AOR N-A-C 500mg - N-Acetyl Cysteine Antioxidant Support | 120-240 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 Capsule (taken once daily) |
| Licensed Natural Health Product | NPN 80005832 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- RELIEVES CHRONIC BRONCHITIS SYMPTOMS: Licensed Natural Health Product claim: N-A-C relieves the symptoms of chronic bronchitis, a classic, well-studied use for N-Acetyl-L-Cysteine.
- SOURCE OF AN ANTIOXIDANT: 500 mg of N-Acetyl-L-Cysteine (NAC) per capsule - a source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals.
- SUPPORTS GLUTATHIONE LEVELS: NAC supplies cysteine, the building block the body uses to synthesize glutathione, one of its principal internal antioxidants.
- SIMPLE ONCE-DAILY DOSE: Just 1 capsule per day with a meal containing protein - up to an 8-month supply in every 240-capsule bottle, or a 4-month supply in the 120-capsule size.
- SINGLE, CLEARLY DOSED INGREDIENT: 500 mg of N-Acetyl-L-Cysteine and only 2 declared non-medicinal ingredients - no proprietary blends, no crowding fillers.
- NON-GMO & GLUTEN-FREE: Manufactured by AOR in Calgary, Canada, under GMP-compliant quality standards.
- 8-MONTH SUPPLY: 120 or 240 capsules at 1 capsule daily - choose the size that fits your routine.
- PREMIUM CANADIAN BRAND: AOR - Advanced Orthomolecular Research - has formulated science-based Natural Health Products since 1991.
Product Description
N-A-C - N-Acetyl Cysteine 500mg
AOR N-A-C delivers 500 mg of N-Acetyl-L-Cysteine (NAC) per capsule to help relieve the symptoms of chronic bronchitis, and as a source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals. One capsule a day. Licensed Natural Health Product, NPN 80005832. Licensed Natural Health Product NPN 80005832.
AOR N-A-C offre 500 mg de N-Acétyl-L-cystéine (NAC) par capsule pour aider à soulager les symptômes de la bronchite chronique, et comme source d'un antioxydant qui aide à protéger les cellules contre les dommages oxydatifs causés par les radicaux libres. Une capsule par jour. Produit de santé naturel homologué. NPN 80005832.
500mg N-Acetyl-L-Cysteine, Once Daily
Single-ingredient NAC in a convenient once-daily capsule - Non-GMO, Gluten-Free
One Capsule, Once a Day
500 mg of NAC in a single daily V-capsule, taken with a meal containing protein - available in a 120-capsule (4-month) or 240-capsule (8-month) bottle.
Single, Clearly Dosed Ingredient
Just N-Acetyl-L-Cysteine at a full 500 mg per capsule, plus two declared non-medicinal ingredients - no proprietary blends, no crowding fillers.
What NAC Does in the Body
Research on N-Acetyl-L-Cysteine spans respiratory, antioxidant, liver and immune biology. Here is what this single ingredient is understood to do.
Respiratory Comfort
This product's licensed claim: relieves the symptoms of chronic bronchitis.
Antioxidant Protection
A source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals.
Glutathione Precursor
NAC supplies cysteine, the building block the body uses to make glutathione, its principal internal antioxidant.
Liver & Detox Pathways
Glutathione is central to the liver's natural detoxification processes; NAC is a classic clinical source of cysteine for glutathione synthesis.
Immune & Cellular Support
Glutathione status is linked to healthy immune cell function; research has studied NAC's role in supporting the body's antioxidant defenses more broadly.
AOR N-A-C: Supplement Facts
Each capsule contains:
- N-Acetyl-L-Cysteine500 mg
Non-Medicinal Ingredients: Sodium stearyl fumarate, microcrystalline cellulose. Capsule: Hypromellose.
Recommended Use or Purpose: Relieves the symptoms of chronic bronchitis. Source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals. Licensed Natural Health Product, NPN 80005832.
Recommended Dose (Adults 18 years and older): Take 1 capsule per day with a meal containing protein, or as directed by a qualified health care practitioner. Do not open the capsules, as this may compromise the stability of the medicinal ingredient. Do not exceed the daily dose unless instructed by a healthcare practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 6 months.
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant or breastfeeding, if you suffer from cystinuria or cystine kidney stones, if symptoms persist or worsen, or for use beyond 6 months. Do not use with charcoal. Contraindications: Do not use if you are taking antibiotics or nitroglycerin. Known Adverse Reactions: Gastrointestinal upset (nausea, vomiting, diarrhea) has been reported. Keep out of reach of children. Store in a cool, dry place.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- N-Acétyl-L-cystéine500 mg
Ingrédients non médicinaux : Stéaryl fumarate de sodium, cellulose microcristalline. Capsule : Hypromellose.
Usage ou fins recommandés : Soulage les symptômes de la bronchite chronique. Source d'un antioxydant qui aide à protéger les cellules contre les dommages oxydatifs causés par les radicaux libres. Produit de santé naturel homologué, NPN 80005832.
Dose recommandée (adultes de 18 ans ou plus) : Prendre 1 capsule par jour avec un repas contenant des protéines, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas ouvrir les capsules, car cela pourrait compromettre la stabilité de l'ingrédient médicinal. Ne pas dépasser la dose quotidienne, sauf indication contraire d'un professionnel de la santé. Durée d'utilisation recommandée : Consultez un professionnel de la santé pour un usage au-delà de 6 mois.
Mises en garde : Consultez un professionnel de la santé avant l'utilisation si vous êtes enceinte ou si vous allaitez, si vous souffrez de cystinurie ou de calculs rénaux de cystine, si les symptômes persistent ou s'aggravent, ou pour un usage au-delà de 6 mois. Ne pas utiliser avec du charbon de bois. Contre-indications : Ne pas utiliser si vous prenez des antibiotiques ou de la nitroglycérine. Réactions indésirables connues : Des troubles gastro-intestinaux (nausées, vomissements, diarrhée) ont été rapportés. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec.
NPN 80005832
Add AOR N-A-C to your daily routine
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Get it on Amazon.caWhy AOR N-A-C
A single, clearly dosed ingredient for respiratory and antioxidant support - premium AOR quality.
One real, full-dose ingredient
500 mg of N-Acetyl-L-Cysteine per capsule - no proprietary blend, no filler herbs.
Licensed respiratory + antioxidant claim
Relieves the symptoms of chronic bronchitis, and a source of an antioxidant that helps protect cells against free-radical damage.
Simple once-daily dose
Just 1 capsule a day with a protein-containing meal - an 8-month supply per bottle.
Premium Canadian brand
AOR - Advanced Orthomolecular Research, since 1991. Licensed Natural Health Product, NPN 80005832.
How to use it
1 capsule, once daily
Adults take 1 capsule per day with a meal containing protein, or as directed by a qualified health care practitioner.
Swallow capsules whole
Do not open or crush the capsules - this may compromise the stability of the medicinal ingredient.
Check in beyond 6 months
Consult a health care practitioner for use beyond 6 months, or if symptoms persist or worsen.
What the research says about N-Acetyl-Cysteine (NAC)
Peer-reviewed studies on N-Acetyl-Cysteine (NAC), verified via PubMed. These summaries are educational and concern the ingredient generally; they are not claims about this finished product. This product's own claim is the statement authorized under its Natural Health Product licence, NPN 80005832: relieves the symptoms of chronic bronchitis, and is a source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals.
The mechanism behind the antioxidant claim
A pharmacology review concludes NAC's real antioxidant strength lies in replenishing intracellular glutathione as its precursor, rather than acting as a potent antioxidant in its own right - most relevant when cells are glutathione-depleted.
ReviewRaised blood glutathione by a third
In physically active men, oral N-acetylcysteine significantly increased blood glutathione levels (+33%) alongside markers of total antioxidant status, a direct human demonstration of the glutathione-precursor mechanism.
Human RCTA pro-glutathione free radical scavenger
Supplementation with NAC, described as a pro-glutathione free radical scavenger, abolished the exercise-induced increase in reactive oxygen species production by human neutrophils in a chemiluminescence study.
Human studyFewer exacerbations, better symptoms in chronic bronchitis
A systematic review of 11 randomized trials (2,011 patients) found oral NAC significantly reduced the risk of exacerbations and improved symptoms in chronic bronchitis compared with placebo, without raising the rate of adverse effects.
Systematic reviewA meta-analysis behind the traditional bronchitis claim
Pooling double-blind, placebo-controlled trials of chronic bronchopulmonary disease, prolonged oral NAC produced a statistically significant reduction in acute exacerbations - an overall effect equivalent to roughly a 23% decrease compared with placebo.
Meta-analysisModern data still confirms the classic finding
A 2024 meta-analysis of 20 studies found NAC significantly reduced exacerbations and improved respiratory symptoms and quality of life in both COPD and chronic bronchitis/pre-COPD patients, reinforcing decades-old trial evidence.
Meta-analysisThe classic antidote, tracked in real patients
In patients treated for severe paracetamol overdose, intravenous N-acetylcysteine achieved its protective effect with liver damage prevented just as effectively at lower peak plasma concentrations as at the highest, informing safer dosing regimens.
Clinical studyComparing NAC, cysteine and glutathione directly
In a mouse model of drug-induced liver injury, NAC, cysteine and glutathione each provided protection; NAC partially restored depleted hepatic glutathione, supporting glutathione repletion as a real part of its protective mechanism.
Animal modelTransformed the outlook for paracetamol poisoning
A clinical review credits the introduction of agents such as N-acetylcysteine with greatly reducing the historical hepatotoxicity and morbidity associated with paracetamol (acetaminophen) overdose.
ReviewFewer, milder influenza-like episodes over a winter
In a 6-month randomized trial of 262 participants, long-term oral NAC (600 mg twice daily) significantly reduced the frequency and severity of influenza-like episodes and shifted cell-mediated immune response from anergy toward normal.
Human RCTReplenishing immune-relevant glutathione
In a randomized, placebo-controlled trial, 8 weeks of oral NAC safely increased whole-blood and T-cell glutathione levels in adults with low baseline glutathione, supporting a role for glutathione status in immune cell function.
Human RCTCalming an overactive innate immune response
A review of exercise immunology describes NAC as effective at attenuating the heightened reactive-oxygen-species-generating capacity of neutrophils, innate immune cells that can otherwise contribute to oxidative tissue stress.
ReviewWhy nitroglycerin is flagged as a caution
A randomized trial in unstable angina found that combining transdermal nitroglycerin with oral N-acetylcysteine raised the incidence of side effects, mainly headache, versus nitroglycerin alone - the real basis for this product's nitroglycerin caution.
Human RCTWhy the label says not to use with charcoal
A clinical pharmacokinetics review found activated charcoal can adsorb up to 96% of an oral NAC dose, and identified gastrointestinal upset (nausea, vomiting, diarrhea) as the most frequently reported side effect.
ReviewThe real reason for the kidney-stone caution
A biochemical and clinical study in patients with cystinuria found NAC treatment increased urinary cystine excretion, and concluded it could not be recommended as a stone-preventive therapy in that specific population.
Clinical studyNAC doesn't always come out ahead
Comparing NAC, alpha-lipoic acid and taurine after intense resistance exercise, both NAC and lipoic acid reduced lipid peroxidation, but lipoic acid scored best on a combined pro-antioxidant ratio measure - an honest reminder no single option leads on every marker.
Human RCTNAC and lipoic acid, head-to-head
A 3-day comparison found both NAC and alpha-lipoic acid raised total antioxidant status and lowered oxidative damage markers after muscle-damaging exercise, while taurine showed no measurable antioxidant effect at the doses tested.
Human RCTA myth-checking look at oral vs IV NAC
Rigorous mechanistic trials found oral NAC at doses used in earlier renal-protection studies was essentially undetectable in plasma, while only the intravenous form measurably changed blood pressure, heart rate and renal blood flow - a reminder that findings from IV-dose NAC research don't automatically transfer to oral supplementation.
Human RCTHow the body actually builds glutathione
A foundational review explains glutathione is synthesized from glutamate, cysteine and glycine, with cysteine availability a key regulator of the reaction - and names N-acetylcysteine as an effective dietary precursor for tissue glutathione synthesis.
ReviewCysteine's role in the body's detox machinery
A review of cysteine metabolism describes its pivotal role in the body's inducible detoxification mechanisms, with glutathione acting as a central protective molecule against everyday toxic exposures.
ReviewOnly a fraction of an oral dose reaches circulation
A pharmacokinetic study found the oral bioavailability of N-acetylcysteine is only about 6 to 10%, with the absorbed drug distributing mainly into extracellular water - basic ADME facts behind why oral NAC dosing is measured in hundreds of milligrams.
Human studyWhy bioavailability rises faster than the dose
A dose-ranging pharmacokinetic study found NAC's oral bioavailability increased disproportionately from a 200 mg to a 600 mg dose, consistent with saturable first-pass metabolism, while repeated twice-daily 600 mg dosing showed no plasma accumulation.
Human studyA range of doses, a consistent benefit
The chronic-bronchitis trials pooled in a major meta-analysis used oral NAC doses of 400 mg, 600 mg or 1200 mg daily for 3 to 6 months, with meaningful exacerbation reduction seen without a clear advantage for the highest dose tested.
Meta-analysisWell tolerated across a wide oral dose range
A dose-escalation trial of oral NAC at 600 mg, 1200 mg and 1800 mg twice daily found the supplement safe and well tolerated over 24 weeks, with self-limited gastrointestinal upset the main adverse effect - doses well above this product's 500 mg once-daily serving.
Human RCTFrequently asked questions
What is AOR N-A-C?
A single-ingredient capsule providing 500 mg of N-Acetyl-L-Cysteine (NAC) per capsule. It is a licensed Natural Health Product, NPN 80005832, that relieves the symptoms of chronic bronchitis and is a source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals.
How do I take it?
Adults take 1 capsule per day with a meal containing protein, or as directed by a qualified health care practitioner. Do not open or crush the capsules, as this may compromise the stability of the medicinal ingredient.
What does NAC do in the body?
NAC supplies cysteine, the amino acid the body uses to build glutathione, one of its main internal antioxidants. This is the basis for NAC's antioxidant claim and its long history of respiratory research.
Is this the same as AOR's Liver Support product?
No. AOR Liver Support is a separate, multi-ingredient formula combining Milk Thistle, Phyllanthus amarus and a lower 200 mg dose of NAC for a liver-function claim, under its own Health Canada product licence. This product, AOR N-A-C, is a separately licensed, single-ingredient, standalone 500 mg NAC capsule (NPN 80005832) with its own respiratory and antioxidant claim - the two are not interchangeable and carry different licensed claims, doses and product licences.
Who should not use it?
Do not use if you are taking antibiotics or nitroglycerin. Do not use with charcoal. Consult a health care practitioner before use if you are pregnant or breastfeeding, if you suffer from cystinuria or cystine kidney stones, if symptoms persist or worsen, or for use beyond 6 months.
How long does a bottle last?
At 1 capsule per day, the 120-capsule bottle is a 4-month supply and the 240-capsule bottle is an 8-month supply.
Is it vegan or allergen-free?
The capsule is Non-GMO and Gluten-Free. It contains 2 declared non-medicinal ingredients (sodium stearyl fumarate, microcrystalline cellulose) plus a hypromellose capsule shell - always read the physical label for the complete, current ingredient and allergen information.
Where is it made?
AOR - Advanced Orthomolecular Research - manufactures N-A-C in Calgary, Alberta, Canada.
Add AOR N-A-C to your daily routine
Get AOR N-A-C on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80005832. Relieves the symptoms of chronic bronchitis. Source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals. Research summaries below concern N-Acetyl-L-Cysteine generally and are educational, not additional product-specific claims. Read and follow the label. Do not use if you are taking antibiotics or nitroglycerin. Do not use with charcoal. Consult a health care practitioner before use if you are pregnant or breastfeeding, if you suffer from cystinuria or cystine kidney stones, if symptoms persist or worsen, or for use beyond 6 months. AOR is the manufacturer; sold by Canadian Health & Care on Amazon.ca. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant or breastfeeding, if you suffer from cystinuria or cystine kidney stones, if symptoms persist or worsen, or for use beyond 6 months. Do not use with charcoal. Contraindications: Do not use if you are taking antibiotics or nitroglycerin. Known Adverse Reactions: Gastrointestinal upset (nausea, vomiting, diarrhea) has been reported. Keep out of reach of children. Store in a cool, dry place.
Indications
Recommended Use or Purpose: Relieves the symptoms of chronic bronchitis. Source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals. Licensed Natural Health Product, NPN 80005832.
Ingredients
Medicinal Ingredients (per capsule): N-Acetyl-L-Cysteine 500 mg. Non-medicinal Ingredients: Sodium stearyl fumarate, microcrystalline cellulose. Capsule: Hypromellose.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule per day with a meal containing protein, or as directed by a qualified health care practitioner. Do not open the capsules, as this may compromise the stability of the medicinal ingredient. Do not exceed the daily dose unless instructed by a healthcare practitioner. Recommended Duration of Use: Consult a health care practitioner for use beyond 6 months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.