AOR Methyl B12 5mg Lozenge - Sublingual Vitamin B12 Supplement | 60 Count
Visit the AOR Store| Brand | AOR |
| Serving | 5 mg (1 lozenge) |
| Licensed Natural Health Product | NPN 80027283 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- METHYLATED VITAMIN B12 LOZENGE: 5 mg of vitamin B12 as methylcobalamin - the active, methylated coenzyme form of B12 - in one easy-to-use lozenge that dissolves under the tongue, no capsule to swallow.
- HELPS PREVENT VITAMIN B12 DEFICIENCY: A source of vitamin B12 that helps prevent vitamin B12 deficiency - the licensed use of this Natural Health Product.
- SUPPORTS NERVE FUNCTION & ENERGY METABOLISM: Vitamin B12 plays a well-established role in healthy nerve function and in the body's energy metabolism.
- AIDS RED BLOOD CELL PRODUCTION: Vitamin B12 is essential for the normal formation of red blood cells.
- SUBLINGUAL, NOT SWALLOWED: Dissolve 1 lozenge under the tongue first thing in the morning, with or without food.
- VEGAN-FRIENDLY, ALLERGEN-CONSCIOUS FORMULA: Vegan, non-GMO and gluten-free; the label states it contains no wheat, corn, nuts, dairy, soy or other major allergens.
- 60-DAY SUPPLY: 60 lozenges per bottle - a full 60-day supply at the standard 1-lozenge daily dose.
- PREMIUM CANADIAN QUALITY: Made in Canada in a GMP-compliant facility by Advanced Orthomolecular Research (AOR), licensed under Health Canada NPN 80027283.
Product Description
AOR Methyl B12 5 mg - Methylated Sublingual Vitamin B12
5 mg of vitamin B12 (as methylcobalamin) in a single sublingual lozenge that dissolves under the tongue - a methylated, ready-to-use form of B12 formulated to be a source of vitamin B12 and help prevent vitamin B12 deficiency, while supporting healthy nerve function and the body's energy metabolism. Licensed Natural Health Product NPN 80027283.
5 mg de vitamine B12 (sous forme de méthylcobalamine) dans une seule pastille sublinguale qui se dissout sous la langue - une forme méthylée de B12, prête à l'emploi, formulée pour être une source de vitamine B12 et aider à prévenir la carence en vitamine B12, tout en soutenant le fonctionnement normal du système nerveux et le métabolisme énergétique de l'organisme. Produit de santé naturel homologué. NPN 80027283.
AOR Methyl B12 5 mg Sublingual Lozenge
A methylated, ready-to-use form of vitamin B12 - dissolves under the tongue, not swallowed.
Methylated Sublingual Lozenge
5 mg of methylcobalamin per lozenge, dissolved under the tongue rather than swallowed like a capsule.
Nerve Function & Energy Metabolism
Vitamin B12 supports healthy nerve function and plays a key role in the body's energy metabolism, alongside red blood cell formation.
Why Vitamin B12 Matters
Research supports vitamin B12's role across nerve health, energy metabolism, cognitive function and red blood cell production - here is what each benefit means.
Nerve Function Support
Vitamin B12 supports the healthy function of the nervous system.
Red Blood Cell Production
Vitamin B12 is essential for the normal formation of red blood cells.
Cognitive Health
Vitamin B12 supports normal cognitive function as part of a healthy nervous system.
Energy Metabolism
Vitamin B12 plays a key coenzyme role in the body's energy metabolism.
AOR Methyl B12 5mg: Supplement Facts
Each lozenge contains:
- Vitamin B12 (as Methylcobalamin)5 mg
Non-Medicinal Ingredients: Sodium stearyl fumarate, microcrystalline cellulose, hydroxypropylcellulose, xylitol, tapioca syrup and distilled water.
Recommended Use or Purpose: Methylcobalamin is a source of vitamin B12 and helps prevent vitamin B12 deficiency. Licensed Natural Health Product, NPN 80027283.
Recommended Dose (Adults 18 years and older): Dissolve 1 lozenge under the tongue first thing in the morning, with or without food, or as directed by a qualified health care practitioner. Consult a health care practitioner for use beyond the duration of 4 months.
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or for use beyond 4 months. Allergen Information: contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, dairy, eggs, fish, shellfish, soy, sulphites or mustard, and no animal byproduct. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place. Keep out of reach of children.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque pastille contient :
- Vitamine B12 (sous forme de méthylcobalamine)5 mg
Ingrédients non médicinaux : Stéarylfumarate de sodium, cellulose microcristalline, hydroxypropylcellulose, xylitol, sirop de tapioca et eau distillée.
Usage ou fins recommandés : La méthylcobalamine est une source de vitamine B12 et aide à prévenir la carence en vitamine B12. Produit de santé naturel homologué, NPN 80027283.
Dose recommandée (adultes de 18 ans et plus) : Dissoudre 1 pastille sous la langue dès le matin, avec ou sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Consultez un professionnel de la santé pour un usage dépassant une durée de 4 mois.
Mises en garde et précautions : Consultez un professionnel de la santé avant l'utilisation si vous êtes enceinte ou si vous allaitez, ou pour un usage dépassant 4 mois. Renseignements sur les allergènes : ne contient ni blé, ni gluten, ni maïs, ni noix, ni arachides, ni graines de sésame, ni produits laitiers, ni œufs, ni poisson, ni crustacés, ni soya, ni sulfites, ni moutarde, ni sous-produit animal. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec. Garder hors de la portée des enfants.
NPN 80027283
Support healthy B12 levels the easy way
Get AOR Methyl B12 5 mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Methyl B12
A methylated, sublingual form of vitamin B12 - premium AOR quality.
Methylated Vitamin B12
5 mg of methylcobalamin per lozenge - the active, coenzyme form of vitamin B12.
Sublingual, Not Swallowed
Dissolves under the tongue rather than being swallowed whole like a capsule.
Nerve Function & Energy Metabolism
Vitamin B12 supports healthy nerve function and plays a key role in the body's energy metabolism.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, since 1991. NPN 80027283.
How to use
Let it dissolve under the tongue
Place 1 lozenge under the tongue first thing in the morning and let it dissolve completely - do not chew or swallow it whole.
With or without food
Take with or without food, whichever fits your morning routine.
Follow the recommended dose
Adults (18 years and older): dissolve 1 lozenge daily. Do not exceed the recommended dose unless directed by a qualified health-care practitioner.
Check in beyond 4 months
Consult a health care practitioner before using beyond 4 months, or if you are pregnant or breastfeeding.
What the research says about vitamin B12 (methylcobalamin)
Peer-reviewed studies and reviews on vitamin B12 and methylcobalamin - shared for education, not as claims about this finished product. AOR Methyl B12 5 mg's claim is the statement authorized under its Natural Health Product licence, NPN 80027283.
A 2026 review weighs the evidence for nerve-repair adjuncts
A 2026 review of strategies to improve outcomes after peripheral nerve repair examined electrical stimulation, erythropoietin, tacrolimus, methylcobalamin, gene therapy and stem-cell approaches, assessing the mechanisms and clinical evidence behind each.
ReviewA methylcobalamin-releasing hydrogel supported nerve repair
In a rat sciatic nerve injury model, a hydrogel that gradually released methylcobalamin at the injury site improved motor function, reduced muscle atrophy, and enhanced nerve regeneration and remyelination compared with the hydrogel alone.
Animal studyMethylcobalamin supported nerve regrowth after surgical repair
In rats undergoing nerve transposition repair with a conical chitosan conduit, adding methylcobalamin as a supplementary treatment improved motor function, nerve conduction and the number of regenerated nerve fibers compared with conduit repair alone.
Animal studySublingual B12 raised blood levels as effectively as injections
A systematic review and meta-analysis pooling 16 studies and more than 6,000 participants found sublingual and oral vitamin B12 raised serum cobalamin and lowered homocysteine to a similar degree as intramuscular injections, with no significant difference between routes.
Meta-analysisResearchers flag an open question for malabsorption specifically
A 2024 clinical review on diagnosing and treating B12 deficiency noted that, while oral and sublingual forms work well for straightforward low intake, there is not yet clear evidence they can safely replace intramuscular injections specifically in people whose deficiency stems from malabsorption.
ReviewSublingual B12 corrected a deficiency without injections
A child with short-bowel syndrome and vitamin B12 malabsorption normalized low serum cobalamin after one month of daily sublingual B12, avoiding the monthly injections typically needed when the gut cannot absorb the vitamin normally.
Case reportB12 is a key cofactor in the body's energy metabolism
A review of vitamins in inflammatory disease notes that vitamin B12 is vital for energy metabolism and neurological function, and that a B12 deficiency can worsen the fatigue patients already experience.
ReviewA B-vitamin and magnesium combination reduced fatigue in a trial
In a randomized, double-blind, placebo-controlled trial in adults with inflammatory bowel disease in remission, four weeks of daily B-vitamin (including B12) and magnesium supplementation produced significantly greater reductions in fatigue scores than placebo.
Human RCTB12's energy role is clearest in people who are actually low
An integrative review of pharmacological treatments for fatigue in inflammatory bowel disease found vitamin B12 alone has not demonstrated efficacy for easing fatigue in that population, underscoring that B12's energy-metabolism benefit is best established in people whose levels are genuinely low.
ReviewA Cochrane review confirms B12 corrects deficiency in children
A 2026 Cochrane systematic review of 16 randomized trials in more than 4,000 children found oral vitamin B12 supplementation reduced the rate of B12 deficiency and increased total B12 concentrations compared with placebo.
Meta-analysisSevere B12 deficiency can mimic a life-threatening blood disorder
A case report described a 74-year-old woman whose severe vitamin B12 deficiency caused hemolytic anemia and low platelets that mimicked a life-threatening clotting disorder; her blood counts fully recovered once the B12 deficiency was identified and treated.
Case reportCorrecting a B12 and folate deficiency reversed low blood counts
A case report described a man whose low blood counts and retinal hemorrhage were traced to combined vitamin B12 and folate deficiency; after treatment with folic acid and B-complex vitamins, his blood counts and vision both recovered over three months.
Case reportMethylcobalamin alone showed the fewest side effects in a trial
In a randomized trial comparing methylcobalamin alone, methylcobalamin plus pregabalin, and methylcobalamin plus duloxetine for painful diabetic neuropathy, the methylcobalamin-only group reported zero adverse effects over 12 weeks, versus 6.9% and 10.3% in the combination groups.
Human RCT24 weeks of oral methylcobalamin was well tolerated
A multicenter, randomized, double-blind trial comparing oral methylcobalamin with acetyl-L-carnitine for diabetic peripheral neuropathy over 24 weeks found both treatments were well tolerated, with no significant difference in adverse events between groups.
Human RCTA rare reaction reported with intravenous methylcobalamin
A published case report described anaphylactic shock following a slow intravenous methylcobalamin injection in a hospitalized patient, who recovered fully after emergency treatment - a reminder that even a well-tolerated nutrient can rarely cause a serious reaction by some routes of administration.
Case reportSublingual methylcobalamin matched cyanocobalamin in children
A retrospective study in children with vitamin B12 deficiency found sublingual methylcobalamin and sublingual cyanocobalamin were both as effective as intramuscular cyanocobalamin at correcting serum B12 levels and related blood abnormalities.
Retrospective studyOne processing enzyme handles every form of B12
Biophysical studies of MMACHC, the human enzyme that processes dietary vitamin B12, show it binds and processes methylcobalamin, adenosylcobalamin and cyanocobalamin alike - the shared first step the body uses before any form of B12 can become biologically active.
Lab studySome cobalamin forms need converting before the body can use them
Research on an inherited cobalamin-processing disorder notes that the MMACHC enzyme pathway must convert cobalamin into methylcobalamin and adenosylcobalamin - the two coenzyme forms the body's cells actually use - before it can function in metabolism.
Clinical studyHow the body converts vitamin B12 into its working coenzyme forms
A 2026 review of vitamin-responsive metabolic pathways traces how dietary vitamin B12 is absorbed, carried into cells, and converted into its active coenzyme forms - the biochemical foundation for its roles in nerve health and energy metabolism.
ReviewMapping the protein that carries B12 through the bloodstream
Researchers solved the structure of transcobalamin, the blood protein that carries vitamin B12 to the body's cells, showing how it binds natural forms of the vitamin before releasing it for cellular uptake.
Structural biology studyB12 can be absorbed through more than one pathway
A review of vitamin B12 delivery systems describes how, alongside the classic intrinsic-factor pathway, B12 can also cross the gut lining through an intrinsic-factor-independent route - part of why forms taken by mouth or under the tongue can still raise B12 levels.
ReviewLong-term acid-reducing medication is linked to falling B12
A retrospective cohort study of 376 adults on proton pump inhibitor therapy for six months or longer found a significant decline in serum vitamin B12, with deficiency prevalence rising from 8.2% to 12.2% and neurological symptoms nearly four times more common in those who became deficient.
Cohort studyLong-term metformin use is a recognized risk factor for low B12
A clinical study correlating vitamin B12 levels with diabetic peripheral neuropathy identified long-term metformin therapy as a recognized risk factor for vitamin B12 deficiency, with lower B12 levels tracking with greater neuropathy severity in type 2 diabetes.
Clinical studyGenetic evidence links B12 deficiency anemia to thyroid risk
A 2026 Mendelian randomization study found vitamin B12 deficiency anemia has a causal association with Hashimoto thyroiditis and hypothyroidism, independent of iron-deficiency anemia, pointing to thyroid autoimmune disease as another factor connected to B12 status.
Genetic epidemiology studyFrequently asked questions
What is AOR Methyl B12 5 mg and what does it do?
AOR Methyl B12 5 mg provides 5 mg of vitamin B12 (as methylcobalamin) per lozenge. It is a source of vitamin B12 and helps prevent vitamin B12 deficiency.
How is this different from AOR's other Methyl B12 lozenge?
AOR also makes a 15 mg Methyl B12 lozenge under a separate Health Canada licence (NPN 80025586). This product is a different, independently licensed 5 mg formulation (NPN 80027283) with its own recommended dose of 1 lozenge daily. Always check the NPN and dose on the bottle you have, and follow that label.
How do I take it - do I swallow the lozenge?
No - this is a sublingual lozenge, not a capsule. Adults (18 years and older) dissolve 1 lozenge under the tongue first thing in the morning, with or without food, or as directed by a qualified health-care practitioner.
Can I use it for more than a few months?
Consult a health care practitioner before using this product beyond a duration of 4 months, or if you are pregnant or breastfeeding.
Is it vegan and allergen-friendly?
The lozenge itself is vegan, non-GMO and gluten-free. The label states it contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, dairy, eggs, fish, shellfish, soy, sulphites or mustard, and no animal byproduct.
Who should check with a health-care practitioner before using it?
Consult a health care practitioner before use if you are pregnant or breastfeeding, or before using beyond 4 months.
Is it made in Canada?
Yes. It is manufactured in Canada by Advanced Orthomolecular Research (AOR) and licensed by Health Canada under NPN 80027283.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support healthy B12 levels the easy way
Get AOR Methyl B12 5 mg on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80027283. Methylcobalamin is a source of vitamin B12 and helps prevent vitamin B12 deficiency. The research summaries below concern vitamin B12 (methylcobalamin) generally and are educational - they are not claims about this finished product. Read and follow the label. Consult a health-care practitioner before use if you are pregnant or breastfeeding, or for use beyond 4 months. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or for use beyond 4 months. Allergen Information: contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, dairy, eggs, fish, shellfish, soy, sulphites or mustard, and no animal byproduct. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place. Keep out of reach of children.
Indications
Recommended Use or Purpose: Methylcobalamin is a source of vitamin B12 and helps prevent vitamin B12 deficiency. Licensed Natural Health Product, NPN 80027283.
Ingredients
Medicinal Ingredients (per lozenge): Vitamin B12 (as Methylcobalamin) 5 mg. Non-medicinal ingredients: Sodium stearyl fumarate, microcrystalline cellulose, hydroxypropylcellulose, xylitol, tapioca syrup and distilled water. Non-medicinal ingredients are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Dissolve 1 lozenge under the tongue first thing in the morning, with or without food, or as directed by a qualified health care practitioner. Consult a health care practitioner for use beyond the duration of 4 months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.