AOR BioFolate 1mg - Methylfolate & B12 Support | 30-60 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 1 mg (1 capsule) |
| Licensed Natural Health Product | NPN 80030511 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- BIOACTIVE FOLATE + B12, ONE CAPSULE: 1 mg of L-5-methyltetrahydrofolate (5-MTHF) plus 2.8 mcg of vitamin B12 (as methylcobalamin) - the bioactive, ready-to-use forms of both nutrients in a single daily capsule.
- SUPPORTS METHYLATION & ENERGY METABOLISM: Methylfolate and methylcobalamin are the methylated forms the body can use directly, supporting the body's ability to metabolize nutrients and vitamin B12's role in energy metabolism.
- HELPS FORM RED BLOOD CELLS: Folate and vitamin B12 both help in the formation of red blood cells, supporting healthy blood and everyday nutritional wellness.
- SUPPORTS EARLY PREGNANCY & FETAL DEVELOPMENT: Helps reduce the risk of neural tube defects when taken daily for at least three months before becoming pregnant and during early pregnancy, and supports normal early development of the fetus (brain and spinal cord).
- SUITABLE FOR VARIOUS LIFE STAGES: A clean, methylated folate and B12 formula for adults 18 and older - from those planning a pregnancy to anyone wanting foundational B-vitamin support.
- VEGAN, CLEAN FORMULA: Vegan, non-GMO and gluten-free, in a vegetarian hypromellose capsule with a short non-medicinal ingredient list and no gelatin.
- TWO SIZES FOR YOUR ROUTINE: Available as a 30-capsule (30-day) or 60-capsule (60-day) supply, both the same 1 mg L-5-MTHF plus B12 formula, so you can stock up and save trips.
- PREMIUM CANADIAN QUALITY: Made in Canada in a GMP-compliant facility by Advanced Orthomolecular Research (AOR), licensed under Health Canada NPN 80030511.
Product description
AOR BioFolate 1mg - Methylfolate (5-MTHF) Plus B12
1 mg of L-5-methyltetrahydrofolate (5-MTHF) and 2.8 mcg of vitamin B12 (as methylcobalamin) in one small vegan capsule - the bioactive, ready-to-use forms of both nutrients, to help form red blood cells, support the body's ability to metabolize nutrients, and support early fetal development. Licensed Natural Health Product NPN 80030511.
AOR BioFolate 1mg
Two bioactive B vitamins, already in the form your body uses - methylfolate and methylcobalamin, in one daily capsule.
Bioactive, Ready-to-Use Forms
L-5-MTHF and methylcobalamin are the active forms of folate and B12 the body uses directly, without needing further conversion.
Red Blood Cells & Nutrient Metabolism
Both nutrients help form red blood cells and support the body's ability to metabolize nutrients, with folate also supporting early fetal development in pregnancy.
Advanced Ingredients, Superior Results
Two real, bioactive B vitamins - here is what L-5-methyltetrahydrofolate and methylcobalamin each contribute.
L-5-Methyltetrahydrofolate (5-MTHF)
The bioactive, ready-to-use form of folate (vitamin B9) the body can use directly - helps in the formation of red blood cells and supports the body's ability to metabolize nutrients.
1 mg per capsule (250% DV)
Vitamin B12 (as Methylcobalamin)
The methylated, bioactive form of vitamin B12 - helps in energy metabolism and the formation of red blood cells, and supports normal function of the nervous system.
2.8 mcg per capsule (47% DV)AOR BioFolate: Supplement Facts
Each capsule contains:
- L-5-Methyltetrahydrofolate (Folate)1 mg
- Vitamin B12 (as Methylcobalamin)2.8 mcg
Non-Medicinal Ingredients: Microcrystalline cellulose, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose.
Recommended Use or Purpose: Helps in the formation of red blood cells. Helps in energy metabolism. Helps to maintain/support immune function and the normal function of the nervous system. Helps to maintain/support the body's ability to metabolize nutrients. Helps to reduce the risk of neural tube defects and supports the normal development of the fetus (brain and spinal cord) when taken daily at least three months before becoming pregnant and during early pregnancy. Licensed Natural Health Product, NPN 80030511.
Recommended Dose (Adults 18 years and older): Take 1 capsule daily with food, or as directed by a qualified health-care practitioner. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Do not exceed the recommended dose unless instructed by a health-care practitioner.
Cautions and Warnings: Consult a health-care practitioner prior to use if you are unsure whether you are getting enough vitamin B12, or if you are pregnant or breastfeeding - a folate supplement may mask the signs of a vitamin B12 deficiency. Do not exceed the recommended dose unless instructed by a health-care practitioner. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Keep out of reach of children. Store in a cool, dry place. Sealed for your protection - do not use if the seal is broken.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- L-5-Méthyltétrahydrofolate (Folate)1 mg
- Vitamine B12 (sous forme de méthylcobalamine)2.8 mcg
Ingrédients non médicinaux : Cellulose microcristalline, dioxyde de silicium, stéaryl fumarate de sodium. Capsule : hypromellose.
Usage ou fins recommandés : Aide à la formation des globules rouges. Aide au métabolisme énergétique. Aide à maintenir/soutenir les fonctions immunitaires et le fonctionnement normal du système nerveux. Aide à maintenir/soutenir les capacités du corps à métaboliser les nutriments. Aide à réduire le risque d'anomalies du tube neural et soutient le développement normal du fœtus (cerveau et moelle épinière) lorsqu'il est pris quotidiennement au moins trois mois avant de devenir enceinte et en début de grossesse. Produit de santé naturel homologué, NPN 80030511.
Dose recommandée (adultes de 18 ans et plus) : Prendre 1 capsule par jour avec de la nourriture, ou selon les recommandations d'un professionnel de la santé. Ne pas ouvrir les capsules, car cela pourrait compromettre la stabilité des ingrédients médicinaux. Ne dépassez pas la dose recommandée sauf indication contraire d'un professionnel de la santé.
Mises en garde et précautions : Consultez un professionnel de la santé avant l'utilisation si vous ne savez pas si vous prenez suffisamment de vitamine B12, ou si vous êtes enceinte ou allaitez - un supplément de folate peut masquer une carence en vitamine B12. Ne dépassez pas la dose recommandée sauf indication contraire d'un professionnel de la santé. Ne pas ouvrir les capsules, car cela pourrait compromettre la stabilité des ingrédients médicinaux. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec. Scellé pour votre protection - ne pas utiliser si le sceau est brisé.
NPN 80030511
Support methylation, red blood cells & nutritional wellness the easy way
Get AOR BioFolate on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR BioFolate
Two bioactive B vitamins, already in the form your body uses.
Bioactive Folate (5-MTHF)
L-5-methyltetrahydrofolate is the active form of folate found in the blood, ready for the body to use without further conversion.
Bioactive B12 (Methylcobalamin)
Methylcobalamin is a methylated, coenzyme form of vitamin B12 that helps in energy metabolism and the formation of red blood cells.
Red Blood Cell Formation
Folate and vitamin B12 both help form red blood cells, supporting healthy blood and everyday nutritional wellness.
Early Pregnancy Support
Helps reduce the risk of neural tube defects when taken daily for at least three months before pregnancy and during its early stages.
Inside every capsule
1 mg of L-5-methyltetrahydrofolate (5-MTHF) plus 2.8 mcg of vitamin B12 (as methylcobalamin) - two bioactive, ready-to-use B vitamins in one small vegan capsule.
How to use
Take with food
Take 1 capsule daily with food, or as directed by a qualified health-care practitioner.
Stay consistent
Take at the same time each day to build a steady daily routine.
Do not open capsules
Swallow the capsule whole - opening it may compromise the stability of the medicinal ingredients.
Choose your supply
Pick the 30-capsule (30-day) or 60-capsule (60-day) bottle to match your routine.
What the research says about folate and vitamin B12
Peer-reviewed studies and reviews on L-5-methyltetrahydrofolate (5-MTHF) and methylcobalamin (vitamin B12) - shared for education, not as claims about this finished product. AOR BioFolate's claims are the statements authorized under its Natural Health Product licence, NPN 80030511.
Comparable bioavailability, different profile
A widely cited pharmacokinetic review found L-5-methyltetrahydrofolate and folic acid have comparable bioavailability at equivalent doses, while noting L-5-MTHF may carry a lower potential for masking vitamin B12 deficiency.
ReviewHigher plasma rise than folic acid
A randomized crossover trial found a single oral dose of the sodium salt of (6S)-5-methyltetrahydrofolate produced a substantially higher rise in plasma 5-MTHF than an equimolar dose of folic acid.
Human RCTComparing folate forms in practice
A 2025 comparative review of folate forms found 5-MTHF avoids the transient rise in unmetabolized folic acid seen with synthetic folic acid, while folic acid remains the only form with proven trial evidence for preventing neural tube defects.
ReviewA common gene variant, higher risk
A molecular genetics study found the homozygous MTHFR 677C-to-T variant - which reduces enzyme activity and raises homocysteine - was associated with about a threefold increase in risk for premature cardiovascular disease.
Human studyMTHFR variant raises homocysteine when folate is low
In the Physicians' Health Study, men carrying the homozygous MTHFR variant had meaningfully higher homocysteine than non-carriers, an effect most pronounced when their folate levels were also low.
Human studyA genotype-folate interaction in heart disease
A study of patients with premature coronary artery disease found the MTHFR variant was linked to reduced enzyme activity, and carriers had higher plasma homocysteine particularly when their folate status was below average.
Human studyHow the body converts B12 to its active coenzymes
A kinetic study in human cells traced how supplemental vitamin B12 forms are taken up and converted into the active coenzymes methylcobalamin and adenosylcobalamin that the body actually uses.
Lab studyTissue handling of B12's active coenzyme forms
A controlled feeding study in vitamin B12-depleted rats found the tissue profile of B12's metabolically active coenzyme forms, including methyl-B12, differed depending on which supplemental form of B12 was given.
Animal studyAbsorption depends on intrinsic factor
A review of vitamin B12 bioavailability describes how absorption is governed by intrinsic factor and uptake in the ileum, with the vitamin's cobalt-centered structure supporting roles in blood cell synthesis, cognitive function and cardiovascular health.
ReviewTwo pathways clear homocysteine
A review explains that homocysteine is normally recycled back to methionine through a folate- and B12-dependent remethylation pathway, or converted to cysteine through a vitamin B6-dependent transsulfuration pathway.
ReviewMethylcobalamin fuels methionine synthase
A review of methionine synthase - the methylcobalamin-dependent enzyme that remethylates homocysteine to methionine - describes how impaired activity disrupts the folate cycle and downstream methylation reactions.
ReviewA biomarker linked to over 100 conditions
A literature review identified more than 100 conditions associated with raised plasma homocysteine and concluded that values at or below 10 micromol/L are probably safe, positioning homocysteine as a modifiable marker rather than a fixed trait.
ReviewCochrane review: B vitamins and stroke
A Cochrane systematic review of 15 randomized trials in over 71,000 participants found homocysteine-lowering B-vitamin supplementation modestly reduced stroke risk compared with placebo, though it found no significant effect on heart attacks or overall mortality.
Meta-analysisCombined B-vitamin meta-analysis
A meta-analysis of 11 randomized trials found combined folic acid, vitamin B12 and B6 supplementation lowered homocysteine and reduced stroke incidence by 14%, though it found no significant effect on overall cardiovascular events.
Meta-analysisA mechanism linking homocysteine to clotting
A mechanistic study found elevated homocysteine activated a receptor on endothelial cells that increased clotting-factor secretion, and identified a positive correlation between homocysteine and this clotting factor in patients with acute coronary syndrome.
Mechanistic + human studyMetabolic insights from the VITACOG trial
A metabolomics analysis of the VITACOG trial found B-vitamin supplementation reprogrammed metabolic pathways tied to brain energy and neurotransmission, beyond simply lowering homocysteine, in adults with mild cognitive impairment.
Human RCT (metabolomics)B vitamins and brain atrophy in the VITACOG trial
In the VITACOG trial, adults with mild cognitive impairment randomized to daily folic acid, B12 and B6 for two years showed metal- and homocysteine-related cognitive associations that were not seen in the placebo group.
Human RCTInternational consensus on homocysteine and dementia
An international expert consensus statement concluded that elevated plasma homocysteine is a modifiable risk factor for cognitive decline and dementia in older adults, and that B-vitamin treatment slows brain atrophy in those with raised homocysteine.
Consensus statementWhy excess folic acid can mask B12 deficiency
A clinical review traced how high-dose folic acid can mask the anemia of vitamin B12 deficiency without correcting the underlying deficiency, underscoring why clinicians should watch for B12 deficiency in people taking high-dose folic acid, especially older adults and others at risk of B12 malabsorption.
ReviewRe-examining the folic acid upper limit
A comprehensive review of the 1945-2017 literature on folic acid and low-B12 status examined the evidence behind the masking concern in detail and concluded it supports the safety of the current 1 mg/day upper intake level for folic acid.
ReviewNIH workshop on excess folate
An NIH expert workshop summary on excess folate/folic acid identified whether elevated folate status affects vitamin B12 function as one of three key open research questions still needing to be resolved.
Expert workshop summaryFolate's role in DNA synthesis
An Annual Review of Nutrition article describes how folate-dependent pathways move into the cell nucleus during DNA replication to supply the building block thymidylate, limiting DNA damage from uracil misincorporation.
ReviewOne network, many folate-dependent jobs
A systems-biology review describes folate-mediated one-carbon metabolism as an interconnected network supporting amino-acid interconversion, DNA building blocks, and the remethylation of homocysteine to methionine.
ReviewWhat makes B12 biologically unique
A comprehensive review of vitamin B12 biology describes its two essential coenzyme reactions - homocysteine methylation and methylmalonyl-CoA conversion - and notes the body stores B12 in far larger reserves than most other B vitamins.
ReviewFrequently asked questions
What is BioFolate and what does it do?
AOR BioFolate provides 1 mg of L-5-methyltetrahydrofolate (5-MTHF) and 2.8 mcg of vitamin B12 (as methylcobalamin) per capsule. It helps in the formation of red blood cells, supports the body's ability to metabolize nutrients, and helps reduce the risk of neural tube defects when taken before and during early pregnancy.
How is this different from regular folic acid?
L-5-methyltetrahydrofolate (5-MTHF) is the bioactive form of folate that normally circulates in the blood and is ready for the body to use directly, rather than folic acid, which the body must first convert.
How do I take it?
Adults (18 years and older) take 1 capsule daily with food, or as directed by a qualified health-care practitioner. Do not open the capsule, and do not exceed the recommended dose unless instructed.
What's the difference between the 30-capsule and 60-capsule bottles?
Both are the same 1 mg L-5-MTHF plus B12 formula at the standard 1-capsule-per-day dose. The 30-capsule bottle is a 30-day supply and the 60-capsule bottle is a 60-day supply, so you can choose based on how long you'd like your supply to last.
What's in it besides folate and B12?
Each capsule's non-medicinal ingredients are microcrystalline cellulose, silicon dioxide and sodium stearyl fumarate, in a vegan hypromellose capsule - no gelatin.
Is it made in Canada?
Yes. It is manufactured in Canada by Advanced Orthomolecular Research (AOR) and licensed by Health Canada under NPN 80030511.
Who should check with a health-care practitioner before using it?
Consult a health-care practitioner before use if you are unsure whether you are getting enough vitamin B12, or if you are pregnant or breastfeeding - a folate supplement can mask the signs of a vitamin B12 deficiency.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support methylation, red blood cells & nutritional wellness the easy way
Get AOR BioFolate on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80030511. BioFolate helps in the formation of red blood cells and helps the body metabolize nutrients, and helps reduce the risk of neural tube defects when taken daily at least three months before becoming pregnant and during early pregnancy. The research summaries below concern the nutrients L-5-methyltetrahydrofolate (folate) and vitamin B12 (methylcobalamin) and are educational - they are not claims about this finished product. Read and follow the label. Consult a health-care practitioner prior to use if you are unsure whether you are getting enough vitamin B12, or if you are pregnant or breastfeeding. Results may vary.
Important information
Safety Information
Cautions and Warnings: Consult a health-care practitioner prior to use if you are unsure whether you are getting enough vitamin B12, or if you are pregnant or breastfeeding - a folate supplement may mask the signs of a vitamin B12 deficiency. Do not exceed the recommended dose unless instructed by a health-care practitioner. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Keep out of reach of children. Store in a cool, dry place. Sealed for your protection - do not use if the seal is broken.
Indications
Recommended Use or Purpose: Helps in the formation of red blood cells. Helps in energy metabolism. Helps to maintain/support immune function and the normal function of the nervous system. Helps to maintain/support the body's ability to metabolize nutrients. Helps to reduce the risk of neural tube defects and supports the normal development of the fetus (brain and spinal cord) when taken daily at least three months before becoming pregnant and during early pregnancy. Licensed Natural Health Product, NPN 80030511.
Ingredients
Medicinal Ingredients (per capsule): L-5-Methyltetrahydrofolate 1 mg, Vitamin B12 (as Methylcobalamin) 2.8 mcg. Non-medicinal ingredients: Microcrystalline cellulose, silicon dioxide, sodium stearyl fumarate. Capsule: hypromellose. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 18 years and older): Take 1 capsule daily with food, or as directed by a qualified health-care practitioner. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Do not exceed the recommended dose unless instructed by a health-care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.