AOR Advanced PCOS Support - Myo & D-Chiro Inositol 40:1 | 120 Caps
Visit the AOR Store| Brand | AOR |
| Serving | 2 Capsules (2-4x daily) |
| Licensed Natural Health Product | NPN 80094150 |
| Quality Standards | GMP-compliant facility |
| Country | Made in Canada  |
About this item
- COMPREHENSIVE PCOS SUPPORT: A blend of Myo-Inositol and D-Chiro-Inositol in a balanced approach to help maintain regular menstrual cycles and support ovarian health - essential care for women with PCOS. Vegan, Non-GMO and Gluten-Free.
- PROMOTES HORMONAL HARMONY: Encourages hormonal balance, helps restore normal ovarian function and ovulation, and contributes to regular menstrual cycles and overall well-being for women managing PCOS.
- SUPPORTS HEALTHY GLUCOSE BALANCE: Myo-Inositol and D-Chiro-Inositol work together to help maintain healthy glucose levels and improve insulin sensitivity, an important part of managing PCOS.
- THE RESEARCHED ~40:1 RATIO: Each capsule delivers Myo-Inositol 275 mg and D-Chiro-Inositol 6.9 mg - approximately the 40:1 ratio researched for restoring ovulation in women with PCOS.
- PLUS BIOACTIVE FOLATE: 100 mcg of folate (as calcium L-5-methyltetrahydrofolate) rounds out the formula, helping form red blood cells and supporting the body's ability to metabolize nutrients.
- HIGH-QUALITY, DEPENDABLE INGREDIENTS: AOR uses pure Myo-Inositol and D-Chiro-Inositol, offering a dependable supplement for women seeking support with PCOS.
- CONVENIENT DAILY USE: 120 capsules per bottle - a 30-day supply at the standard dose, for easy integration into your daily wellness routine.
- TRUSTED CANADIAN QUALITY: Made in Canada in a GMP-compliant facility by Advanced Orthomolecular Research (AOR), licensed under Health Canada NPN 80094150.
Product description
Advanced PCOS Support - Myo-Inositol & D-Chiro-Inositol in the Researched ~40:1 Ratio
A closer look at AOR Advanced PCOS Support - Myo-Inositol and D-Chiro-Inositol combined in approximately the 40:1 ratio, plus bioactive folate, to help manage PCOS by supporting healthy glucose metabolism, ovarian function and menstrual cycle regularity. Licensed Natural Health Product NPN 80094150.
Why AOR Advanced PCOS Support
Myo-inositol and D-chiro-inositol in approximately the 40:1 ratio researched for PCOS - not just myo-inositol alone.
Backed by science
Myo-Inositol and D-Chiro-Inositol both occur naturally in the body and are involved in insulin signaling. Research has focused on the ~40:1 ratio of these two inositols as the combination studied for restoring ovulation in women with PCOS.
The AOR difference
Each capsule delivers Myo-Inositol 275 mg and D-Chiro-Inositol 6.9 mg (approximately a 40:1 ratio) plus 100 mcg of bioactive folate - vegan, non-GMO, gluten-free and made in Canada.
Advanced Ingredients, Superior Results
Three real ingredients working together - here is what each one contributes.
Myo-Inositol
The most-studied inositol isomer for PCOS - myo-inositol is involved in insulin signaling and has been researched for its role in restoring ovarian function and ovulation.
275 mg per capsuleD-Chiro-Inositol
An epimer of myo-inositol formed through an insulin-dependent conversion pathway - research has focused on the ~40:1 myo-inositol to D-chiro-inositol ratio found naturally in the body as the combination studied for restoring ovulation in PCOS.
6.9 mg per capsule (~40:1 ratio with Myo-Inositol)
Folate (Calcium L-5-Methyltetrahydrofolate)
A bioactive, ready-to-use form of folate that helps form red blood cells and supports the body's ability to metabolize nutrients - a foundational nutrient for women's reproductive health.
100 mcg per capsuleAOR Advanced PCOS Support: Supplement Facts
Each Capsule contains:
- Myo-inositol275 mg
- D-Chiro-inositol6.9 mg
- Folate (as calcium L-5-methyltetrahydrofolate)100 mcg
Non-Medicinal Ingredients: Hypromellose, Rosemary Extract, Silicon dioxide, Vitamin E. Contains a corn-derived ingredient.
Recommended Use or Purpose: Aids in the management of PCOS (polycystic ovary syndrome) by promoting healthy glucose metabolism and helping to restore normal ovarian function, ovulation and oocyte quality, and to normalize menstrual cycle irregularities. Also aids in the management of hormonal and metabolic conditions and improves insulin sensitivity in women with PCOS, and helps promote/restore pregnancy rates in women under 36 years old with PCOS undergoing in vitro fertilization (IVF). Helps to form red blood cells. Helps to prevent folate deficiency. Helps to maintain/support the body's ability to metabolize nutrients. Licensed Natural Health Product, NPN 80094150.
Recommended Dose (Adults 19 years and older): Take 2 capsules, 2 to 4 times daily, with or without food, or as directed by a qualified health-care practitioner. Recommended Duration of Use: Use for a minimum of 12 weeks to see beneficial effects. Do not open capsules; do not exceed the recommended dose unless instructed by a health-care practitioner.
Cautions and Warnings: If symptoms persist or worsen, consult a health-care practitioner. If you are pregnant or breastfeeding, consult a health-care practitioner before taking this product. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Do not exceed the recommended dose unless instructed by a health-care practitioner. Keep out of reach of children. Store in a cool, dry place. Do not use if the safety seal is broken.
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.
Chaque capsule contient :
- Myo-inositol275 mg
- D-chiro-inositol6.9 mg
- Folate (sous forme de L-5-méthyltétrahydrofolate de calcium)100 mcg
Ingrédients non médicinaux : Hypromellose, extrait de romarin, dioxyde de silicium, vitamine E. Contient un ingrédient dérivé du maïs.
Usage ou fins recommandés : Aide à normaliser la fonction ovarienne, l'ovulation, la qualité de l'ovocyte et les irrégularités du cycle menstruel chez les femmes souffrant du SOPK (syndrome des ovaires polykystiques). Aide également à gérer les conditions hormonales et métaboliques, améliore la sensibilité à l'insuline, et aide à promouvoir et à restaurer les taux de grossesse chez les femmes de moins de 36 ans atteintes de SOPK qui subissent une fécondation in vitro (FIV). Aide à la formation des globules rouges. Aide à prévenir une carence en folate. Aide à maintenir/soutenir les capacités du corps à métaboliser les nutriments. Produit de santé naturel homologué, NPN 80094150.
Dose recommandée (Adultes de 19 ans et plus) : Prendre 2 capsules, 2 à 4 fois par jour, avec ou sans nourriture, ou selon les recommandations d'un professionnel de la santé qualifié. Durée d'utilisation recommandée : Utiliser pendant un minimum de 12 semaines pour observer des effets bénéfiques. Ne pas ouvrir les capsules; ne pas dépasser la dose recommandée sauf indication contraire d'un professionnel de la santé.
Mises en garde et précautions : Si les symptômes persistent ou s'aggravent, consultez un professionnel de la santé. Si vous êtes enceinte ou si vous allaitez, consultez un professionnel de la santé avant de prendre ce produit. Ne pas ouvrir les capsules, car cela pourrait compromettre la stabilité des ingrédients médicinaux. Ne dépassez pas la dose recommandée sauf indication contraire d'un professionnel de la santé. Garder hors de la portée des enfants. Conserver dans un endroit frais et sec. Ne pas utiliser si le sceau de sécurité est brisé.
NPN 80094150
Support hormonal balance and healthy ovarian function the easy way
Get AOR Advanced PCOS Support on Amazon.ca - fast, protected delivery.
Get it on Amazon.caWhy AOR Advanced PCOS Support
Myo-inositol and D-chiro-inositol in approximately the 40:1 ratio, plus bioactive folate - four ways this formula supports women with PCOS.
Hormonal Balance
Helps restore normal ovarian function and encourages hormonal balance for women managing PCOS.
Glucose & Insulin Support
Promotes healthy glucose metabolism and helps improve insulin sensitivity - a core part of managing PCOS.
Menstrual Cycle Regularity
Helps normalize the menstrual cycle irregularities common in PCOS.
The Researched ~40:1 Ratio
Myo-Inositol and D-Chiro-Inositol in approximately the 40:1 ratio studied for restoring ovulation, plus bioactive folate for red blood cell formation and nutrient metabolism.
Inside every capsule
Myo-inositol 275 mg and D-chiro-inositol 6.9 mg in the researched ~40:1 ratio, plus 100 mcg of bioactive folate (as calcium L-5-MTHF) - three real ingredients, nothing hidden.
How to use
Take 2 capsules
Adults (19 years and older) take 2 capsules, 2 to 4 times daily, with or without food.
Stay consistent
Use for a minimum of 12 weeks to see beneficial effects, or as directed by a qualified health-care practitioner.
Do not open capsules
Swallow capsules whole - opening them may compromise the stability of the medicinal ingredients.
Do not exceed the dose
Do not exceed the recommended daily dose unless instructed by a health-care practitioner.
What the research says about myo-inositol, D-chiro-inositol and folate
Peer-reviewed studies and reviews on myo-inositol, D-chiro-inositol and folate - shared for education, not as claims about this finished product. AOR Advanced PCOS Support's claims are the statements authorized under its Natural Health Product licence, NPN 80094150.
Meta-analysis informing the 2023 PCOS guidelines
A systematic review of 30 trials (2,230 women) conducted to inform the 2023 International Evidence-based PCOS Guidelines found benefits for myo-inositol or D-chiro-inositol on several metabolic measures, with myo-inositol causing fewer gastrointestinal adverse events than metformin.
Meta-analysisMeta-analysis of nine randomized trials
Pooling 9 RCTs (247 women with PCOS on treatment, 249 controls), this meta-analysis found significant reductions in fasting insulin and the HOMA insulin-resistance index with myo-inositol supplementation, alone or combined with D-chiro-inositol.
Meta-analysisComparing myo-inositol with the standard drug metformin
A meta-analysis of randomized trials comparing metformin with myo-inositol in PCOS found the two approaches produced broadly similar short-term hormonal improvements, while metformin's use is more often limited by gastrointestinal side effects.
Meta-analysisCochrane review of insulin-sensitising treatments
This Cochrane review evaluated insulin-sensitising agents, including D-chiro-inositol, for improving reproductive and metabolic outcomes in women with PCOS undergoing ovulation induction for anovulation linked to insulin resistance.
Cochrane reviewInositol's insulin-mimetic role in metabolic disease
This review describes how myo-inositol and D-chiro-inositol show insulin-mimetic properties and help lower post-prandial blood glucose, positioning dietary myo-inositol as a nutritional strategy in conditions linked to insulin resistance such as PCOS.
ReviewHead-to-head trial against the standard insulin sensitizer
In a randomized trial of 50 women with PCOS and insulin resistance, 4 g/day of myo-inositol improved insulin sensitivity (measured by the Matsuda index) similarly to 1500 mg/day of metformin over 6 months.
Human RCTHow the inositols act on the ovary
This narrative review describes myo-inositol and its epimer D-chiro-inositol as both necessary participants in the biochemical signaling network that governs ovarian steroid hormone production.
ReviewA precursor with roles in FSH and insulin signaling
This review explains that myo-inositol is the precursor of inositol triphosphate, a second messenger regulating thyroid-stimulating hormone and FSH as well as insulin, while D-chiro-inositol derives from myo-inositol through an insulin-dependent conversion pathway.
ReviewHormonal profile in PCOS phenotype A
In 34 women with PCOS phenotype A given myo-inositol and D-chiro-inositol in a 40:1 ratio (2,255 mg/day total) for 3 months, researchers tracked changes in FSH, LH, estradiol, testosterone, SHBG and anti-Mullerian hormone alongside glucose and insulin measures.
Human studyCycles grew more regular the longer women stayed on treatment
In a retrospective study of 47 women with PCOS, the share reporting regular menstrual cycles rose from 24% at a mean of 6 months of D-chiro-inositol treatment to 51.6% at a mean of 15 months, alongside falling insulin-resistance markers.
Human studyRestoring spontaneous cycles without hormonal contraception
In a randomized trial of 70 young women (15-24) with PCOS and delayed cycles, 6 months of myo-inositol plus D-chiro-inositol (550+150 mg twice daily) restored spontaneous menstruation in about 85% of participants and shortened average cycle length from roughly 125 to 58 days.
Human RCTComparing myo-inositol with oral contraceptives in teenagers
This follow-up study in lean adolescents with PCOS compared myo-inositol with oral contraceptives across two teenage age groups, evaluating which approach better suited the menstrual and metabolic features of non-severe PCOS at this age.
Human studyTesting seven inositol ratios head-to-head
This clinical trial compared seven myo-inositol to D-chiro-inositol ratios (from D-chiro-inositol alone up to 80:1) in 56 women with PCOS and found the 40:1 ratio was the most effective for restoring ovulation and normalizing hormonal and metabolic parameters.
Human RCTWhy 40:1 is the studied combination ratio
This narrative review concludes that the myo-inositol/D-chiro-inositol combination is effective for PCOS when used at a ratio of at least 40:1 - the same ratio found naturally in blood plasma - while noting that other ratios such as 66:1 to 100:1 warrant further study.
ReviewWhy the physiological plasma ratio matters
This review notes that while myo-inositol alone benefits reproductive function, combining it with D-chiro-inositol in their physiological plasma ratio of 40:1 was found to enhance outcomes further.
ReviewMyo-inositol plus folic acid in a large real-world cohort
In an open observational study of 3,602 infertile women with PCOS given 2x2000 mg myo-inositol plus 2x200 mcg folic acid daily for 2-3 months, researchers reported improvements in PCOS symptoms and fertility markers, including in women preparing for IVF.
Human studyDietary folate intake and IVF outcomes
In a cohort of 232 women undergoing assisted reproduction, those with higher dietary folate intake (median 1,778 mcg/day) had more favorable clinical outcomes than women with lower intake, after adjusting for age, BMI and other factors.
Human studyFolate status and pregnancy rate: a systematic review
This systematic review and meta-analysis examined folate levels in women undergoing fertility treatment and their relationship to pregnancy success in assisted reproduction, an area where data remain relatively scarce.
Systematic reviewWeighing myo-inositol against metformin's side effects
This systematic review compared the therapeutic advantages and adverse effects of metformin against myo-inositol (alone or combined with other remedies) for PCOS management, drawing on studies published from 2012-2022.
Systematic reviewWhy natural alternatives gained research interest
This review notes that metformin and thiazolidinediones, long the default PCOS drug choices, carry side effects and inconsistent results in non-insulin-resistant patients, motivating growing research interest in dietary supplements and complementary approaches.
ReviewReal-world safety data from 283 women
This multi-center Indian study of 283 women with PCOS treated with myo-inositol plus D-chiro-inositol (550-150 mg) evaluated treatment patterns, clinical effectiveness and safety, reporting weight reduction in about 70% of participants alongside improved hirsutism and insulin markers.
Human studyD-chiro-inositol's mediator molecules
This review traces the discovery of D-chiro-inositol-containing phospho-oligosaccharides as insulin second messengers, a signaling pathway distinct from the classic insulin-receptor phosphorylation cascade that helps explain how insulin activates key metabolic enzymes.
Mechanism reviewTwo candidate second messengers for insulin
This review describes two proposed second messengers for insulin's signal, both derived from the same membrane glycolipid: an inositolphosphoglycan implicated in insulin's effects on metabolic enzymes, and diacylglycerol implicated in glucose transport.
Mechanism reviewThe 1988 search for insulin's missing signal
This early review describes the search for a novel second-messenger system for insulin, identifying a low-molecular-weight, inositol-glycan-structured substance capable of mimicking some of insulin's effects on metabolic enzymes.
Mechanism reviewFrequently asked questions
What is AOR Advanced PCOS Support?
It combines Myo-Inositol (275 mg) and D-Chiro-Inositol (6.9 mg) - approximately a 40:1 ratio - with 100 mcg of bioactive folate (as calcium L-5-methyltetrahydrofolate) per capsule. It is a licensed Natural Health Product, NPN 80094150, formulated to help manage PCOS.
How do I take it?
Adults (19 years and older) take 2 capsules, 2 to 4 times daily, with or without food, or as directed by a qualified health-care practitioner. Use for a minimum of 12 weeks to see beneficial effects.
Why a ~40:1 ratio of Myo-Inositol to D-Chiro-Inositol?
Approximately 40:1 is the ratio in which these two inositols naturally occur in the body, and it is the ratio that has been studied for restoring ovulation in women with PCOS.
What does the folate do in this formula?
The 100 mcg of folate (as calcium L-5-methyltetrahydrofolate) helps form red blood cells and supports the body's ability to metabolize nutrients.
Is it vegan and allergen-friendly?
Yes, it is vegan, non-GMO and gluten-free. It contains a corn-derived ingredient, so anyone with a corn allergy should not consume it.
Who should check with a health-care practitioner before using it?
Consult a health-care practitioner before use if you are pregnant or breastfeeding, or if your symptoms persist or worsen while using this product.
How long does one bottle last?
Each bottle has 120 capsules - a 30-day supply at 2 capsules twice daily, or as little as 15 days at the maximum labelled dose of 2 capsules four times daily.
Where do I buy it?
Use the orange button on this page - it takes you to the AOR listing on Amazon.ca for secure checkout and fast delivery.
Support hormonal balance and healthy ovarian function the easy way
Get AOR Advanced PCOS Support on Amazon.ca - fast, protected delivery.
Get it on Amazon.caNatural Health Product NPN 80094150. AOR Advanced PCOS Support aids in the management of PCOS by promoting healthy glucose metabolism, helping restore normal ovarian function, ovulation and oocyte quality, normalizing menstrual cycle irregularities, and improving insulin sensitivity in women with PCOS. The research summaries below concern myo-inositol, D-chiro-inositol and folate generally and are educational - they are not claims about this finished product beyond its own licensed use. Read and follow the label. If you are pregnant or breastfeeding, consult a health-care practitioner before use. If symptoms persist or worsen, consult a health-care practitioner. Results may vary.
Important information
Safety Information
Cautions and Warnings: If symptoms persist or worsen, consult a health-care practitioner. If you are pregnant or breastfeeding, consult a health-care practitioner before taking this product. Do not open capsules, as this may compromise the stability of the medicinal ingredients. Do not exceed the recommended dose unless instructed by a health-care practitioner. Keep out of reach of children. Store in a cool, dry place. Do not use if the safety seal is broken.
Indications
Recommended Use or Purpose: Aids in the management of PCOS (polycystic ovary syndrome) by promoting healthy glucose metabolism and helping to restore normal ovarian function, ovulation and oocyte quality, and to normalize menstrual cycle irregularities. Also aids in the management of hormonal and metabolic conditions and improves insulin sensitivity in women with PCOS, and helps promote/restore pregnancy rates in women under 36 years old with PCOS undergoing in vitro fertilization (IVF). Helps to form red blood cells. Helps to prevent folate deficiency. Helps to maintain/support the body's ability to metabolize nutrients. Licensed Natural Health Product, NPN 80094150.
Ingredients
Medicinal Ingredients (per capsule): D-Chiro-inositol 6.9 mg, Folate (as calcium L-5-methyltetrahydrofolate) 100 mcg, Myo-inositol 275 mg. Non-medicinal Ingredients: Hypromellose, Rosemary Extract, Silicon dioxide, Vitamin E. Contains a corn-derived ingredient. Vegan, non-GMO and gluten-free. NMIs are subject to change - always read and follow the label.
Directions
Recommended Dose (Adults 19 years and older): Take 2 capsules, 2 to 4 times daily, with or without food, or as directed by a qualified health-care practitioner. Recommended Duration of Use: Use for a minimum of 12 weeks to see beneficial effects. Do not open capsules; do not exceed the recommended dose unless instructed by a health-care practitioner.
Legal Disclaimer
Actual product packaging and materials may contain more and different information than shown on our website. Always read labels, warnings and directions before using or consuming a product. This item is sold and shipped by Amazon.ca; purchases are completed on Amazon.