principal active compounds) improved oxygen uptake during high-intensity intermittent exercise and reduced markers of exercise-induced muscle damage and fatigue-related mood changes compared with placebo.

Human RCT
Schwarz, Stratton, Colquhoun et al., Journal of the International Society of Sports Nutrition (2024)
Ashwagandha & Cortisol

Sustained-release ashwagandha significantly lowered stress and cortisol

In a randomized, double-blind, placebo-controlled trial in 126 stressed adults, 60 days of a sustained-release ashwagandha root extract reduced Perceived Stress Scale scores by up to 41.6% and significantly lowered serum cortisol versus placebo, with no safety concerns reported.

Human RCT
Thanawala, Shah, Alluri et al., Medicine (2026)
Ashwagandha & Cortisol

Proprietary ashwagandha extract reduced cortisol and anxiety over 8 weeks

An 8-week, three-arm, placebo-controlled trial in 141 adults with moderate stress and anxiety found a proprietary ashwagandha root extract significantly reduced serum cortisol and improved Perceived Stress Scale, Hamilton Anxiety, and mood scores compared with both placebo and a standard ashwagandha extract.

Human RCT
West, Biswas, Rao, Tayade & Ademola, Journal of Medicine and Life (2026)
Ashwagandha & Cortisol

Meta-analysis confirms ashwagandha's effect on stress and anxiety

A systematic review and meta-analysis of ashwagandha (Withania somnifera) trials concluded the herb produces a measurable reduction in stress and anxiety symptoms, reinforcing its traditional use as an adaptogen for the body's response to everyday stress.

Meta-analysis
Arumugam et al., Explore (2024)
Licorice Root & Digestive Health

Licorice among the medicinal plants reviewed for peptic ulcer protection

A review of North African medicinal plants used for peptic ulcer disease highlighted licorice among the botanicals whose gastroprotective mechanisms include strengthening the gastric mucosal barrier, inhibiting excess acid secretion, and reducing inflammation.

Review
Cherrada, Chemsa, Gheraissa et al., Food Science & Nutrition (2024)
Licorice Root & Digestive Health

Licorice flavonoid eased ethanol-induced gastric ulcers via a cell-signaling pathway

In a rat model, a flavonoid isolated from licorice (Glycyrrhiza species, including G. glabra) reduced ethanol-induced gastric ulceration and suppressed cell death in the stomach lining by activating the PI3K/AKT signaling pathway, supporting a mechanism behind licorice's traditional digestive use.

Animal study
Guo, Wu, Huang et al., Journal of Ethnopharmacology (2024)
Licorice Root & Digestive Health

Licorice flavonoids promote energy-driven repair of the gastric lining

Using spatial metabolomics, researchers found licorice flavonoids nearly doubled ATP levels and repaired the gastric mucosa in alcohol-induced ulcers by boosting glycolysis, the TCA cycle, and mitochondrial activity via the mTOR energy-sensing pathway.

Animal study
Wu, Guo, Huang et al., Food Research International (2025)
Licorice Safety & Blood Pressure

Standard licorice's glycyrrhizin content can raise blood pressure

A review of licorice's cardiovascular effects found its main compound, glycyrrhizin, is converted to a metabolite that blocks an enzyme that normally protects the body from cortisol's blood-pressure-raising action; pooled analyses of clinical studies found licorice intake significantly raised both systolic and diastolic blood pressure.

Review
Deutch, Grimm, Wehland, Infanger & Kruger, Foods (2019)
Licorice Safety & Blood Pressure

A specific glycyrrhizin metabolite linked to licorice's blood-pressure effect

A multi-centre study measuring glycyrrhizin metabolites in patients with licorice-related symptoms identified a specific metabolite associated with lower renin, aldosterone, and potassium levels, clarifying the biochemical pathway behind licorice-induced pseudoaldosteronism (fluid retention, high blood pressure, low potassium).

Human study
Takahashi, Yoshino, Maki et al., Archives of Toxicology (2019)
Licorice Safety & Blood Pressure

A real case: daily licorice root tea drove severe high blood pressure

A case report described an adult with previously well-controlled blood pressure who developed severe hypertension, low potassium, and muscle weakness after three months of daily licorice root tea; symptoms resolved after stopping the licorice, illustrating why standard (non-deglycyrrhizinated) licorice carries cautions for blood pressure, potassium, and cardiovascular conditions.

Case report
Karthik, Alam, Nair & Asok, BMJ Case Reports (2025)
Siberian Ginseng & Energy

Health regulators recognize eleuthero for fatigue and weakness

A comprehensive review of Eleutherococcus senticosus (Siberian ginseng) root noted it is approved by the European Medicines Agency for symptoms of asthenia such as fatigue and weakness, with preclinical evidence pointing to anti-inflammatory, immunomodulatory, and neuroprotective mechanisms behind its traditional adaptogen use.

Review
Patyra, Koltun-Jasion, Kupniewska, Parzonko & Kiss, Frontiers in Pharmacology (2025)
Siberian Ginseng & Energy

Evidence on endurance benefits is mixed, review finds

A review of controlled studies on Eleutherococcus senticosus and endurance performance found that while some early reports suggested improved cardiorespiratory fitness and fat metabolism, the more methodologically rigorous trials showed no consistent advantage - a reminder to weigh the full body of evidence rather than isolated positive results.

Review
Goulet & Dionne, International Journal of Sport Nutrition and Exercise Metabolism (2005)
Siberian Ginseng & Energy

An eleuthero preparation improved oxygen uptake in an endurance trial

In healthy volunteers aged 50-57 performing constant endurance exercise, a Ciwujia (Eleutherococcus senticosus) preparation increased oxygen uptake per heartbeat by over 16% and reduced heart rate, consistent with improved exercise endurance and lipid utilization as an energy source.

Human study
Wu et al., Wei Sheng Yan Jiu [Journal of Hygiene Research] (1998)
Combined Adaptogen Blends

Two different multi-herb adaptogen formulas both eased stress and improved sleep

In a 60-day randomized, double-blind, placebo-controlled trial in 186 stressed adults, both a rhodiola/holy basil/schisandra blend and a full-spectrum ashwagandha formula significantly reduced Perceived Stress Scale scores versus placebo, while also improving sleep quality, restorative sleep, and anxiety symptoms.

Human RCT
McKinney, Stewart, Kewalramani & Singh, Trials (2026)
Combined Adaptogen Blends

A magnesium, B-vitamin, rhodiola and green tea combination blunted acute stress

In a randomized, placebo-controlled trial, a combination of magnesium, B vitamins, rhodiola and green tea extract increased calming brain-wave activity and reduced subjective stress, anxiety and mood disturbance following an acute social stress test, compared with placebo.

Human RCT
Boyle, Billington, Lawton, Quadt & Dye, Nutritional Neuroscience (2021)
Combined Adaptogen Blends

Magnesium, B-vitamins and rhodiola reduced chronic stress scores over 28 days

A randomized, placebo-controlled trial in chronically stressed adults found a combination of magnesium, B vitamins, rhodiola and green tea/L-theanine significantly reduced validated stress-scale scores versus placebo, with benefits sustained at a 56-day follow-up and improvements also seen in sleep quality.

Human RCT
Noah, Morel, Bertin et al., Nutrients (2022)
Comparative Adaptogens & HPA Axis

Systematic review: ashwagandha and rhodiola both act on the HPA axis

A systematic review of 24 randomized controlled trials (19 on ashwagandha, 5 on rhodiola) found both adaptogens reduced stress, anxiety and depressive symptoms and improved sleep, cognition, and hormonal balance, with mechanisms converging on regulation of the hypothalamic-pituitary-adrenal (HPA) axis, neurotransmission, and immune pathways.

Systematic review
Luszczak & Kocki, Annals of Agricultural and Environmental Medicine (2025)
Comparative Adaptogens & HPA Axis

Classic adaptogens share anti-neuroinflammatory mechanisms

A mini-review comparing Withania somnifera (ashwagandha), Rhodiola rosea, Eleutherococcus senticosus (Siberian ginseng) and Schisandra chinensis found all four traditional adaptogens modulate inflammatory signaling pathways in the brain, suggesting a shared biochemical basis for their traditional stress-resilience use.

Review
Wrobel-Biedrawa & Podolak, Molecules (2024)
Comparative Adaptogens & HPA Axis

An integrative-medicine review maps HPA-axis dysfunction to adaptogenic support

A clinical review of hypothalamic-pituitary-adrenal (HPA) axis dysfunction described how chronic psychological stress, poor diet, and disrupted circadian rhythms can dysregulate the body's central stress-response system, and identified adaptogenic herbs alongside diagnostic cortisol testing and lifestyle measures as part of an evidence-based, integrative approach to recovery.

Review
Ring, American Journal of Medicine (2025)
Vitamin C, B5 & Adrenal Biochemistry

Pantothenic acid boosted the adrenal gland's own hormone output

In a controlled study, female rats supplemented with pantothenic acid showed a significantly greater adrenal corticosterone and progesterone response to adrenocorticotropic hormone (ACTH) than unsupplemented controls, demonstrating that pantothenic acid is an essential cofactor for adrenal steroid hormone production.

Animal study
Jaroenporn, Yamamoto, Nagaoka et al., Reproductive Medicine and Biology (2011)
Vitamin C, B5 & Adrenal Biochemistry

The same adrenal-supporting effect confirmed in males

A parallel study in male rats found pantothenic acid supplementation increased both baseline and ACTH-stimulated adrenal secretion of corticosterone and progesterone, reinforcing pantothenic acid's (vitamin B5's) direct biochemical role in supporting the adrenal cortex's hormone-producing capacity.

Animal study
Jaroenporn, Yamamoto, Itabashi et al., Biological & Pharmaceutical Bulletin (2008)
Vitamin C, B5 & Adrenal Biochemistry

Vitamin C supports the collagen production behind wound healing

A tissue-regeneration study combining ascorbic acid (vitamin C) with a natural antioxidant found the combination promoted fibroblast proliferation and collagen production at the wound site, consistent with vitamin C's well-established biochemical role as a required cofactor for collagen synthesis and wound healing.

Animal study
Majie, Roy, Jha, Lim & Gorain, Injury (2026)

Frequently asked questions

How do I take AOR Ortho Adapt?

Adults 18 years and older take 2 to 4 capsules daily, after a meal, or as directed by a qualified health care practitioner. Do not open the capsules, do not exceed the daily dose, and consult a health care practitioner for use beyond 1 month.

What are the 7 ingredients in Ortho Adapt, and how much of each?

Each capsule contains porcine adrenal gland cortex 125 mg, Vitamin C 125 mg, pantothenic acid (B5) 50 mg, licorice root extract (Glycyrrhiza glabra) 200 mg, Siberian ginseng (Eleutherococcus senticosus) 50 mg, rhodiola rosea extract 37.5 mg, and ashwagandha (Withania somnifera) 50 mg - 638 mg total.

Is Ortho Adapt vegan or vegetarian?

No. Ortho Adapt contains porcine adrenal gland cortex, an animal-derived ingredient, and the label's allergen statement notes it contains animal by-product. If you need a vegan option, this is not it.

How is Ortho Adapt different from AOR Gandha-600 Ashwagandha?

Gandha-600 is a single-ingredient, vegan 600 mg ashwagandha extract under its own NPN. Ortho Adapt is a 7-ingredient, non-vegan adaptogen and nutrient complex that includes a smaller 50 mg ashwagandha extract alongside adrenal gland cortex, Vitamin C, B5, licorice, Siberian ginseng and rhodiola, under its own separate NPN (80039354). The two are not interchangeable and are dosed independently.

How is the licorice in Ortho Adapt different from AOR DGL Licorice Root?

AOR DGL uses deglycyrrhizinated licorice, processed to remove most of the glycyrrhizin, which is why DGL's Health Canada monograph carries no blood-pressure or potassium cautions. Ortho Adapt uses standard (non-deglycyrrhizinated) licorice root extract, which keeps its natural glycyrrhizin - so Ortho Adapt carries real cautions around blood pressure, potassium, and cardiovascular or kidney conditions that DGL does not. Check the Important Information on this page before using Ortho Adapt if any of those apply to you.

What is the difference between the 120-capsule and 240-capsule bottles?

Both bottles contain the exact same 638 mg, 7-ingredient formula and NPN (80039354) - the 120-count is a 60-day supply and the 240-count is a 120-day supply at the top dose of 4 capsules per day, so you can choose the size that fits how often you want to reorder.

Who should not use Ortho Adapt?

Do not use if you are taking thiazide diuretics, cardiac glycosides, corticosteroids, or stimulant laxatives; if you have hypokalemia, high blood pressure, or a kidney or cardiovascular disorder; or if you have bipolar spectrum disorder. Consult a health care practitioner before use if you are taking antidepressants, hormone replacement therapy, or birth control pills, have an acute infection or liver disorder, or are pregnant or breastfeeding.

Is AOR Ortho Adapt made in Canada?

Yes. It is manufactured by Advanced Orthomolecular Research (AOR) in Calgary, Alberta, and licensed by Health Canada under NPN 80039354.

638 mg, 7-ingredient adaptogen complex120 or 240 capsules · 60- or 120-day supplyNon-GMO · Gluten-FreeMade in Canada

Add AOR Ortho Adapt to your daily routine

Get AOR Ortho Adapt on Amazon.ca - fast, protected delivery.

Get it on Amazon.ca

Natural Health Product NPN 80039354. Ortho Adapt combines porcine adrenal gland cortex, Vitamin C, pantothenic acid, licorice root (Glycyrrhiza glabra), Siberian ginseng (Eleutherococcus senticosus), rhodiola rosea and ashwagandha (Withania somnifera). Used in Herbal Medicine to help improve mental and/or physical performance after periods of exertion, as a tonic for general debility and convalescence, and to help relieve inflammatory conditions of the gastrointestinal tract such as gastritis. Contains animal by-product and corn - not suitable for vegans or those with a corn allergy. Do not use if you are taking thiazide diuretics, cardiac glycosides, corticosteroids, or stimulant laxatives; if you have hypokalemia, high blood pressure, a kidney or cardiovascular disorder, or bipolar spectrum disorder. Consult a health care practitioner before use if pregnant, breastfeeding, or taking antidepressants, hormone replacement therapy, or birth control pills, or if you have an acute infection or liver disorder. Results may vary.

Important information

Safety Information

Cautions and Warnings: This product contains animal by-product and corn - do not use if you have an allergy to these ingredients. Do not use if: you are taking thiazide diuretics, cardiac glycosides, corticosteroids, stimulant laxatives, or other medications which may aggravate electrolyte imbalance; you have hypokalemia, high blood pressure, or a kidney or cardiovascular disorder; or you have bipolar spectrum disorder. Consult a health care practitioner before use if: you are taking antidepressant medications, hormone replacement therapy (HRT), or birth control pills; you have any type of acute infection or a liver disorder; or you are pregnant or breastfeeding. When using this product, consult a health care practitioner if symptoms persist or worsen. Consumption with alcohol, other drugs, or natural health products with sedative properties is not recommended. Headaches, mild gastrointestinal disturbances (such as nausea), heart palpitations, or hyperactivity/insomnia may occur.

Indications

Recommended Use or Purpose: Ortho Adapt helps in wound healing and contains antioxidants and factors for the maintenance of good health. Used in Herbal Medicine to help relieve inflammatory conditions of the gastrointestinal tract, such as gastritis, in adults. Also used in Herbal Medicine to help improve mental and/or physical performance after periods of mental and/or physical exertion, and as a tonic to help relieve general debility and/or to aid during convalescence.

Ingredients

Medicinal Ingredients (per capsule): Porcine adrenal gland cortex 125 mg. Vitamin C (ascorbic acid) 125 mg. Pantothenic acid / Vitamin B5 (as pantethine, calcium D-pantothenate) 50 mg. Glycyrrhiza glabra (licorice extract 5:1; dried herb equivalent 1000 mg) 200 mg. Eleutherococcus senticosus (Siberian ginseng extract 9-15:1; dried herb equivalent 450-750 mg) 50 mg. Rhodiola rosea extract (1-6% rosavins, 0.8-3% salidroside) 37.5 mg. Withania somnifera / ashwagandha (extract 10:1; dried herb equivalent 500 mg) 50 mg. Non-medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate, silicon dioxide, dextrin (tapioca). Capsule: hypromellose.

Directions

Recommended Dose (Adults 18 years and older): Take 2 to 4 capsules daily after a meal, or as directed by a qualified health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 1 month. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Do not exceed the daily dose unless instructed by a health care practitioner.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. Other Information: GMP Manufacturing, Independent Testing, Quality Assured. Do not use if safety seal is broken. Store tightly sealed in a cool, dry place. Manufactured by Advanced Orthomolecular Research (AOR), Calgary, Alberta. This item is sold and shipped by Amazon.ca.