AOR Cardio Mag 2.0 - Magnesium Orotate for Heart Health | 120 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 capsule, 4 times daily (120 per bottle) |
| Licensed Natural Health Product | NPN 80005854 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- TRUE MAGNESIUM OROTATE, FULLY REACTED: 770 mg of a fully-reacted magnesium orotate complex per capsule - not a food-grade blend of orotic acid with an inorganic magnesium salt like many other 'magnesium orotate' products on the market.
- 50 MG ELEMENTAL MAGNESIUM PER CAPSULE: Each capsule provides 50 mg of elemental magnesium plus 720 mg of orotic acid, reaching 200 mg of elemental magnesium at the full labelled dose of 4 capsules daily.
- SUPPORTS CARDIAC FUNCTION UNDER STRESS: Magnesium and orotic acid exert complementary effects on the biosynthesis of pyrimidine nucleotides, helping maintain normal glycogen stores, protein synthesis, ATP levels and contractile function.
- SUPPORTS HEALTHY BLOOD PRESSURE AND MUSCLE FUNCTION: Helps support normal, healthy blood pressure and proper muscle function - foundational roles for cardiovascular health and everyday activity.
- SIMPLE, CLEAN-LABEL FORMULA: Just one non-medicinal ingredient (sodium stearyl fumarate) in a vegan hypromellose capsule - no fillers or unnecessary binders.
- FLEXIBLE 4-TIMES-DAILY DOSING WITH FOOD: Take 1 capsule four times daily with food, or as directed by a qualified health care practitioner.
- VEGAN, NON-GMO, GLUTEN-FREE: Vegan hypromellose capsules, non-GMO and gluten-free, made in Canada.
- TRUSTED CANADIAN QUALITY: Manufactured by Advanced Orthomolecular Research (AOR), a licensed Natural Health Product, NPN 80005854, since 1991.
Product description
Cardio Mag 2.0 - True Magnesium Orotate for Cardiac Function Under Stress
A closer look at AOR Cardio Mag 2.0 - a fully-reacted, 100% pure magnesium orotate supplement combining 50 mg of elemental magnesium with 720 mg of orotic acid per capsule. Licensed Natural Health Product, NPN 80005854. Licensed Natural Health Product NPN 80005854.
Un regard plus approfondi sur AOR Cardio Mag 2.0 - un supplément d'orotate de magnésium pur à 100 %, entièrement réagi, combinant 50 mg de magnésium élémentaire et 720 mg d'acide orotique par capsule. Produit de santé naturel homologué, NPN 80005854.
Why True Magnesium Orotate
Fully-reacted magnesium orotate - not a food-grade blend of orotic acid with an inorganic magnesium salt.
Fully Reacted, Not Just Blended
Most 'magnesium orotate' products on the market are food-grade mixtures of orotic acid with an inorganic magnesium salt. AOR's Cardio Mag 2.0 is a fully-reacted magnesium orotate complex, matching the form studied in cardiac research.
The AOR Difference
770 mg of true magnesium orotate per capsule - 50 mg of elemental magnesium plus 720 mg of orotic acid - vegan, non-GMO, gluten-free and made in Canada.
Cardiac & Muscle Function Support
Magnesium and orotic acid exert complementary effects on the biosynthesis of pyrimidine nucleotides, supporting the heart's ability to endure and recover from stress.
Cardiac Function Under Stress
Supports the heart's ability to endure and recover from physical and stress-related demands, helping maintain contractile function.
Healthy Blood Pressure
Magnesium and orotic acid work together to help support normal, healthy blood pressure.
Muscle Function
Helps maintain proper muscle contraction and relaxation, from everyday movement to the heart muscle itself.
Cellular Energy (ATP)
Orotic acid helps maintain normal glycogen stores and ATP levels - the cell's primary energy currency.
Protein Synthesis
Magnesium and orotic acid exert complementary effects on the biosynthesis of pyrimidine nucleotides that support protein synthesis.
Foundational Good Health
Magnesium is essential to hundreds of bodily processes and is a factor in the maintenance of good health overall.
AOR Cardio Mag 2.0: Supplement Facts
Medicinal Ingredients (per 1 capsule)
- Magnesium orotate providing 50 mg elemental magnesium and 720 mg orotic acid770 mg
Non-Medicinal Ingredients: Sodium stearyl fumarate. Capsule: Hypromellose.
Recommended Use or Purpose: Magnesium and orotic acid exert complementary effects on the biosynthesis of pyrimidine nucleotides, maintain normal glycogen stores, protein synthesis, ATP levels, and contractile function. Research supports the ability of true magnesium orotate to support cardiac function under stress. Magnesium supports and maintains good health. Licensed Natural Health Product, NPN 80005854.
Recommended Dose (Adults 18 years and over): Take 1 capsule four times daily with food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules; swallow capsules whole. Do not exceed daily dose unless instructed by a healthcare practitioner.
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant, nursing, or taking other supplements. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Ingrédients médicinaux (par 1 capsule)
- Orotate de magnésium fournissant 50 mg de magnésium élémentaire et 720 mg d'acide orotique770 mg
Ingrédients non médicinaux : Stéarylfumarate de sodium. Capsule : Hypromellose.
Usage ou fins recommandés : Le magnésium et l'acide orotique exercent des effets complémentaires sur la biosynthèse des nucléotides pyrimidiques, maintiennent les réserves normales de glycogène, la synthèse des protéines, les niveaux d'ATP et la fonction contractile. La recherche soutient la capacité du véritable orotate de magnésium à soutenir la fonction cardiaque en cas de stress. Le magnésium soutient et maintient une bonne santé. Produit de santé naturel homologué, NPN 80005854.
Dose recommandée (Adultes de 18 ans et plus) : Prendre 1 capsule quatre fois par jour avec de la nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Ne pas écraser, mixer ou mélanger les capsules; avaler les capsules entières. Ne pas dépasser la dose quotidienne, sauf indication contraire d'un professionnel de la santé.
Mises en garde et précautions : Consulter un professionnel de la santé avant l'usage si vous êtes enceinte, si vous allaitez, ou si vous prenez d'autres suppléments. Ne pas utiliser si le sceau de sécurité est brisé. Conserver hermétiquement fermé dans un endroit frais et sec.
NPN 80005854
Support cardiac function the true magnesium orotate way
Get AOR Cardio Mag 2.0 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Cardio Mag 2.0
True magnesium orotate - not a food-grade blend - for cardiac function under stress.
Fully-Reacted Magnesium Orotate
A true magnesium orotate complex, not a mixture of orotic acid with an inorganic magnesium salt like many other 'magnesium orotate' products on the market.
Cardiac Function Under Stress
Magnesium and orotic acid exert complementary effects on ATP levels, glycogen stores, protein synthesis and contractile function.
Simple, Clean Formula
Just one non-medicinal ingredient (sodium stearyl fumarate) in a vegan hypromellose capsule.
Premium Canadian Brand
AOR - Advanced Orthomolecular Research, since 1991. Vegan, non-GMO, gluten-free. NPN 80005854.
How to use
Take 1 capsule, 4 times daily
Adults (18 years and over) take 1 capsule four times daily with food, or as directed by a qualified health care practitioner.
Take with food
Each dose is taken with food, spaced through the day - a 120-capsule bottle is up to a 1-month supply at the full 4-capsule daily dose.
Swallow whole
Do not crush, mix or blend capsules - swallow capsules whole.
Stay consistent
Do not exceed the daily dose unless instructed by a healthcare practitioner; use consistently as part of your daily routine.
What the research says about magnesium orotate
Peer-reviewed studies and reviews on magnesium orotate, orotic acid and magnesium generally - shared for education, not as claims about this finished product. Cardio Mag 2.0's claim is the statement authorized under its Natural Health Product licence, NPN 80005854.
Adjuvant magnesium orotate improved survival in severe heart failure
In a controlled, double-blind trial of 79 patients with severe (NYHA IV) congestive heart failure already on optimal medication, adding magnesium orotate for one year raised the survival rate to 75.7% versus 51.6% under placebo, and clinical symptoms improved in 38.5% of patients versus deterioration in 56.3% on placebo.
Human RCTMeta-analysis of 19 trials links magnesium orotate to fewer arrhythmias
Pooling 19 randomized trials (603 patients on magnesium orotate versus 587 on placebo, averaging roughly 1878 mg/day for over 4 months), the therapy was associated with significantly reduced risk of hypomagnesemia, exercise intolerance, supraventricular and ventricular premature contractions, and hypertension.
Meta-analysisMagnesium orotate improved heart function and exercise duration in coronary disease
In a double-blind pilot trial, 14 patients with coronary heart disease and left-ventricular dysfunction who took magnesium orotate for 4 weeks showed a significant decrease in left-ventricular end-systolic volume, a significant increase in ejection fraction, and significantly longer exercise duration than the placebo group.
Human RCTOrotic acid acts as a 'magnesium-fixing agent' for the heart's energy stores
A pharmacology review describes orotic acid as a key intermediate in pyrimidine biosynthesis that improves the energy status of stressed heart muscle by stimulating glycogen and ATP synthesis, and by providing binding sites that help retain magnesium inside the cell during hypoxic stress.
ReviewMagnesium orotate is grouped among 'metabolic therapies' that support cellular ATP production
Reviewing metabolic approaches to heart disease, cardiac researchers describe magnesium orotate as a key intermediate in the glycogen biosynthetic pathway that can improve the heart's energy status and its recovery from cardioplegic arrest during surgery.
ReviewOrotic acid pairs with magnesium as a cellular antioxidant transport system
A review of myocardial and neuronal protection proposes that the orotic acid component of magnesium orotate acts as a carrier that helps transport magnesium into cells, while its pyrimidine bases support the synthesis of enzymes that scavenge free radicals generated during stress.
ReviewMagnesium is an 'overlooked guardian' of the heart's electrical stability
A 2026 review describes magnesium's role in suppressing and terminating cardiac arrhythmias by regulating ion flow across cardiac membranes, and highlights its established clinical use in treating ventricular arrhythmias and reperfusion injury after a heart attack.
ReviewMagnesium is the heart's natural counterbalance to calcium
A structural review explains how magnesium acts as the body's only active calcium antagonist in heart muscle, competing with calcium at multiple protein binding sites to help tune the strength of each heartbeat (excitation-contraction coupling) and keep it stable.
MechanismFifteen years of orotic acid use tracked fewer arrhythmias and steadier blood pressure
Following 31 patients with mitral valve prolapse over 15 years of periodic orotic acid use, researchers recorded significant reductions in heart rate, tachycardia episodes, and both supraventricular and ventricular premature beats, alongside lower and more stable blood pressure readings.
Human studyMagnesium deficiency is linked to cardiometabolic and cardiovascular disease
A 2026 clinical review of hypomagnesemia found consistent associations between low magnesium status and increased risk of hypertension, metabolic syndrome and cardiovascular disease, noting that meta-analyses of controlled trials show supplementation modestly improves blood pressure and related markers in people with low baseline magnesium.
ReviewA magnesium-depletion score tracked stiffer arteries in a 2,048-person heart study
In the Brisighella Heart Study, a validated magnesium depletion score was independently associated with greater arterial stiffness (augmentation index and pulse wave velocity) after adjusting for age, blood pressure, cholesterol and kidney function, suggesting magnesium imbalance may affect vascular health.
Cohort studyMagnesium is among the minerals reviewed for their role in nutrient-deficiency heart disease
A review of cardiac manifestations of nutritional deficiencies lists magnesium alongside calcium, potassium and selenium as minerals contributing to myocardial function, vascular regulation and arrhythmia risk, noting that many of these nutrition-linked cardiac effects are reversible with appropriate repletion.
ReviewLactate signals the cell to move magnesium into its energy-producing mitochondria
Using a genetic rat model of a muscle energy disorder, researchers showed that lactate produced during muscle contraction triggers magnesium uptake into mitochondria, and that this magnesium movement is required for normal ATP synthesis and mitochondrial respiration in muscle.
MechanismA combined metabolic-therapy regimen aimed to protect the aging heart under stress
Cardiac researchers combined magnesium orotate with other metabolic cofactors (coenzyme Q10, alpha-lipoic acid, omega-3s) alongside exercise and stress reduction in a program designed to help the senescent heart recover from ischemic stress, reporting promising preliminary results.
ReviewCorrecting magnesium insufficiency is a feasible strategy in chronic heart failure
A systematic analysis of thousands of publications on trace elements and chronic heart failure concluded that magnesium insufficiency affects vascular tone, mitochondrial function, heart rhythm and cardiomyocyte sensitivity to stress hormones, and identified magnesium orotate as a practical way to correct it.
ReviewA magnesium form matters: magnesium oxide carried more risk in kidney disease patients
A large Taiwanese cohort study found that magnesium oxide use in people with chronic kidney disease was associated with a higher risk of acute kidney injury and cardiac arrhythmia, particularly in advanced disease stages - a reminder that magnesium's form and a person's kidney function both matter, and support for the standard advice to consult a health care practitioner before use if you have kidney disease or are taking other supplements.
Cohort studyA magnesium-citrate combination reversed a blood-pressure drug's blood-sugar side effect
In a randomized trial of hypertension patients on the diuretic chlorthalidone, potassium-magnesium citrate reduced the rise in fasting blood glucose seen with the drug alone, performing better than a standard potassium-chloride supplement without magnesium.
Human RCTA review of post-1997 data argues magnesium's diarrhea threshold may be too conservative
Reviewing 10 studies (five meta-analyses, five randomized trials) published after magnesium's tolerable upper intake level was first set at 350 mg/day, researchers found most reported no significant difference in diarrhea between magnesium supplementation (128-1200 mg/day) and placebo, and FDA adverse-event reports for single-ingredient magnesium products were rare.
ReviewOrganic magnesium forms absorb better than inorganic ones, a systematic review found
Reviewing 14 human studies that directly compared magnesium formulations, researchers concluded that organic forms are generally more bioavailable than inorganic ones, with the percentage absorbed also depending on the dose given.
Systematic ReviewMagnesium citrate outperformed oxide and amino-acid chelate over 60 days
In a randomized, double-blind, placebo-controlled trial comparing three magnesium forms at an identical elemental dose, magnesium citrate produced the greatest rise in blood and salivary magnesium levels, while magnesium oxide performed no better than placebo.
Human RCTNot all magnesium salts behave the same when taken with other medication
A crossover pharmacokinetic trial in healthy adults found that magnesium aspartate reduced the absorption of a thyroid medication significantly more than magnesium citrate did, illustrating that different magnesium compounds are not interchangeable even at a similar elemental dose.
Human RCTMagnesium is a cofactor in more than 600 enzymatic reactions
A 2026 review of magnesium status biomarkers describes magnesium as the body's second most abundant intracellular cation, essential to over 600 enzymatic reactions spanning endocrine, nervous, cardiovascular and immune function - yet notes that blood tests capture only a tiny fraction of the body's total stores.
ReviewNinety-nine percent of the body's magnesium is invisible to a standard blood test
A clinical reference on magnesium physiology explains that only about 1% of total-body magnesium circulates in the blood, with the rest stored in bone and muscle - meaning normal serum levels can mask a real underlying deficiency, and reinforcing why magnesium is best maintained through consistent daily intake.
ReviewA magnesium-sensing channel links blood-vessel metabolism to blood pressure control
A review of the TRPM7 magnesium channel describes magnesium as an essential cofactor for ATP, nucleic acids and hundreds of metabolic enzymes in the cells lining blood vessels, and outlines how low magnesium is linked to endothelial dysfunction, vascular inflammation and the remodeling seen in hypertension.
ReviewFrequently asked questions
What is AOR Cardio Mag 2.0?
A fully-reacted, 100% pure magnesium orotate supplement - 770 mg of magnesium orotate per capsule, providing 50 mg of elemental magnesium and 720 mg of orotic acid. It is a licensed Natural Health Product, NPN 80005854.
How do I take it?
Adults (18 years and over) take 1 capsule four times daily with food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules - swallow whole.
How is magnesium orotate different from other forms of magnesium?
Cardio Mag 2.0 uses a fully-reacted magnesium orotate complex, rather than the food-grade mixture of orotic acid with an inorganic magnesium salt used in many other 'magnesium orotate' products. Orotic acid is thought to help carry magnesium into cells, including into the mitochondria.
How much elemental magnesium does each capsule provide?
Each capsule provides 50 mg of elemental magnesium (from 770 mg of magnesium orotate, alongside 720 mg of orotic acid). At the full labelled dose of 4 capsules daily, that is 200 mg of elemental magnesium per day.
How long does one bottle last?
120 capsules is up to a 1-month supply at the full labelled dose of 1 capsule four times daily.
Is it vegan and allergen-friendly?
Yes - vegan hypromellose capsules, non-GMO and gluten-free, with only one non-medicinal ingredient (sodium stearyl fumarate).
Who should not use it?
Consult a health care practitioner before use if you are pregnant, nursing, or taking other supplements.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support cardiac function the true magnesium orotate way
Get AOR Cardio Mag 2.0 on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80005854. Cardio Mag 2.0 provides true, fully-reacted magnesium orotate (50 mg elemental magnesium and 720 mg orotic acid per capsule). The research summaries below concern magnesium, orotic acid and magnesium orotate generally and are educational - they are not claims about this finished product. Read and follow the label. Consult a health care practitioner before use if you are pregnant, nursing, or taking other supplements. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health care practitioner before use if you are pregnant, nursing, or taking other supplements. Do not use if the safety seal is broken. Store tightly sealed in a cool, dry place.
Indications
Recommended Use or Purpose: Magnesium and orotic acid exert complementary effects on the biosynthesis of pyrimidine nucleotides, maintain normal glycogen stores, protein synthesis, ATP levels, and contractile function. Research supports the ability of true magnesium orotate to support cardiac function under stress. Magnesium supports and maintains good health. Licensed Natural Health Product, NPN 80005854.
Ingredients
Medicinal Ingredients (per 1 capsule): Magnesium orotate 770 mg, providing 50 mg elemental magnesium and 720 mg orotic acid. Non-medicinal Ingredients: Sodium stearyl fumarate. Capsule: Hypromellose. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and over): Take 1 capsule four times daily with food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules; swallow capsules whole. Do not exceed daily dose unless instructed by a healthcare practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.