AOR L-Lysine 500mg - Cold Sore Support & Collagen Formation | 150 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 2 vegan capsules, 3 times daily |
| Licensed Natural Health Product | NPN 80002854 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- L-LYSINE 500 MG, VEGAN CAPSULE: A single-ingredient, essential amino acid supplement in a vegan capsule - not a cream or patch. Helps to reduce the recurrence, severity and healing time of cold sores.
- HELPS WITH COLD SORE RECURRENCE: Health Canada-licensed to help reduce the recurrence, severity and healing time of cold sores (herpes simplex virus), for a proactive daily oral routine.
- SUPPORTS COLLAGEN FORMATION: L-Lysine helps in collagen formation, the structural protein that supports healthy skin, connective tissue and bone.
- AN ESSENTIAL AMINO ACID: The body cannot make L-Lysine on its own - it must come from diet or supplementation. AOR's L-Lysine is produced from biofermentation.
- HOW TO USE: Adults 18 years and older take 2 capsules, 3 times per day, for up to 6 months, or as directed by a qualified health care practitioner. Swallow capsules whole; do not mix, crush or blend.
- VEGAN, NON-GMO & GLUTEN-FREE: 150 vegan V-Capsules with just two non-medicinal ingredients - no artificial colours or unnecessary fillers.
- CLEAN CANADIAN QUALITY YOU CAN TRUST: Made in Canada in a GMP-compliant facility. Licensed Natural Health Product, NPN 80002854 - read the label for full details.
Product description
AOR L-Lysine - Daily Support for Cold Sore Recurrence & Collagen Formation
A pure, single-ingredient 500 mg L-Lysine supplement in a vegan capsule. L-Lysine is an essential amino acid the body cannot make on its own - Health Canada licensed to help reduce the recurrence, severity and healing time of cold sores, and to help in collagen formation. Licensed Natural Health Product NPN 80002854.
Un supplément pur, à ingrédient unique, de 500 mg de L-Lysine en capsule végétalienne. La L-Lysine est un acide aminé essentiel que le corps ne peut pas fabriquer lui-même - homologué par Santé Canada pour aider à réduire la récurrence, la gravité et le temps de guérison des feux sauvages, et pour aider à la formation du collagène. Produit de santé naturel homologué. NPN 80002854.
Pure L-Lysine, 500 mg
Single-ingredient, vegan capsule - Non-GMO, Gluten-Free, Made in Canada
Backed by real research
Multiple published clinical trials have studied oral L-lysine for recurrent cold sores (herpes simplex), the authorized use behind this product's Health Canada licence.
The AOR difference
500 mg of vegan, biofermentation-derived L-Lysine per capsule - just two non-medicinal ingredients, made in Canada to GMP standards.
What AOR L-Lysine Supports
L-Lysine is an essential amino acid the body cannot make - here is what its licensed use and the wider research base support.
Cold Sore Recurrence
Helps to reduce the recurrence, severity and healing time of cold sores (herpes simplex virus) - the authorized purpose of this product.
Collagen Formation
Helps in collagen formation, supporting the structural protein behind healthy skin, connective tissue and bone.
Essential Amino Acid
Lysine cannot be made by the body and must come from diet or supplementation - a foundational building block for protein synthesis.
Daily Vegan Capsule
A simple swallowed vegan V-Capsule, not a cream or patch - fits easily into a daily routine.
AOR L-Lysine: Supplement Facts
Each Capsule contains:
- L-Lysine (produced from biofermentation)500 mg
Non-Medicinal Ingredients: Non-medicinal ingredients: microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose.
Recommended Use or Purpose: L-Lysine helps to reduce the recurrence, severity and healing time of cold sores. Helps in collagen formation.
Recommended Dose (Adults 18 years and older): Take 2 capsules, 3 times per day, for up to 6 months, or as directed by a qualified health care practitioner. Do not mix, crush or blend capsules. Swallow capsules whole. Recommended Duration of Use: Consult a health care practitioner for use beyond 6 months.
Cautions and Warnings: Consult a health care practitioner if symptoms persist or worsen. Do not mix, crush or blend capsules; swallow capsules whole. Store in a cool, dry place, away from children. Contra-Indications: Do not use if pregnant or breastfeeding. Known Adverse Reactions: None known.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- L-Lysine (produite par biofermentation)500 mg
Ingrédients non médicinaux : Ingrédients non médicinaux : cellulose microcristalline, stéarylfumarate de sodium. Capsule : hypromellose.
Usage ou fins recommandés : la L-Lysine aide à réduire la récurrence, la gravité et le temps de guérison des feux sauvages. Aide à la formation du collagène.
Dose recommandée (adultes de 18 ans et plus) : prendre 2 capsules, 3 fois par jour, pendant une période maximale de 6 mois, ou selon les recommandations d'un praticien de soins de santé qualifié. Ne pas mélanger, écraser ou broyer les capsules. Avaler les capsules entières. Durée d'utilisation recommandée : consulter un praticien de soins de santé pour un usage au-delà de 6 mois.
Mises en garde : consulter un praticien de soins de santé si les symptômes persistent ou s'aggravent. Ne pas mélanger, écraser ou broyer les capsules; avaler les capsules entières. Conserver dans un endroit frais et sec, hors de la portée des enfants. Contre-indications : ne pas utiliser en cas de grossesse ou d'allaitement. Réactions indésirables connues : aucune connue.
NPN 80002854
A simple daily routine for cold sore support
Get AOR L-Lysine on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR L-Lysine
A single-ingredient, essential amino acid - licensed for cold sore recurrence and collagen formation.
Cold Sore Support
Helps to reduce the recurrence, severity and healing time of cold sores - the authorized purpose of this Health Canada-licensed product.
Collagen Formation
Helps in collagen formation, supporting healthy skin, connective tissue and bone.
Essential Amino Acid
The body cannot make L-Lysine on its own; AOR's L-Lysine is produced from biofermentation in a vegan capsule.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, since 1991. NPN 80002854.
How AOR L-Lysine compares
Why a licensed, single-ingredient lysine capsule matters for cold sore support.
| AOR L-Lysine | Topical creams/patches | Unlicensed lysine products | |
|---|---|---|---|
| Format | Vegan oral capsule | Spot-treat cream/patch | Varies |
| L-Lysine per serving | 500 mg/capsule | None (topical) | Varies |
| Health Canada licensed | NPN 80002854 | Varies | Not always |
| Authorized cold sore claim | Recurrence, severity & healing time | Varies | Varies |
| Allergen profile | Vegan, Non-GMO, Gluten-free | Varies | Varies |
| Sourcing | Made in Canada - GMP | Varies | Varies |
How to use
Take 2 capsules
Adults 18 years and older: take 2 vegan capsules, 3 times per day.
Swallow whole
Do not mix, crush or blend capsules - swallow capsules whole.
Use for up to 6 months
Use as a daily routine for up to 6 months, or as directed by a qualified health care practitioner.
Check with your practitioner
Consult a health care practitioner for use beyond 6 months, or if symptoms persist or worsen.
What the research says about L-lysine
Peer-reviewed studies and reviews on the amino acid L-lysine - shared for education, not as claims about this finished product. AOR L-Lysine's claims are the statements authorized under its Natural Health Product licence, NPN 80002854.
Fewer, milder, faster-healing cold sores in a 6-month trial
A double-blind, placebo-controlled multicentre trial of oral L-lysine (1000 mg, three times daily for six months) found the lysine group averaged 2.4 fewer herpes simplex recurrences, with significantly reduced symptom severity and healing time.
Human RCTMore patients stayed recurrence-free on lysine
In a double-blind, placebo-controlled crossover study of 65 patients (1000 mg L-lysine daily for 12 weeks), significantly more patients were recurrence-free during lysine than during placebo treatment, suggesting some people may benefit from prophylactic use.
Human RCTEvidence is mixed - a lower-dose trial found no benefit
A double-blind, placebo-controlled trial using a lower dose (400 mg, three times daily) detected no substantial benefit on episode frequency, duration or severity, underlining that the research on lysine and cold sores is genuinely mixed across studies and doses.
Human RCTLysine is essential for collagen cross-linking
Lysyl oxidase enzymes catalyze the cross-linking of lysine and hydroxylysine residues in collagen and elastin, the chemical step that gives connective tissue its strength and structure.
ReviewHydroxylysine cross-links stabilize collagen fibrils
Reviews describe how lysyl hydroxylase enzymes convert lysine residues into hydroxylysine within procollagen, forming the covalent cross-links that stabilize mature collagen fibrils in tissue.
ReviewA building block found across the collagen family
Collagen glycosylation attaches sugar groups specifically to hydroxylysine residues, a modification conserved from sponges to mammals and essential to collagen's role throughout the body.
ReviewImproved renal conservation of calcium
In healthy women given an oral calcium load, adding 400 mg of L-lysine blunted the usual rise in urinary calcium loss (calciuria), suggesting lysine helps the kidneys conserve absorbed calcium.
Human studyLysine, not other amino acids, boosted calcium absorption
In osteoporotic patients, short-term supplementation with L-lysine (but not L-valine or L-tryptophan at the same dose) significantly increased intestinal absorption of calcium, pointing to a lysine-specific effect.
Human studyA cellular role in calcium regulation
In cultured human cells, depriving them of L-lysine raised intracellular calcium levels and altered calcium flux, indicating lysine helps regulate cytosolic calcium homeostasis at the cellular level.
Lab studyThe "limiting" amino acid in many diets
Lysine is widely regarded as the main limiting essential amino acid for human health in cereal-based diets, meaning overall protein quality often depends on getting enough of it.
ReviewProtein quality is about more than quantity
Protein deficiency involves both how much protein is eaten and its essential amino acid content; lysine is among the amino acids most often targeted to improve the nutritional quality of staple diets.
ReviewWhy some proteins need lysine added back
Lysine and threonine are described as the primary limiting amino acids in rice protein; adding them back improves the protein's nutritional completeness, illustrating lysine's foundational dietary role.
ReviewWell tolerated across two dose levels
In a randomized, double-blind crossover trial, both 1248 mg and 624 mg of L-lysine daily were administered without reported adverse effects, with the higher dose showing evidence of reduced recurrence and severity.
Human RCTSustained real-world use over six months
A survey of 1,543 people using lysine supplementation (average dose 936 mg per day) over a six-month period gathered patient-reported outcomes on recurrence, severity and healing time without describing safety concerns.
Survey studyNo increased adverse events across long-term trials
A Cochrane systematic review of 32 randomized trials (2,640 participants) evaluating interventions for cold sore prevention, including lysine, found no evidence of increased adverse events with long-term use of the interventions studied.
Systematic reviewThe lysine-to-arginine ratio matters in the lab
Tissue-culture research found that a high lysine-to-arginine ratio suppressed herpes simplex viral replication, while the opposite ratio (more arginine than lysine) favoured it - a proposed rationale for oral lysine.
Lab studyNot every essential amino acid is made the same way
A biochemical review explains that lysine, like threonine, cannot be produced through the reversible transamination pathway the body uses to make several other essential amino acids.
ReviewComparing safe intake levels across amino acids
A narrative review of clinical dose-response studies established tolerable upper intake levels for several essential amino acids, finding lysine well tolerated up to a no-observed-adverse-effect level of 6 g per day - alongside comparable data for leucine, methionine and histidine.
ReviewAn amino acid the body cannot make
Reviews of amino acid metabolism classify L-lysine as an essential amino acid that cannot be synthesized by humans or most animals, meaning it must come entirely from diet or supplementation.
ReviewOne of five "aspartate-family" essential amino acids
Lysine belongs to the L-aspartate family of amino acids (with threonine, methionine and isoleucine) that, unlike aspartate itself, are essential amino acids the body cannot synthesize.
ReviewWhat makes an amino acid "essential"
Essential amino acids - including lysine, leucine, methionine, threonine and histidine - are defined as those the body cannot synthesize (or cannot make quickly enough), so they must be supplied through the diet.
ReviewRefining how much dietary lysine adults need
Using the modern indicator amino acid oxidation technique, researchers estimated the mean dietary lysine requirement of healthy adults at about 30 mg per kilogram of body weight per day - notably higher than the earlier 1985 FAO/WHO/UNU estimate of 12 mg/kg/day.
Human studyRequirements can shift with nutritional status
The same research group found that chronically undernourished adults required even more dietary lysine (about 44 mg/kg/day) than well-nourished individuals, suggesting requirements are not identical across populations.
Human studyHow food processing affects lysine availability
In healthy young men, the metabolic availability of lysine from milk powder dropped from 92% to 70% after heat treatment, showing that processing - not just the amount present - affects how much dietary lysine the body can actually use.
Human studyFrequently asked questions
What is AOR L-Lysine for?
It is a Health Canada-licensed Natural Health Product that helps to reduce the recurrence, severity and healing time of cold sores (herpes simplex virus), and helps in collagen formation.
How do I take it?
Adults 18 years and older take 2 vegan capsules, 3 times per day, for up to 6 months, or as directed by a qualified health care practitioner. Swallow capsules whole; do not mix, crush or blend.
How much L-Lysine is in each capsule?
Each vegan capsule provides 500 mg of L-Lysine, produced from biofermentation.
What else is in the capsule?
Just two non-medicinal ingredients - microcrystalline cellulose and sodium stearyl fumarate - in a hypromellose (vegan) capsule shell.
How long does one bottle last?
Each bottle has 150 vegan capsules - up to a 25-day supply at 2 capsules, 3 times per day.
Is it made in Canada?
Yes. It is manufactured in Canada in a GMP-compliant facility and licensed by Health Canada under NPN 80002854.
Are there any cautions?
Do not use if pregnant or breastfeeding. Consult a health care practitioner if symptoms persist or worsen, or for use beyond 6 months.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
A simple daily routine for cold sore support
Get AOR L-Lysine on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80002854. L-Lysine helps to reduce the recurrence, severity and healing time of cold sores, and helps in collagen formation. The research summaries below concern the amino acid L-lysine generally and are educational - they are not claims about this finished product beyond its licensed use. Read and follow the label. Consult a health care practitioner if symptoms persist or worsen. Do not use if pregnant or breastfeeding. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner if symptoms persist or worsen. Do not mix, crush or blend capsules; swallow capsules whole. Store in a cool, dry place, away from children. Contra-Indications: Do not use if pregnant or breastfeeding. Known Adverse Reactions: None known.
Indications
Recommended Use or Purpose: L-Lysine helps to reduce the recurrence, severity and healing time of cold sores. Helps in collagen formation.
Ingredients
Medicinal Ingredient (per capsule): L-Lysine 500 mg (produced from biofermentation). Non-medicinal ingredients: microcristalline cellulose, sodium stearyl fumarate. Capsule: hypromellose. Vegan, Non-GMO and gluten-free. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 2 capsules, 3 times per day, for up to 6 months, or as directed by a qualified health care practitioner. Do not mix, crush or blend capsules. Swallow capsules whole. Recommended Duration of Use: Consult a health care practitioner for use beyond 6 months.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.