AOR NMN-250mg Capsules - High Potency Nicotinamide Mononucleotide | 30 Count
Visit the AOR Store| Brand | AOR |
| Serving | 250 mg (1 capsule) |
| Licensed Natural Health Product | NPN 80125215 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- 250 MG OF NMN PER CAPSULE: Each vegan capsule delivers a high-potency 250 mg dose of nicotinamide mononucleotide (NMN, the beta-nicotinamide mononucleotide form), a direct NAD+ precursor.
- SUPPORTS NAD+ METABOLISM: Health Canada-licensed to help increase blood NAD+ levels and support cellular health, NAD+ metabolism and turnover in the blood - a source of vitamin B3 involved in NAD+ metabolism.
- STUDIED FOR CELLULAR ENERGY & HEALTHY AGING: NAD+ is a coenzyme central to cellular energy metabolism; NMN is among the most actively studied compounds for supporting healthy NAD+ levels as they naturally decline with age.
- SINGLE-INGREDIENT FORMULA: Just NMN, microcrystalline cellulose and sodium stearyl fumarate in a vegan hypromellose capsule - no wheat, gluten, corn, nuts, peanuts, sesame, soy, dairy, egg, fish, shellfish or animal by-products.
- VEGAN, NON-GMO, GLUTEN-FREE: A clean, simple formulation suitable for vegan and allergen-conscious households.
- SIMPLE ONE-CAPSULE DAILY DOSE: Take one capsule daily with or without food, or as directed by a health care practitioner - a 30-capsule bottle is up to a one-month supply.
- PREMIUM CANADIAN QUALITY: Made in Canada in a GMP-compliant, independently tested facility by Advanced Orthomolecular Research (AOR), licensed under Health Canada NPN 80125215.
- TRUSTED SINCE 1991: From AOR - three decades of science-based, evidence-informed formulations manufactured in Canada.
Product Description
NMN-250 - High-Potency Nicotinamide Mononucleotide
A single-ingredient, high-potency source of NMN (nicotinamide mononucleotide) - a direct precursor to NAD+, the coenzyme cells rely on for energy metabolism. Vegan, Non-GMO, Gluten-Free capsules manufactured in Canada. Licensed Natural Health Product. NPN 80125215. Licensed Natural Health Product NPN 80125215.
Une source d'ingrédient unique et de haute puissance de NMN (nicotinamide mononucléotide) - un précurseur direct du NAD+, la coenzyme utilisée par les cellules pour le métabolisme énergétique. Capsules végétaliennes, sans OGM et sans gluten, fabriquées au Canada. Produit de santé naturel homologué. NPN 80125215.
Pure NMN, High Potency
250 mg beta-nicotinamide mononucleotide per vegan capsule - Vegan, Non-GMO, Gluten-Free
High-Potency 250 mg Dose
Each vegan capsule provides 250 mg of NMN, within the dose range used in published human NMN trials (studies have used 250-2000 mg per day).
Direct NAD+ Precursor
NMN is metabolized toward NAD+, the coenzyme cells rely on for energy production and hundreds of enzymatic reactions.
What AOR NMN-250 Supports
NMN is a Health Canada-licensed source of vitamin B3 involved in NAD+ metabolism, studied for its roles in cellular energy, healthy aging pathways and metabolic health.
NAD+ Metabolism
Helps increase blood NAD+ levels to support cellular health, NAD+ metabolism and turnover in the blood.
Cellular Energy
NAD+ is a coenzyme central to how cells convert nutrients into usable energy.
Mitochondrial Function
NAD+ availability supports the mitochondrial pathways cells use to maintain energy metabolism.
Healthy Aging Research
NAD+ levels are studied to decline with age; NMN is among the most-researched compounds for supporting healthy aging pathways.
AOR NMN-250: Supplement Facts
Each Vegan Capsule contains:
- Nicotinamide Mononucleotide (NMN)250 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose.
Recommended Use or Purpose: NMN (nicotinamide mononucleotide) provides vitamin B3, which is involved in NAD+ metabolism. Helps increase blood NAD+ levels to support cellular health, NAD+ metabolism and turnover in the blood for the maintenance of good health. Licensed Natural Health Product, NPN 80125215.
Recommended Dose (Adults 18 years and older): Take one capsule daily with or without food, or as directed by a health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 3 months.
Cautions and Warnings: Consult a health care practitioner if you are pregnant or breastfeeding, if you have malignant neoplasms, serious infections, psychiatric disorders, ophthalmic disorders, metabolic diseases, cardiac tumours, cardiac failure or myocardial infarction, or if you are taking prescription medication, or if you have a history of serious hepatic, renal, cardiac, pulmonary or gastrointestinal disease. Consult a health care practitioner prior to use if you have diabetes. Do not take vitamin B3 or related products with this product. Do not use if safety seal is broken. Store tightly sealed in a cool, dry place, away from children.
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings and directions before using or consuming a product. AOR guarantees that all ingredients have been declared on the label. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule végétalienne contient :
- Nicotinamide mononucléotide (NMN)250 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : cellulose microcristalline, fumarate de stéaryle de sodium. Capsule : hypromellose.
Usage ou fins recommandés : Le NMN (nicotinamide mononucléotide) fournit de la vitamine B3, qui est impliquée dans le métabolisme du NAD+. Il aide à augmenter les niveaux de NAD+ dans le sang pour soutenir la santé cellulaire, le métabolisme du NAD+ et le renouvellement dans le sang pour le maintien d'une bonne santé. Produit de santé naturel homologué, NPN 80125215.
Dose recommandée (adultes de 18 ans et plus) : Prendre une capsule par jour avec ou sans nourriture, ou selon les directives d'un praticien de soins de santé. Durée d'utilisation recommandée : Consulter un praticien de soins de santé pour une utilisation au-delà de 3 mois.
Mises en garde et précautions : Consultez un praticien de soins de santé si vous êtes enceinte ou si vous allaitez, si vous souffrez de néoplasmes malins, d'infections graves, de troubles psychiatriques, de troubles ophtalmiques, de maladies métaboliques, de tumeurs malignes, d'insuffisance cardiaque ou d'infarctus du myocarde, ou si vous prenez des médicaments sur ordonnance, ou si vous avez des antécédents de maladies hépatiques, rénales, cardiaques, pulmonaires ou gastro-intestinales graves. Consultez un praticien de soins de santé avant d'utiliser le produit si vous souffrez de diabète. Ne prenez pas de vitamine B3 ou de produits apparentés avec ce produit. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement dans un endroit frais et sec, hors de la portée des enfants.
NPN 80125215
Support your NAD+ metabolism the easy way
Get AOR NMN-250 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR NMN-250
A single, high-potency NAD+ precursor - premium AOR quality.
Single, high-potency ingredient
Just 250 mg of NMN per vegan capsule - nothing else needed to support NAD+ metabolism.
A direct, well-studied NAD+ precursor
NMN is one of the two most-studied NAD+ precursor compounds, alongside nicotinamide riboside.
Licensed Canadian Natural Health Product
Manufactured in Canada under Health Canada NPN 80125215, GMP-compliant and independently tested.
Premium Canadian brand since 1991
AOR - Advanced Orthomolecular Research, Calgary AB - three decades of evidence-informed formulations.
How to use it
Take 1 capsule daily
Take one capsule daily with or without food, or as directed by a health care practitioner.
Stay consistent
NAD+ changes build gradually; published human trials measuring blood NAD+ have run 2-8 weeks, with functional-benefit evidence still early.
Know when to check in
Consult a health care practitioner for use beyond 3 months, or right away if you are pregnant, breastfeeding, have diabetes, or have a serious medical condition.
What the research says about NMN and NAD+
Educational summaries of published NMN (nicotinamide mononucleotide) and NAD+ research; not product-specific claims. AOR NMN-250's own claim is the licensed use under NPN 80125215 (a source of vitamin B3 involved in NAD+ metabolism). NMN research in humans is still a young and actively developing field - many findings below come from animal models or short, small human trials, and are noted as such.
Long-term NMN raises NAD+ markers in healthy men
In an 8-week open-label pilot in 11 healthy, middle-aged Japanese men taking 250 mg NMN daily, NAD+ levels in blood immune cells rose over the course of supplementation and the regimen was well tolerated.
Human pilot study (open-label)How oral NMN and NR actually reach NAD+
Tracing orally and intravenously dosed NMN and nicotinamide riboside in mice, researchers found most is not absorbed directly - gut bacteria convert it to nicotinic acid, which travels to the liver via the gut-liver (enterohepatic) circulation before becoming NAD+.
Mechanism (animal study)Aging immune cells drain the NAD+/NMN pool
The enzyme CD38 accumulates on immune cells in fat and liver tissue during aging and inflammation, actively breaking down NMN and NAD+ - one proposed reason NAD+ levels fall with age.
Mechanism (animal study)Reversing an age-related energy deficit in the heart
In old mice, NMN treatment fully reversed an age-related decline in heart systolic function under higher workloads and improved the heart's phosphocreatine-to-ATP energy ratio, a marker of mitochondrial energy capacity.
Mechanism (animal study)Better oxygen use during exercise training
In a 6-week trial of 48 amateur runners randomized to placebo or 300/600/1200 mg NMN daily alongside training, the medium- and high-dose groups showed larger gains in oxygen uptake and ventilatory-threshold power than placebo.
Human RCTA nutraceutical candidate for the aging heart
A pharmacology review describes NAD+ decline as a driver of age-related cardiac remodeling and dysfunction, and summarizes preclinical evidence that restoring cardiac NAD+ with NMN shows a cardioprotective effect without significant side effects in animal studies.
ReviewA year-long mouse study with no signs of toxicity
Daily NMN for 12 months in normally aging mice suppressed age-related weight gain, improved insulin sensitivity and physical activity, and enhanced mitochondrial function in skeletal muscle - without obvious toxicity, though this remains an animal model, not a human outcome trial.
Animal study (12-month)NAD+ precursors among 8 anti-aging candidates now in human trials
A survey of drugs and compounds being tested against human aging - metformin, NAD+ precursors, GLP-1 agonists, TORC1 inhibitors, spermidine, senolytics, probiotics and anti-inflammatories - notes multiple clinical trials are underway but frames the results as still emerging, not an established anti-aging therapy.
ReviewResearch progress - and open challenges
A 2025 review of NMN's proposed anti-aging mechanisms (DNA repair, mitochondrial regulation, inflammation, gut microbiota, autophagy) concludes that dosage modeling by age group, long-term safety and real-world efficacy "still require in-depth research."
ReviewImproved muscle insulin sensitivity in a 10-week human trial
In a randomized, placebo-controlled trial in postmenopausal women with prediabetes who were overweight or obese, 10 weeks of NMN supplementation increased insulin-stimulated glucose uptake and skeletal-muscle insulin signaling versus placebo.
Human RCTA meta-analysis found no significant edge on blood sugar or lipids - yet
Pooling 8 randomized trials (342 adults, doses of 250-2000 mg/day for 14 days to 12 weeks), a 2024 meta-analysis found NMN did not significantly improve fasting glucose, fasting insulin, HbA1c, HOMA-IR or lipid profile in mostly healthy, non-diabetic adults over these short trial windows.
Meta-analysis (8 human RCTs)The original finding behind NMN's metabolic research
The foundational 2011 mouse study showing NMN restores NAD+ and improves glucose tolerance and hepatic insulin sensitivity in diet- and age-induced type 2 diabetes models - the discovery that launched the modern NMN research field.
Foundational animal studyWell tolerated at 1,250 mg in a 4-week human trial
A randomized, placebo-controlled trial in 31 healthy adults found daily oral NMN at 1,250 mg - among the highest doses tested in humans - produced no severe adverse events and no changes beyond normal physiological variation over 4 weeks.
Human RCTA 2023 review: a young but active clinical research field
Summarizing the state of human NMN research, this review notes that while animal and cell studies show promise, safety evidence at the time still came from a limited number of human trials, with roughly a dozen more trials then underway.
ReviewPromise and open safety questions, reviewed together
An overview of NMN as an anti-aging product explicitly weighs its proposed benefits against safety concerns, concluding that with many NMN products already on the market, more rigorous clinical safety and efficacy investigation is "urgently needed."
ReviewThe review that framed the modern NMN-vs-NR research field
This widely cited review lays out the biology and therapeutic potential of the two leading NAD+ intermediates, NMN and nicotinamide riboside (NR), noting they can behave differently depending on the tissue distribution of the enzymes and transporters that handle each.
ReviewComparing NMN and NR as dietary NAD+ precursors
A nutrition-science review comparing NMN and NR discusses their biochemistry, natural food sources (both occur in vegetables, meat and milk), and interplay with gut microbiota as two distinct routes to raising NAD+.
ReviewWhere NAD+ precursor researchers agree - and don't
A comparative review of NAD+ precursor candidates (NR, NMN and related molecules) concludes there is "no consensus between researchers" on their relative bioavailability and potency, and calls for more head-to-head research.
ReviewA major review of what we still don't know about NAD+
A 2024 review in a leading cell-biology journal highlights unresolved questions in NAD+ science - including the gut microbiome's role in processing NAD+ precursors and distinct NAD+ pools in different parts of the cell - as areas needing more basic research before supplementation claims can be fully verified.
ReviewNMN as a molecular signal, not just a building block
Structural biology work shows the enzyme SARM1 - involved in nerve-fiber signaling - acts as a sensor for the ratio of NMN to NAD+ inside the cell, illustrating that NMN's biological role goes beyond simply being raw material for NAD+.
Mechanism (structural/cellular study)A decade of human NAD+-boosting research, synthesized
Reviewing a decade of human trials of NAD+-boosting compounds (chiefly nicotinamide riboside and NMN), researchers found supplementation safe and able to raise NAD+ and related metabolites in tissue, but noted study durations and doses vary widely and small sample sizes limit conclusions about physical-function benefits.
ReviewA dose-ranging trial across placebo, 300, 600 and 900 mg
In an 80-person, 60-day randomized trial, blood NAD+ rose in a dose-dependent way at all three NMN doses tested, with the largest gains in 6-minute-walk distance and self-reported health at 600 mg and 900 mg per day; all doses were well tolerated.
Human RCT (dose-ranging)Why the same dose doesn't raise everyone's NAD+ equally
A post-hoc analysis of that same 80-person trial found the rise in blood NAD+ varied enormously between individuals at a given dose (roughly 29-113% coefficient of variation), suggesting future dosing may need to be personalized rather than one-size-fits-all.
Human RCT (post-hoc analysis)1,000 mg once or twice daily in a pharmacokinetic study
In 32 overweight or obese adults aged 55-80, a 14-day trial of a pharmaceutical-grade NMN formulation at 1,000 mg once or twice daily was well tolerated and produced dose-related increases in blood NAD+, with very little unmetabolized NMN excreted in urine.
Human RCT (pharmacokinetic)Frequently asked questions
What is NMN and what does AOR NMN-250 do?
NMN (nicotinamide mononucleotide) is a direct precursor to NAD+, a coenzyme every cell needs for energy metabolism. AOR NMN-250 is Health Canada-licensed (NPN 80125215) as a source of vitamin B3 involved in NAD+ metabolism - it helps increase blood NAD+ levels to support cellular health, NAD+ metabolism and turnover in the blood.
How is this different from AOR's NMN + Wheat Germ Extract product?
AOR NMN-250 is single-ingredient: 250 mg of NMN per vegan capsule, nothing else. AOR also offers a separate NMN + wheat germ extract (spermidine) combination product under its own NPN and label. If you want NMN on its own, without an added spermidine source, this standalone formula is the one to choose.
How do I take it?
Take one capsule daily with or without food, or as directed by a health care practitioner. Consult a health care practitioner for use beyond 3 months.
How much NMN have human studies actually used?
Published human trials have tested a range of NMN doses, roughly 250 mg to 2,000 mg per day, for anywhere from two weeks to several months. AOR NMN-250's 250 mg daily dose sits at the lower end of that studied range.
Is NMN proven to slow aging?
Not yet, and we don't claim that. Animal research on NMN is extensive and encouraging, but human evidence is still early: trials are generally short (weeks, not years), and a 2024 meta-analysis of 8 human trials found no significant benefit on fasting glucose, insulin or lipid markers over that timeframe. NMN-250's licensed claim is about supporting NAD+ metabolism and cellular health, not reversing or slowing aging.
Is NMN safe? Are there any cautions?
Human trials have found oral NMN well tolerated at doses up to 1,250 mg/day for up to 4 weeks and up to 900 mg/day for 60 days, without serious adverse events. That said, consult a health care practitioner before use if you are pregnant or breastfeeding, have malignant neoplasms, serious infections, psychiatric disorders, ophthalmic disorders, metabolic diseases, cardiac tumours, cardiac failure or myocardial infarction, a history of serious hepatic, renal, cardiac, pulmonary or gastrointestinal disease, diabetes, or are taking prescription medication. Do not take vitamin B3 or related products with this product.
Is it vegan and allergen-friendly?
Yes - vegan (hypromellose capsule), non-GMO and gluten-free. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or animal by-products.
How does NMN compare to NR (nicotinamide riboside)?
Both are NAD+ precursor compounds studied for raising NAD+ levels, and both are found naturally in some foods. Researchers note they can behave differently depending on which tissues take them up and how each is metabolized, but no large head-to-head human trial has yet shown one is more effective than the other. AOR NMN-250 provides NMN specifically, under its own NPN.
Support your NAD+ metabolism the easy way
Get AOR NMN-250 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80125215. NMN (nicotinamide mononucleotide) provides vitamin B3, involved in NAD+ metabolism; it helps increase blood NAD+ levels to support cellular health, NAD+ metabolism and turnover in the blood for the maintenance of good health. The research summaries below concern NMN generally and are educational - they are not claims about this finished product beyond its licensed use. Read and follow the label. Consult a health care practitioner prior to use if you are pregnant, breastfeeding, have malignant neoplasms, serious infections, psychiatric disorders, ophthalmic disorders, metabolic diseases, cardiac tumours, cardiac failure or myocardial infarction, a history of serious hepatic, renal, cardiac, pulmonary or gastrointestinal disease, diabetes, are taking prescription medication, or for use beyond 3 months. Do not take vitamin B3 or related products with this product. AOR is the manufacturer; sold by Canadian Health & Care on Amazon.ca. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner if you are pregnant or breastfeeding, if you have malignant neoplasms, serious infections, psychiatric disorders, ophthalmic disorders, metabolic diseases, cardiac tumours, cardiac failure or myocardial infarction, or if you are taking prescription medication, or if you have a history of serious hepatic, renal, cardiac, pulmonary or gastrointestinal disease. Consult a health care practitioner prior to use if you have diabetes. Do not take vitamin B3 or related products with this product. Do not use if safety seal is broken. Store tightly sealed in a cool, dry place, away from children.
Indications
Recommended Use or Purpose: NMN (nicotinamide mononucleotide) provides vitamin B3, which is involved in NAD+ metabolism. Helps increase blood NAD+ levels to support cellular health, NAD+ metabolism and turnover in the blood for the maintenance of good health. Licensed Natural Health Product, NPN 80125215.
Ingredients
Medicinal Ingredients: Nicotinamide Mononucleotide (NMN) 250 mg per capsule. Non-medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate. Capsule: Hypromellose. Vegan, Non-GMO, Gluten-Free. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or animal by-products. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take one capsule daily with or without food, or as directed by a health care practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 3 months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings and directions before using or consuming a product. AOR guarantees that all ingredients have been declared on the label. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.