AOR Indole-3-Carbinol (I3C) 200mg - Estrogen Metabolism Support | 60 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 Capsule (60 per bottle) |
| Licensed Natural Health Product | NPN 80023077 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- SUPPORTS HEALTHY ESTROGEN BALANCE: Indole-3-Carbinol (I3C) helps to support and promote healthy estrogen metabolism, a natural process your body relies on to help keep hormone levels balanced.
- A NATURAL CRUCIFEROUS-VEGETABLE COMPOUND: I3C is a phytochemical found in cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts - AOR I-3-C delivers a concentrated, consistent 200 mg dose in every capsule.
- PROVIDES ANTIOXIDANT PROTECTION: A source of antioxidants that help protect cells against the oxidative damage caused by free radicals.
- SUPPORTS SKIN CLARITY AND HORMONAL HEALTH: As part of its role in healthy estrogen metabolism, I3C is studied for its relationship to skin clarity and overall hormonal wellness.
- SINGLE INGREDIENT, NO SURPRISES: Just 200 mg of Indole-3-Carbinol per vegan capsule, with only microcrystalline cellulose and sodium stearyl fumarate as non-medicinal ingredients.
- VEGAN, NON-GMO AND GLUTEN-FREE: Formulated without animal products, genetically modified ingredients or gluten - a 60-day supply in every bottle.
- TRUSTED CANADIAN MANUFACTURING: Made by AOR (Advanced Orthomolecular Research) in Calgary, Alberta - a Canadian Natural Health Product manufacturer since 1991, licensed by Health Canada (NPN 80023077).
- SIMPLE, FLEXIBLE DOSING: Take one capsule one to two times daily, with or without food - a 60-capsule bottle provides up to a two-month supply.
Product Description
I-3-C - Indole-3-Carbinol 200 mg
Supporting healthy estrogen metabolism and balance. AOR I-3-C delivers a concentrated 200 mg dose of Indole-3-Carbinol, a natural phytochemical found in cruciferous vegetables, in a single vegan capsule. A source of antioxidants that help protect cells against the oxidative damage caused by free radicals. Licensed Natural Health Product. NPN 80023077. Licensed Natural Health Product NPN 80023077.
Favorise un métabolisme et un équilibre sains des œstrogènes. AOR I-3-C offre une dose concentrée de 200 mg d'indole-3-carbinol, un phytonutriment naturel présent dans les légumes crucifères, dans une seule capsule végétalienne. Source d'antioxydants qui aident à protéger les cellules contre les dommages oxydatifs causés par les radicaux libres. Produit de santé naturel homologué. NPN 80023077.
Cruciferous Vegetable Extract
Single-ingredient I3C, 200 mg per capsule - Vegan, Non-GMO, Gluten-Free
Concentrated 200 mg Dose
Each vegan capsule delivers a full 200 mg of Indole-3-Carbinol - within Health Canada's permitted daily range for supporting healthy estrogen metabolism (200-400 mg per day).
Flexible Once- or Twice-Daily Dosing
Take 1 capsule one to two times daily, with or without food - a 60-capsule bottle provides up to a two-month supply.
How I-3-C Supports Your Body
Research points to several ways this cruciferous-vegetable compound supports the body, from estrogen metabolism to cellular antioxidant defense.
Healthy Estrogen Metabolism
Helps support and promote healthy estrogen metabolism and balance, a process your body relies on to help break down and clear estrogen.
Antioxidant Protection
A source of antioxidants that help protect cells against the oxidative damage caused by free radicals.
Skin Clarity Support
Estrogen balance is linked to skin clarity - I3C's role in healthy estrogen metabolism is studied for this connection.
Cruciferous-Vegetable Nutrition
Concentrates the same phytochemical found in broccoli, cabbage, cauliflower and Brussels sprouts into one consistent daily capsule.
AOR Indole-3-Carbinol: Supplement Facts
Each capsule contains:
- Indole-3-Carbinol (I3C)200 mg
Non-Medicinal Ingredients: Microcrystalline cellulose, sodium stearyl fumarate.
Recommended Use or Purpose: Source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals. Helps to support healthy estrogen metabolism and balance. Licensed Natural Health Product, NPN 80023077.
Recommended Dose (Adults 18 years and older): Take 1 capsule one to two times daily (200-400 mg Indole-3-Carbinol per day), with or without food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules; swallow capsules whole. Do not exceed the daily dose unless instructed by a health care practitioner. Recommended Duration of Use: No statement required.
Cautions and Warnings: Ask a health care practitioner before use to exclude the diagnosis of a serious cause of hormonal imbalance. Ask a health care practitioner before use if you are taking medications or natural health products, or if you are attempting to conceive. Ask a health care practitioner before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations. Stop use and ask a health care practitioner if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. Contraindications: Do not use if you are pregnant or breastfeeding. Known Adverse Reactions: No statement required. Store in a cool, dry place, away from children.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- Indole-3-Carbinol (I3C)200 mg
Ingrédients non médicinaux : Cellulose microcristalline, stéaryl fumarate de sodium.
Usage ou fins recommandés : Source d'antioxydants qui aident à protéger les cellules contre les dommages oxydatifs causés par les radicaux libres. Aide à soutenir un métabolisme et un équilibre sains des œstrogènes. Produit de santé naturel homologué, NPN 80023077.
Dose recommandée (adultes de 18 ans ou plus) : Prendre 1 capsule une à deux fois par jour (200 à 400 mg d'indole-3-carbinol par jour), avec ou sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas écraser, mélanger ou broyer les capsules; avaler les capsules entières. Ne pas dépasser la dose quotidienne recommandée à moins d'avis contraire d'un professionnel de la santé. Durée d'utilisation recommandée : Énoncé non requis.
Mises en garde et précautions : Consulter un professionnel de la santé avant l'utilisation afin d'exclure un diagnostic d'une cause sérieuse de déséquilibre hormonal. Consulter un professionnel de la santé avant l'utilisation si vous prenez des médicaments ou des produits de santé naturels, ou si vous essayez de concevoir. Consulter un professionnel de la santé avant l'utilisation si vous avez un trouble du foie ou des symptômes associés à un faible niveau d'œstrogènes tels que des douleurs articulaires, des changements d'humeur, des changements de la libido, des bouffées de chaleur, des sueurs nocturnes, de la sécheresse vaginale ou des menstruations irrégulières. Cessez l'utilisation et consultez un professionnel de la santé si vous développez des symptômes associés au foie (par ex. jaunissement des yeux et/ou de la peau, urine foncée, douleur abdominale, jaunisse) ou des symptômes associés à un faible niveau d'œstrogènes. Contre-indications : Ne pas utiliser si vous êtes enceinte ou si vous allaitez. Réactions indésirables connues : Énoncé non requis. Conserver dans un endroit frais et sec, hors de la portée des enfants.
NPN 80023077
Support healthy estrogen balance the easy way
Get AOR I-3-C on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR I-3-C
Concentrated, single-ingredient Indole-3-Carbinol - premium AOR quality.
Single-ingredient purity
Just I3C plus two non-medicinal ingredients - a clean, concentrated 200 mg dose in every capsule.
Estrogen metabolism support
Helps support and promote healthy estrogen metabolism and balance.
Antioxidant protection
A source of antioxidants that help protect cells against the oxidative damage caused by free radicals.
Premium Canadian brand
AOR - Advanced Orthomolecular Research, since 1991. NPN 80023077.
How to use it
1 capsule, 1-2 times daily
Adults take 1 capsule one to two times daily (200-400 mg Indole-3-Carbinol), with or without food, or as directed by a qualified health care practitioner.
Swallow whole
Do not crush, mix or blend capsules - swallow whole, and do not exceed the daily dose unless instructed by a health care practitioner.
Guided use if needed
Ask a health care practitioner before use if you are taking medications or natural health products, or if you are attempting to conceive.
What the research says about Indole-3-Carbinol (I3C)
Educational summaries of published research on I3C and its natural conversion product DIM; not product-specific claims. AOR I-3-C's claim is the authorized use under NPN 80023077.
A measurable link between crucifer intake and I3C uptake
In a controlled feeding trial, volunteers ate brussels sprouts or cabbage at seven different glucobrassicin (the natural precursor of I3C) dose levels; urinary DIM - the compound I3C converts into after digestion - rose predictably with intake, giving researchers a reliable biomarker of I3C exposure from cruciferous vegetables.
Human clinical trialA favorable shift in estrogen metabolite ratio
In a randomized, placebo-controlled, cross-over trial in 148 premenopausal women, 12 weeks of a daily nutraceutical containing indole-3-carbinol produced a significantly higher urinary 2-hydroxyestrone to 16alpha-hydroxyestrone ratio than placebo - a metabolite balance researchers associate with a more favorable estrogen profile.
Human RCTEstrogen receptor signaling among I3C's key targets
A 2025 pharmacology review mapped the molecular targets through which indole-3-carbinol and its dimer DIM act, identifying estrogen receptor signaling alongside NF-kB and Wnt/PI3K/Akt pathways as key routes by which these cruciferous-vegetable compounds influence cell behavior.
ReviewBroccoli and cabbage extracts rich in I3C studied on cells
Aqueous extracts of broccoli sprouts and red cabbage - naturally high in glucosinolate breakdown products including indole-3-carbinol, sulforaphane and iberin - reduced proliferation of breast cancer cell lines in vitro, with the whole-extract effect stronger than any single isolated compound tested alone, pointing to a synergy among cruciferous phytochemicals.
ResearchI3C survives digestion from real cruciferous food sources
Using a dynamic model of human digestion, researchers tracked indole-3-carbinol and sulforaphane from red cabbage extract and found high retention of both compounds through a simulated 14-day digestive process, supporting that these cruciferous compounds remain bioaccessible after eating.
ResearchCruciferous extracts counter carcinogen-driven cell stress
Broccoli sprout and red cabbage extracts, both rich in glucosinolate-derived indole and isothiocyanate compounds, reduced reactive oxygen species and modulated protective autophagy in breast cells exposed to the carcinogen benzo(a)pyrene, illustrating a protective cellular mechanism tied to crucifer phytochemistry.
ResearchCalming inflamed skin in a preclinical eczema model
In a mouse model of atopic dermatitis, both oral and topical indole-3-carbinol reduced ear and skin thickening, calmed inflammatory cell infiltration, and lowered expression of the itch- and inflammation-linked signals IL-4 and IL-13.
Preclinical studyQuieting the allergic skin-inflammation signal
Indole-3-carbinol lowered periostin and thymic stromal lymphopoietin - two proteins that drive allergic skin inflammation - in both lab-grown skin cells and a mouse model of atopic dermatitis, acting through the aryl hydrocarbon receptor pathway and easing skin barrier disruption.
ResearchDisrupting the bacteria behind blemish-prone skin
Indole-3-carbinol measurably inhibited biofilm formation by Cutibacterium acnes, the bacterium most associated with acne, without harming normal cell growth - part of a broader look at how indole compounds found in cruciferous vegetables interact with skin-dwelling microbes.
ResearchProtecting liver tissue from toxic stress
In rats challenged with a liver toxin, oral indole-3-carbinol lowered an overactive detox enzyme (CYP2E1), reduced oxidative stress and inflammatory markers, and helped protect liver tissue from injury - preclinical evidence for I3C's role in the body's detoxification pathways.
Preclinical studySwitching on estrogen-clearing liver enzymes
Indole-3-carbinol and its conversion product DIM both induced CYP1-family enzymes - the phase I liver enzymes responsible for breaking down estrogen - in human breast cell lines, with the specific enzyme balance varying by cell type.
ResearchBoosting the body's own antioxidant defenses
A topical indole-3-carbinol formulation increased activity of the antioxidant enzyme catalase and vitamin C levels while lowering oxidative damage markers in a rat wound-healing model, alongside reduced inflammatory signaling.
Preclinical studyNo red flags over months of daily use
Rats fed indole-3-carbinol at several multiples of a typical human supplement dose for up to 12 months showed no significant adverse changes in blood chemistry, supporting a favorable long-term safety profile at supplement-relevant intakes.
Preclinical studyA track record described as well-tolerated
Reviewing indole-3-carbinol's newly identified senolytic (aging-cell-clearing) activity, researchers noted its already well-established high tolerability and safety across prior preclinical and clinical research.
ResearchWhy 'tell your practitioner about other medications' matters
Dietary indoles, including indole-3-carbinol, were shown to induce liver cytochrome P450 enzymes while suppressing a separate detox enzyme system in rats - a reminder that compounds affecting liver metabolism can also influence how other medications are cleared from the body.
MechanismHow I3C transforms after you take it
Indole-3-carbinol is unstable in the acidic environment of the stomach and readily converts into 3,3'-diindolylmethane (DIM) and related compounds; researchers describe I3C as a natural dietary precursor that gives rise to DIM as part of its normal digestion and activity in the body.
ResearchAn active scientific conversation about I3C's own chemistry
A 2008 review examined how indole-3-carbinol's rapid conversion into DIM and other condensation products after oral intake shapes its biological activity, part of an ongoing scientific discussion about how this cruciferous-vegetable compound works once consumed.
ReviewDIM's research trail traces back to I3C
A comprehensive review of DIM - generated when I3C condenses in the acidic environment of the stomach - summarized its effects on cell-signaling pathways including the aryl hydrocarbon receptor, NF-kB and Wnt/Akt/mTOR, illustrating how research on I3C and its natural conversion product inform one another.
ReviewMapping I3C's molecular structure
Using X-ray diffraction, nuclear quadrupole resonance and computational modeling, researchers characterized the precise crystal structure of indole-3-carbinol, classifying it among the plant-derived antioxidant and anticarcinogenic compounds found in cruciferous vegetables.
ResearchIndoles and isothiocyanates: two crucifer chemistries
Comparing indole-3-carbinol and DIM against the isothiocyanates sulforaphane and PEITC in colon cancer cells, researchers found the indole compounds inhibited cell growth gently (cytostatically) while the isothiocyanates were more directly cytotoxic - a foundational distinction between the two major phytochemical families cruciferous vegetables produce.
ResearchA phytochemical family with a long research history
A review of the patent and research literature traced indole-3-carbinol and DIM to their shared origin in cruciferous vegetables, cataloguing decades of chemopreventive research and formulation development built around these glucosinolate-derived indole compounds.
ReviewTracing I3C through the body across a dose range
A phase I trial in women tested oral indole-3-carbinol from 400 mg up to 1,200 mg; I3C itself was undetectable in blood, while its conversion product DIM rose with dose and plateaued around 1,000-1,200 mg, informing the dose ranges studied in later research.
Clinical Trial, Phase IComparing lower and higher oral doses
A Cochrane systematic review of treatments for a precancerous vulval skin condition included a randomized trial comparing lower- and higher-dose oral indole-3-carbinol, part of the broader clinical evidence base examining how dose relates to response for this compound.
Systematic reviewLessons from early dose-finding trials
A review of cervical chemoprevention research noted that early-phase dose-finding trials of agents including indole-3-carbinol produced promising response rates, underscoring why rigorous, placebo-controlled follow-up trials are needed to confirm effects seen in initial dosing studies.
ReviewFrequently asked questions
How do I take AOR I-3-C?
Adults take 1 capsule one to two times daily (200-400 mg Indole-3-Carbinol), with or without food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules - swallow whole.
What is Indole-3-Carbinol (I3C)?
I3C is a phytochemical naturally found in cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts. It helps to support healthy estrogen metabolism and balance, and is a source of antioxidants.
Is I3C the same as DIM?
No. I3C and DIM (3,3'-diindolylmethane) are related but distinct compounds - I3C is the natural precursor found in cruciferous vegetables, and DIM is what I3C converts into within the acidic environment of the stomach. AOR I-3-C provides pure Indole-3-Carbinol at 200 mg per capsule.
Why does it have a strong smell?
Indole-3-Carbinol can have a strong, characteristic smell that may be unpleasant to some people. This odour is harmless and is not indicative of a loss of potency.
Is it vegan and allergen-friendly?
Yes - AOR I-3-C is vegan, non-GMO and gluten-free, with only microcrystalline cellulose and sodium stearyl fumarate as non-medicinal ingredients.
Who should not use it?
Do not use if you are pregnant or breastfeeding. Ask a health care practitioner before use if you are taking medications or natural health products, if you are attempting to conceive, or if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations.
How long will one bottle last?
A 60-capsule bottle provides up to a two-month supply at the standard dose of 1 capsule, one to two times daily.
What should I do if I notice a side effect?
Stop use and ask a health care practitioner if you develop liver-related symptoms (e.g., yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen.
Support healthy estrogen balance the easy way
Get AOR I-3-C on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80023077. AOR I-3-C (Indole-3-Carbinol) is a source of antioxidants and helps to support healthy estrogen metabolism and balance. Read and follow the label. Do not use if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you are attempting to conceive, taking medications or natural health products, or if you have a liver disorder or symptoms of low estrogen. Results may vary.
Important information
Safety Information
Cautions and Warnings: Ask a health care practitioner before use to exclude the diagnosis of a serious cause of hormonal imbalance. Ask a health care practitioner before use if you are taking medications or natural health products, or if you are attempting to conceive. Ask a health care practitioner before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations. Stop use and ask a health care practitioner if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. Contraindications: Do not use if you are pregnant or breastfeeding. Known Adverse Reactions: No statement required. Store in a cool, dry place, away from children.
Indications
Recommended Use or Purpose: Source of an antioxidant that helps protect cells against the oxidative damage caused by free radicals. Helps to support healthy estrogen metabolism and balance. Licensed Natural Health Product, NPN 80023077.
Ingredients
Medicinal Ingredient (per 1-capsule serving): Indole-3-Carbinol (I3C) 200 mg. Non-medicinal ingredients: microcrystalline cellulose, sodium stearyl fumarate. Note: Indole-3-Carbinol (I-3-C) can have a strong, characteristic smell that may be unpleasant to some people; this odour is harmless and is not indicative of a loss of potency. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule one to two times daily (200-400 mg Indole-3-Carbinol per day), with or without food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules; swallow capsules whole. Do not exceed the daily dose unless instructed by a health care practitioner. Recommended Duration of Use: No statement required.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.